mupirocin / Generic mfg. - LARVOL DELTA

BI32 Something fishy about that ulcer: a leg ulcer on an immunocompromised scuba diver. (PubMed, Br J Dermatol) - "He had a history of psoriatic arthritis, on dual immunosuppression for the past 5 years with methotrexate and adalimumab...He received penicillin antibiotics, topical steroids and mupirocin cream from his general practitioner. He was switched from adalimumab to infliximab for a presumed diagnosis of pyoderma gangrenosum by his treating rheumatology team...His immunosuppression is on hold, both ulcerated lesions continue to slowly enlarge and he remains under close review. This case demonstrates the importance of a full medical and social history, including hobbies and travel, in all patients on immunosuppressive therapy, as they are at risk of atypical infections and presentations."

Journal • Hepatitis B • Hepatitis C • Hepatology • Human Immunodeficiency Virus • Immunology • Infectious Disease • Inflammation • Inflammatory Arthritis • Oncology • Pain • Psoriasis • Psoriatic Arthritis • Pyoderma Gangrenosum • Rheumatology • Seronegative Spondyloarthropathies • Varicella Zoster • IFNG

DS24 Secondary intention healing should be offered for shallow lower-lip defects involving the vermilion border following Mohs micrographic surgery. (PubMed, Br J Dermatol) - "Wound care included application of mupirocin or yellow soft paraffin, followed by an initial pressure dressing consisting of a nonadhesive layer, gauze and self-adhesive tape, which was removed after 48 h. Hydrocolloid dressings were then applied and changed three times weekly until full granulation and re-epithelialization were achieved...It offers a balance between minimizing the morbidity associated with complex repairs and achieving acceptable cosmetic and functional outcomes. Appropriate patient selection, shared decision making and meticulous wound care are essential for achieving favourable outcomes."

Journal • Oncology • Squamous Cell Carcinoma

SG12 A rare case of perianal granular cell tumour in a patient with localized recessive dystrophic epidermolysis bullosa. (PubMed, Br J Dermatol) - "The wound site was left open to promote healing; however, this was complicated by concomitant RDEB resulting in persisting well-demarcated ulceration unresponsive to topical Oleogel-S10, mupirocin 2% and Trimovate®. Botulinum toxin injections, topical glyceryl trinitrate and diltiazem are now being considered as the next step for this patient, with the aim of encouraging skin healing by relaxing the anal sphincter muscle...Additionally, this case presents the importance of tailored examinations under anaesthesia to facilitate perianal diagnoses in patients with EB, where skin fragility and pain limit the feasibility of routine examination methods. This case joins the existing literature that reports the challenges of wound healing in EB postoperatively, but importantly suggests that future management of other, nonsurgical perianal wounds in EB could also utilize similar techniques involving therapeutic anal sphincter muscle relaxation."

Journal • Anesthesia • Oncology • Pain • CD68

Biological Characterization of Mupirocin-KGF Hydrogel and Its Regenerative Potential in Human Fibroblast-Mediated Wound Healing. (PubMed, Molecules) - "Cellular assays demonstrated significant fibroblast migration and proliferation, with flow cytometry confirming increased wound healing markers. The formulation showed potent antimicrobial activity, including against Methicillin-resistant Staphylococcus aureus (MRSA), highlighting its promise for infected wound treatment and advanced clinical wound care."

Journal • Infectious Disease

Metagenomic insights into microbial communities and antibiotic resistance in treated wastewater for urban irrigation. (PubMed, BMC Microbiol) - "This study underscores the ecological risks of using treated wastewater in urban environment, particularly due to the persistence of ARGs and pathogenic bacteria. Targeted removal of nutrients and heavy metals during wastewater treatment could help reduce microbial and resistance-related contamination, improving the safety of treated wastewater reuse."

Journal

Reduction of surgical-site infections and improvement of scar parameters with a uniform fractional ultra-pulse CO₂ laser protocol in cosmetic surgery: a five-center retrospective cohort. (PubMed, Front Med (Lausanne)) - "A multicenter retrospective cohort enrolled 562 adults undergoing elective rhinoplasty, liposuction, breast augmentation, facelift, abdominoplasty, or Botox...All patients followed a five-day antibiotic regimen (oral cefalexin + topical mupirocin)...Standardized fractional ultra-pulse CO₂ laser therapy reduces SSIs, improves scar outcomes, and enhances patient satisfaction in cosmetic surgery. These findings support wider adoption of laser protocols, warranting further prospective, pathogen-specific research."

Journal • Retrospective data • Aesthetic Medicine • Cardiovascular • Fibrosis • Infectious Disease

Prevalence of PVL and TSST-1 genes in nasal Staphylococcus aureus carriage among healthcare workers in a tertiary hospital. (PubMed, J Infect Dev Ctries) - "A high rate of S. aureus/MRSA carriage among HCWs was observed . The presence of PVL and TSST-1 raises concern due to poor infection control compliance. Periodic screening and improved infection prevention protocols are recommended."

Journal • Infectious Disease

High-Throughput Screening Using the Self-Controlled Tree-Based Scan Statistic to Identify Medications Associated With Hospitalization for Severe Acute Liver Injury. (PubMed, Pharmacoepidemiol Drug Saf) - "High-throughput screening using tree-based scan statistics detected potentially hepatotoxic drugs for investigation in future pharmacoepidemiology studies."

Journal • CNS Disorders • Gastroenterology • Hepatology • Liver Failure • Pain

Design, synthesis, and evaluation of mupirocin prodrugs restoring systemic efficacy against MRSA. (PubMed, Eur J Med Chem) - "In both systemic and neutropenic murine lung infection models, 3d exhibited potent anti-MRSA efficacy (50-100 mg/kg). This study validates the prodrug approach as a viable strategy to unlock the systemic therapeutic potential of mupirocin against bacterial infections."

Journal • Infectious Disease • Respiratory Diseases

Antimicrobial susceptibilities and genomic characteristics of mupirocin resistant Staphylococcus aureus isolates from Tehran, Iran. (PubMed, Acta Microbiol Immunol Hung) - "Additionally, the study reveals a diverse genetic landscape, with isolates belonging to various clonal complexes, particularly CC8, CC22, and CC5. The high frequency of biofilm formation and resistance to other antibiotics underscores the need for ongoing surveillance and the development of more effective treatment strategies to combat these multidrug-resistant strains."

Journal • Infectious Disease

Therapeutic Efficacy of 2% Mupirocin in Managing Staphylococcus aureus and Streptococcus pyogenes Wound Infections (ISDS 2025) - "Topical 2% mupirocin cream proved highly effective and well tolerated for superficial wounds infected with S. aureus and/or S. pyogenes. Its excellent safety profile and efficacy support its role as a first-line treatment, potentially reducing the need for systemic antibiotics and contributing to antimicrobial stewardship."

Clinical • Dermatology • Infectious Disease

Universal Exit-Site Antibiotic Prophylaxis Reduces Exit-Site Infections in Pediatric Peritoneal Dialysis. (PubMed, Kidney Int Rep) - "Thirty-seven and 5 patients from the postprophylaxis period received mupirocin and gentamicin, respectively. Hospitalization days due to PD-related infection were significantly lower in the postprophylaxis group (2.08, 95% CI: 1.72-2.49, vs. 4.22, 95% CI: 3.68-4.81 days/patient-yrs; incidence rate ratio: 0.49, 95% CI: 0.39-0.62; P < 0.001). Daily exit-site antibiotic prophylaxis prevents gram-positive ESI or TI and shortens hospital stays in children undergoing PD."

Journal • Chronic Kidney Disease • Infectious Disease • Nephrology • Pediatrics • Renal Disease

Preoperative nasal decolonization using mupirocin vs neomycin vs placebo intranasal ointment and prevention of surgical site infections among adult patients undergoing cardiac surgery. (PubMed, Indian J Thorac Cardiovasc Surg) - "Similarly, group 2 (neomycin) also showed a reduction in risk compared to the control (RR = 0.60; 95% CI: 0.30-1.10; p ≈ 0.05) suggesting that both mupirocin and neomycin may be effective in reducing the incidence of SSIs, with mupirocin demonstrating a stronger and statistically significant effect. Preoperative nasal decolonization using 2% mupirocin intranasal ointment was effective in reducing the incidence and severity of SSIs among adult patients undergoing cardiac surgery."

Journal • Cardiovascular • Infectious Disease • Otorhinolaryngology

Evaluating Personal and Environmental Decolonization Strategies for Children with Skin and Soft Tissue Infection and Their Households - A Randomized Clinical Trial. (PubMed, Clin Infect Dis) - "While an Integrated-Approach of prolonged personal and environmental decolonization reduced SSTIs among participants with prior year SSTI, prior SSTI strongly predicted SSTI incidence longitudinally. Novel prevention strategies are needed."

Clinical • Journal • Infectious Disease

Mupirocin-Nanoemulsion Infused Salicylic Acid Gel Utilizing Nigella sativa Oil for Treatment of Imiquimod-Induced Psoriasis in Mice. (PubMed, J Drug Target) - "Histopathological and immune-histology revealed notable recovery in the MUP-SA-NEG group of mice in comparison with the control and conventional treatment groups. These findings align with promising clinical acceptability."

Journal • Preclinical • Dermatology • Immunology • Inflammation • Psoriasis

Recurrent familial furunculosis associated with Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus sublineage of the USA300 clone in Tokyo. (PubMed, J Infect Chemother) - "The index case, a 34-year-old female, and her family members (her husband and their 8-month-old son) were also affected, and all recovered after treatment with oral clindamycin, intranasal mupirocin, and hygiene interventions...All isolates were resistant to levofloxacin but susceptible to other anti-MRSA agents...In Japan, PVL-positive USA300-related clones have been increasingly identified in recent years, indicating ongoing diversification of community-associated MRSA lineages. This case illustrates the growing presence of USA300-related clones in Japan and the need for genomic surveillance and early intervention to prevent further spread in community settings."

Journal • Infectious Disease

Evening Slide Symposium (ASDP 2025) - "Her eruption was unresponsive to topical urea, ammonium lactate, and petroleum jelly as well as clobetasol ointment 0.05%...He was on tacrolimus, everolimus and prednisone as well as prophylaxis with valgangicolvir and sulfamethoxazole-trimethoprim...She was on methotrexate, adalimumab and prednisone 1mg as needed for joint swelling. She failed treatment with mupirocin, topical steroids, and oral antihistamines...Case 14 Case Summary This 67-year-old male presented with a bullous eruption on the bilateral lower legs, which developed approximately three days after an infusion of tocilizumab for his rheumatoid arthritis, which he had previously received two weeks prior. Topical triamcinolone treatment was not helpful...The provided clinical history was "rule out angioma". Session Chairs"

B Cell Lymphoma • Back Pain • Chronic Lymphocytic Leukemia • Congestive Heart Failure • Contact Dermatitis • Dermatitis • Dermatology • Diabetes • Endocrine Disorders • Gastroenterology • Gastrointestinal Disorder • Grave’s Disease • Heart Failure • Hematological Disorders • Hematological Malignancies • Hypertension • Immunology • Infectious Disease • Inflammatory Arthritis • Inflammatory Bowel Disease • Leukemia • Lyme Disease • Lymphoma • Lymphoplasmacytic Lymphoma • Metabolic Disorders • Musculoskeletal Diseases • Musculoskeletal Pain • Nephrology • Neutropenia • Non-Hodgkin’s Lymphoma • Pruritus • Rare Diseases • Renal Disease • Rheumatoid Arthritis • Rheumatology • Septic Shock • Solid Tumor • Thyroid Gland Carcinoma • Thyroid Gland Papillary Carcinoma • Type 1 Diabetes Mellitus • Type 2 Diabetes Mellitus • Ulcerative Colitis • Waldenstrom Macroglobulinemia

A Case of Immunotherapy-Induced Balanitis. (PubMed, Cureus) - "Although dermatitis can be common, serious dermatologic complications (such as Stevens-Johnson syndrome) have also been reported. In this case report we present a case of balanitis caused by pembrolizumab, briefly review the current literature on more common dermatologic immunotherapy toxicities, and discuss the more common causes and treatments of balanitis. Although drug eruptions commonly respond to discontinuation of the offending agent, here we were able to treat with topical agents, such as steroid cream and mupirocin ointment. The ability to treat the balanitis without needing to discontinue the patient's immunotherapy highlights the success in both controlling the cancer and the treatment-related toxicity."

Journal • Dermatitis • Dermatology • Immunology • Lung Cancer • Oncology • Solid Tumor • Steven-Johnson Syndrome

Laxative-induced contact burns from accidental ingestion of senna in a 2-year-old female. (PubMed, JPGN Rep) - "In the emergency department, the blisters were treated by unroofing, topical mupirocin application, a petrolatum dressing, and a 5-day course of oral cephalexin. Inquiries about sennoside use should be made when perineal burns are observed in pre-continent children to prevent misdiagnosis of child abuse. Preventive measures, including caregiver education, child-resistant packaging, and safe medication storage, are essential."

Journal • Constipation • Dermatology • Gastroenterology • Gastrointestinal Disorder • Pain • Pediatrics • Thermal Injury

Investigation and control of an outbreak of methicillin-susceptible Staphylococcus aureus skin and soft tissue infections in a neonatal intensive care unit. (PubMed, Infect Control Hosp Epidemiol) - "WGS analysis furthered the MLST analysis and identified a single MLST as the outbreak-related strain. Successful control of this outbreak was achieved with a multitude of infection prevention and control methods."

Journal • Critical care • Infectious Disease

Comparing the wound healing properties of two antibacterial peptides, CM11 and FR7, using a rat model with an infected wound. (PubMed, Biochem Biophys Res Commun) - "This study demonstrates the antibacterial and wound healing potential of CM11 and FR7 peptides, with CM11 showing greater efficacy and potential for developing treatments for wound infections, especially those caused by antibiotic-resistant strains."

Journal • Preclinical • Infectious Disease

BADMC: Bacterial Decolonization Within Dyads (clinicaltrials.gov) - P=N/A | N=20 | Recruiting | Sponsor: Duke University | Trial primary completion date: Oct 2025 ➔ Apr 2026

Trial primary completion date

Prescribing Patterns in Pediatric Cellulitis: A Multi-State Analysis Stratified by Penicillin Allergy Status (ACAAI 2025) - "Results Among 1,051,086 pediatric cellulitis patients, cephalexin was the most prescribed antibiotic (n=398,547; 37.92%), followed by mupirocin and amoxicillin/clavulanate. Of 28,871 patients with documented penicillin allergy, cephalexin (n=8,682; 30.07%) remained most prescribed, followed by TMP-SMX, clindamycin, and cefdinir...Conclusions Despite allergy labels, lower-cost β-lactams like cephalexin were still frequently prescribed, resulting in slightly lower average drug costs in the penicillin-allergic group. These findings support the need for improved allergy documentation, de-labeling strategies, and adherence to evidence-based guidelines to optimize both care quality and cost-effectiveness."

Clinical • Allergy • Dermatology • Immunology • Infectious Disease • Pediatrics

Low Rate of Infection-Related Adverse Events in Patients With Cirrhosis Treated With Rifaximin Soluble Solid Dispersion Tablets: An Analysis of Two Phase 2, Randomized, Double-Blind, Placebo-Controlled Trials (ACG 2025) - "†Topical antibiotic use: mupirocin (n=1), bacitracin + neomycin + polymyxin B (n=2), and bacitracin zinc (n=1).IR = immediate-release; PBO = placebo; SER = sustained extended-release.Figure: Figure. 516 (Study 1) and 71 (Study 2) patients were included. In Study 1, the overall median (range) age was 57.0 (26-83) y, 61.0% were male, and the majority (63.4%) had a MELD-Na score of 11-18; person-y of exposure ranged from 33.0 (IR 80 mg + SER 80 mg) to 38.8 (PBO). In Study 2, overall mean age was 61.4 y, 53.5% were male, 30% had a baseline HESI grade >2, and the median MELD score was 19.0; median treatment duration was 3.0 to 4.0 days across groups."

Adverse events • Clinical • P2 data • CNS Disorders • Fibrosis • Gastroenterology • Gastrointestinal Disorder • Hepatic Encephalopathy • Hepatology • Immunology • Infectious Disease • Nephrology • Pneumonia • Respiratory Diseases • Septic Shock

Bioactive composite based on chitosan obtained from the exoskeleton of dead Apis mellifera and selenium nanoparticles for accelerated skin wound healing: Synthesis, characterisation and in vivo assesment. (PubMed, Int J Biol Macromol) - "In vivo wound-healing studies demonstrated a significantly accelerated recovery: the CS-SeNPs group healed in (14.8 ± 0.4) days, two days earlier than the control (16.8 ± 0.7) days, and with superior performance compared to previously reported SeNP-based systems such as mupirocin-SeNP-CS hydrogels (~92 % healing after 21 days). These results highlight the novelty, biocompatibility, and therapeutic significance of insect-derived CS-SeNPs as a stable and bioactive delivery system, offering a scalable, low-cost, effective and ethical approach for skin wound therapy."

Journal • Preclinical • CNS Disorders • Psychiatry