nimodipine / Generic mfg. - LARVOL DELTA

Commentary on: "Impact of Nimodipine-Induced Blood Pressure Reductions on Cerebral Autoregulation and Functional Outcome after Aneurysmal Subarachnoid Hemorrhage". (PubMed, Neurocrit Care) - No abstract available

Journal • Cardiovascular • Hematological Disorders • Subarachnoid Hemorrhage

Response to Letter by Michael Veldeman Regarding Article "Impact of Nimodipine-Induced Blood Pressure Reductions on Cerebral Autoregulation and Functional Outcome after Aneurysmal Subarachnoid Hemorrhage". (PubMed, Neurocrit Care) - No abstract available

Journal • Cardiovascular • Hematological Disorders • Subarachnoid Hemorrhage

AMYLOID-BETA MODULATES L-TYPE CALCIUM CHANNELS TO CAUSE DYSFUNCTION IN SELECT HYPOTHALMAIC NEURONAL POPULATIONS (ADPD 2026) - "Collectively, these data support Cav1.3 but not Cav1.2 is required for the pathological effects of Aβ42 on ARC NPY/AgRP neurons. Nevertheless, blocking these effects were insufficient to restore the metabolic deficits in vivo, suggesting dysfunction in additional hypothalamic regions such as the VMH contribute to non-cognitive manifestations of AD."

Clinical • Alzheimer's Disease • CNS Disorders • APP • Aβ42 • FOS

Therapeutic efficacy of nimodipine and topiramate on migraine and vestibular migraine; A prospective multicenter open-label study. (PubMed, PLoS One) - "Nimodipine was associated with improvements in headache-related outcomes in migraine and in both headache- and dizziness-related outcomes in vestibular migraine. Given the observed improvements and favorable tolerability, nimodipine may be a valuable treatment option for migraine and vestibular migrain. Trial registration cris.nih.go.kr (KCT0010555)."

Clinical • Journal • CNS Disorders • Migraine • Pain

Unrevealing possible mechanism of Riluzole, Salsalate and Nimodipine in Alzheimer's disease: multi-target network pharmacological perspective. (PubMed, Inflammopharmacology) - No abstract available

Journal • Alzheimer's Disease • CNS Disorders

Pilot Study: Effects of Nimodipine on Alcohol Drinking (clinicaltrials.gov) - P2 | N=5 | Not yet recruiting | Sponsor: Yale University | Trial completion date: Jun 2026 ➔ Jun 2032 | Initiation date: Oct 2025 ➔ Sep 2026 | Trial primary completion date: Jun 2026 ➔ Jun 2032

Trial completion date • Trial initiation date • Trial primary completion date • Addiction (Opioid and Alcohol)

Unmet needs in aSAH: Limitations of Current Nimodipine Therapy and Emerging Evidence (SCCM 2026) - "However, many factors conspire to hinder full dosing, such as hypotension and gastrointestinal side effects. This workshop reviews the recommended prescribing of oral nimodipine and introduces data from a randomized clinical trial of a new intravenous nimodipine formulation (GTX‑104) that avoids the shortcomings of oral nimodipine."

Cardiovascular • Hematological Disorders • Hypotension • Subarachnoid Hemorrhage

Early Detection of Vasospasm Using Alpha-Delta Ratio Trends on EEG in a Subarachnoid Hemorrhage (SCCM 2026) - "Nimodipine was initiated for vasospasm prevention and an external ventricular drain (EVD) was placed for ventriculomegaly and somnolence...While TCD remains a standard tool for vasospasm surveillance, it is limited to certain vascular territories and performed intermittently. cEEG in contrast, offers real-time monitoring and may be particularly useful in neurologically intact patients."

Cardiovascular • CNS Disorders • Hematological Disorders • Subarachnoid Hemorrhage • Ventriculomegaly

Effect of ZHU Lian's acupuncture stimulation method on neurological function in rats with ischemic stroke based on the miR-34a-5p/YWHAG pathway (PubMed, Zhongguo Zhen Jiu) - "The rats in the positive drug group were treated with 10.8 mg/kg nimodipine via gavage...In addition, the miR-34a-5p and YWHAG have a targeted regulatory relationship (P<0.05). The ZHU Lian 's acupuncture stimulation method could improve neurological function in IS model rats, possibly by modulating the miR-34a-5p/YWHAG pathway."

Journal • Preclinical • Cardiovascular • Ischemic stroke • Oncology • IL6 • MIR34A • TNFA • YWHAG

Delayed cerebral ischaemia after subarachnoid haemorrhage: pathophysiology, diagnosis and neurotherapeutic opportunities. (PubMed, Discov Med (Singap)) - "Neuroprotective agents, such as calcium channel blockers like nimodipine, play a crucial role by reducing neuronal calcium influx and improving collateral circulation. Multimodal monitoring, incorporating techniques like transcranial Doppler, continuous EEG, and intracranial pressure monitoring, is essential for guiding treatment decisions and evaluating the efficacy of interventions. In the future, research should focus on a comprehensive approach to DCI management with pharmacological interventions and individualised treatment strategies."

Journal • Cardiovascular • Subarachnoid Hemorrhage

Rational development of a drug-delivery device based on MOF UiO-66 for calcium-channel-blocker drugs. (PubMed, Dalton Trans) - "The administration of drugs with low solubility or absorption, such as the calcium-channel-blocker (CCB) drugs amlodipine, nifedipine, and nimodipine, affects the management of complicated health conditions related to cardiovascular diseases. Finally, the effect on the biological activity of the drugs was evaluated using human microvascular endothelial cells, demonstrating that the material can improve the bioavailability of each drug, allowing a 90% reduction in the doses needed to attain a physiological effect. These results support the potential of UiO-66 as a central component in the development of a versatile drug-delivery system aimed at improving the treatment of patients with cardiovascular diseases."

Journal • Cardiovascular

Safety and Tolerability of GTX-104 (Nimodipine Injection for IV Infusion) Compared With Oral Nimodipine in Patients With Aneurysmal Subarachnoid Hemorrhage: A Prospective, Randomized Trial (AAN 2026) - "GTX-104, an IV formulation of nimodipine that can be administered through central or peripheral veins, is safer and potentially more efficacious than oral nimodipine."

Clinical • Cardiovascular • Hematological Disorders • Hypotension • Subarachnoid Hemorrhage

Idiopathic Intracranial Hypertension Following Non-aneurysmal Spontaneous Subarachnoid Hemorrhage in a Sickle Cell Disease Patient with Suspected Reversible Cerebral Vasoconstriction Syndrome (AAN 2026) - "He was started on nimodipine and repeat imaging 7 days after admission revealed interval development of several small foci of ischemia in the posterior greater than anterior white matter, left parasagittal occipital, and parietal lobes with mild associated cortical swelling...Lumbar puncture obtained showed an opening pressure of > 55 cm H20 consistent with IIH, for which he was started on acetazolamide, with gradual improvement in headache and his papilledema.Design/ NA NA This case is notable as a novel report of spontaneous SAH in a pediatric sickle cell patient with delayed cerebral ischemia and subsequent IIH. This case is notable as a novel report of spontaneous SAH in a pediatric sickle cell patient with delayed cerebral ischemia and subsequent IIH. While sickle cell-related vasculopathy is well-documented, its association with RCVS remains unclear. Post-inflammatory changes, possible venous outflow obstruction and CSF pressure disorders in sickle cell..."

Clinical • Asthma • Cardiovascular • CNS Disorders • Genetic Disorders • Hematological Disorders • Hypertension • Immunology • Ophthalmology • Respiratory Diseases • Sickle Cell Disease • Subarachnoid Hemorrhage

Comparison of the Effects of Amantadine, Methylprednisolone and Nimodipine in Sciatic Nerve Crush Injury. (PubMed, Turk Neurosurg) - "Overall, amantadine had the most positive cellular effects after sciatic nerve injury, though further research is required to explore optimal dosage, frequency, administration route, and additional clinical parameters In this study, amantadine was found to have the most favorable effects on nerve regeneration, but other drugs showed limited effects on some parameters. However, the lack of superiority in combined applications and the lack of clarification of ideal treatment conditions suggest the need for more comprehensive research in the future."

Journal

Nimodipine dosing and pharmacokinetic variability in subarachnoid hemorrhage patients. (PubMed, J Clin Neurosci) - "Nasogastric administration and non-fasting states may reduce nimodipine's bioavailability. CSF penetration was minimal and highly variable. The population pharmacokinetic model identified age as a significant determinant of clearance. Optimizing the administration of nimodipine may be required. Further large-scale studies focusing on the definition of nimodipinés optimal dosing are warranted."

Journal • PK/PD data • Cardiovascular • Hematological Disorders • Subarachnoid Hemorrhage

Pharmaceutically Assisted Angioplasty to Relieve Cerebral Vasospasm after Aneurysmal Subarachnoid Hemorrhage-A Retrospective, Single-Center, Observational Comparison of Established and New Treatment Techniques. (PubMed, Cardiovasc Intervent Radiol) - "EVT effectiveness remains a key target in vasospasm rescue treatment but relies on the right treatment modality. TBA remains most effective in vessel dilation. Stent-Retriever-Angioplasty may present an alternative to just pharmacological treatment balancing accessibility and risk profile. Using a combination of vasodilators may enhance treatment efficacy but the combination of nimodipine and papaverine shows little effect in our study."

Journal • Retrospective data • Cardiovascular • Hematological Disorders • Subarachnoid Hemorrhage

A molecularly imprinted electrochemical sensor based on dual functional monomers for selective determination of nimodipine. (PubMed, Anal Methods) - "Under optimal experimental conditions, the response of the MIECS to NMD showed a linear relationship ranging from 10-14 M to 10-8 M, with a detection limit of 2.97 × 10-15 M. Satisfactory recovery rates were obtained in the detection of human serum and tablets. This multi-parametric enhancement establishes a new paradigm for therapeutic drug monitoring in clinical neurology and pharmaceutical quality control."

Journal • Cardiovascular • Hematological Disorders • Subarachnoid Hemorrhage

Cost-Effectiveness Framework to Evaluate Therapeutic Interventions Targeting Reduction in Cerebral Infarction Among Aneurysmal Subarachnoid Hemorrhage Patients (ISC 2026) - "We present a cost-effectiveness framework which allows pre-trial assessment based on the cost of a therapeutic intervention and the expected magnitude of reduction in occurrence of cerebral infarction in aSAH patients."

Clinical • Cost effectiveness • HEOR • Cardiovascular • CNS Disorders • Hematological Disorders • Subarachnoid Hemorrhage

Protection of metabolic-haemodynamic coupling by nimodipine in an animal model of cerebral small vessel disease. (PubMed, J Cereb Blood Flow Metab) - "Coherence and semblance were significantly (p < 0.001) reduced in aged SHRSPs, indicating impaired metabolic-haemodynamic coupling, but these measures were significantly (p < 0.001) protected by treatment with nimodipine. We reveal dysregulation of cerebral metabolic-haemodynamic coupling in SHRSP, and, importantly, demonstrate the protective effect of nimodipine, a drug suitable for clinical use in cSVD."

Journal • Preclinical • Cardiovascular

Postpartum reversible cerebral vasoconstriction syndrome: a rare but severe cause of postpartum headache. (PubMed, BMJ Case Rep) - "However, digital subtraction angiography (DSA), revealed multifocal segmental narrowing of intracranial arteries, with complete reversibility after 3 months, consistent with RCVS.The patient was treated with oral nimodipine and experienced gradual symptom resolution. There was no complication associated, with no recurrence so far."

Journal • CNS Disorders • Giant Cell Arteritis • Migraine • Pain

GABA Receptor Activation in Müller Glia as a Molecular Switch for Controlling VEGF-A in the Retina. (PubMed, ASN Neuro) - "Cells were exposed to GABA and selective agonists or antagonists of GABAA (muscimol, gabazine) and GABAB receptors (baclofen, CGP55845)...To assess Ca2+ involvement, we used Ca2+-free Ringer-Krebs solution and the L-type channel blocker nimodipine, and examined MAPK signaling with the ERK1/2 inhibitor FR180204...Short-term assays revealed that GABA rapidly elevates VEGF-A protein and secretion within ∼30 minutes. Together, these findings identify a Ca2+- and GABAA-dependent pathway through which Müller glia regulate VEGF-A production and release, providing new insight into glial signaling and neurotransmitter-driven modulation of retinal angiogenic factors."

Journal • Developmental Disorders • VEGFA

Study on the application value of oxalidine fumarate injection for analgesia in emergency pre-hospital patients with severe trauma (ChiCTR) - P4 | N=80 | Recruiting | Sponsor: Fushun County People's Hospital; Fushun County People's Hospital

New P4 trial • Mood Disorders

Branch-Critical Clipping of a Ruptured Carotid-Posterior Communicating Aneurysm with Fetal PCA Configuration. (PubMed, Diagnostics (Basel)) - "Postoperatively, the blood pressure was kept within the range of 110-130 mmHg with nimodipine and closely monitored...By POD 5 CT scan, the clip remained positioned in a stable fashion without evidence of infarct, hemorrhage, or hydrocephalus; at three months she was neurologically intact (mRS 0; Barthel 100; MoCA 28/30), and CTA confirmed persistent exclusion of the aneurysm and preservation of fPCA flow. In cases where the ruptured aneurysm is located at the carotid communicating junction with the PCom artery in a configuration of the posterior cerebral artery that is described as fetal, clip treatment should be viewed as a form of branch-preserving junction reconstruction of the carotid-PCom junction supported by adherence to controlled postoperative physiology and close ppostoperativesurveillance."

Journal • Asthma • Cardiovascular • Cerebral Hemorrhage • CNS Disorders • Hematological Disorders • Hypertension • Immunology • Obesity • Pain • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Subarachnoid Hemorrhage • Ventriculomegaly

Retraction: Investigating new bilosomes for ex vivo skin deposition, in vitro characterization, and transdermal delivery of nimodipine. (PubMed, Nanoscale Adv) - "[This retracts the article DOI: 10.1039/D4NA00510D.]."

Journal • Preclinical

Epidemiological and Clinical Profile of Patients With Non-traumatic Subarachnoid Hemorrhage in a Brazilian Referral Hospital. (PubMed, Cureus) - "In unadjusted analyses, in-hospital death was more frequent among patients requiring endotracheal intubation, ventricular shunting, or who developed hydrocephalus, and less frequent among those who received nimodipine...In unadjusted, exploratory analyses, patients undergoing aneurysm coiling or clipping had more favorable crude outcomes than those managed conservatively; however, these differences are likely influenced by baseline severity and treatment selection and should not be interpreted as evidence of treatment efficacy. These findings underscore the need for improved early recognition, control of vascular risk factors, and expanded access to specialized neurosurgical and neurocritical care in resource-limited settings."

Journal • Cardiovascular • CNS Disorders • Hematological Disorders • Hypertension • Subarachnoid Hemorrhage • Ventriculomegaly