DBXO-1
/ Deck Bio
- LARVOL DELTA
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March 18, 2026
Preclinical characterization of DBXO-1, a multi-pMHC targeted bispecific T cell engager for major solid tumors
(AACR 2026)
- "Finally, DBXO-1 mediated potent, dose-dependent cytotoxicity on multiple HLA-A*02:01+ cell lines expressing the target signature, while no activity was observed in absence of either target expression or HLA restriction.Taken together, these data support continued preclinical development of DBXO-1, with the goal of entering a first-in-human clinical trial in 2027. Initial clinical development is anticipated in biomarker-selected patient populations across major solid tumors, including non-small cell lung, head and neck, and gastroesophageal cancers."
Bispecific • First-in-human • IO biomarker • Preclinical • Gastroesophageal Cancer • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • HLA-A
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