bisnorcymserine (ANVS-301) / Annovis Bio, National Institute on Aging, National Institutes of Health, Amgen - LARVOL DELTA

Annovis Bio to Present at The LD 500 Virtual Conference (StockHouse) - "Annovis Bio Inc....today announced that it will be presenting at the LD 500 investor conference on Tuesday, September 1 at 9:20 AM EDT. Annovis Bio CEO Maria Maccecchini, Ph.D. will be presenting. 'Annovis Bio is at a very exciting stage right now with two Phase 2 trials underway...I look forward to sharing our unique and promising approach to treating Alzheimer's, Parkinson's, and other neurodegenerative diseases with the LD 500 audience.'"

Clinical • Alzheimer's Disease • CNS Disorders • Parkinson's Disease

Analysis of risk factors leading to postoperative urethral stricture and bladder neck contracture following transurethral resection of prostate. (PubMed) - Int Braz J Urol - "Lower resection speed, intraoperative urethral mucosa rupture and postoperative continuous infection were associated with a higher risk of US while severer storage phase symptom and smaller prostate size were associated with a higher risk of BNC after TURP."

Journal • Biosimilar • Immunology

Bladder Neck Urothelial Carcinoma: A Urinary Bladder Subsite Carcinoma With Distinct Clinicopathology. (PubMed) - "In conclusion, BNCs present with a significantly higher frequency of muscle invasion and advanced tumor stage, lymphovascular invasion, as well as local and distant metastasis at diagnosis compared with the non-BNCs group. Recognition of these unique clinicopathologic features with early detection and possibly more aggressive management of BNC can potentially have a significant impact on the patient's outcome."

Journal • Biosimilar • Oncology

The repetitive DNA element BncDNA, enriched in the B chromosome of the cichlid fish Astatotilapia latifasciata, transcribes a potentially noncoding RNA. (PubMed) - Chromosoma - "The potential for interaction between BncRNA and known miRNAs were computationally predicted, resulting in the identification of possible binding of this sequence in upregulated miRNAs related to the presence of B chromosomes. In conclusion, Bnc is a transcriptionally active repetitive DNA enriched in B chromosomes with potential action over B chromosome maintenance in somatic cells and meiotic drive in gametic cells."

Journal • Biosimilar

Preliminary Study on Biosynthesis of Bacterial Nanocellulose Tubes in a Novel Double-Silicone-Tube Bioreactor for Potential Vascular Prosthesis. (PubMed) - "Scanning electron microscopy inspection showed that the tubular BNC had a multilayer structure in the beginning but finally it disappeared and an intact BNC tube formed. The mechanical properties of BNC tubes were comparable with the reported value in literatures, demonstrating a great potential in vascular implants or in functional substitutes in biomedicine."

Journal • Biosimilar

Bisnorcymserine in Healthy Adult Volunteers (clinicaltrials.gov) - P1; N=72; Completed; Sponsor: National Institute on Aging (NIA); Recruiting ➔ Completed; N=200 ➔ 72; Trial completion date: Jul 2019 ➔ Jan 2019; Trial primary completion date: Jul 2019 ➔ Jan 2019

Clinical • Enrollment change • Trial completion • Trial completion date • Trial primary completion date