ofloxacin otic / Generic mfg. - LARVOL DELTA

Does Topical Otic Drop Use at Time of Tympanostomy Tube Surgery Improve Outcomes When no Middle Ear Effusion is Present (clinicaltrials.gov) - P4 | N=9 | Terminated | Sponsor: Boston Children's Hospital | N=125 ➔ 9 | Recruiting ➔ Terminated; There was limited enrollment in the study.

Enrollment change • Trial termination • Otorhinolaryngology

Efficacy of Multiple Interventions for Moderate to Large Traumatic Tympanic Membrane Perforations: A Systematic Review and Network Meta-Analysis. (PubMed, Clin Otolaryngol) - "This network meta-analysis provides hypothesis-generating evidence that active intervention may be superior to watchful waiting for moderate to large TTMPs. FGF-2-based strategies, particularly when combined with physical scaffolds, show promise in improving healing outcomes. Additionally, ofloxacin otic solution may offer benefits in controlling local infections and optimising the middle ear microenvironment. In contrast, edge approximation appears less effective in this population. However, given the geographic homogeneity, limited number of studies and methodological constraints, these findings should be considered exploratory and require confirmation in large-scale, multicentre RCTs with standardised protocols and robust blinding procedures."

Journal • Retrospective data • Review • Infectious Disease • Otorhinolaryngology • FGF2

Does Topical Otic Drop Use at Time of Tympanostomy Tube Surgery Improve Outcomes When no Middle Ear Effusion is Present (clinicaltrials.gov) - P4 | N=125 | Recruiting | Sponsor: Boston Children's Hospital | Trial completion date: Sep 2025 ➔ Sep 2026

Surgery • Trial completion date • Otorhinolaryngology

Rare Case of Staphylococcus Lugdunensis Malignant Otitis Externa With Osteomyelitis (ATS 2023) - "Case Presentation: A 62-year-old non-swimmer type II diabetic male presented with worsening left ear pain for three weeks despite outpatient treatment with ofloxacin otic drops...He was treated with intravenous levofloxacin and piperacillin/tazobactam without improvement...Antibiotics were deescalated to cefazolin for four weeks, followed by oral levofloxacin for two weeks...Case Presentation: A 62-year-old non-swimmer type II diabetic male presented with worsening left ear pain for three weeks despite outpatient treatment with ofloxacin otic drops...He was treated with intravenous levofloxacin and piperacillin/tazobactam without improvement...Antibiotics were deescalated to cefazolin for four weeks, followed by oral levofloxacin for two weeks...It can cause various infections of the skin, soft tissue, endocarditis, and bones, especially in prosthetic joints. Although infection and osteomyelitis of the ear canal are rare, they can be life-threatening, requiring a..."

Clinical • Cardiovascular • Diabetes • Hematological Disorders • Infectious Disease • Metabolic Disorders • Otorhinolaryngology • Pain • Thrombosis • Type 2 Diabetes Mellitus

Does Topical Otic Drop Use at Time of Tympanostomy Tube Surgery Improve Outcomes When no Middle Ear Effusion is Present (clinicaltrials.gov) - P4 | N=125 | Recruiting | Sponsor: Boston Children's Hospital | Trial completion date: Sep 2022 ➔ Sep 2025 | Trial primary completion date: Sep 2021 ➔ Sep 2024

Surgery • Trial completion date • Trial primary completion date • Otorhinolaryngology

Efficacy of Tympanostomy Tubes for Children With Recurrent Acute Otitis Media (clinicaltrials.gov) - P=N/A; N=250; Completed; Sponsor: Alejandro Hoberman; Active, not recruiting ➔ Completed; Phase classification: P3 ➔ PN/A

Clinical • Phase classification • Trial completion • Otorhinolaryngology

Does Topical Otic Drop Use at Time of Tympanostomy Tube Surgery Improve Outcomes When no Middle Ear Effusion is Present (clinicaltrials.gov) - P4; N=125; Recruiting; Sponsor: Boston Children's Hospital; Not yet recruiting ➔ Recruiting

Enrollment open • Otorhinolaryngology