Hernicore (condoliase) / Seikagaku, Ferring - LARVOL DELTA

Associations between longitudinal resting-state functional connectivity changes and pain recovery following condoliase injection for lumbar disc herniation. (PubMed, J Orthop Sci) - "Pain improvement following condoliase injection is accompanied by longitudinal reorganization of SN-related functional connectivity, highlighting salience-cerebellar and salience-temporoparietal brain plasticity during recovery from LDH."

Journal • Musculoskeletal Diseases • Pain

Does pretreatment Pfirrmann grade modify response to intradiscal condoliase injection for lumbar disc herniation? (PubMed, J Orthop Sci) - "More advanced pretreatment disc degeneration was associated with a lower likelihood of achieving substantial leg pain improvement at 1 year after intradiscal condoliase injection. Pretreatment Pfirrmann grade may be useful for patient counseling and treatment selection."

Journal • Musculoskeletal Diseases • Pain

Reply to letter to the editor by Maji et al. (PubMed, J Orthop Sci) - No abstract available

Journal • Musculoskeletal Diseases

Comment on "A clinical study of ten-year prognosis in patients with lumbar disc herniation treated with condoliase in a phase III trial". (PubMed, J Orthop Sci) - "The 10-year follow-up contributes important evidence on condoliase-treated lumbar disc herniation, but stronger handling of missing data, clearer reporting of time to surgery and reasons for reintervention, imaging symptom linkage, and more explicit causal framing would improve interpretability. These refinements would better guide clinicians and patients discussing long-term durability, reintervention risk, and the clinical meaning of progressive imaging change after intradiscal condoliase."

Journal • P3 data • Musculoskeletal Diseases • Pain

The effectiveness of chemonucleolysis with condoliase for lumbar disc herniation in elderly patients over 70 years old. (PubMed, Neurosurg Rev) - No abstract available

Journal • Musculoskeletal Diseases

Clinical Outcomes of Intradiscal Condoliase Injection for Lumbar Disc Herniation: A Retrospective Analysis of the First 100 Cases. (PubMed, Cureus) - "No major complications were observed, including neurological deterioration, infection (discitis), anaphylaxis, hospitalization related to the procedure, or death. Conclusions Intradiscal condoliase injection was associated with a significant early reduction in leg pain in the majority of patients with LDH and may serve as an effective intermediate treatment between conservative management and surgery."

Clinical data • Journal • Retrospective data • Infectious Disease • Musculoskeletal Diseases • Pain

Impact of symptom duration on the effectiveness of intradiscal condoliase injection for lumbar disc herniation: A multicenter retrospective study. (PubMed, J Orthop Sci) - "Longer symptom duration was associated with reduced clinical and radiologic response to intradiscal condoliase injection, with duration-dependent effects becoming more evident at 12 months than at 3-6 months. Early intervention-ideally within 6-12 months of symptom onset-may maximize therapeutic benefit. These findings support a time-sensitive approach to chemonucleolytic treatment for LDH."

Journal • Retrospective data • Back Pain • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

Efficacy of Chemonucleolysis with Condoliase for Lumbar Disc Herniation in Elderly Patients Over 70 Years of Age. (PubMed, Spine Surg Relat Res) - "Condoliase offers a less invasive alternative for treating elderly patients with multiple comorbidities. Careful patient selection is critical for ensuring optimal clinical results."

Journal • Back Pain • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

Disc Level-Specific outcomes of intradiscal condoliase injection for lumbar disc herniation: A multicenter retrospective study. (PubMed, J Orthop Sci) - "The effectiveness of condoliase injection therapy differs by disc level and appears particularly favorable at upper lumbar levels. Condoliase represents a safe, minimally invasive alternative for treating upper lumbar LDH. These findings support disc-level-based treatment selection when choosing between condoliase and surgical intervention."

Journal • Retrospective data • Back Pain • Lumbar Back Pain • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

Predictive factors for outcomes of chemonucleolysis with condoliase in lumbar disc herniation: A multi-institutional study. (PubMed, J Orthop Sci) - "This study identified key factors associated with successful outcomes of condoliase in LDH. Baseline pain intensity, MRI findings (herniation occupancy rate, slip), injection level, and disease duration were significant predictors of treatment outcomes. These findings may aid clinicians in patient selection and improve treatment success."

Biomarker • Clinical • Journal • Back Pain • Lumbar Back Pain • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

Cost-effectiveness of intradiscal injection with condoliase versus microendoscopic discectomy for lumbar disc herniation: a retrospective multicenter study. (PubMed, Sci Rep) - "A probabilistic sensitivity analysis revealed that condoliase injection was cost-saving compared to MED in 92.6% of cases. These findings indicate that intradiscal condoliase injection is cost-saving compared to MED for the treatment of LDH."

Clinical • HEOR • Journal • Retrospective data • Musculoskeletal Diseases

Cost and outcome comparison between intradiscal condoliase injection and surgical treatment for lumbar disc herniation based on real-world data analysis. (PubMed, Sci Rep) - "In the first month after treatment, ICIT was associated with the least amount of analgesic prescriptions (76.1% vs. 91.2%, P < 0.001; 76.1% vs. 96.2%, P < 0.001), whereas ICIT was associated with the most in the third month (25.6% vs. 16.0%, P < 0.001; 25.6% vs. 15.7%, P < 0.001). ICIT presents a viable, low-cost treatment alternative to surgery for LDH."

Clinical • Journal • Real-world evidence • Infectious Disease • Musculoskeletal Diseases • Orthopedics • Pain

Chemonucleolysis for Lumbar Disc Herniation: History and Current State of the Technology. (PubMed, J Pain Res) - "SI-6603 (condoliase) is a mucopolysaccharidase that selectively degrades chondroitin sulfate glycosaminoglycan (GAG) chains in the nucleus pulposus...Chemonucleolytic agents with less substrate specificity include gelified ethanol and oxygen-ozone, which are under postmarket surveillance in Europe, as well as collagenase in China. The re-emergence of chemonucleolysis is anticipated to improve the treatment landscape for LDH, providing patients with the option to avoid more invasive surgical intervention."

Journal • Review • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

Enzymatic Behavior of Condoliase in Porcine Nucleus Pulposus: Ex Vivo and In Vitro Assessment. (PubMed, JOR Spine) - "We demonstrated that condoliase is retained in the nucleus pulposus and exerts its pharmacological effects by locally degrading CS without degrading collagen fibers. The results obtained in this study can be useful in predicting the mechanism of the pharmacological action of condoliase in clinical practice."

Journal • Preclinical • Musculoskeletal Diseases

Alterations in brain functional connectivity associated with pain relief following intradiscal injection of condoliase: A prospective observational study. (PubMed, Clin Neurol Neurosurg) - "Our findings demonstrate that pain relief following condoliase injection is accompanied by functional reorganization within salience network-related brain connectivity, thereby providing new insights into the central mechanisms underlying therapeutic effects in low back pain."

Journal • Observational data • Back Pain • Lumbar Back Pain • Musculoskeletal Pain • Pain

Efficacy of Chemonucleolysis With Condoliase Versus Minimally Invasive Discectomy for Lumbar Disc Herniation: A Propensity Score-Matched Retrospective Cohort Study. (PubMed, Global Spine J) - "In contrast, disc height reduction was significantly greater in the condoliase group than in the surgery group at 3 months and 1 year after treatment (P < .001, mixed-effects model). Condoliase treatment was identified as an independent risk factor for progression of disc degeneration (odds ratio, 23.60; P = .001, logistic regression analysis).ConclusionCondoliase treatment demonstrated mid-term efficacy comparable to surgical treatment; however, it required more time for pain relief and was potentially associated with progression of disc degeneration."

Journal • Retrospective data • Musculoskeletal Diseases • Orthopedics • Pain

Characteristics of hernia reduction and signal intensity changes on magnetic resonance images after condoliase therapy for lumbar disc herniation. (PubMed, J Orthop Sci) - "The present study revealed that patients with hernia reduction had a shorter duration of symptoms, more frequent HIZ of herniation, and pain relief early after condoliase therapy. Furthermore, approximately 50 % of cases without hernia reduction showed signal intensity changes within the herniation. These cases also had a shorter duration of symptoms and achieved pain relief after condoliase therapy."

Journal • Gastroenterology • Musculoskeletal Diseases • Pain

A clinical study of ten-year prognosis in patients with lumbar disc herniation treated with condoliase in a phase III trial. (PubMed, J Orthop Sci) - "No significant imaging findings necessitating surgery were observed, suggesting that chemonucleolysis with condoliase remains a safe and effective treatment option for LDH over the long term."

Journal • P3 data • Back Pain • Lumbar Back Pain • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

Clinical and Economic Outcomes of Intradiscal Injection of Condoliase for a Treatment of Lumbar Disc Herniation with Severe Low Back Pain: A Multicenter Study. (PubMed, Spine Surg Relat Res) - "Medical costs, which include remuneration for injection, drug fees, inpatient costs, and other expenses, were similar between the LBP group and all cases. This retrospective multicenter study revealed that patients with LDH with severe LBP frequently experienced improvement in radicular pain and LBP, which is similar to LDH cases without severe LBP."

Clinical • HEOR • Journal • Back Pain • Lumbar Back Pain • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

A CLINICAL OVERVIEW OF SI-6603 (CONDOLIASE) FOR RADICULAR LEG PAIN ASSOCIATED WITH LUMBAR DISC HERNIATION (ASRA-SPRING 2025) - "Summary of AEs Up to Week 13 in Four RCTs •The incidence of SAEs was similar for condoliase 1.25 U and placebo/sham groups •TEAEs leading to study discontinuation were less frequent in the condoliase groups vs placebo/sham No deaths were considered treatment-related; 3 participants died from unrelated causes The incidence of post-treatment lumbar surgery at the target level was 5.5% for condoliase 1.25 U, 0% for condoliase >1.25 U, and 7.2% for placebo/sham Table 6. AESIs by PT in ≥1% of Participants in Four RCTs Across All Time Intervals •There was a low incidence of AESIs in both treatment groups KEY TAKEAWAYS 1) Chemonucleolysis has reemerged as a potential treatment for LDH that is less invasive than surgery 2) In two phase 3 RCTs, condoliase significantly improved worst leg pain at Week 13 (vs sham/placebo) in participants with LDH 3) Integrated safety data from four RCTs showed that condoliase was well tolerated in adults with LDH-associated radicular leg pain..."

Clinical • Back Pain • Lumbar Back Pain • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

Age-specific Comparative Clinical Outcomes of Chemonucleolysis with Condoliase versus Microendoscopic Discectomy in Patients with Lumbar Disc Herniation. (PubMed, Spine Surg Relat Res) - "Condoliase and MED had equivalent 1-year outcomes, with no differences observed in efficacy across age groups. For informed decision-making, the advantages and disadvantages of each treatment must be understood."

Clinical data • Journal • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

Condoliase Injection Therapy for Lumbar Disc Herniation With Incomplete Motor Deficits in a Professional Footballer: A Case Report. (PubMed, Cureus) - "Approximately 13 weeks after the injection, his symptoms had completely disappeared, and his motor deficits had improved. After 14 weeks, the patient was able to return to competition. Condoliase injection therapy for athletes is one of the useful treatments with the potential to avoid surgery and return to competition, and it may also be effective for athletes with mild incomplete motor deficits."

Journal • Back Pain • Lumbar Back Pain • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

Pretreatment Prognostic Factors for Intradiscal Condoliase Injection in Patients with Lumbar Disc Herniation: Insights from Clinical and MRI-Based Quantitative Analysis. (PubMed, J Clin Med) - "Treatment decisions should be made with particular attention to patients with a longer symptom duration, psychological factors, and fewer degenerative discs. The most important determinant of treatment efficacy may be how condoliase acts on the herniation mass."

Biomarker • Journal • Musculoskeletal Diseases • Pain

Impact of Condoliase on Health-Related Quality of Life in Participants with Radicular Leg Pain Associated with Lumbar Disc Herniation: Results From a United States Phase 3 Clinical Trial. (PubMed, Spine (Phila Pa 1976)) - P3 | "Previous findings confirmed the efficacy and tolerability of condoliase for LDH management. Condoliase showed notable improvements in exploratory HRQoL-related outcomes, which were consistent across multiple patient-reported measures. Condoliase has the potential to enhance QoL and work productivity in individuals with LDH."

Clinical • HEOR • Journal • P3 data • Musculoskeletal Diseases • Pain

Immediate effectiveness of condoliase chemonucleolysis for lumbar disc herniation: a comparative study between patients with difficulty walking because of severe leg pain and those who can walk. (PubMed, Neurosurg Rev) - "In group N, the mean NRS-LP decreased significantly over time, and 69% of the patients were ambulatory after 1 week, 88% after 1 month, and 94% after 3 months. CC provides early pain relief and can be an immediate treatment option for patients who cannot walk independently because of severe leg pain."

Clinical • Journal • Retrospective data • Back Pain • Musculoskeletal Diseases • Musculoskeletal Pain • Pain