GZ402663 / Sanofi, Beacon Therapeutics - LARVOL DELTA

Leveraging the htsFLT01/MiRGD Complex to Enhance Apoptosis and Suppress Angiogenesis in MCF7 Breast Cancer Cells. (PubMed, Iran J Med Sci) - "This study evaluated the effect of this complex on apoptosis induction in MCF7 cells via the extrinsic apoptotic pathway, revealing increased expression of FADD, CASP8, and p53 genes. These findings highlight a synergistic relationship between anti-angiogenic and pro-apoptotic mechanisms, offering promising avenues for future breast cancer therapies."

Journal • Breast Cancer • Gene Therapies • Oncology • Solid Tumor • CASP8 • FADD

In vivo inhibition of angiogenesis by htsFLT01/MiRGD nano complex. (PubMed, Transl Oncol) - "Beyond its anti-angiogenic effects, the treatment also induces apoptosis and inhibits tumor cell proliferation, reinforcing its role as a promising targeted therapy for angiogenesis-dependent malignancies. These results underscore the potential of htsFLT01/MiRGD in cancer treatment and pave the way for future clinical applications in anti-angiogenic therapies."

Journal • Preclinical • Breast Cancer • Gene Therapies • Oncology • Solid Tumor • CD31 • PECAM1

MiRGD peptideticle targeted delivery of hinge-truncated soluble VEGF receptor 1 fusion protein to the retinal pigment epithelium cell line and newborn mice retina. (PubMed, Int J Biol Macromol) - "The vascular development was inhibited in the deep, intermediate, and superficial capillary plexus layers in the retina. The novel drug MiRGD/htsFLT01 complex, represents a promising potential platform for targeted gene therapy in the eye due to its biocompatibility, likely safety and highly effective function."

Journal • Preclinical • Gene Therapies • VEGFA

Design, construction and in vivo functional assessment of a hinge truncated sFLT01. (PubMed, Gene Ther) - "The AAV2-htsFLT01 virus suppressed vascular development in the eyes of newborn mice. The htsFLT01 gene construct is a novel anti-angiogenic tool with promising improvements compared to existing treatments."

Journal • Preclinical • Age-related Macular Degeneration • Gene Therapies • Macular Degeneration • Ophthalmology • Retinal Disorders • Wet Age-related Macular Degeneration • FLT1

sFLT01 modulates invasion and metastasis in prostate cancer DU145 cells by inhibition of VEGF/GRP78/MMP2&9 axis. (PubMed, BMC Mol Cell Biol) - "Overall, these data indicated that the inhibitory impact of sFLT01 on cancer cells growth and invasiveness could be mediated through the modulation of VEGF/GRP78/MMP2&9 axis and activation of TIMPs."

Journal • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor • HSPA5 • MMP2 • MMP9 • PGF • TIMP1

[VIRTUAL] sFLT01-anti-ANG2: a Novel Potent Inhibitor as a Next-generation Anti-angiogenic Molecule (ARVO 2021) - "We propose that targeting various angiogenic pathways by sFLT01-anti-ANG2 may be a fundamental approach in development of the next generation antiangiogenic therapeutic drugs."

Age-related Macular Degeneration • Macular Degeneration • Ophthalmology • Retinal Disorders • Wet Age-related Macular Degeneration • PGF

Basic FGF or VEGF gene therapy corrects insufficiency in the intrinsic healing capacity of tendons (Nature) - "...resulted in substantial amelioration of the low growth factor activity with significant increases in bFGF or VEGF from weeks 4 to 6 in the treated tendons (p < 0.05 or p < 0.01), (2) significantly promoted production of type I collagen and other extracellular molecules (p < 0.01) and accelerated cellular proliferation, and (3) significantly increased tendon strength by 68–91% from week 2 after AAV2-bFGF treatment and by 82–210% from week 3 after AAV2-VEGF compared with that of the controls (p < 0.05 or p < 0.01)."

Preclinical • Gene Therapies • Inherited Retinal Dystrophy • Ophthalmology

New gene therapy for vision loss is safe in humans, study suggests (ScienceDaily) - "From that result, the researchers conclude that even if further studies affirm the safety and value of their gene therapy, it may have limitations for broad use."

Retrospective data