OS-140 / RVL Pharma - LARVOL DELTA

OS140 - Exploring frontiers: cutting-edge vaccines in development for a healthier tomorrow (ECCMID 2024) - No abstract available

Identification of cyclin L1 as a hepatitis B virus host factor regulating viral transcription (EASL-ILC 2022) - "Furthermore, loss of function of cyclin L1 resulted in reduced levels Figure: (abstract: OS140) of HBV nascent RNA, highlighting its role during HBV transcription... Here, we report that cyclin L1 is a novel HBV host factor modulating the production and stability of viral RNAs. Our data contributes towards the understanding of HBV infection biology and provide a new perspective towards developing host-directed anti- HBV therapies."

Gastrointestinal Cancer • Hepatitis B • Hepatocellular Cancer • Hepatology • Infectious Disease • Inflammation • Liver Cancer • Solid Tumor • MCM2

Lymphadenectomy in gallbladder adenocarcinoma: Are we doing enough? (PubMed, Am J Surg) - "The majority of patients with gallbladder adenocarcinoma do not undergo the recommended nodal dissection, resulting in a survival disadvantage, likely due to understaging, decisions regarding adjuvant therapy and local tumor recurrence."

Journal • Gallbladder Cancer • Gastrointestinal Cancer • Hepatology • Oncology • Solid Tumor

Neuronal Cell Death and Degeneration through Increased Nitroxidative Stress and Tau Phosphorylation in HIV-1 Transgenic Rats. (PubMed) - PLoS One - "Confocal microscopy and cell viability analyses showed that treatment with an antioxidant N-acetylcysteine or a specific inhibitor of iNOS 1400W significantly prevented the increased apoptosis of neuro-2A cells by HIV-1 Tat or gp120 protein, demonstrating the causal role of HIV-1 mediated nitroxidative stress and protein nitration in promoting neuronal cell death. These changes were accompanied with elevated levels of many apoptosis-related proteins Bax and cleaved (activated) caspase-3 as well as proinflammatory cytokines including TNF-α, IL-6 and MCP-1. Collectively, these results indicate that raised nitroxidative stress accompanied by elevated inflammation, cell death signaling pathway including activated p-JNK, C-terminal C99 amyloid fragment formation and tau hyperphosphorylation are responsible for increased apoptosis of neuronal cells and neurodegeneration in 5-month old HIV-Tg rats."

Journal • Biosimilar • Gene Therapies • Immunology