Campral EC (acamprosate delayed release) / EMD Serono, Nippon Shinyaku - LARVOL DELTA

TEMACA: Investigation of the Efficacy of Acamprosate and Calcium in Comparison to Placebo as Validation of a Behavioural Test for Alcohol Dependence (clinicaltrials.gov) - P3 | N=82 | Completed | Sponsor: Technische Universität Dresden | Recruiting ➔ Completed | Trial completion date: Dec 2023 ➔ May 2024

Trial completion • Trial completion date • Addiction (Opioid and Alcohol)

A prevention program for binge drinking among students based on mindfulness and implementation intention (ALCOMEDIIT): a randomized controlled trial. (PubMed, Trials) - P=N/A | "The purpose of this study is to evaluate the interest of associating mindfulness meditation practices and implementation of self-regulation strategies to optimize their use, with a motivational interview in an innovative prevention program aiming at reducing alcohol use and BD practice in the student population."

Journal

The pharmacological effect of acamprosate originates from different drug moieties (Neuroscience 2023) - "However, available pharmacological treatment options are limited, with Campral® (acamprosate; calcium-bis(N-acetylhomotaurinate)) being used as a relapse prevention therapy...In conclusion, these findings suggest that the combination of CaCl2 and NaAcamp has beneficial effects in terms of elevating dopamine and taurine levels within the nAc and reducing ethanol consumption. Enhancing our understanding of the mechanisms of action of acamprosate could facilitate the development of novel drugs to combat AUD."

Addiction (Opioid and Alcohol) • CNS Disorders

Acamprosate reduces ethanol intake in the rat by a combined action of different drug components. (PubMed, Sci Rep) - "Alcohol misuse accounts for a sizeable proportion of the global burden of disease, and Campral (acamprosate; calcium-bis-(N-acetylhomotaurinate)) is widely used as relapse prevention therapy...Both acamprosate and CaCl combined with sodium acamprosate blocked the ADE following acute treatment. The data presented suggest that CaCl and N-acetylhomotaurine act in concert on a neurochemical level, but calcium appears to have the predominant effect on ethanol intake."

Journal • Preclinical • Addiction (Opioid and Alcohol)

Safety of Acamprosate for Alcohol Dependence in the Elderly: An Open-Label Study (SAFADIE) (clinicaltrials.gov) - P4 | N=0 | Withdrawn | Sponsor: University of New Mexico | N=25 ➔ 0 | Unknown status ➔ Withdrawn

Enrollment change • Trial withdrawal • Addiction (Opioid and Alcohol)

"@cspramesh @drsabita @AmitJos98615230 @ns_chd @Anil_Tibdewal @Sushilberiwal @TataMemorial @CancerGridIndia @ND_Foundation @Friends_Of_Max @chaiforcancer @CPAAIndia @BalcoMedical @TeamUmeedein @Cankidz @StJudeChildCare @NagFoundation @CanSupportND @ics_1951 @Cuddles4cancer" (@NavyaCare)

Oncology

"Today is GIST Awareness Day! @TataMemorial | @CancerGridIndia @gopikalall | @nayakprakash | @docgulia | @drnidhhitandon | @JyotiBajpai01 | @malolan | @Sushilberiwal @ND_Foundation @Friends_Of_Max @chaiforcancer @CPAAIndia @BalcoMedical @TeamUmeedein @Cankidz #Navya" (@NavyaCare)

Oncology

"Planning some amazing meetings this year to drive education & research in india and globally ! @ecancer @curecc @JavleMilind @SusannahStanwa1 @royalmarsdenNHS @RoySocMed @BalcoMedical @TataMemorial @Shrikhande_SV @LGCW2023 @UKIGlobalCancer @ICMRDELHI @shankarprinja @AnilAgarwalF" (@SirohiBhawna)

Oncology

"Also proud of you ashish … reach the heights for india .. honoured to be with you and @drshonanag @NagFoundation @BalcoMedical @AnilAgarwalF" (@SirohiBhawna)

"Workshop on audit & research @BalcoMedical @AnilAgarwalF GI DMG from @TataMemorial @ACTREC_TMC took me back .. @Shrikhande_SV @prachipatil #reena engineer making a great start to asking the right research question ! @oncology_bg" (@SirohiBhawna)

Oncology

"@balcomedical @togetheragainstcancer @@SirohiBhawna Exciting panel on carcinoma cervix Day2" (@gupta_drgourav)

Cervical Cancer • Oncology • Solid Tumor

"Looking forward ! @BalcoMedical @AnilAgarwalF" (@SirohiBhawna)

"Waiting for the amazing GI session @BalcoMedical @AnilAgarwalF led by @Shrikhande_SV @Manishbhandare4 #priya tiwari - how we drive RWE in cancer care @oncology_bg @ecancer @OncoAlert" (@SirohiBhawna)

Oncology

"Installation of the second linac at @BalcoMedical - halcyon ! Serving the nation in capacity building @PMOIndia @ICMRDELHI @CancerGridIndia @AnilAgarwalF inaugurated by @JyotiAgarwal_ #Chattisgarh #raipur #cancercare @gupta_drgourav" (@SirohiBhawna)

Oncology

"Agree Ameya ! Opt for upfront PRRT for most of our pts ..and thankfully most of our pts can access it via @AyushmanNHA too !! @BalcoMedical" (@SirohiBhawna)

Clinical

"So proud of you @SirohiBhawna @BalcoMedical" (@ship10)

TEMACA: Investigation of the Efficacy of Acamprosate and Calcium in Comparison to Placebo as Validation of a Behavioural Test for Alcohol Dependence (clinicaltrials.gov) - P3 | N=84 | Recruiting | Sponsor: Technische Universität Dresden | Trial completion date: Feb 2023 ➔ Dec 2023 | Trial primary completion date: Oct 2022 ➔ Jul 2023

Trial completion date • Trial primary completion date • Addiction (Opioid and Alcohol)

"@SirohiBhawna @JyotiAgarwal_ @VedantaLimited @SunilDuggal_Ved @BalcoMedical @AyushmanNHA @iaeaorg @drramansingh" (@vj_baghel)

"Happy Republic Day from @BalcoMedical … and #kalinga university .. inspiring positive day ! Amazing #Chhattisgarh #Raipur" (@SirohiBhawna)

"Excellence in cancer care @BalcoMedical @SirohiBhawna & @TataMemorial" (@ship10)

Oncology

"Telehealth is the future ! Thanks @OncoAlert @ONCOassist for this work … @VanitaNoronha @devnani_bharti @TataMemorial @AIIMSJOfficial @BalcoMedical our poster @myESMO #ESMOAsia2022 @weoncologists" (@SirohiBhawna)

Oncology

"Thanks amol ! Starting DNB @BalcoMedical next year…" (@SirohiBhawna)

"wl Thorough @Andreagreenrn @JMclearns @FORTANIMALS @foodvers @JaxonMehK @SCARFACE_SHINO @pepscoo1 @azukimikka @CoolMib @Thushsiv @george_yaghmour @nontantocrypto @samanthaf148 @DecentralComedy @schilck" (@MVPWang03213484)

"Learnt a lot about breast oncoplasty and single port RATS / VATS today @TataMemorial oncosurg!! Thank you amazing @drsabita … great day ! @BalcoMedical. #oncosurg2022" (@SirohiBhawna)

Preclinical

"@SirohiBhawna @JyotiAgarwal_ @BalcoMedical @IMAIndiaOrg @HealthCgGov @HumansofCG" (@RaviJaiswal___)