Compound E / Southeast University, Beijing Normal University, University of Brescia Medical School - LARVOL DELTA

Escalating Ecological Droughts Driven by Compound Soil and Atmospheric Dryness. (PubMed, Glob Chang Biol) - "Notably, compound drought regions account for the majority of global increases in ecological drought frequency (57%), intensity (64%), and carbon losses (63%) over the past four decades. Our findings highlight the growing importance of compound ecological droughts in shaping ecosystem vulnerability, threatening the stability of terrestrial carbon sinks, and potentially amplifying carbon-climate feedbacks."

Journal

Plastisphere as a resistome incubator: Substrate biodegradability escalates compounded genetic risks. (PubMed, J Hazard Mater) - "Substrate biodegradability amplifies both pathways by intensifying these spatial and competitive interactions, rendering plastispheres critical incubators for resistant pathogens in riverine ecosystems. Ultimately, this resistome expansion independent of antibiotic selective pressure reveals the potential ecological hazards of biodegradable plastics, substantiating the need for a systematic reassessment of their widespread use within the "One Health" framework."

Journal • Gene Therapies

Mortality risk in patients with urological malignancies and human immunodeficiency virus (HIV) coinfection: A systematic review and meta-analysis of cohort studies. (PubMed, Cancer Pathog Ther) - "PLWH exhibit unique clinical patterns, including a younger age at diagnosis for renal cell carcinoma and more advanced stage at presentation of prostate and bladder cancers, which are compounded by inequities in health care access and HIV-specific mechanisms such as chronic immunosuppression...These findings highlight the need to integrate urological cancer screening and tailored management into long-term HIV care. Future multicenter studies will be essential to strengthen the evidence, particularly for kidney and bladder cancers, and to clarify the roles of HIV-specific factors, tumor biology, and social determinants of health in optimizing precision medicine for this population."

Journal • Retrospective data • Review • Bladder Cancer • Genito-urinary Cancer • Human Immunodeficiency Virus • Infectious Disease • Kidney Cancer • Oncology • Prostate Cancer • Renal Cell Carcinoma • Solid Tumor • Urethral Cancer

CRISPR/Cas9 screen identifies DCAF4 as a novel protector of hepatocellular carcinoma against brachytherapy via stress granule-dependent NRF2 activation. (PubMed, Cell Death Dis) - "Targeting this axis, we performed computational screening to identify a small-molecule inhibitor that disrupts the DCAF4-KEAP1 interaction. This compound effectively enhanced brachytherapy (BT) sensitivity and inhibited tumor growth in preclinical HCC models."

Journal • Hepatocellular Cancer • Oncology • Solid Tumor • Targeted Protein Degradation • DCAF4 • DDB1 • IL17RB • KEAP1 • XBP1

Warming and vegetation greening drive recent surge in flash droughts. (PubMed, Sci Adv) - "Using an explainable artificial intelligence-based clustering framework with reanalysis products and Earth system models, we show that the major driving mechanisms of global flash droughts have shifted from precipitation dominance to a compound effect of temperature, transpiration, and precipitation...The transition, which has emerged beyond natural climate variability since 2017 and is mainly detected in Eurasia, Amazon, and Africa, exposes ~650 million people under threat and reduces gross primary productivity by 0.15 ± 0.1 petagrams of carbon per year. Our results demonstrate that biosphere and atmosphere responses to anthropogenic forcing have altered flash drought drivers, emphasizing the urgent need for targeted mitigation strategies."

Journal

Decoupling MCI-specific signatures from shared neurobiological substrates of cognitive aging via deep learning. (PubMed, NPJ Digit Med) - "This problem is compounded by the inability of conventional neuroimaging methods to disentangle these overlapping influences...The robustness of this structural-cognitive impairment association model established in BABRI dataset was validated in the ADNI dataset. Moreover, predictive modeling using these features achieved superior AD-conversion prediction (AUC = 0.83) versus whole-brain atrophy (AUC = 0.74; p < 0.001) or CSF biomarkers (AUC = 0.77; p < 0.001).This work establishes a novel paradigm for isolating MCI-specific brain alterations from physiological aging."

Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders

Dynamic morphological staging of Drosophila pupal development. (PubMed, Sci Rep) - "We document pupal shell dynamics, including color transitions and spiracle development as staging markers, along with internal transformations like larval tracheal degeneration, mouthpart retraction, and the formation of the compound eyes, wings, appendages, and bristles...These observations offer a detailed developmental map of the Drosophila pupal stage, which is essential for accurate experimental staging and sampling. This study's findings not only contribute to the fundamental understanding of insect metamorphosis but also provide a valuable resource for researchers utilizing Drosophila as a model system to study gene expression, development, and behavior."

Journal

Impacts of timescales on the relationship between compound drought-hot extremes based on precipitation and groundwater. (PubMed, J Environ Manage) - "We further estimate the optimal timescale of accumulated precipitation corresponding to groundwater droughts to reduce differences in the distribution and changes in the two compound extremes...Based on the optimal timescale of accumulated precipitation, the difference in the distribution and changes is significantly reduced (e.g., with higher correlation coefficients between spatial extents of the two extremes), providing potential for near-real time monitoring of CGHDEs. The findings of this study can be useful for mitigating groundwater droughts to aid water resources management."

Journal

Spatiotemporal dynamics and drivers of groundwater pollution risk: insight from multi-source remote sensing and machine learning. (PubMed, J Environ Manage) - "Importantly, the Geodetector analysis demonstrates that two-factor interactions, such as precipitation × gross domestic product (GDP) and precipitation × compounded night light index (CNLI), possess significantly greater explanatory power than any single factor...The primary novelty of this work lies in the successful transition from a static snapshot to a dynamic, high-resolution reconstruction of GPR. These findings provide a powerful tool for predictive hotspot identification and offer practical guidance for targeted monitoring, sustainable groundwater management, and early-warning systems, ultimately supporting ecological security in rapidly developing regions."

Journal

Nitrogen addition reduces alpine grassland stability via enhanced temporal synchrony and population variability. (PubMed, Oecologia) - "In the second non-overlapping time window, decrease in stability was largely driven by compounded effects of persistent synchrony and amplified dominant species variability...We posit that diversity help to sustains grassland functioning not only  by increasing productivity, but also by maintaining a dynamic balance between synchrony and population variability. This highlights the necessity of conserving plant diversity to secure ecosystem functioning under global change."

Journal

Global mapping of pharmaceutical ecological risk in rivers using machine learning: drivers, hotspots, and compounded water stress. (PubMed, Water Res) - "This analysis highlighted high-concern rivers facing multiple stressors, including the Yellow River in China, the Sutlej River in Pakistan, and the River Nile in Egypt. Our adaptable framework offers a spatially explicit foundation for targeted surveillance and mitigation strategies, and is extensible to other emerging contaminants."

Journal

Pediatric MASLD in China: epidemiology, screening, diagnosis, and management. (PubMed, Lancet Reg Health West Pac) - "In China, this escalating burden is compounded by regional disparities, diagnostic challenges, and limited access to pediatric-specific screening and management tools...This review synthesizes the latest epidemiological data, screening strategies, diagnostic innovations, and therapeutic approaches for pediatric MASLD in the Chinese context. By integrating emerging evidence with national public health priorities, we aim to inform actionable policies and tailored intervention strategies to confront this growing epidemic."

Journal • Review • Fibrosis • Genetic Disorders • Hepatocellular Cancer • Hepatology • Immunology • Liver Cirrhosis • Metabolic Disorders • Metabolic Dysfunction-Associated Steatotic Liver Disease • Oncology • Pediatrics • Solid Tumor

AHAD: African major crops harvested area dataset for the years of 2000, 2010, and 2020. (PubMed, Sci Data) - "Africa faces significant challenges in food security, which are compounded by rapid population growth...In addition to the primary datasets, we also provide data quality assessments for each step of the process. The AHAD could provide geospatial and temporal patterns of harvested area, offering potential for advancing agricultural practices and enhancing food security across Africa."

Journal

BAICALEIN INDUCES HEPATIC STELLATE CELL SENESCENCE VIA INHIBITING GLYCOLYSIS BY CEBPZ/P53/HK2 SIGNALING PATHWAY TO INHIBIT LIVER FIBROSIS (AASLD 2025) - "Baicalein (BA) is a flavonoid compound extracted from the dried root of Scutellaria baicalensis, which can inhibit the mechanisms of cancer development such as metastasis, angiogenesis, and inflammation without harming healthy cells... Our findings suggested that BA had a protective effect on liver fibrosis, and the underlying mechanism might be related to the CEBPZ/p53/HK2 signaling pathway."

Fibrosis • Hepatology • Immunology • Liver Cirrhosis • Liver Failure • CEBPZ

A Chemical Glycoproteomic Approach Decrypts Urinary Extracellular Vesicle Surfaceome for Prostate Cancer Diagnosis and Grading. (PubMed, Angew Chem Int Ed Engl) - "These hurdles are further compounded by the inherent heterogeneity of EVs and the low abundance of surface targets in biofluids...Applied to urine samples from 368 individuals with prostate-related diseases, EVscope identified 1,121 EV surface proteins, establishing the largest urine-derived EV surfaceome dataset to date and identifying cathepsin L, integrin alpha 3, fibrinogen beta chain, and tetraspanin-1 as characteristic proteins with potential as noninvasive biomarkers for prostate cancer diagnosis and grading. In summary, this study establishes an innovative methodology for high-resolution EV surfaceome analysis, facilitating noninvasive biomarker discovery and enabling direct detection in population-scale screening."

Journal • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor

Combined environmental and natural disaster risk assessment of tailing ponds in China and diverse responses analysis. (PubMed, Environ Int) - "In summary, this study provides a scientific basis for the risk management and natural disasters adaptation of TPs in China. Considering the compounded effect of rainstorm on the environmental risks of TPs, the importance of addressing the impacts of climate change, warranting attention."

Journal • Psychiatry

Pinosylvin Inhibits Inflammatory and Osteoclastogenesis via NLRP3 Inflammasome. (PubMed, Adv Sci (Weinh)) - "In the current study, it is observed that Pinosylvin (PIN), a compound extracted from European red pine, selectively inhibits LPS- and RANKL-induced release of IL-1β effectively reducing osteoclastogenesis...Importantly, PIN alleviates inflammatory bone loss due to estrogen deficiency, reduces cranial bone destruction from local LPS injections, and improves survival in LPS-induced septic mice. This study uncovers the specific mechanism behind PIN's potent anti-inflammatory effects and identifies a new therapeutic target for NLRP3-driven diseases."

Journal • Osteoporosis • CASP1 • IL1B • IL6 • NLRP3

Bio-Inspired Observability Enhancement Method for UAV Target Localization and Sensor Bias Estimation with Bearing-Only Measurement. (PubMed, Biomimetics (Basel)) - "Inspired by the compound eye vision, a bio-inspired observability analysis method is proposed for stochastic systems...The proposed method demonstrates superior convergence in both target localization and sensor bias estimation. The nonlinear constrained multi-objective whale optimization algorithm achieves minimal values for both generational distance and inverted generational distance, demonstrating superior convergence and diversity characteristics."

Journal

Double [8]Helicene Featuring a Dibenzo[g,p]chrysene Core: Synthesis and Chiroptical Response. (PubMed, Org Lett) - "The compound exhibits red fluorescence with an emission maximum at 618 nm (λem) and a quantum yield of 16.2%, highlighting its potential in optoelectronic applications. Furthermore, circular dichroism (CD) and circularly polarized luminescence (CPL) measurements reveal notable chiroptical activity, with absorption and emission dissymmetry factors of;gabs| = 5.11 × 10-3 and;glum| = 7.1 × 10-4, respectively."

Journal

Embryonic developmental toxicity to estuarine fish: Single and co-exposure to EHMC and its phototransformation products in Mugilogobius chulae. (PubMed, Environ Res) - "This indicates that the phototransformation products exhibit greater developmental toxicity than the parent compound EHMC...The mixture further exacerbated oxidative imbalance through SOD and GST reduction and catalase (CAT) induction (p < 0.05). These findings underscore the critical need to consider photochemical transformation products in ecological risk assessments of OUVFs in estuarine ecosystems."

Journal • BMP2 • BMP4 • CAT • FGF4 • MATN3 • TGFB1 • TGFB2 • WNT3A

Baicalein induces hepatic stellate cell senescence via inhibiting glycolysis by CEBPZ/p53/HK2 signaling pathway to inhibit liver fibrosis (APASL 2025) - "Baicaliein (BA) is a flavonoid compound extracted from the dried root of Scutellaria baicalensis, which can inhibit the mechanisms of cancer development such as metastasis, angiogenesis, and inflammation without harming healthy cells... Our findings suggested that BA had a protective effect on liver fibrosis, and the underlying mechanism might be related to the CEBPZ/p53/HK2 signaling pathway. Table and Figure:Figure 1."

Fibrosis • Hepatology • Immunology • Liver Cirrhosis • Liver Failure • Oncology • CEBPZ

Elderly vulnerability to temperature-related mortality risks in China. (PubMed, Sci Adv) - "Furthermore, by identifying heterogeneous impacts based on location, sex, age, obesity, income, and diet, we reveal the pathways through which temperature metrics are likely to influence mortality risk. Our study highlights the compound effects of rising temperatures for elderly populations, and it could be expanded to other countries and regions experiencing similar challenges due to an aging population experiencing warming conditions."

Journal • Genetic Disorders • Obesity

Study protocol for a randomized controlled trial evaluating the effectiveness of a mother-child intervention model of neurogenic tremor as an add-on to treatment for emotional disorders in adolescents. (PubMed, BMC Complement Med Ther) - P=N/A | "This research endeavors to identify a straightforward and potent body-oriented psychological intervention that could improve the clinical outcomes for adolescent patients with emotional disorders. Such findings would carry profound implications not only for the healthy development of teenagers but also for potentially mitigating the burden on families, educational institutions, and society as a whole."

Clinical • Clinical protocol • Journal • CNS Disorders • Depression • Infectious Disease • Mood Disorders • Movement Disorders • Novel Coronavirus Disease • Psychiatry

Observation of Spin Splitting in Room-Temperature Metallic Antiferromagnet CrSb. (PubMed, Adv Sci (Weinh)) - "The magnitude of such SS reaches up to at least 0.8 eV at non-high-symmetry momentum points, which is significantly higher than the largest known SOC-induced SS. This compound expands the choice of materials in the field of antiferromagnetic spintronics and is likely to stimulate subsequent investigations of high-efficiency spintronic devices that are functional at room temperature."

Journal

From brain connectivity to cognitive function: Dissecting the salience network in pediatric BECTS-ESES. (PubMed, Prog Neuropsychopharmacol Biol Psychiatry) - "Our study heralds dFC within the SN as a vital biomarker for cognitive impairment in pediatric epilepsy, advocating for targeted cognitive-specific interventions in managing BECTS-ESES. The preliminary nature of our findings invites further studies to substantiate these associations, offering profound implications for the prognosis and therapeutic strategies in BECTS-ESES, thereby underlining the importance of this research in the field of pediatric neurology and epilepsy management."

Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Epilepsy • Pediatrics