TOP-V122 / Topadur Pharma - LARVOL DELTA

In situ swelling of hydrogel microneedles facilitates suprachoroidal space expansion for targeted delivery of TOP-V122 to the posterior segment. (PubMed, Acta Biomater) - "Using a clinically relevant hydrophobic compound with dual vascular activity, we demonstrate rapid, short-duration drug delivery and preliminary outcomes comparable to intravitreal injection, with reduced tissue disruption. This platform offers a practical, minimally invasive alternative for managing blinding posterior segment diseases."

Journal • Ocular Infections • Ocular Inflammation • Ophthalmology • Retinal Disorders

The combined treatment with TOP-V122, a dual-acting NO-releasing PDE-5 inhibitor, and ionizing irradiation as a novel therapeutical strategy for colorectal carcinoma. (PubMed, Radiother Oncol) - "The PDE-5 inhibitor TOP-V122 represents a novel therapeutic option for colorectal cancer alone and in combination with radiotherapy."

Journal • Colon Cancer • Colorectal Cancer • Oncology • Solid Tumor • CDKN1A