nystatin oral / Generic mfg. - LARVOL DELTA

Bioprospecting of Curcuma longa rhizomes reveals a 2.5 kDa antifungal peptide with potent anti-Candida albicans activity and synergistic interaction with nystatin. (PubMed, Nat Prod Res) - "Strong synergistic interactions were observed with nystatin and fluconazole (FIC indices of 0.11 and 0.30, respectively). The peptide also inhibited germ-tube formation at 2 x MIC. These findings highlight a promising plant-derived peptide for antifungal combination therapy."

Journal

In silico pathway-based subtractive proteomics for identifying novel drug targets in Candida albicans with structure-guided drug repurposing of aspartate-semialdehyde dehydrogenase inhibitors. (PubMed, J Mol Model) - "The structure-guided virtual screening identified five potent hits: Acarbose, Iotrolan, Iodixanol, Nystatin, and Ferric derisomaltose, which exhibit better affinity, ranging from -12.25 to -11.90 kcal/mol with CaASADH and exhibits stable binding during 500 ns MD simulations, highlighting their potential as lead compounds for anti-C. Subtractive proteomics pipeline was performed in a standalone Linux environment, and the three-stage Schrödinger's Glide docking algorithm was used for molecular docking studies. All MD simulations were conducted using GROMACS for 500 ns, and the conformational dynamic stability was examined using RMSD, RMSF, Rg, SASA, PCA, CD-HIT, BLASTp, DrugBank, BlastKOALA, screening, SiteMap, LigPrep, SwissParam, MMPBSA, and CHARMM36 force field."

Journal • Infectious Disease

An Unusual Cause of Esophageal Obstruction in an Immunosuppressed Patient (ACG 2026) - "Hospital course complicated by recurrent neutropenic fevers, severe HSV mucositis on ganciclovir, recurrent epistaxis, chronic cancer-related pain on opioids, right internal jugular vein thrombus requiring anticoagulation, and progressive dysphagia for which GI was consulted...Empiric treatment with nystatin also provided no improvement...It also underscores the complexity of patients with hematologic malignancies undergoing stem cell transplantation. Figure: Figure 1: CT chest showing marked luminal distention of the esophagus with near-complete obstruction extending from the level of the thyroid to the gastroesophageal junction, concerning for foreign body, presumably extensive food impaction, without evidence of stricture or other mass lesion"

Clinical • Acute Lymphocytic Leukemia • Bone Marrow Transplantation • Febrile Neutropenia • Gastrointestinal Disorder • Hematological Malignancies • Infectious Disease • Leukemia • Mucositis • Pneumonia • Respiratory Diseases • T Acute Lymphoblastic Leukemia • T-cell Acute Lymphoblastic Lymphoma • Thrombosis

Last Call from the Small Bowel: A Case of Autobrewery Syndrome (ACG 2026) - "We present a case of ABS which resulted in a DUI conviction and incomplete response to fluconazole. Case Description/ A 51-year-old Hispanic male with history of seborrheic dermatitis and GERD on intermittent omeprazole presented to clinic with repeatedly elevated BAC in the absence of self-reported alcohol intake...He was ultimately transitioned to nystatin along with limiting carbohydrates and ongoing infectious disease follow-up...A negative carbohydrate challenge does not rule out ABS despite later culture confirmation highlighting a limitation in diagnosing this syndrome. ABS remains an under-diagnosed condition that carries a clinical, psychosocial, and medicolegal burden, warranting appropriate testing."

Clinical • Dermatitis • Fibrosis • Gastroesophageal Reflux Disease • Immunology • Infectious Disease • Seborrheic Dermatitis

From Gut to Skin: A Rare Extraintestinal Manifestation of Crohnâs Disease (ACG 2026) - "Case Description/ A 46-year-old female with Crohnâs disease on infliximab presented with dysphagia and painful oral ulcers for four days (Figure 1)...Empiric nystatin therapy for suspected oral candidiasis showed minimal improvement...She was discharged on an oral prednisone taper with plans to adjust biologic therapy outpatient...Figure: Figure 1: shows oral multiple painful ulcerative lesions on dorsal surface of tongue, buccal mucosa. Figure: Figure 2: showing histopathologic features- papillary dermal edema with infiltration of neutrophils and histocytes in superficial and mid dermis."

Candidiasis • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammatory Bowel Disease • Musculoskeletal Pain • Vasculitis

A Near-infrared Fluorescent Probe for Sensitive Detection of Viscosity in Biosystems and Beverages Spoilage. (PubMed, J Fluoresc) - "Probe CDM was applied to monitor the viscosity changes induced by Nystatin and Momantin in liver cancer cells and effectively monitored the dynamic changes of intracellular viscosity in APAP-induced liver injury. Furthermore, this probe has successfully measured the viscosity changes of two different juices during spoilage. These research results indicate that CDM can serve as a novel analytical method for monitoring the viscosity changes of beverage spoilage during the spoilage process, and also as a reliable tool for early diagnosis of liver diseases and exploration of their underlying pathogenesis."

Journal • Hepatology • Liver Cancer • Liver Failure • Oncology • Solid Tumor

Machine learning-based modeling and analysis of solubility behavior in supercritical CO₂ systems under different operating conditions. (PubMed, Front Med (Lausanne)) - "Overall, this research provides valuable insights into the estimation of solubility of Nystatin and the density of SC-CO2 under varying temperature and pressure conditions. Specifically, machine learning models, specifically GB for solubility and RF and ET for density, has been demonstrated as valuable tools in the prediction of these significant properties."

Journal

Blocking lipid raft-associated RANK/c-Src signaling inhibits TRAF6-mediated non-small cell lung cancer migration. (PubMed, Biochim Biophys Acta Gen Subj) - "Blocking the lipid raft-localized RANK/c-Src pathway reverses TRAF6-mediated pro-tumor effects in NSCLC in vitro, providing novel insights into the mechanism by which TRAF6 regulates NSCLC progression."

Journal • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • CAV1 • TNFRSF11A • TRAF6

A facilely synthesized near-infrared fluorescent probe for selective lysosomal viscosity imaging. (PubMed, Chem Commun (Camb)) - "The probe exhibits a 480-fold fluorescence turn-on enhancement at 755 nm upon viscosity increase, with good linearity, high selectivity, and low cytotoxicity. It successfully tracked viscosity changes induced by nystatin, monensin, and H2O2 in living cells, and also visualized elevated lysosomal viscosity in tumor-bearing mice, demonstrating its potential for investigating lysosome-associated pathology."

Journal • Oncology

"Simultaneous quantification of nystatin, triamcinolone acetonide, neomycin sulfate and gramicidin D in transferosomal gel by rapid stability indicating HPLC method with PDA detector". (PubMed, J Chromatogr Sci) - "The analytes exhibited degradation ranging from ~11 to 12.1%, confirming the stability-indicating capability of the method. The proposed method is simple, accurate, precise, robust and suitable for the routine quantification of Nys, NS, TAC and Gr in bulk drug substances, transferosomal gel formulations and marketed pharmaceutical products."

Journal

Assessment of Nystatin-Loaded pH-Responsive Pectin-Carboxymethyl Cellulose-Based Polyelectrolyte Nanofiber Matrices for Antifungal Therapy. (PubMed, ACS Appl Bio Mater) - "Nys-NF demonstrated considerable antioxidant activity and cytocompatibility with HEK-293 cells. Conclusively, the developed pH-adaptive polyelectrolyte-based nanofibrous matrices represented a promising localized antifungal delivery system for combatting resilient mucosal fungal biofilms."

Journal • Infectious Disease

A scientometric study on research characteristics of HIV/AIDS involving the oral cavity with an implication for public health. (PubMed, J Dent Sci) - "The trend of drug aspect, e.g., antifungal agent, nystatin, and azole drugs before 2006 has changed to reverse transcriptase inhibitors efavirenz and lamivudine. Herein, we highlight the awareness of early diagnosis, and screening and testing of HIV, e.g., using saliva seems well-suited in dental setting. This study is the first scientometric analysis of HIV-related oral diseases with an implication for public health, underpinning that dentists and stomatologists can play active roles in providing early recognition and timely diagnosis of HIV/AIDS when it involved the oral cavity."

Journal • Candidiasis • Dental Disorders • Human Immunodeficiency Virus • Infectious Disease • Kaposi Sarcoma • Oncology • Periodontitis • Sarcoma • Solid Tumor

Effect of Selective Decontamination of the Digestive Tract on Hospital Mortality in Critically Ill Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial. (PubMed, JAMA) - P3 | "Patients in the SDD group (n = 2791) received a 6-hourly application of an oral paste and administration of a gastric suspension containing colistin, tobramycin, and nystatin for the duration of mechanical ventilation, plus a 4-day course of an intravenous antibiotic with a suitable antimicrobial spectrum. However, the confidence interval around the effect estimate includes a clinically important benefit. ClinicalTrials.gov Identifier: NCT02389036."

Clinical • Journal • Critical care • Infectious Disease

Antifungal therapy improves microbiome dynamics in inflammatory bowel disease. (PubMed, Nat Med) - "Here we leveraged the observation that Candida albicans strains are shared between the oral cavity and gut in patients with IBD with mild oral thrush, a condition caused by Candida overgrowth, to design a prospective observational study comparing oral antifungal therapy (swish-and-spit nystatin; oral nystatin fungal targeting (ORNT); n = 18) with orogastrointestinal antifungal therapy (fluconazole; gastrointestinal and oral fluconazole fungal targeting (GIFT); n = 35). These microbiome and metabolomic changes coincided with improved disease activity indices and a decreased risk of disease progression over the 8-week follow-up period. These findings demonstrate the feasibility of mycobiome-based patient stratification, provide evidence that targeted antifungal therapy can reshape the intestinal microbiota in IBD and establish a framework for implementing antifungal cotherapy in patients with fungal-associated disease manifestations."

Journal • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis

Onychomycosis caused by Syncephalastrum species in a patient with Crohn's Disease in Iraq: A case report. (PubMed, Med Mycol Case Rep) - "The fungus was sensitive to itraconazole, nystatin, clotrimazole, amphotericin B, miconazole, and ketoconazole, but showed resistance to fluconazole and voriconazole. This case demonstrates that Syncephalastrum species can cause clinically significant onychomycosis and should not automatically be dismissed as laboratory contaminants. A combination of clinical assessment, direct microscopy, culture-based identification, and antifungal susceptibility testing is essential for establishing diagnosis and guiding appropriate management."

Journal • Crohn's disease • Gastroenterology • Immunology • Infectious Disease • Inflammatory Bowel Disease • Pain

Mucoadhesive Gel Based on Cinnamomum cassia Essential Oil and Punica granatum Extract for Oral Candidiasis: A Pilot Study of Plant Synergism. (PubMed, Pharmaceutics) - "The gel was characterized and subsequently evaluated in denture-wearing patients with clinical manifestations of oral candidiasis for 14 days, with the results compared to treatment with nystatin... These findings indicate that the mucoadhesive gel represents a promising topical strategy for the management of oral candidiasis in denture wearers. However, studies with longer follow-up periods are required to consolidate the clinical evidence."

Journal • Candidiasis • Dental Disorders • Infectious Disease • Stomatitis

A dual-targeted mitochondria and lipid droplets near-infrared probe for visualizing viscosity and sulfur dioxide fluctuations during inflammatory microenvironment. (PubMed, Mikrochim Acta) - "Furthermore, it sensitively monitored nystatin-induced viscosity increases in cells and zebrafish. These results demonstrated that TTBP showed potential as a molecular tool for investigating inflammation-associated microenvironmental changes, metabolic dysfunction, and related disease mechanisms."

Journal • Inflammation • Metabolic Disorders

Surface-Engineered Carbon Dots for Monitoring of Lysosomal Viscosity and Organelle Dysfunction. (PubMed, Small) - "This turn-on response allows for the high-fidelity tracking of lysosomal microviscosity changes induced by exogenous stimuli, such as nystatin, and endogenous processes like rapamycin-induced autophagy. Furthermore, the LysoDots were successfully employed in a neuronal model, SH-SY5Y cells, where the probe effectively tracked glutamate-induced lysosomal dysfunction, mimicking the pathology of lysosomal storage disorders, along with the viscosity restoration mediated by trehalose. These findings highlight the potential of LysoDots as a biocompatible, photostable, multi-functional nanomaterial for long-term monitoring of lysosomal dynamics and cellular homeostasis."

Journal • Lysosomal Storage Diseases • Metabolic Disorders • Oncology • Oral Cancer • Rare Diseases • Solid Tumor

Amine-conjugated FRET coumarin-cyanine ratiometric probes for sensitive viscosity and HSA imaging in live cells and tissues | Poster Board #1112 (ACS-Fall 2026) - "Using confocal microscopy, probe B sensitively detected intracellular viscosity increases induced by Monensin, Lipopolysaccharide, and Nystatin treatments in HeLa cells, with ratiometric fluorescence changes correlating with viscosity elevations...Probe A enabled quantitative ratiometric imaging of HSA dynamics in live cells, with fluorescence changes strongly correlated to albumin concentration. Application of probe A to kidney tissue sections from normal and polycystic kidney disease models revealed significantly elevated fluorescence in diseased tissues, indicating increased intracellular viscosity linked to pathological remodeling."

Genetic Disorders • Nephrology • Polycystic Kidney Disease • Renal Disease

Vinyl-Bonded Naphthalic and Coumarin Fluorophores for Ratiometric Sensing of Lysosomal Viscosity and HSA in Living Cells and Fruit Fly Larvae | Poster Board #1002 (ACS-Fall 2026) - "We show that Sensor A can accurately detect lysosomal viscosity changes in response to treatments with monensin, nystatin, and bacterial lipopolysaccharide, all of which increase lysosomal viscosity...The ratiometric design of Sensor A offers a significant advantage over traditional methods, providing more reliable and precise viscosity measurements that are less susceptible to environmental fluctuations. This innovative tool enables deeper insights into cellular processes, such as autophagy, and offers promising applications in cancer research, viral infections, and the study of diseases involving lysosomal dysfunction."

CNS Disorders • Infectious Disease • Influenza • Lysosomal Storage Diseases • Metabolic Disorders • Rare Diseases • Respiratory Diseases

In Vitro Evaluation of the Antifungal Activity of Salvia Leriifolia Leaf Hydroalcoholic Extract Compared to Nystatin and Fluconazole Against Candida albicans. (PubMed, Clin Exp Dent Res) - "This study demonstrated that while the hydroalcoholic extract of Salvia leriifolia is less potent than nystatin and fluconazole, it is still capable of partially inhibiting the growth of Candida albicans. These results underscore the potential role of medicinal plants in the treatment of fungal infections, especially in cases involving drug resistance or undesirable side effects from conventional medications."

Clinical • Journal • Preclinical • Infectious Disease

Optimization of microencapsulation process for the fabrication of methyleugenol microcapsules and investigation of their antifungal effects on Fusarium avenaceum. (PubMed, Food Chem) - "After microencapsulation, the antifungal activity of methyleugenol was greatly improved, with its microcapsules exhibiting comparable efficacy to nystatin against Fusarium avenaceum, demonstrating the minimum inhibitory concentration (MIC) of 0.10 mg/mL and 0.07 mg/mL, respectively. These findings provide a scientific basis for exploring the potential applications of ME microcapsules in food preservation and related industrial sectors."

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Experimental Analysis of HPV16 L1/L2 Chimeric VLP Internalization by Human Peripheral Blood Leukocytes. (PubMed, Int J Mol Sci) - "Uptake occurred via the CD71 transferrin receptor-mediated pathway, in addition to other endocytic routes analyzed, as confirmed by blockage assays using chlorpromazine, rCTB, filipin, nystatin, liquemine, and sodium azide. These findings demonstrate that HPV16 L1/L2 chimeric VLPs interact with and are internalized by human peripheral blood mononuclear cells through CD71-associated and other endocytic pathways. The study provides new insights into HPV16 VLP-leukocyte interactions and contributes to a better understanding of the cellular mechanisms involved in VLP uptake, which may be relevant for future studies on HPV biology and VLP-based vaccine development."

Journal • Infectious Disease • Oncology • TFRC

RETRACTION: Antimicrobial and Controlled Release Studies of a Novel Nystatin Conjugated Iron Oxide Nanocomposite. (PubMed, Biomed Res Int) - No abstract available

Journal

Biocompatibility and Antifungal Effects of Chitosan Nanoparticles Loaded With Nystatin and Carvacrol Against Candida albicans. (PubMed, J Oral Pathol Med) - "Co-loading nystatin and carvacrol into chitosan nanoparticles yielded a synergistic antifungal and antibiofilm effect against C. albicans, coupled with excellent hemocompatibility and minimal cytotoxicity, highlighting its potential as a topical therapeutic for oral candidiasis particularly where resistance to azoles is rising. Further in vivo studies are warranted."

Journal • Candidiasis • Hematological Disorders