amlitelimab SC (KY1005 SC) / Sanofi - LARVOL DELTA

Press Release: AAD: new results from Sanofi’s amlitelimab phase 3 studies in atopic dermatitis presented in late-breaking research session (GlobeNewswire) - "In the COAST 1 and COAST 2 studies, amlitelimab met the primary endpoint. In COAST 1, key secondary endpoints, including vIGA-AD 0/1 with barely perceptible erythema (BPE), the proportion of patients reaching a 75% or greater improvement in the eczema area, severity index total score (EASI-75), and a ≥4-point reduction in peak pruritus-numerical rating scale (PP-NRS) were statistically significant. In COAST 2, EASI-75 and PP-NRS≥4 reached nominal significance; vIGA-AD 0/1 with BPE did not reach statistical significance. In the SHORE study, amlitelimab in combination with topical corticosteroids (TCS) with or without topical calcineurin inhibitors (TCI), dosed at both Q4W and Q12W, demonstrated significant improvements in AD clinical signs and symptoms versus placebo as measured across primary and key secondary endpoints at Week 24."

Late-breaking abstract • P3 data • Atopic Dermatitis

At the AAD meeting, Sanofi presented the second case, identified in the still-blinded ESTUARY phase 3 study (clinical study identifier: NCT06407934) (GlobeNewswire) - "In each case, the patient stopped treatment with amlitelimab and is in the recovery phase. Sanofi has not identified any further cases of KS across an estimated 4,630 patients in the full amlitelimab development program, including still-blinded studies. Sanofi believes that amlitelimab continues to have the potential to be a meaningful and convenient option for patients with AD. Results from ESTUARY, a phase 3 extension study evaluating Q12W maintenance dosing and longer-term safety, are anticipated in H2 2026."

P3 data • Atopic Dermatitis

Combined Oral: Efficacy and Safety of Monotherapy Amlitelimab, a Non-Depleting Anti-OX40 Ligand Antibody, in Moderate-to-Severe Atopic Dermatitis: 24-Week Results From the Pivotal COAST 1 and COAST 2 Phase 3 Trials and Efficacy and Safety of Amlitelimab, a Non-Depleting Anti-OX40 Ligand Antibody, in Combination With Topical Therapy in Participants With Moderate-to-Severe Atopic Dermatitis:... (AAD 2026) - No abstract available

Clinical • Combination therapy • Late-breaking abstract • Monotherapy • P3 data • Atopic Dermatitis • Dermatitis • Dermatology • Immunology

Prostate-Specific Antigen Response With Darolutamide Plus Androgen-Deprivation Therapy in Patients With Metastatic Hormone-Sensitive Prostate Cancer in ARANOTE (HOPA 2026) - "More patients receiving darolutamide achieved undetectable PSA at any time versus placebo, regardless of baseline PSA. Undetectable PSA response with darolutamide correlated with clinical benefit in terms of radiologic progression or death and longer times to mCRPC and PSA progression. Saad F, Vjaters E, Shore N, et al."

Clinical • Metastases • Castration-Resistant Prostate Cancer • Genito-urinary Cancer • Hormone Sensitive Prostate Cancer • Oncology • Prostate Cancer • Solid Tumor

Stochastic Dynamic Analysis and Vibration Suppression of FG-GPLRC Cylinder-Plate Combined Structures with Distributed Dynamic Vibration Absorbers. (PubMed, Materials (Basel)) - "Cylinder-plate combined structures (CPCS) are widely used in aerospace, marine engineering, and offshore platform systems...The results demonstrate that the incorporation of distributed DVAs can achieve superior vibration suppression performance. This study provides an efficient and reliable theoretical framework for stochastic vibration analysis and damping design of advanced composite plate-shell coupled structures operating in complex random environments, offering important theoretical support for dynamic optimization design in aerospace and marine engineering applications."

Journal • Fatigue

Hybrid Resins Derived from Abies alba Exudate as Matrices for Composite Materials. (PubMed, Polymers (Basel)) - "The turpentine-based hybrid resin (HR1) showed a rigid mechanical response, with tensile strengths of approximately 13.2-13.5 MPa, compressive strengths of about 30 MPa, Shore D hardness values of 56-58.5, and a low damping ratio (≈0.026)...To demonstrate their applicability in composite manufacturing, the HR1 matrix was reinforced with cotton fabric, leading to a substantial improvement in tensile strength (25-26 MPa) and flexural strength (35-36 MPa), together with an increased natural frequency. Water absorption tests revealed limited moisture uptake for the neat hybrid resins (≤0.04 g), while the cotton-reinforced composite exhibited higher but largely reversible water absorption (≈21.5%), associated with the hydrophilic nature of the reinforcement."

Journal

UAV-Based Oil Leakage Spot Detection Under Complex Illumination via a Collaborative Low-Light Enhancement and Detection Framework. (PubMed, Sensors (Basel)) - "However, UAV-based inspection in onshore oilfields often suffers from complex illumination conditions, such as low light, backlighting, and mixed shadows, which simultaneously degrade image visibility and obscure leakage-sensitive features, thereby causing missed detection of minute and weak-texture oil leakage targets...Experiments on UAV oilfield datasets demonstrate that the proposed method achieves a precision of 94.25% and a mean average precision (mAP) of 87.54%, outperforming existing approaches. The proposed framework provides an effective and robust solution for oil leakage spot detection under complex illumination."

Journal

Investigations on the Performances of Corn Starch/PBAT Blends. (PubMed, Polymers (Basel)) - "Based on these, the degradation properties of PBAT and the blend containing 50 wt.% CS (50%CS/PBAT) in water and open-air storage were comparatively studied via visual appearance observation, Shore hardness testing, and water absorption measurement...Immersion in water or being placed in air could accelerate the degradation of 50%CS/PBAT much more seriously than PBAT. Compared with PBAT, 50%CS/PBAT was of much lower cost and easier to be degraded, especially in water; it should be an ideal degradable blend for applications in packaging, agricultural mulch, and some other areas."

Journal

Characterization of PC-ABS and PETG Multi-Material Laminates Fabricated by MEX Method. (PubMed, Polymers (Basel)) - "Tensile behavior was measured using ISO 527-2 Type 1B specimens at 5 and 50 mm/min, complemented by three-point bending in horizontal/vertical orientations, unnotched Charpy impact (ISO 179), Shore D hardness (ISO 868), and SEM fractography...In tension, COMP strength decreased by ~21-23% relative to PETG and by ~5-6% relative to PC-ABS at both speeds, consistent with interface-controlled damage. SEM revealed void-assisted crack initiation and interfacial debonding aligned with raster paths, highlighting interfacial strengthening and porosity reduction as key routes to improve tensile performance while retaining favorable flexural and impact response."

Journal

Integrated Analysis of Physiological and Transcriptional Mechanisms in Response to Drought Stress in Scaevola taccada Seedlings. (PubMed, Plants (Basel)) - "Scaevola taccada, as a key dominant plant in coastal ecosystems, plays an irreplaceable role in sand fixation, shoreline protection, and maintaining the ecological stability of coastal zones...In summary, Scaevola taccada effectively responds to drought stress through multi-level mechanisms, including photosynthetic regulation, carbon metabolism regulation, antioxidant defense, and transcriptional reprogramming, demonstrating strong drought resistance and post-rewatering recovery potential. These findings provide scientific evidence for plant selection and application in ecological restoration projects in coastal areas in the context of global climate extremes."

Journal

Investigation of Hardness, Microstructure, and Mechanical Properties of Goat Horn Powder-Reinforced Wood-like Polyurethane Composites. (PubMed, Polymers (Basel)) - "Shore D hardness increased systematically with higher GHP content across all ratios. The study demonstrates that GHP is a functional, sustainable reinforcing element that improves toughness and hardness while supporting environmental waste management."

Journal

Atmospheric Corrosion Behavior of Q235 Steel Exposed to the Subtropical Marine Environment in the East China Sea for Two Years. (PubMed, Materials (Basel)) - "Despite the increase in exposure time from 6 to 24 months, during which the electrochemical stability of the rust layer enhanced over time, it failed to prevent the initiation and propagation of severe localized corrosion-an issue of critical importance for load-bearing structures. The findings provide important theoretical and data support for service-life assessment and corrosion protection design of offshore photovoltaic steel structures."

Journal

Feasibility Study of Suitable Surface Treatments for 3D-Printed Parts to Increase Abrasion Resistance Stability. (PubMed, Polymers (Basel)) - "Surface layer thickness, roughness (ISO 21920-2:2021), coefficient of friction (ASTM G99-23), and Shore D hardness (ASTM D2240-15R21) were measured...The findings demonstrate that surface treatments substantially alter the tribological and mechanical surface behavior of MJF-printed PA12GB parts. The suitability of a given treatment strongly depends on the intended functional requirements, particularly with respect to friction and surface hardness."

Journal

Effects of Simulated Precipitation Treatment on Denitrifying Microbial Communities in the Wayan Mountains. (PubMed, Biology (Basel)) - "Here, we investigated the response of nirK-type denitrifying microbial communities to altered precipitation in an alpine wetland on the northern shore of Qinghai Lake...Together, these findings elucidate how precipitation shifts reconfigure the structure and functional potential of denitrifying microbial communities in alpine wetlands, primarily via changes in soil pH and moisture under variable selection. This work provides critical insights into microbial regulation of the nitrogen cycle on the Tibetan Plateau under ongoing climate change."

Journal

In Vitro and In Ovo CAM Model Evaluation of Periosteum-Derived Micrografts. (PubMed, J Funct Biomater) - "Notable enhancement of total vessel area, total length, and branching points were obtained when Fisiograft® (p = 0.0007, p = 0.0002, and p < 0.0001, respectively), New Shore® (p = 0.0006, p = 0.0149, and p = 0.0083, respectively), and Bio-Oss® (p = 0.0038 and p = 0.0010, respectively) were combined with micrografts, compared to the positive controls. The histological and immunohistochemical analyses confirmed increased vascularisation (positive staining for SMA) in the micrograft groups. Periosteum-derived micrografts represent a promising adjunct to conventional bone-grafting materials, promoting vascularisation and potentially enhancing tissue regeneration and healing outcomes."

Journal • Preclinical • Orthopedics • CD31 • CD34 • CD73 • ENG • PECAM1 • PTPRC • THY1

Seasonal-Spatial Habitat Variation and Resource Status of Spear Shrimp Mierspenaeopsis hardwickii (Miers, 1878) in the Southern Yellow Sea and East China Sea. (PubMed, Biology (Basel)) - "In winter, a few individuals were sparsely distributed in the offshore water areas of the southern Yellow and East China Seas, and part of the recruitment in the Taiwan Strait might migrate northward to Yushan and Wentai fishing grounds for the nursery. The present investigations provide baseline data that will enable fishers and policymakers to better manage and conserve this resource for future use."

Journal

Levels, sources, and risk assessment of Polycyclic Aromatic Hydrocarbons in surface sediments of Houshui Bay and adjacent waters, Hainan, China. (PubMed, Mar Pollut Bull) - "The total concentrations of the 16 PAHs ranged from 7.90 to 110.40 ng/g (dry weight, dw), with a mean value of 56.22 ng/g dw, and nearshore concentrations were generally higher than offshore ones...Ecological risk assessment was conducted via sediment quality guidelines (ERL/ERM), toxic equivalent quantity (TEQ) and risk quotient (RQ) all stations had PAH concentrations below the ERL value; the TEQ of PAHs (an indicator for toxicity evaluation) ranged from 0.014 to 3.322 ng/g dw; RQ (an indicator for ecological risk assessment) revealed that all stations were at medium-low ecological risk. This study is the first comprehensive PAH assessment in Houshui Bay, providing a scientific basis for PAH pollution management in this bay and analogous marine ecosystems."

Journal

Accounting for Intra- and Intergenomic Sequence Variation in Reference Barcodes Improves eDNA Metabarcoding Biodiversity Assessment. (PubMed, Mol Ecol Resour) - "We collected coral tissue and water samples at deep sites offshore Puerto Rico for reference barcoding and eDNA metabarcoding...Integrating reference genome skimming and eDNA metabarcoding expanded known coral family richness by 36% at depths shallower than 1000 m and by 181% at depths greater than 1000 m. eDNA also detected two coral families previously unknown off Puerto Rico and nearby islands, underscoring its potential for biodiversity discovery."

Journal

A comprehensive analysis of retrieving optically inactive indicators from multi-level remote sensing product(s) in Irish waters using data science techniques. (PubMed, Water Res) - "In terms of product, S3-OLCI outperformed MS data with low uncertainty, whereas spatio-temporal analysis showed the highest DOX in inshore/semi-enclosed bays and the lowest offshore...Despite the validation challenges, the results highlight key difficulties in retrieving optically inactive water quality (WQ) indicators like DOX using RS and ML/AI approaches. The findings of the research could be effective for supporting the mapping of baseline oxygen conditions, the application of ML/AI techniques to retrieve WQ indicators from RS products and their further technological advancement, such as managing the anthropogenic water cycle (i.e., human-altered hydrological and nutrient dynamics)."

Journal

A One Health assessment of antimicrobial-resistant Enterobacterales in migratory little stints (Calidris minuta) and aquatic ecosystems in the Kenyan Rift Valley. (PubMed, PLoS One) - "Isolates were recovered from fecal samples of C. minuta foraging at the shores of Lakes Bogoria (low anthropogenic activities) and Magadi (high anthropogenic activities), as well as from peripheral freshwater sources shared by birds, humans, livestock and wildlife...Resistance was highest for ampicillin (50%) and lowest for meropenem (1.0%). The predominant MDR phenotype was a combination of resistances to ampicillin, tetracycline, and sulfamethoxazole-trimethoprim...This is the first study to link C. minuta to the antimicrobial resistance (AMR) epidemiological circuit. Our findings underscore the need to include migratory wild birds in AMR surveillance and utilizing whole-genome sequencing to accurately trace the origin and dissemination pathways of AMR strains."

Journal

YOLO-MFD: a multi-scale feature and dynamic head framework for prefabricated shoreline underwater object detection. (PubMed, Sci Rep) - No abstract available

Journal

The Very Long-term Iberian Fish Database Archaeological Fish Occurrences within the Iberian Peninsula. (PubMed, Sci Data) - "Humans have inhabited the sea shores and rivers of the Iberian Peninsula for thousands of years, leaving behind numerous traces and a wide variety of fish remains...The identified portion of the assemblages (NISP = 81,312) comprises identifications at the species, genus, family, and order or higher taxonomic levels. Spanning approximately 90,000 years - from the Middle Palaeolithic to the 19th century - the VLT_IberianFISH Database offers a resource for a range of disciplines concerned with aquatic environments, human occupancy and resource exploitation."

Journal

A distributed differential game approach to trajectory planning for offshore wind farm inspection. (PubMed, PLoS One) - "The convergence of the proposed strategy to a global Nash equilibrium (G-NE), as confirmed by theoretical analysis, ensures system-level coordination optimality subject to round-trip and energy constraints. Simulation results demonstrate that the method significantly enhances inspection efficiency and reduces task completion time by up to [Formula: see text] compared to conventional approaches, while guaranteeing the safe return of all UAVs."

Journal • Metabolic Dysfunction-Associated Steatohepatitis

Assessing the ecosystem health of tropical mangroves using biliary, urinary and hemolymph fluids from organisms of the Brazilian Equatorial Margin (Jaguaribe River, Ceará, Brazil). (PubMed, Mar Pollut Bull) - "Mangrove forests along the Brazilian Equatorial Margin (BEM) occur in a coastal zone influenced by strong hydrodynamics and increasing anthropogenic pressures, and which has recently become a new frontier for offshore oil development and marine mineral extraction...This study shows that contaminant levels in urine, hemolymph, and bile provide complementary and sensitive indicators of ecosystem health in tropical mangroves. The three matrices captured different aspects of exposure and metabolism, with bile reflecting hydrophobic PAHs, urine indicating soluble metabolites and hemolymph signaling short-term physiological responses."

Journal

Spatial patterns of 'pink spots' on Porites coral in Mo'orea, French Polynesia imply a positive association with anthropogenic impacts. (PubMed, Mar Environ Res) - "Our study explores spatial patterns of MPS on fringing reefs off the north shore of Mo'orea, French Polynesia during 2016 and 2021...We hypothesize that this dispersion pattern may be related to differences in the two known causative agents' life cycles and emphasize the importance of more research on identifying causes. Our research provides the first documentation of spatial patterns of MPS for South Pacific islands and demonstrates MPS are more widespread and may have a broader relationship to human impacts than previously known."

Journal