cannabidiol/omega-3 (CQ-001) / CanaQuest - LARVOL DELTA

Dose-dependent effects of cannabidiol in drinking water on yolk fatty acid profile and hepatic expression of polyunsaturated fatty acids (PUFAs) -related genes in laying hens: insights into the cannabidiol (CBD) systemic and molecular mechanisms of action. (PubMed, BMC Vet Res) - "While hemp-derived products such as seeds and meals have been tested in poultry diets, the specific role of purified cannabidiol (CBD) in regulating lipid metabolism and liver health in laying hens has not been previously addressed. This is the first study to investigate the molecular impact of purified CBD on lipid metabolism and liver function in laying hens, explaining its potential as a functional feed additive in poultry nutrition."

Journal • Metabolic Disorders • FADS2 • PPARA

Orally consumed cannabinoids: the effect of carrier oil on acute tissue distribution in male C57BL/6 mice. (PubMed, J Cannabis Res) - "This study profiled the greatest number of tissues to-date for the acute distribution of CBD and THC following oral consumption with a lipid carrier in mice which demonstrated a non-uniform distribution to tissues over time. SES oil proved to be far more effective as a carrier oil at delivering orally consumed cannabinoids to tissues compared to two different n-3 PUFA containing oils. Further developing our fundamental understanding of cannabinoid distribution across tissues following their consumption from foods and pharmaceuticals are necessary to establish specific pharmacokinetic profiles to aid oral dosing strategies and maximize the bioactive potential of cannabinoids."

Journal • Preclinical

Targeting Neuroinflammation in Schizophrenia: A comprehensive review of mechanisms and pharmacological interventions. (PubMed, Int Immunopharmacol) - "Therapeutically, anti-inflammatory strategies show promise: Non-steroidal anti-inflammatory drugs inhibit the cyclooxygenase pathway; minocycline modulates microglial activity; cytokine inhibitors regulate immune responses; and antioxidants and mitochondrial agents (e.g., N-acetylcysteine, omega-3 fatty acids) reduce oxidative damage...Future research should integrate single-cell genomics, neuroimaging, and biomarker stratification to elucidate neuroinflammatory mechanisms and enable precise combination therapies. Combining immunomodulatory and neurotransmitter-based strategies may overcome the limitations of traditional antipsychotics and improve clinical outcomes."

Journal • Review • CNS Disorders • Cognitive Disorders • Inflammation • Mental Retardation • Psychiatry • Schizophrenia • IL6 • TNFA

Full spectrum cannabis oil combined with omega-3 fish oil for neuropathic pain management: a novel therapeutic approach. (PubMed, J Pharm Pharmacol) - "These findings underscore the potential of CBD-enriched cannabis oil and ω-3 as a novel therapeutic approach for neuropathic pain management, offering promising implications for future research and clinical practice."

Journal • Immunology • Neuralgia • Pain • Peripheral Neuropathic Pain

PROGRESSIVE DISEASE IN A PATIENT WHO ELECTS HOLISTIC AND NATUROPATHIC TREATMENT OF PULMONARY ADENOCARCINOMA (CHEST 2024) - "In this case, patient selected supplementation did not show any favorable effect on progression based on staging imaging nor prognosis. Overall, there remains a gap in knowledge where it relates to possible protective, preventative, and harmful effects of non-traditional treatment in lung cancers and pulmonary disease whether in conjunction with or independent of standard of care therapies."

Clinical • Lung Adenocarcinoma • Lung Cancer • Oncology • Otorhinolaryngology • Pain • Pulmonary Disease • Respiratory Diseases • Solid Tumor

To face two faces of endocannabinoid system: friend or foe? (ECNP 2024) - "The AA as a precursor of endocannabinoid endogenous mediators has a vast impact on ECS' modulation and activity. There are indications of finding links between the AEA level and the risk of developing a psychotic episode. The condition that determines the status of AA as an essential fatty acid exists when there is a deficiency of linoleic acid."

CNS Disorders • Depression • Mental Retardation • Mood Disorders • Psychiatry • Schizophrenia

Feeding spent hemp biomass does not adversely affect fertility in rams. (PubMed, Am J Vet Res) - "Supplementing young rams with SHB is unlikely to affect fertility."

Journal • DAZL

Hemp Seed Oil Inhibits the Adipogenicity of the Differentiation-Induced Human Mesenchymal Stem Cells through Suppressing the Cannabinoid Type 1 (CB1). (PubMed, Molecules) - "HSO treatment significantly decreased CB1, CB2, TRPV1, and G-protein-coupled receptor 55 (GPCR55) protein levels in DM-hMSC compared to hMSC in western blot analysis. In this study, HSO initiated adipogenic differentiation in hMSC without DM, but it suppressed CB1 gene and protein expression, potentially decreasing adipocyte lipid accumulation and lipogenic enzymes."

Journal • GPR55 • PPARG • TRPV1

Anti-inflammatory effects of cannabidiol in early stages of neuroinflammation induced by high-fat diet in cerebral cortex of rats. (PubMed, Toxicol Appl Pharmacol) - "Our results strongly suggest the ability of CBD to reduce the formation of lipid inflammation precursors in rat cerebral cortex, as a primary event in the development of neurodegenerative diseases. This can raise hopes for the future use of this cannabinoid for therapeutic purposes since it is a substance lacking lasting and severe side effects."

Journal • Preclinical • CNS Disorders • Inflammation

Neuroinflammation in fetal alcohol spectrum disorders and related novel therapeutic approaches. (PubMed, Biochim Biophys Acta Mol Basis Dis) - "Despite evidence of its importance, neuroinflammation is not usually considered at diagnosis or treatment for FASD. Here, we discuss the literature regarding anti- inflammatory drugs and nutraceuticals, which hold promise for future therapeutical interventions in these disorders."

Journal • Review • Addiction (Opioid and Alcohol) • Inflammation

Pharmacist and Student Knowledge and Perceptions of Herbal Supplements and Natural Products. (PubMed, Pharmacy (Basel)) - "The median score on the objective knowledge quiz was 50% for pharmacists and 45% for pharmacy students. Ultimately, herbal supplements/natural products are recognized by pharmacists/pharmacy students as a consistent and embedded part of pharmacy practice, although there is a need to enhance knowledge and skills in this area."

Journal

Research Progress on Cannabinoids in Cannabis (Cannabis sativa L.) in China. (PubMed, Molecules) - "There are still relatively little research on cannabinoids, and a comprehensive introduction to research progress in this area is needed. This paper reviews domestic and foreign research progress on cannabinoids in cannabis sativa, which is expected to support cannabis-related research and development."

Journal • Review

Pharmacotherapy of high-risk population for developing psychosis (EPA 2023) - "There are only a few randomized controlled trials with antipsychotics (olanzapine, risperidone, aripiprazole, ziprasidone, amisulpride), either as a monotherapy or in combination with other interventions. The results did not show a superiority of drug therapy in prevention of transition to psychosis over alternative strategies; long-term antipsychotic treatment with a primarily preventive aim is not generally recommended. Other pharmacological interventions also include experimental drugs or food supplements (omega-3 polyunsaturated fatty acids, cannabidiol, D-serine)."

Clinical • CNS Disorders • Mood Disorders • Psychiatry

CanaQuest Achieves Statistically Significant Reduction of Seizures for Epilepsy Compared to Standard CBD (Yahoo Finance) - "CANAQUEST MEDICAL CORP...announced Statistically Significant efficacy results from the Clinical Dose & Efficacy Study ('Study') conducted by Dr. W McIntyre Burnham, emeritus professor of the University of Toronto's Temerty Faculty of Medicine. In comparison to standard CBD, CQ-001 (cannabidiol 'CBD' + IP formula - essential fatty acids) demonstrated 40% more seizure reduction at a medium dose in the maximal electroshock seizure (MES) model. This result indicates that CQ-001 is stronger than standard CBD, and could be used a lower dose to achieve seizure control."

Preclinical • CNS Disorders • Epilepsy