Compound E / Southeast University, Beijing Normal University, University of Brescia Medical School - LARVOL DELTA

Pediatric MASLD in China: epidemiology, screening, diagnosis, and management. (PubMed, Lancet Reg Health West Pac) - "In China, this escalating burden is compounded by regional disparities, diagnostic challenges, and limited access to pediatric-specific screening and management tools...This review synthesizes the latest epidemiological data, screening strategies, diagnostic innovations, and therapeutic approaches for pediatric MASLD in the Chinese context. By integrating emerging evidence with national public health priorities, we aim to inform actionable policies and tailored intervention strategies to confront this growing epidemic."

Journal • Review • Fibrosis • Genetic Disorders • Hepatocellular Cancer • Hepatology • Immunology • Liver Cirrhosis • Metabolic Disorders • Metabolic Dysfunction-Associated Steatotic Liver Disease • Oncology • Pediatrics • Solid Tumor

AHAD: African major crops harvested area dataset for the years of 2000, 2010, and 2020. (PubMed, Sci Data) - "Africa faces significant challenges in food security, which are compounded by rapid population growth...In addition to the primary datasets, we also provide data quality assessments for each step of the process. The AHAD could provide geospatial and temporal patterns of harvested area, offering potential for advancing agricultural practices and enhancing food security across Africa."

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BAICALEIN INDUCES HEPATIC STELLATE CELL SENESCENCE VIA INHIBITING GLYCOLYSIS BY CEBPZ/P53/HK2 SIGNALING PATHWAY TO INHIBIT LIVER FIBROSIS (AASLD 2025) - "Baicalein (BA) is a flavonoid compound extracted from the dried root of Scutellaria baicalensis, which can inhibit the mechanisms of cancer development such as metastasis, angiogenesis, and inflammation without harming healthy cells... Our findings suggested that BA had a protective effect on liver fibrosis, and the underlying mechanism might be related to the CEBPZ/p53/HK2 signaling pathway."

Fibrosis • Hepatology • Immunology • Liver Cirrhosis • Liver Failure • CEBPZ

A Chemical Glycoproteomic Approach Decrypts Urinary Extracellular Vesicle Surfaceome for Prostate Cancer Diagnosis and Grading. (PubMed, Angew Chem Int Ed Engl) - "These hurdles are further compounded by the inherent heterogeneity of EVs and the low abundance of surface targets in biofluids...Applied to urine samples from 368 individuals with prostate-related diseases, EVscope identified 1,121 EV surface proteins, establishing the largest urine-derived EV surfaceome dataset to date and identifying cathepsin L, integrin alpha 3, fibrinogen beta chain, and tetraspanin-1 as characteristic proteins with potential as noninvasive biomarkers for prostate cancer diagnosis and grading. In summary, this study establishes an innovative methodology for high-resolution EV surfaceome analysis, facilitating noninvasive biomarker discovery and enabling direct detection in population-scale screening."

Journal • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor

Combined environmental and natural disaster risk assessment of tailing ponds in China and diverse responses analysis. (PubMed, Environ Int) - "In summary, this study provides a scientific basis for the risk management and natural disasters adaptation of TPs in China. Considering the compounded effect of rainstorm on the environmental risks of TPs, the importance of addressing the impacts of climate change, warranting attention."

Journal • Psychiatry

Pinosylvin Inhibits Inflammatory and Osteoclastogenesis via NLRP3 Inflammasome. (PubMed, Adv Sci (Weinh)) - "In the current study, it is observed that Pinosylvin (PIN), a compound extracted from European red pine, selectively inhibits LPS- and RANKL-induced release of IL-1β effectively reducing osteoclastogenesis...Importantly, PIN alleviates inflammatory bone loss due to estrogen deficiency, reduces cranial bone destruction from local LPS injections, and improves survival in LPS-induced septic mice. This study uncovers the specific mechanism behind PIN's potent anti-inflammatory effects and identifies a new therapeutic target for NLRP3-driven diseases."

Journal • Osteoporosis • CASP1 • IL1B • IL6 • NLRP3

Bio-Inspired Observability Enhancement Method for UAV Target Localization and Sensor Bias Estimation with Bearing-Only Measurement. (PubMed, Biomimetics (Basel)) - "Inspired by the compound eye vision, a bio-inspired observability analysis method is proposed for stochastic systems...The proposed method demonstrates superior convergence in both target localization and sensor bias estimation. The nonlinear constrained multi-objective whale optimization algorithm achieves minimal values for both generational distance and inverted generational distance, demonstrating superior convergence and diversity characteristics."

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Double [8]Helicene Featuring a Dibenzo[g,p]chrysene Core: Synthesis and Chiroptical Response. (PubMed, Org Lett) - "The compound exhibits red fluorescence with an emission maximum at 618 nm (λem) and a quantum yield of 16.2%, highlighting its potential in optoelectronic applications. Furthermore, circular dichroism (CD) and circularly polarized luminescence (CPL) measurements reveal notable chiroptical activity, with absorption and emission dissymmetry factors of;gabs| = 5.11 × 10-3 and;glum| = 7.1 × 10-4, respectively."

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Embryonic developmental toxicity to estuarine fish: Single and co-exposure to EHMC and its phototransformation products in Mugilogobius chulae. (PubMed, Environ Res) - "This indicates that the phototransformation products exhibit greater developmental toxicity than the parent compound EHMC...The mixture further exacerbated oxidative imbalance through SOD and GST reduction and catalase (CAT) induction (p < 0.05). These findings underscore the critical need to consider photochemical transformation products in ecological risk assessments of OUVFs in estuarine ecosystems."

Journal • BMP2 • BMP4 • CAT • FGF4 • MATN3 • TGFB1 • TGFB2 • WNT3A

Baicalein induces hepatic stellate cell senescence via inhibiting glycolysis by CEBPZ/p53/HK2 signaling pathway to inhibit liver fibrosis (APASL 2025) - "Baicaliein (BA) is a flavonoid compound extracted from the dried root of Scutellaria baicalensis, which can inhibit the mechanisms of cancer development such as metastasis, angiogenesis, and inflammation without harming healthy cells... Our findings suggested that BA had a protective effect on liver fibrosis, and the underlying mechanism might be related to the CEBPZ/p53/HK2 signaling pathway. Table and Figure:Figure 1."

Fibrosis • Hepatology • Immunology • Liver Cirrhosis • Liver Failure • Oncology • CEBPZ

Elderly vulnerability to temperature-related mortality risks in China. (PubMed, Sci Adv) - "Furthermore, by identifying heterogeneous impacts based on location, sex, age, obesity, income, and diet, we reveal the pathways through which temperature metrics are likely to influence mortality risk. Our study highlights the compound effects of rising temperatures for elderly populations, and it could be expanded to other countries and regions experiencing similar challenges due to an aging population experiencing warming conditions."

Journal • Genetic Disorders • Obesity

Study protocol for a randomized controlled trial evaluating the effectiveness of a mother-child intervention model of neurogenic tremor as an add-on to treatment for emotional disorders in adolescents. (PubMed, BMC Complement Med Ther) - P=N/A | "This research endeavors to identify a straightforward and potent body-oriented psychological intervention that could improve the clinical outcomes for adolescent patients with emotional disorders. Such findings would carry profound implications not only for the healthy development of teenagers but also for potentially mitigating the burden on families, educational institutions, and society as a whole."

Clinical • Clinical protocol • Journal • CNS Disorders • Depression • Infectious Disease • Mood Disorders • Movement Disorders • Novel Coronavirus Disease • Psychiatry

Observation of Spin Splitting in Room-Temperature Metallic Antiferromagnet CrSb. (PubMed, Adv Sci (Weinh)) - "The magnitude of such SS reaches up to at least 0.8 eV at non-high-symmetry momentum points, which is significantly higher than the largest known SOC-induced SS. This compound expands the choice of materials in the field of antiferromagnetic spintronics and is likely to stimulate subsequent investigations of high-efficiency spintronic devices that are functional at room temperature."

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From brain connectivity to cognitive function: Dissecting the salience network in pediatric BECTS-ESES. (PubMed, Prog Neuropsychopharmacol Biol Psychiatry) - "Our study heralds dFC within the SN as a vital biomarker for cognitive impairment in pediatric epilepsy, advocating for targeted cognitive-specific interventions in managing BECTS-ESES. The preliminary nature of our findings invites further studies to substantiate these associations, offering profound implications for the prognosis and therapeutic strategies in BECTS-ESES, thereby underlining the importance of this research in the field of pediatric neurology and epilepsy management."

Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Epilepsy • Pediatrics

Consensus for antifungal stewardship in China (2024 edition). (PubMed, J Thorac Dis) - "Currently, the misdiagnosis rate of IFD is extremely high, compounded with the low quality of prescription antifungals and the high incidence of adverse events associated with IFD treatment, resulting in lengthy hospitalization, low clinical response, and high disease burden, which have become serious challenges in clinical practice...Forty-six authoritative experts assessed and reviewed the above metrics, and a consensus was reached with a final agreement level of ≥80% for 22 metrics. This consensus is the first to propose a set of AFS metrics suitable for China, which helps to establish AFS standards in China and is also the first AFS consensus in Asia, and may improve the standard of clinical diagnosis and treatment of IFD, and guide hospitals to implement AFS, ultimately promoting the rational use of antifungal drugs and improving patient prognosis."

Journal • Review • Critical care • Dermatology • Hematological Disorders • Infectious Disease • Respiratory Diseases

Celastrol inhibits mouse B16-F10 melanoma cell survival by regulating the PI3K/AKT/mTOR signaling pathway and repressing HIF-1α expression. (PubMed, Discov Oncol) - "Celastrol inhibits the function of B16-F10 cells by inhibiting the PI3K/AKT/mTOR cellular pathway and regulating the expression of downstream HIF-α mRNA."

Journal • Preclinical • Genetic Disorders • Melanoma • Oncology • Ophthalmology • Skin Cancer • Solid Tumor • HIF1A

Identifying protected areas in biodiversity hotspots at risk from climate and human-induced compound events for conserving threatened species. (PubMed, Sci Total Environ) - "Our work highlights PAs in the biodiversity hotspots where high risk of compound event occurrence poses a greater threat to species. We encourage researchers to adapt and apply this framework across other globally significant sites for conserving biodiversity to identify high risk-prone areas, and prevent further biodiversity decline."

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The dangers of having only one pandemic exit strategy. (PubMed, J Infect Public Health) - "This paper underscored the importance of having multiple exit strategies for societies to prepare for pandemics. The insights of this study can help inform health policies so that they can more comprehensively and compassionately protect the needs and wants of the "public" in public health, particularly in grave times like COVID-19."

Journal • Infectious Disease • Novel Coronavirus Disease

Exploring the influence of sludge dewatering agents on Microplastic aging under hydrothermal treatment: Insights from Polylactic Acid microplastics. (PubMed, Environ Res) - "Under hydrothermal treatments, the presence of dewatering agents leads to pronounced alterations in PLA-MPs as evidenced by SEM, showing the compound effects of both treatments...The hydrothermal samples in water showed the earliest structural alterations, whereas the presence of iron and persulfate in sludge led to the most pronounced molecular transitions, emphasizing the intricate interactions of the microplastics with different chemicals. This study highlights the impact of hydrothermal treatment and dewatering agents on the properties of the microplastics."

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Sulfonated magnetic graphite carbon nitride solid-phase extraction-ultra performance liquid chromatography-tandem mass spectrometry for screening malachite green and leucomalachite green in freshwater fish (PubMed, Se Pu) - "It has a wide range of application prospects in adsorption and can be used in food safety testing when compounded with FeO to form magnetic graphite carbon nitride (MGCN)...The test results of actual samples were consistent with those obtained via the national standard method, thus confirming the practical feasibility of the developed method. The proposed MSPE method based on S-MGCN is an efficient and environmentally friendly method that could provide a new methodological reference for the sensitive screening of MG and LMG in actual samples."

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Evidence-based identification of breast cancer and associated ovarian and uterus cancer risk components in source waters from high incidence area in the Pearl River Basin, China. (PubMed, Sci Total Environ) - "Moreover, these identified water components were present at levels comparable to other regions with high female cancer prevalence, suggesting that the potential risk of these components may not be exclusive to the study region. Together, multiple levels of evidence suggested that long-term co-exposures to source water estrogenic components may be important to the development of breast, ovarian, and uterus cancers."

Journal • Breast Cancer • Endocrine Cancer • Hormone Receptor Breast Cancer • Oncology • Ovarian Cancer • Solid Tumor • Uterine Cancer • ER

The 2022 Sichuan-Chongqing spatio-temporally compound extremes: a bitter taste of novel hazards. (PubMed, Sci Bull (Beijing)) - No abstract available

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Octahedral Distortion and Displacement-Type Ferroelectricity with Switchable Photovoltaic Effect in a 3d^{3}-Electron Perovskite System. (PubMed, Phys Rev Lett) - "This compound exhibits an unusually large octahedral distortion enhanced by approximately 2 orders of magnitude compared with that observed in other 3d^{3} perovskite systems like RCr^{3+}O_{3} (R=rare earth)...More interestingly, a prominent net photocurrent and switchable photovoltaic effect with a sustainable photoresponse were observed in the current polycrystalline HPMO. This Letter provides an exceptional d^{3} material system which shows unusually large octahedral distortion and displacement-type ferroelectricity violating the "d^{0}-ness" rule."

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Plantamajoside Alleviates Substantia Nigra Damage in Parkinson's Disease Mice by Inhibiting HDAC2/MAPK Signaling and Reducing Microglia Polarization. (PubMed, ACS Chem Neurosci) - "Plantamajoside (PMS) is a natural compound extracted from plantain seeds...The limitation of this study was the lack of experiments for investigating the further molecular mechanism and in vivo animal validation, which needs to be further confirmed in the future. Collectively, our data suggested that PMS could serve as a promising drug for PD."

Journal • Preclinical • CNS Disorders • Movement Disorders • Oncology • Parkinson's Disease • HDAC2

A temporospatial assessment of environmental quality in urbanizing Ethiopia. (PubMed, J Environ Manage) - "In this study, the compounded night light index (CNLI) and remote sensing ecological index (RSEI) were used respectively to evaluate the urbanization level and environmental quality in Ethiopia from 2010 to 2020...Continuous increase in impervious surfaces resulted in a six-fold increase in surface runoff, which raised the flooding risk in sub areas and rural landscapes. This demands reforms of climate strategies and proper livestock management."

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