nimodipine / Generic mfg. - LARVOL DELTA

Postpartum reversible cerebral vasoconstriction syndrome: a rare but severe cause of postpartum headache. (PubMed, BMJ Case Rep) - "However, digital subtraction angiography (DSA), revealed multifocal segmental narrowing of intracranial arteries, with complete reversibility after 3 months, consistent with RCVS.The patient was treated with oral nimodipine and experienced gradual symptom resolution. There was no complication associated, with no recurrence so far."

Journal • CNS Disorders • Giant Cell Arteritis • Migraine • Pain

GABA Receptor Activation in Müller Glia as a Molecular Switch for Controlling VEGF-A in the Retina. (PubMed, ASN Neuro) - "Cells were exposed to GABA and selective agonists or antagonists of GABAA (muscimol, gabazine) and GABAB receptors (baclofen, CGP55845)...To assess Ca2+ involvement, we used Ca2+-free Ringer-Krebs solution and the L-type channel blocker nimodipine, and examined MAPK signaling with the ERK1/2 inhibitor FR180204...Short-term assays revealed that GABA rapidly elevates VEGF-A protein and secretion within ∼30 minutes. Together, these findings identify a Ca2+- and GABAA-dependent pathway through which Müller glia regulate VEGF-A production and release, providing new insight into glial signaling and neurotransmitter-driven modulation of retinal angiogenic factors."

Journal • Developmental Disorders • VEGFA

Study on the application value of oxalidine fumarate injection for analgesia in emergency pre-hospital patients with severe trauma (ChiCTR) - P4 | N=80 | Recruiting | Sponsor: Fushun County People's Hospital; Fushun County People's Hospital

New P4 trial • Mood Disorders

Cost-Effectiveness Framework to Evaluate Therapeutic Interventions Targeting Reduction in Cerebral Infarction Among Aneurysmal Subarachnoid Hemorrhage Patients (ISC 2026) - "We present a cost-effectiveness framework which allows pre-trial assessment based on the cost of a therapeutic intervention and the expected magnitude of reduction in occurrence of cerebral infarction in aSAH patients."

Clinical • Cost effectiveness • HEOR • Cardiovascular • CNS Disorders • Hematological Disorders • Subarachnoid Hemorrhage

Branch-Critical Clipping of a Ruptured Carotid-Posterior Communicating Aneurysm with Fetal PCA Configuration. (PubMed, Diagnostics (Basel)) - "Postoperatively, the blood pressure was kept within the range of 110-130 mmHg with nimodipine and closely monitored...By POD 5 CT scan, the clip remained positioned in a stable fashion without evidence of infarct, hemorrhage, or hydrocephalus; at three months she was neurologically intact (mRS 0; Barthel 100; MoCA 28/30), and CTA confirmed persistent exclusion of the aneurysm and preservation of fPCA flow. In cases where the ruptured aneurysm is located at the carotid communicating junction with the PCom artery in a configuration of the posterior cerebral artery that is described as fetal, clip treatment should be viewed as a form of branch-preserving junction reconstruction of the carotid-PCom junction supported by adherence to controlled postoperative physiology and close ppostoperativesurveillance."

Journal • Asthma • Cardiovascular • Cerebral Hemorrhage • CNS Disorders • Hematological Disorders • Hypertension • Immunology • Obesity • Pain • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Subarachnoid Hemorrhage • Ventriculomegaly

Retraction: Investigating new bilosomes for ex vivo skin deposition, in vitro characterization, and transdermal delivery of nimodipine. (PubMed, Nanoscale Adv) - "[This retracts the article DOI: 10.1039/D4NA00510D.]."

Journal • Preclinical

Epidemiological and Clinical Profile of Patients With Non-traumatic Subarachnoid Hemorrhage in a Brazilian Referral Hospital. (PubMed, Cureus) - "In unadjusted analyses, in-hospital death was more frequent among patients requiring endotracheal intubation, ventricular shunting, or who developed hydrocephalus, and less frequent among those who received nimodipine...In unadjusted, exploratory analyses, patients undergoing aneurysm coiling or clipping had more favorable crude outcomes than those managed conservatively; however, these differences are likely influenced by baseline severity and treatment selection and should not be interpreted as evidence of treatment efficacy. These findings underscore the need for improved early recognition, control of vascular risk factors, and expanded access to specialized neurosurgical and neurocritical care in resource-limited settings."

Journal • Cardiovascular • CNS Disorders • Hematological Disorders • Hypertension • Subarachnoid Hemorrhage • Ventriculomegaly

Flow diverter therapy for mirror-like aneurysms at the middle cerebral artery trifurcation: a case report. (PubMed, Front Surg) - "The continuous nimodipine infusion treatment resulted in the relief of the symptom...This case demonstrates that for mirror-like MCA aneurysms located at the superior and inferior branches of a MCA trifurcation, deploying a FD in the normal middle branch to cover the origins of the two aneurysmal branches may result in occlusion of the parent arteries harboring the aneurysms. However, this novel approach warrants cautious application as it remains non-routine."

Journal • Anesthesia • Cardiovascular • Hematological Disorders • Subarachnoid Hemorrhage • Vascular Neurology

Hypericin alleviates cerebral ischemia/reperfusion injury by modulating endoplasmic reticulum stress. (PubMed, Front Pharmacol) - "Male Sprague-Dawley rats were subjected to middle cerebral artery occlusion (MCAO) and treated intraperitoneally with hypericin (5, 10, or 20 mg/kg) 30 minutes before reperfusion or nimodipine (10 mg/kg) as a positive control...These findings demonstrate that hypericin confers significant neuroprotection against cerebral I/R injury by attenuating ER stress-mediated apoptosis and preserving neuronal integrity. Hypericin may represent a promising therapeutic candidate for ischemic stroke."

IO biomarker • Journal • Cardiovascular • CNS Disorders • Inflammation • Ischemic stroke • Reperfusion Injury • ANXA5 • BAX • BCL2 • CASP1 • CASP12 • CASP3 • HSPA5

Hidden Drug-Excipient Interaction by HPLC-MS/MS Analysis: Polysorbate 80 Enhances Nimodipine Systemic Exposure Through Competitive Metabolic Inhibition. (PubMed, Biomed Chromatogr) - "Mechanistic investigations using rat liver microsomes demonstrated that polysorbate 80 competitively inhibited nimodipine metabolism with an IC50 of 103.30 μmol/L and Ki of 94.35 μmol/L, while remaining minimally metabolized itself. These findings provide the first evidence of a clinically significant pharmacokinetic interaction between nimodipine and polysorbate 80, challenging the assumption of excipient inertness and highlighting the critical importance of evaluating excipient-drug interactions in pharmaceutical development and clinical practice."

Journal

An Anatomy-Guided, Stepwise Microsurgical Reconstruction of a Posteriorly Projecting ICA-PCoA Aneurysm Beneath the Optic Apparatus: A Detailed Operative Sequence. (PubMed, Diagnostics (Basel)) - "The authors describe a 62-year-old female who was stabilized by nimodipine and aggressive blood pressure control in the systolic range 140-160 mmHg after an aneurysmal subarachnoid hemorrhage... In posteriorly projecting ICA-PCoA aneurysms that are disturbed beneath the optic apparatus, an anatomy-guided strategy-early cisternal decompression, true posteromedial neck exposure, brief purposeful quieting of the proximal ICA and two-clip closure parallel to the PCoA in selected cases-may provide the opportunity for durable occlusion whilst the physiology of branching is preserved. We intend for this transparent description to be adopted, refined or discarded based on local anatomy and practice."

Journal • Cardiovascular • CNS Disorders • Epilepsy • Hematological Disorders • Subarachnoid Hemorrhage • Ventriculomegaly

AMYLOID-BETA MODULATES L-TYPE CALCIUM CHANNELS TO CAUSE DYSFUNCTION IN SELECT HYPOTHALMAIC NEURONAL POPULATIONS (ADPD 2026) - " In whole-cell voltage-clamp studies, exogenous soluble Aβ42 shifted the peak current of LTCC I-V curves in wildtype ARC NPY neurons from a high to low voltage-threshold, an effect reversed by LTCC antagonist nimodipine... Collectively, these data support Cav1.3 but not Cav1.2 is required for the pathological effects of Aβ42 on ARC NPY/AgRP neurons. Nevertheless, blocking these effects were insufficient to restore the metabolic deficits in vivo, suggesting dysfunction in additional hypothalamic regions such as the VMH contribute to non-cognitive manifestations of AD."

Clinical • Alzheimer's Disease • CNS Disorders • APP • Aβ42 • FOS

Inhibiting L-type calcium channel promotes cardiomyocyte proliferation through activating the canonical Wnt signaling pathway. (PubMed, Acta Pharmacol Sin) - "Among the 6 clinically approved calcium channel blockers tested in secondary screening and confirmatory experiments, nimodipine (NM) consistently enhanced CM proliferation both in vitro and in vivo...In the MI mouse model established by ligating the left anterior descending coronary artery, administration of NM (10 mg/kg, i.p.) for 7 consecutive days significantly improved cardiac contractile function and enhanced resident CM proliferation, which was attenuated by co-treatment with Wnt inhibitor Wnt-C59 (10 mg/kg, i.p.). Our data suggest that L-type calcium channel blockers that induce CM proliferation may be potentially used in the treatment of MI and heart failure to promote cardiac regeneration."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Myocardial Infarction • CTNNB1

Recurrent severe headache with a background of functional vomiting and normal brain MRI, in paediatric reversible cerebral vasoconstriction syndrome (RCVS) (EHF-EHC 2025) - "Sumatriptan had made his headaches worse... After the diagnosis of RCVS, he was started on oral Nimodipine and his headaches events reduce in frequency and severity to once a day... RCVS is a rare condition normally seen in middle age. The pathogenesis is unknown and recurrence is uncommon. Severe cases can lead to stroke due to vasoconstriction."

Cardiovascular • Chronic Kidney Disease • CNS Disorders • Cognitive Disorders • Migraine • Pain • Pediatrics

Drug-Dependent Enhancement of Blood-Brain Barrier Permeation by Polysorbate 80 Minor Components. (PubMed, Pharmaceutics) - "Drug-loaded formulations were then prepared using the solvent evaporation method incorporating five model drugs: 1,1'-dioctadecyl-3,3,3',3'-tetramethylindotricarbocyanine iodide (DiR, MW = 1013.39 Da), donepezil (MW = 379.49 Da), nimodipine (MW = 418.44 Da), chlorogenic acid (MW = 354.31 Da), and paclitaxel (MW = 853.92 Da). Conversely, none of the different minor components enhanced the delivery of chlorogenic acid or paclitaxel, underscoring the critical role of specific drug-component interactions. This component-resolved insight challenges the conventional perception of PS80 and provides a rational framework for engineering precision brain-targeted delivery systems by selecting functional minor components."

Journal • CNS Disorders

Investigation of the Mechanism of Action of the Mongolian Medicine Eerdun Wurile Basic Formula in the Treatment of Ischemic Stroke Through Transcriptomics and Metabolomics Integration. (PubMed, Dose Response) - "SD rats were divided into six groups: Sham operation group, MCAO/R group, MCAO/R + Nimodipine group, MCAO/R + EWB low-dose group (EWB-L group), MCAO/R + EWB medium-dose group (EWB-M group), and MCAO/R + EWB high-dose group (EWB-H group)...Furthermore, qRT-PCR and western blot analyses confirmed that EWB mitigates inflammation and inhibits relevant metabolic pathways by regulating the gene and protein expression of these core targets. In summary, this study revealed that EWB reduces neuroinflammation and protects against ischemic stroke by modulating SLC17A6, SLC6A11, SLC6A9, ADORA1, GNG7, and the NF-κB signaling pathway, as well as regulating metabolites such as adenosine monophosphate and succinic acid."

Journal • Alzheimer's Disease • Cardiovascular • CNS Disorders • Ischemic stroke • Metabolic Disorders • Oncology • IL1B • IL6 • TNFA

Use of nootropics in Alzheimer's disease: An analysis of regulatory positions and drug policies in the countries of the Commonwealth of Independent States. (PubMed, Int J Risk Saf Med) - "We compared the results of Russia with other countries regulatory and policy positions.ResultsE-Library searches identified 11 nootropicspiracetam, citicoline, idebenone, vinpocetine, choline alfoscerate, Cerebrolysin®, Kortexin®, ethylmethylhydroxypyridine succinate, glycine, nicergoline, nimodipine. Eight nootropic have registration for use in all CIS countries (excluding idebenone, nimodipine), four (piracetam, nimodipine, nicergoline, idebenone) - in UK, nimodipine - in the USA, and idebenone - in EU...None is included on the WHO Model EML and the National EML of Kyrgyzstan, Only CPG of the RF recommend using two nootropics as adjuvant therapy of Alzheimer's disease, Cerebrolysin® and choline alfoscerate. CPG of the European Union, the United Kingdom, and the USA do not mention nootropics as potential treatment options for Alzheimer's disease."

Journal • Alzheimer's Disease • CNS Disorders • Dementia

Drug Development. (PubMed, Alzheimers Dement) - "The use of calcium channel blockers Cav2.1, in combination with monoclonal antibodies may provide a new intervention strategy to reduce the occurrence and alleviate the symptoms of ARIA-E."

Journal • Review • Alzheimer's Disease • Cerebral Hemorrhage • CNS Disorders • Hematological Disorders • Metabolic Disorders • CAV2

Reveal the mechanism of action of donepezil combined with nimodipine in the treatment of Alzheimer's disease via metabolomics and lipidomics analyses in rats. (PubMed, J Alzheimers Dis) - "These metabolites are mainly involved in glycerophospholipid metabolism, sphingolipid metabolism, amino acid metabolism, unsaturated fatty acid metabolism and other processes in AD rats.ConclusionsDN could improve cognitive function and nerve damage in AD rats. It may plays a therapeutic role in AD rats by regulating cholinergic damage, Ca2+ overload, oxidative stress, neuroinflammation, and energy deficiency caused by metabolic disorders, which has practical significance for further research and clinical application of DN."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders • Inflammation • Metabolic Disorders

Clinical outcomes in spontaneous subarachnoid hemorrhage after introduction of continuous intra-arterial vasospasmolysis for treatment of refractory delayed cerebral ischemia. (PubMed, Front Neurol) - "In our center, continuous intra-arterial vasospasmolysis with nimodipine (ciaN) has been introduced as the standard endovascular therapy for cerebral vasospasms since 2016...Our data indicate a contribution of the changes in treatment standard for endovascular vasospasm therapies from angioplasties to ciaN. Prospective studies are needed to compare the effect of ciaN in DCI with standard medical therapy."

Clinical data • Journal • Cardiovascular • Hematological Disorders • Subarachnoid Hemorrhage

A cause and protective treatment for acute and progressive disability and grey matter atrophy. (PubMed, Brain) - "Remarkably, both the temporary initial disability and the ensuing progressive disability and atrophy are significantly reduced if the acute hypoxia is avoided by four days of treatment with vasodilating nimodipine, or by simply breathing raised oxygen concentration. Thus, a lifetime of progressive disability and neurodegeneration can be the legacy of a few days of inflammatory hypoxia experienced in young adulthood, and avoided by maintaining lesion oxygenation. The findings may help to understand and treat some progressive neurological disorders, including multiple sclerosis."

Journal • CNS Disorders • Inflammation • Multiple Sclerosis

Improving Timely Administration of Nimodipine in Aneurysmal Subarachnoid Hemorrhage: A Quality Improvement Initiative (ASHP 2025) - No abstract available

Cardiovascular • Hematological Disorders • Subarachnoid Hemorrhage

Phase 1, randomized, crossover study comparing intravenous GTX-104 to oral nimodipine in healthy human subjects. (PubMed, PLoS One) - "The average oral bioavailability for nimodipine capsules was 7%. These results enabled a Phase 3 safety study of GTX-104 in humans with aneurysmal subarachnoid hemorrhage."

Clinical • Journal • P1 data • Cardiovascular • Hematological Disorders • Subarachnoid Hemorrhage

Unraveling NAGMA: A Case Series of Intravenous Nimodipine-Induced Metabolic Acidosis in Neuro-ICU Patients. (PubMed, Asian J Neurosurg) - "This phenomenon was later corroborated in a similar case from another hospital. The case highlights the importance of pharmacovigilance, postmarketing surveillance, and regulatory oversight in identifying rare drug-related adverse events, particularly in high-acuity settings like NICU."

Journal • Cardiovascular • Critical care • Hematological Disorders • Metabolic Disorders • Pain • Subarachnoid Hemorrhage • Vascular Neurology

Vasospasm During Endovascular Treatment of Ischemic Stroke: Associated Factors, Impact on Outcomes, and the Effect of Intraarterial Nimodipine. (PubMed, Stroke) - "Younger patients who are active smokers, presenting with distal occlusions, and require multiple recanalization attempts are at higher risk. Intraarterial nimodipine appears to be a sensible treatment as it may mitigate neurological deterioration without signals of potential harm."

Journal • Cardiovascular • Cerebral Hemorrhage • CNS Disorders • Hematological Disorders • Ischemic stroke