nystatin oral / Generic mfg. - LARVOL DELTA

Characterization and employment of novel α-ketoglutarate dependent oxygenases for efficient synthesis of antifungal alkyl citrates. (PubMed, Bioresour Technol) - "Bioactivity assays demonstrated that sporothriolide 2 exhibits antifungal activity comparable to nystatin, while epoxide 9 and lactone 10 showed modest inhibition. Our study sheds light on the development and large-scale synthesis of novel alkyl citrates with promising antifungal activity."

Journal

In silico screening of potential FGF2 inhibitors for cancer therapy. (PubMed, In Silico Pharmacol) - "Molecular docking study showed Elbasvir (1) to exhibit the strongest binding affinity (-8.1 kcal/mol), followed by Velpatasvir (2) (-7.6 kcal/mol), Daclatasvir (3) (-7.5 kcal/mol), Ritonavir (4) (-6.2 kcal/mol), Paliperidone Palmitate (5) (-5.9 kcal/mol), Saralasin (6) (-5.4 kcal/mol), Nystatin (8) (-5.2 kcal/mol), and Cobicistat (-5.1 kcal/mol)...Overall, the study provides mechanistic insights into the molecular interactions between FGF2 and these candidate drugs, highlighting the promising potential of compounds 1-6 and 8 for subsequent in vitro validation in cancer therapeutics. The online version contains supplementary material available at 10.1007/s40203-025-00495-2."

Journal • Acute Myelogenous Leukemia • Brain Cancer • Breast Cancer • Gastric Cancer • Glioblastoma • Hematological Malignancies • Leukemia • Lung Cancer • Nasopharyngeal Carcinoma • Non Small Cell Lung Cancer • Oncology • Solid Tumor • FGF2 • FGFR

Oral scald injury misdiagnosed as oral thrush in a newborn. (PubMed, BMJ Case Rep) - "A neonate with a history of a brief resolved unexplained event presented to the emergency department with white oral plaques initially diagnosed as thrush and treated with nystatin...With multidisciplinary therapy, swallow function improved and the infant transitioned to full oral feeds. This case highlights the importance of maintaining a broad differential when evaluating common neonatal findings and demonstrates the potential complications of overlooked thermal injuries in this population."

Journal • Gastrointestinal Disorder • Inflammation • Pediatrics • Pneumonia • Thermal Injury

Malassezia pachydermatis Acquires Resistance to Polyenes in the Laboratory Model. (PubMed, Pathogens) - "This study presents a model investigation into the development of tolerance to polyene antifungal drugs (nystatin and natamycin) in strains of Malassezia pachydermatis. Such an approach may support targeted therapy development and help identify strains predisposed to drug adaptation. These findings hold promise for assessing therapeutic risk in immunosuppressed patients and for building resistance datasets that can support artificial intelligence algorithms in predicting fungal resistance mechanisms."

Journal • Gastrointestinal Disorder • Infectious Disease

Beauveria bassiana keratitis - the first Hungarian case report. (PubMed, BMC Ophthalmol) - "Following the failure of initial antibiotic treatment, local antifungal therapy (nystatin eye ointment and propamidine isethionate eye drops) was administered, resulting in significant vision improvement over three months. Timely recognition and targeted treatment of B. bassiana keratitis are crucial for successful disease management. The significance of this case lies in the fact that this pathogen has not been previously documented in Hungary, highlighting the diagnostic and therapeutic challenges of rare opportunistic fungal infections."

Journal • Cardiovascular • Diabetes • Hypertension • Infectious Disease • Keratitis • Metabolic Disorders • Ocular Infections • Ocular Inflammation • Ophthalmology • Pain • Type 2 Diabetes Mellitus

Targeted Synthesis, In Vitro Antimicrobial Profiling and In Silico Investigation of Furan- and Pyrrole-Linked Indoline Hybrids Incorporating Amide and Sulfonamide Functionalities. (PubMed, Chem Biodivers) - "The antifungal activity of these newly synthesize compounds was also assessed in vitro against Aspergillus niger and Candida albicans, the results emphasized that compounds 6k and 13e displayed the highest activity, compared to the standard antifungal drug nystatin. Furthermore, in silico investigations of compounds 6a-k and 13a-k with E. coli DNA gyrase, using molecular docking and molecular dynamics simulations, revealed exceptional binding affinity of these derivatives to the protein's active site. Additionally, in silico ADMET analysis indicated favorable pharmacokinetic properties with no major toxicity concerns, highlighting their potential as effective antimicrobial agents."

Journal • Preclinical

Fluorescent Probes Derived from the Polyene Class of Antifungal Drugs Reveal Distinct Localization Patterns and Resistance-Associated Vacuolar Sequestration in Candida Species. (PubMed, Angew Chem Int Ed Engl) - "Amphotericin B, nystatin, and natamycin are the only polyene antifungals in clinical use and remain last-resort therapies for severe fungal infections. These findings suggest that vacuolar sequestration contributes to polyene resistance and may represent an unrecognized aspect of the fungal stress response. More broadly, this work provides the first direct visual evidence that polyene structure dictates subcellular distribution patterns in fungal cells."

Journal • Infectious Disease

TICT-activated viscosity sensitive mitochondrial probes for imaging and early diagnosis of drug-induced liver injury. (PubMed, Anal Chim Acta) - "Collectively, probe WAC2 provides a powerful platform for real-time, in situ monitoring of mitochondrial viscosity and offers valuable insights for early diagnosis and mechanistic investigation of DILI."

Journal • Hepatocellular Cancer • Hepatology • Inflammation • Liver Cancer • Liver Failure • Metabolic Disorders • Solid Tumor

Comparing the Effect of Photodynamic Therapy With 660 and 450 nm Lasers and Cold Atmospheric Plasma on Candida albicans: An Invitro Study. (PubMed, J Lasers Med Sci) - " Cold plasma with the feeding gas of helium for 180 seconds exposure and the low-power 660 nm laser showed inhibitory effects on C. albicans colonies and were more effective than PDT. Nystatin application significantly reduced the number of C. albicans colonies and was more effective than cold plasma, laser irradiation, and PDT."

Journal • Preclinical • Infectious Disease

Investigating inhibitory effect of sterol targeting compounds against B. anthracis: Membrane Microdomain a probable target. (PubMed, Res Microbiol) - "These findings highlight membrane microdomains as crucial regulators of virulence in B. anthracis and identify RALBIs as promising adjunctive agents. By targeting MMd, sterol inhibitors disrupt multiple pathogenic pathways and enhance antibiotic efficacy, underscoring their potential as novel antibacterial strategies."

Journal

Use of selective decontamination of the digestive tract in burn patients: A European survey. (PubMed, Burns) - "A minority of European burn centres routinely used SDD, while the majority did not. Among those that used SDD, treatment regimens were largely aligned with practices commonly used in ICU patients. Notably, there was significant interest among European burn centres in participating in future clinical trials comparing SDD versus no SDD in burn patients."

Journal • Anesthesia • Critical care • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Pneumonia • Thermal Injury

Characterization and Phenolic Profiling of Anticandidal Polycladia myrica and Its Mediated Iron Nanoparticles with the Evaluation of Their Antioxidant, Anti-Alzheimer, Catalytic Degradation, and Anticancer Activity via the P53 Pathway. (PubMed, ACS Omega) - "The inhibition zone diameters of PFeNPs and Nystatin reference drug (mean ± SD) were about 18.82 ± 0.87 and 19.74 ± 0.98, respectively...These results were confirmed by scanning electron microscopy, which revealed lysis and bursting of the exterior cell surface, along with deformation and death of Candida albicans cells in treated Candida isolate. These results strongly suggested the possibility of introducing PFeNPs as a cotherapy for Candida infections in diabetic cancer patients."

Journal • Alzheimer's Disease • Candidiasis • CNS Disorders • Infectious Disease • Lung Cancer • Oncology • Solid Tumor • TP53

Antifungal prophylaxis-Where are we today? (PubMed, Semin Fetal Neonatal Med) - "Compared to nystatin, fluconazole prophylaxis for ELBW infants is more effective in preventing ICI and since it can be given intravenously, it is not dependent on enteral feeding status. Risk factors (e.g., receiving treatment with antibiotics or parenteral nutrition, presence of a CVC, vaginal delivery) can be used to both identify high-risk patients and define the time period when antifungal prophylaxis is beneficial. Independently of GA, high-risk infants also include those receiving third and fourth generation cephalosporins or carbapenems and those with complex gastrointestinal conditions (e.g. necrotizing enterocolitis, bowel perforation, gastroschisis)."

Journal • Review • Candidiasis • Gastrointestinal Disorder • Infectious Disease • Rare Diseases

Invasive Pulmonary Infection Secondary To Immunodeficiency/STAT1 Mutation (ACAAI 2025) - "Thrush did not clear with Nystatin...She was treated with IV amphotericin B and fluconazole, then discharged on oral fluconazole maintenance treatment. This case emphasizes the importance of considering immunodeficiency in children with recurrent or atypical infections and highlights the value of early multidisciplinary collaboration."

Anemia • Candidiasis • Cough • Gastrointestinal Disorder • Hematological Disorders • Human Immunodeficiency Virus • Infectious Disease • Pneumonia • Respiratory Diseases • Tetanus • IL17A • STAT1

Advanced Cirrhosis in a Patient with Suspected Auto-Brewery Syndrome and Recurrent Alcohol Intoxication-Like Episodes (ACG 2025) - "She was taking fluconazole, nystatin, and Lactobacillus at presentation.Prior GI evaluations were inconclusive, with a failed carbohydrate challenge and no biopsy-proven ABS...She exhibited grade II hepatic encephalopathy and was started on lactulose...Psychiatry and infectious disease were consulted for evaluation of antifungal/probiotic use and underlying behavioral concerns. This case underscores the difficulty of diagnosing ABS in patients with coexisting AUD and advanced liver disease. A multidisciplinary approach is vital in evaluating unexplained alcohol levels and safely managing cirrhosis-related complications.Figure: Portal hypertension is evidenced by cirrhotic liver with splenomegaly."

Clinical • Metastases • Addiction (Opioid and Alcohol) • Cardiovascular • CNS Disorders • Fatigue • Fibrosis • Hematological Disorders • Hepatic Encephalopathy • Hepatology • Immunology • Infectious Disease • Portal Hypertension • Psychiatry • Thrombocytopenia

A Rare Case of Immune Checkpoint Inhibitor Esophagitis Due to Pembrolizumab (ACG 2025) - "We describe a case of grade 3/4 pembrolizumab-induced esophagitis and mucositis in a patient receiving treatment for stage IIA breast adenocarcinoma.Case Description/ A 72-year-old female with triple-negative, poorly differentiated stage IIA breast adenocarcinoma achieved complete response to neoadjuvant therapy (doxorubicin, cyclophosphamide, and pembrolizumab)...Her symptoms proved refractory to empiric therapies including azithromycin, nystatin, fluconazole, micafungin, and saline gargles...Flexible laryngoscopy confirmed ulcerative mucositis with concomitant laryngopharyngitis.Pembrolizumab was discontinued, and she was initiated on prednisone 1 mg/kg, achieving significant pain improvement within one week...Treatment with fluconazole and pantoprazole was initiated...Management includes acid suppression (PPIs, H2 blockers), mucosal protectants (sucralfate), and corticosteroids for moderate to severe cases. This case highlights the need for clinician awareness of rare..."

Checkpoint inhibition • Clinical • Breast Cancer • Dermatology • Gastroenterology • Gastrointestinal Disorder • Immunology • Mucositis • Oncology • Triple Negative Breast Cancer

Persistent Gastrointestinal Dysbiosis in a Male Patient With Post-Acute COVID-19 Syndrome: A Case Report Highlighting Microbiome-Related Sequelae (ACG 2025) - "He was treated with nystatin, probiotics, enzymes, and a gluten-free, low-sugar diet...Calprotectin and eosinophil activation protein were within normal range, ruling out active intestinal inflammation. Occult blood was undetectable, and β-glucuronidase was in the expected range."

Case report • Clinical • Dysbiosis • Alzheimer's Disease • Cognitive Disorders • Fatigue • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Novel Coronavirus Disease • Respiratory Diseases • ELANE

Esophageal Lichen Planus: An Underdiagnosed Cause of Dysphagia -- A Case Report (ACG 2025) - "She was started on budesonide and nystatin, with initial improvement. Diagnosis relies on high clinical suspicion, endoscopy, and biopsy. A multidisciplinary approach is needed with further research into targeted therapies."

Case report • Clinical • Dermatology • Dermatopathology • Esophageal Cancer • Esophageal Squamous Cell Carcinoma • Fibrosis • Gastroenterology • Gastrointestinal Disorder • Hepatitis C • Human Immunodeficiency Virus • Immunology • Infectious Disease • Lichen Planus • Mucositis • TP53

Effect of preirradiation time of erythrosine + potassium iodide-mediated photodynamic therapy on candidal inhibition and singlet oxygen formation. (PubMed, Photochem Photobiol) - "Phosphate-buffered saline, and nystatin were negative and positive controls, respectively...Singlet oxygen levels correlated mildly with candidal reduction in the lower erythrosine group but not the higher group, likely due to singlet oxygen saturation. A 1-min preirradiation with 200 μM erythrosine + 100 mM KI generates singlet oxygen to inhibit C. albicans biofilms and shows potential for clinical oral candidiasis treatment."

Journal • Candidiasis

Evaluation of Antifungal Activity Against Candida albicans Isolates From HIV-Positive Patients with Oral Candidiasis in a Major Referral Hospital, West Java, Indonesia. (PubMed, HIV AIDS (Auckl)) - "albicans predominated, with fluconazole and voriconazole showing high susceptibility, while nystatin and itraconazole demonstrated inhibition zones but could not be categorically interpreted due to the absence of established breakpoints. Routine species identification and susceptibility testing remain essential to guide therapy and monitor emerging resistance in immunocompromised populations, highlighting the need for further validation studies."

Journal • Candidiasis • Human Immunodeficiency Virus • Infectious Disease

Antifungal Resistance of Candida spp. Isolates From HIV/AIDS Patients in Iran 1999-2024: A Systematic Review and Meta-Analysis. (PubMed, J Clin Lab Anal) - "The use of amphotericin B, caspofungin, and nystatin for the treatment of Candida spp. in HIV-AIDS patients in Iran is recommended based on clinical indication."

Journal • Retrospective data • Review • Human Immunodeficiency Virus • Infectious Disease

Antifungal Drug Efficacy Profiles Against Vaginal Candida albicans: A Multi-Drug Comparative Analysis. (PubMed, J Clin Med) - " This comparative observational study was carried out to determine the in vitro susceptibility of six antifungal compounds [fluconazole, voriconazole, itraconazole, ketoconazole, nystatin, and amphotericin B] to 163 vaginal Candida albicans isolates obtained in three hospitals in Tabuk, Saudi Arabia. There is a high rate of resistance to fluconazole, suggesting it should no longer be the first choice of treatment in this area. These findings highlight the need for local monitoring of drug resistance to guide treatment choices and emphasize the importance of using antifungals properly to prevent increased resistance."

Journal • Infectious Disease

Aetiology of Vulvovaginal Candidiasis in Ecuador and In Vitro Antifungal Activity Against Candida Vaginal Isolates. (PubMed, J Fungi (Basel)) - "In vitro antifungal susceptibilities to amphotericin B, clotrimazole, fluconazole, itraconazole, miconazole, and nystatin were determined by CLSI methods. Fluconazole- and miconazole-resistant C. albicans isolates were recovered from 5 (8.9%) and 24 (42.9%) of 56 AVVC patients, respectively, and from 1 (8.3%) and 5 (41.7%) of 12 RVVC patients, respectively. Fluconazole and miconazole resistance is relevant in Ecuador, emphasising the need for targeted antifungal strategies."

Journal • Preclinical • Candidiasis • Vaginitis

Development and Evaluation of Nystatin-Loaded Novasomal Gel for the Treatment of Candida albicans Infection: In Vitro Microbiological and Skin Compatibility Study. (PubMed, Gels) - "Skin irritation assessment in rats revealed only minor, temporary erythema, and the calculated Primary Irritation Index (0.22) confirmed a non-irritant profile. These findings suggest that the developed novasomal gel offers a promising approach for enhancing the treatment of fungal infections by enabling prolonged drug release, minimizing dosing frequency, and improving patient compliance."

Journal • Preclinical • Candidiasis • Dermatology • Infectious Disease

Specialized Pro-Resolving Mediator Loaded Extracellular Vesicles Mitigate Pulmonary Inflammation. (PubMed, Am J Respir Cell Mol Biol) - "Human embryonic kidney 293T (HEK293T) cells transfected with the multigene expression vector and cultured in the presence of fatty acid free bovine serum albumen (BSA)-complexed docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and aspirin produced multiple members of the Resolvin D, aspirin-triggered Resolvin D series, and Resolvin E1 and E2, along with their biosynthetic precursors, which were subsequently packaged into EVs (referred to as Resolvin-EVs)...Effects of Resolvin-EVs on endothelial permeability and macrophage activation were abrogated by pharmacological inhibition of EV uptake using nystatin and cytochalasin D. Furthermore, Resolvin-EVs enhanced efferocytosis in THP-1 derived macrophages compared to Control-EVs. Notably, post-injury administration of Resolvin-EVs attenuated pulmonary inflammation in LPS-treated mice without inducing systemic or pulmonary toxicity. Together, these findings establish a novel, scalable platform for generating..."

Journal • Acute Lung Injury • Inflammation • Pneumonia • Respiratory Diseases • CDH5 • IL6 • TNFA