SYX-5219 / Sitryx - LARVOL DELTA

PKM2 is a promising novel target in atopic dermatitis (ISDS 2025) - "The PKM2 modulator, SYX-5219, has recently entered clinical trials in healthy volunteers and patients with moderate to severe AD. SYX-5219 could address the major unmet needs of AD as a safe oral, convenient and effective therapy for AD."

Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation • CD4 • CORT • FLG • IL13 • IL17A • IL6 • LORICRIN • PKM

Sitryx presents new preclinical data highlighting PKM2 as a promising metabolic target for the treatment of atopic dermatitis at the Inflammatory Disease Skin Summit 2025 (GlobeNewswire) - "PKM2 has been identified as a key enzyme in the central metabolic pathway and shown to be upregulated in inflamed tissues, with Sitryx’s preclinical data demonstrating that it is overexpressed in immune cell infiltrate and in keratinocytes in atopic dermatitis compared to healthy skin. The Company’s novel small molecule PKM2 modulator, developed as a potential atopic dermatitis therapeutic, potently activated PKM2 enzymes in human and preclinical models of inflammatory skin diseases, resulting in a decrease of itch cytokines and normalization of gene expression required for barrier function....The Company expects to initiate the trial in Q1 2026."

New P1 trial • Preclinical • Atopic Dermatitis

Sitryx receives FDA clearance of IND application for SYX-5219 for the treatment of atopic dermatitis (The Manila Times) - "Phase 1b trial to investigate the safety, tolerability and initial efficacy of SYX-5219 in patients with atopic dermatitis starting Q1 2026"

IND • New P1 trial • Atopic Dermatitis

Sitryx initiates Phase 1 clinical trial of potential disease-modifying treatment for atopic dermatitis SYX-5219 (GlobeNewswire) - "Sitryx Therapeutics...today announces the initiation of its first-in-human Phase 1a clinical trial evaluating SYX-5219 for the treatment of atopic dermatitis....The Phase 1a trial, initiated in the UK, is an interventional placebo-controlled study designed to assess the safety, tolerability and pharmacokinetics of SYX-5219 in healthy volunteers. It is the first of a two-part study, with the Phase 1b trial in adults with moderate to severe atopic dermatitis expected to commence later in 2025 in the UK, Europe and the US."

Trial status • Atopic Dermatitis

Sitryx nominates SYX-5219 a novel, oral and targeted PKM2 activator for clinical development in atopic dermatitis (GlobeNewswire) - "Sitryx Therapeutics...has nominated SYX-5219 as the first candidate from its proprietary pipeline to progress to regulatory non-clinical studies to support a clinical trial authorization (CTA). SYX-5219 has the potential to address a broad range of inflammatory diseases and will advance into the clinic for the treatment of atopic dermatitis, the most common inflammatory skin disease....Regulatory submission preparation for SYX-5219 is underway, with clinical trials expected to commence in early 2025. SYX-5219 is expected to be the first program to enter clinical development from Sitryx’s proprietary pipeline of potential therapies that leverage metabolism to modulate immune cell function."

New molecule • New trial • Atopic Dermatitis • Dermatitis • Dermatology • Immunology