mupirocin / Generic mfg. - LARVOL DELTA

Single-dose intranasal 10% povidone-iodine for perioperative nasal decolonization of Staphylococcus spp.: a randomized, open label, placebo-controlled trial. (PubMed, J Hosp Infect) - "Single-dose intranasal 10% PI administered preoperatively rapidly suppresses nasal staphylococcal carriage with excellent tolerability. Clinical outcomes, including SSIs, were exploratory. Larger studies are needed to determine whether this microbiologic suppression translates into reduced postoperative infection risk."

Journal • Infectious Disease

Novel topical antibacterial therapies (EADV 2026) - "These were followed by topical antibiotics such as Fucidin and Mupirocin although some of the topical azole antifungals, such as miconazole and econazole, also had good activity against bacteria such as Staph. These include :the development of new topically active antibacterial antibiotics such as ozenoxacin 1% or peceleganan,adapting nano particle technology to enhance penetration of existing antibacterials into the epidermisadopting innate mechanisms by using synthetic antimicrobial peptide compounds eg PXL150 or antibacterial enzymes or endolysins as treatments. While many of these developments are some distance from registration there is now a new wave of drug development focusing on novel approaches to enhance skin penetration or adaptation of innate forms of antimicrobial defense as well as novel antibiotics."

Infectious Disease

AMPLE-4: The Australasian Malignant PLeural Effusion (AMPLE)-4 Trial: Topical Antibiotic Prophylaxis for Infections of Indwelling Pleural Catheters in Patients with Malignant Pleural Effusions (ANZCTR) - P1/2 | N=418 | Active, not recruiting | Sponsor: Institute for Respiratory Health | Recruiting ➔ Active, not recruiting

Enrollment closed • Infectious Disease • Respiratory Diseases

VASCULAR ACCESS BEST PRACTICES TEAM IMPROVES MRSA BACTEREMIA OUTCOMES WITH MUPIROCIN COMPARED TO ETHYL ALCOHOL OR NO PROPHYLAXIS (CHEST 2026) - No abstract available

Critical care

Development and comparative evaluation of in vitro, ex vivo, and in vivo models for the assessment of broad-spectrum topical antimicrobial efficacy. (PubMed, Sci Rep) - "This study evaluates a robust, ethical preclinical screening platform for topical antimicrobials. The findings suggest that a high-concentration ceftriaxone gel has the potential to address the "mupirocin gap" by providing broad-spectrum coverage against both resistant staphylococci and Pseudomonas in experimental models."

Clinical • Journal • Preclinical • Infectious Disease

STaph Aureus Resistance-Treat Early and Repeat (STAR-TER) (clinicaltrials.gov) - P2 | N=49 | Completed | Sponsor: University of North Carolina, Chapel Hill | N=37 ➔ 49

Enrollment change • Cystic Fibrosis • Genetic Disorders • Immunology • Pulmonary Disease • Respiratory Diseases

Genomic epidemiology demonstrates increased transmission risk and persistent colonization with mupirocin resistant Staphylococcus aureus (IDWeek 2026) - No abstract available

Clinical • Infectious Disease

Bacterial Decolonization for Prevention of Radiation Dermatitis: A Randomized Clinical Trial. (PubMed, JAMA Oncol) - P2/3 | "Intranasal mupirocin ointment twice daily and chlorhexidine body cleanser once daily for 5 days prior to RT and repeated for 5 days every 2 weeks through RT...The results of this randomized clinical trial suggest that BD is effective for ARD prophylaxis, specifically for patients with breast cancer. ClinicalTrials.gov Identifier: NCT03883828."

Clinical • Journal • Breast Cancer • Dermatitis • Dermatology • Head and Neck Cancer • Immunology • Oncology • Solid Tumor

Thigh abscess following alternate-site continuous glucose monitoring sensor placement. (PubMed, Am J Health Syst Pharm) - "This case underscores the potential for a skin and soft tissue infection following off-label CGM placement, especially in patients with uncontrolled hyperglycemia. Pharmacists play a critical role in reinforcing appropriate device use, identifying early signs of infection, and coordinating interdisciplinary care to mitigate device-related complications."

Journal • Contact Dermatitis • Dermatitis • Dermatology • Diabetes • Immunology • Infectious Disease • Metabolic Disorders • Pain • Type 2 Diabetes Mellitus

Community-Associated Methicillin-Resistant Staphylococcus aureus Among Gay, Bisexual, and Other Men Who Have Sex with Men Living with HIV Who Engage in Chemsex in Barcelona, Spain: Epidemiological Patterns and Implications for Infection Control. (PubMed, Microorganisms) - "CA-MRSA infections were frequent, with substantial recurrence and antimicrobial resistance. These findings highlight challenges for infection control and antimicrobial stewardship and support further evaluation of preventive and decolonization strategies in this population."

Journal • Human Immunodeficiency Virus • Infectious Disease

Interventions for the eradication of meticillin-resistant Staphylococcus aureus (MRSA) in people with cystic fibrosis. (PubMed, Cochrane Database Syst Rev) - "Early eradication of MRSA is possible in pwCF; evidence from one trial suggested active MRSA treatment may result in a higher proportion of MRSA-negative respiratory cultures after one month compared with observation. However, longer follow-up showed treatment may make little or no difference in the proportion of participants remaining MRSA-negative. One trial of nebulised antibiotics alone compared to placebo reported a decrease in MRSA CFUs with a higher antibiotic dose. The longer-term clinical consequences of any treatment option - in terms of lung function, mortality and cost of care - remain unclear. We judged the evidence to range from high to very low-certainty, due to potential biases from trial design, high attrition rates and small sample sizes. While early eradication of respiratory MRSA in pwCF may be possible, the currently available evidence does not demonstrate that routine treatment of respiratory MRSA in pwCF is effective. Research is needed to assess..."

Clinical • Journal • Review • Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Pulmonary Disease • Respiratory Diseases • IL3RA

Impact of ethyl alcohol nasal treatment on hospital-onset Staphylococcus aureus bacteremia at a tertiary health system. (PubMed, Infect Control Hosp Epidemiol) - "Twice daily ethyl alcohol nasal treatment may be a viable alternative to existing S. aureus nasal decolonization options."

Journal • Infectious Disease

Molecular characterization of mupirocin-resistant MRSA from Germany and South Africa. (PubMed, Front Cell Infect Microbiol) - "This study highlights the genetic diversity and potential for horizontal gene transfer among mupA-positive MRSA lineages in the two countries, further supported by the regional clustering of mupA plasmids. Integrating genomic surveillance of chromosomal- and plasmid-mediated resistance with antimicrobial use and clinical data is needed for targeted MRSA infection prevention and control."

Journal • Dermatology • Gene Therapies • Infectious Disease

Dense DNA functionalization of lactoperoxidase enhances antimicrobial potency against drug-resistant wound pathogens | Poster Board #1114 (ACS-Fall 2026) - "When mupirocin fails, clinicians must turn to intravenous vancomycin. Notably, Nano-Lac has also shown efficacy against multidrug-resistant Escherichia coli, suggesting broader utility in the treatment of polymicrobial wounds where multiple resistant pathogens co-exist. This work represents a fundamental shift in how bacterial infections can be treated, moving beyond conventional antibiotics toward immune-inspired nanoscale therapeutics."

Infectious Disease • Septic Shock

Dense DNA functionalization of lactoperoxidase enhances antimicrobial potency against drug-resistant wound pathogens | Poster Board #1122 (ACS-Fall 2026) - "When mupirocin fails, clinicians must turn to intravenous vancomycin. Notably, Nano-Lac has also shown efficacy against multidrug-resistant Escherichia coli, suggesting broader utility in the treatment of polymicrobial wounds where multiple resistant pathogens co-exist. This work represents a fundamental shift in how bacterial infections can be treated, moving beyond conventional antibiotics toward immune-inspired nanoscale therapeutics."

Infectious Disease • Septic Shock

Layer-by-layer assembled chitosan/gellan gum-based smart wound dressing for sustained mupirocin delivery and enhanced wound healing activity. (PubMed, Int J Pharm) - "LbL-MUPs can be sprinkled onto an infected wound with minimal contact, transforming into a gel-based wound dressing that provides sustained release and maintains a moist wound environment. Thus, LbL-MUP highlights its potential as a scalable biopolymer-based formulation for the topical management of infected wounds, which may help address challenges in wound management and antimicrobial resistance."

Journal • TGFB1

Distribution of Mupirocin Resistance in Nasal Carriers of Methicillin-resistant Staphylococcus aureus Among ICU Healthcare Workers and Patients in Rasht, Iran. (PubMed, Arch Razi Inst) - "Resistance rates to other antibiotics included rifampin (74.07%), penicillin (87.65%), amikacin (34.56%), gentamicin (56.79%), tetracycline (83.95%), erythromycin (100%), and clindamycin (100%). No resistance was observed for linezolid or Synercid. The study revealed higher mupirocin resistance among healthcare workers compared to patients, underscoring the need for regular screening of healthcare staff and comprehensive antibiotic resistance profiling to mitigate MRSA transmission within hospital settings."

Journal • Critical care • Infectious Disease

Hospital transmission of methicillin-resistant Staphylococcus aureus driven by addictive mupA plasmids. (PubMed, medRxiv) - "This work shows that mupirocin resistance promotes hospital transmission of MRSA, identifies a previously unappreciated mechanism of plasmid addiction, and exposes a collateral vulnerability. These findings underscore the need for genomic surveillance and provide a framework to preserve mupirocin effectiveness."

Journal • CNS Disorders • Infectious Disease • Psychiatry

The Role of Decolonization in Prevention of Staphylococcus aureus Infection. (PubMed, Infect Dis Clin North Am) - "However, widespread implementation of decolonization protocols in hospitals and the community has been associated with antimicrobial resistance and microbiome perturbation. Thus, novel methods of S aureus decolonization and prevention remain a public health priority."

Journal • Review • Infectious Disease

Steatocystoma multiplex occurring during a strict diet: report of a case treated with Er:YAG laser. (PubMed, J Cosmet Laser Ther) - "Topical mupirocin and a short course of oral azithromycin were prescribed post-procedure. Cosmetic outcomes were good with minimal postinflammatory erythema. Er:YAG laser treatment may represent a safe and effective option for the management of SM with excellent cosmetic outcomes and minimal recurrence, particularly in cases with numerous lesions where surgical excision is impractical."

Journal • Dermatology

Hidden reservoirs in clinical settings: Clonal dissemination and virulence profile of multidrug-resistant Staphylococcus aureus from healthcare workers' mobile phones. (PubMed, Acta Microbiol Immunol Hung) - "High-level mupirocin-resistant isolates carrying mupA were distributed among several epidemic clones, including ST5-SCCmec IV/t002 (36.4%), ST8-SCCmec IV/t008 (27.2%), ST239-SCCmec III/t037 (18.2%), and ST22/t1869 (18.2%). Overall, the findings demonstrate substantial circulation of multidrug-resistant and virulence-associated S. aureus lineages on healthcare workers' mobile phones, underscoring their potential role in pathogen dissemination and emphasizing the necessity for targeted infection prevention and mobile device decontamination strategies in healthcare settings."

Journal • Infectious Disease • Septic Shock

Rethinking Preoperative MRSA/MSSA Screening Through Molecular Triage. (PubMed, Diagnostics (Basel)) - "However, many molecular assays reduce this decision to a binary positive/negative result, potentially obscuring clinically important distinctions in organism identity, methicillin resistance attribution, and mupirocin resistance risk...Assay-specific analytical thresholds, locked target combination rules, and prospective clinical and implementation validation are required before the framework can be used to assign patients reproducibly to management pathways. Until such validation is completed, the proposed categories should be interpreted as a testable reporting and validation architecture rather than as universal prophylaxis or decolonization instructions."

Journal • Review • Infectious Disease

Determining the Value of Screening and Decolonization in Burn Unit Management. (PubMed, J Burn Care Res) - "Phase 1: all patients who screened positive for MRSA received a decolonization protocol consisting of intranasal mupirocin twice daily for 5 days and daily chlorhexidine gluconate baths; Phase 2: all patients were screened but no decolonization measures were taken. No differences in length of stay, LOS/TBSA, incidence of infection by screened result or TBSA (once adjusted) or mortality were observed in either phase. The additional cost and resource utilization required for screening and decolonization did not appear to provide meaningful clinical advantage."

Journal • Infectious Disease

Decolonization, containment or source control? pathogen-specific anti-infective prevention for methicillin-resistant staphylococcus aureus (MRSA), carbapenem-resistant enterobacterales (CRE) and Candida auris. (PubMed, Expert Rev Anti Infect Ther) - "MRSA has the most developed trial evidence for topical decolonization in selected settings, although chlorhexidine effects may also be horizontal. CRE and C. auris prevention generally requires universal IPC measures combined with targeted screening, placement, environmental control or emerging adjunctive decolonization according to local epidemiology and capacity."

Journal • Review • Infectious Disease

Cold atmospheric plasma mediates antibiofilm activity and sensitization to further plasma and antibiotic challenges against Staphylococcus aureus. (PubMed, FEMS Microbes) - "Importantly, CAP treatment enhances bacterial susceptibility to the topical antibiotic for wound care mupirocin. These findings provide novel insights into the mechanisms underlying CAP-mediated biofilm control and offer a promising strategy to potentiate existing antimicrobial therapies."

Journal