amlitelimab SC (KY1005 SC) / Sanofi - LARVOL DELTA

Multidrug-Resistant Bacteria in South Atlantic Cetaceans over a Decade of Surveillance. (PubMed, Microorganisms) - "Because carcass-based sampling inherently targets a diseased or senescent fraction, these high prevalences may overestimate the resistome burden of healthy free-ranging populations. The detection of human pathogens across coastal and offshore habitats indicates persistent deficiencies in terrestrial effluent management, reinforcing cetaceans as One Health sentinels."

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Frontier Advances in Wind-Driven Triboelectric Nanogenerators for Realistic Wind Environments: Scenario-Oriented Architecture Design, System Integration, and Critical Assessment. (PubMed, Micromachines (Basel)) - "This review examines wind-driven TENGs from the perspective of realistic wind-field constraints, focusing on three representative scenarios: urban micro-winds, offshore wind-wave environments, and low-altitude complex flows...Key challenges involving usable regulated energy, environmental reliability, lifetime prediction, array scaling, sustainability, and deployment economics are critically discussed. Finally, five grand challenges with actionable milestones are proposed to facilitate the transition of wind-driven TENGs from laboratory prototypes toward deployable distributed micro-energy systems."

Journal • Review

Mercury in Red Knots (Calidris canutus rufa): Inter-Annual and Geographic Variation in Blood Mercury and Associated Toxicological Risk Along the Atlantic Flyway. (PubMed, Toxics) - "Shorebird populations are declining sharply, and trace metal contaminants may compound the many migration-related threats they face by affecting feeding, migration, and reproductive success...Two cohorts had small samples, and site, season, and migratory stage are confounded in the design. Risk varies markedly among years, and a single sampling event is unlikely to characterize mercury exposure or its associated risk."

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Genome-Wide Identification and Bioinformatics Analysis of Thaumatin-like Proteins in Aegiceras corniculatum. (PubMed, Genes (Basel)) - "Heterologous expression and antibacterial tests showed that recombinant AcTLP19 had no direct antifungal activity against B. cinerea or Fusarium oxysporum under the tested conditions, leaving open the possibility that it contributes to mangrove defense through indirect mechanisms, or that its antifungal activity was not captured under the specific assay conditions. This study advances our knowledge of mangrove stress responses and may contribute to future conservation strategies."

Journal • Infectious Disease

Transcriptomic Landscape of Gut Microbiota-Host Interactions Reveals Domestication-Related Changes in the Pearl Oyster Pinctada maxima. (PubMed, Animals (Basel)) - "Collectively, these coordinated transcriptomic and microbial alterations reflect a multifaceted host-microbiome adaptive response to nearshore conditions. Our findings provide valuable molecular markers and microbial indicators for selective breeding and health monitoring, offering a scientific basis for improving the resilience of P. maxima aquaculture under changing environmental conditions."

Journal • CDC37 • HSP90AA1

Polymeric Kinetic Hydrate Inhibitors in NaCl Brine-Sediment Media: Hydrate Performance, Rheological Structuring, and Interfacial Responses. (PubMed, Gels) - "Gas hydrate plugging remains a persistent flow-assurance challenge in offshore oil and gas operations...These results show that small-deformation stiffness, steady yielding, oscillatory flow transition, post-shear recovery, and KHI performance are distinct but partially coupled material responses. The combined evidence supports weak, deformable polymer-sediment structuring rather than a single rheological strength mechanism governing hydrate inhibition."

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Application of High-Strength, High-Temperature-Resistant, and Degradable Inorganic Gel for Preferential Flow Path Plugging in Cyclic Steam Stimulation of Bohai N Extra-Heavy Oil Reservoir. (PubMed, ACS Omega) - "Field application in Well A15H increased the daily oil production from 30 m3 to 63 m3, reduced the water cut from 75% to 54%, and achieved an input-output ratio of 6.29 at an oil price of $50 per barrel. This work provides a reliable enhanced oil recovery (EOR) technique for offshore extra-heavy oil reservoirs with well-developed preferential flow paths."

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Synergistic effects of perfluoropolyether alcohol modification on the hydrophobicity and flexibility of waterborne nano-polyurea coatings. (PubMed, RSC Adv) - "With increasing PFPE-OH content, the water contact angle increased from 63.3° to 108.4°, the elongation at break first increased from 2.40% to 3.98% and then decreased to 0.69% at excessive PFPE-OH loadings, and the Shore hardness decreased from 61 to 42, indicating significant improvements in both hydrophobicity and flexibility...In particular, when the MDI/PFPE-OH feed ratio was 1 : 0.08, the coating exhibited an adhesion strength of 5.33 MPa and superior overall performance. These findings demonstrate that PFPE-OH modification is an effective strategy for achieving simultaneous enhancement of hydrophobicity and flexibility in waterborne nano-polyurea coatings."

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Cumulative Duration and Habitat Selection Across the Annual-Cycle Stages: Links to Human Modification in Two Declining Shorebirds. (PubMed, Integr Zool) - "Notably, both species repeatedly used highly modified coastal regions for extended periods, particularly basins draining into the Gulf of Thailand between the Mekong and Kolok rivers, the Chao Phraya River Basin, the Tianjin coast, and the Putian coast. These findings improve our understanding of the full annual-cycle habitat use and highlight the critical need to conserve key coastal regions while mitigating anthropogenic pressures across the flyway."

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Study on the Effects of Flow Fields Under the Refuge Effect of Artificial Reefs on the Behavior and Physiology of Juvenile Lutjanus erythopterus. (PubMed, Biology (Basel)) - "This study confirms that under the sheltering conditions of artificial reefs, flow-field differences significantly affect the behavioral and physiological characteristics of fish. These findings provide an important scientific basis and theoretical reference for the ecological design and site selection of offshore wind farm pile foundations, as well as for assessing the impacts of habitat alterations following pile foundation construction on fishery resources."

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Microplastics Contamination and Ecological Risk Assessment in Natural and Afforested Mangrove Stands of Bahrain: Abundance, Polymer Composition, and Onshore-Offshore Variability. (PubMed, Toxics) - "Although ecological risk indices suggested an overall low-to-moderate environmental risk, the ubiquitous occurrence of MPs throughout Bahrain's mangrove sediments raises concern regarding their long-term ecological implication. These findings provide a robust baseline for future spatiotemporal monitoring, refined ecological risk assessments, and the formation of targeted management strategies to safeguard coastal ecosystems."

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Automatic Classification of Hydrogen-Induced Acoustic Emission Signals in High-Strength Offshore Bolts Using Time-Frequency Feature Engineering. (PubMed, Materials (Basel)) - "The introduction of spectral and temporal energy-distribution features improved cluster separability under in situ hydrogen-charged conditions. The results demonstrate that physically informed feature engineering combined with automatic clustering provides a promising proof-of-concept approach for mechanism-informed identification of hydrogen-assisted AE activity in high-strength steel fasteners."

Journal • Fatigue • Musculoskeletal Diseases • Orthopedics

Generation and Characterization of a Sexual Tetraploid Genotype of Seashore Paspalum (Paspalum vaginatum) for Novel Breeding Strategies. (PubMed, Plants (Basel)) - "Both seeds and seedlings from a diploid population were treated with 0.2% colchicine for either 24 or 48 h. Morphological, anatomical, and reproductive traits were evaluated in both cytotypes. No seed set was observed under self-pollination, whereas limited seed set under open-pollination confirmed that the tetraploid is an outcrosser. This new tetraploid provides a valuable bridge parent for introgressing genetic variation from cross-compatible polyploid Paspalum species through interspecific hybridization and the manipulation of apomixis."

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Synergistic Effects of GGBS and Recycled Aggregates on the Tribological, Mechanical, and Fracture Behavior of Polymer Concretes. (PubMed, Polymers (Basel)) - "To evaluate the performance of the developed PCs, parameters including unit weight, water absorption capacity, flexural and compressive strengths, Shore D hardness, surface roughness, acid resistance, Bohme abrasion resistance, and fracture energy were analyzed...Regarding fracture energy, while the W20 series absorbed more energy than the B25 series, it still remained 47.8% lower than the reference. Additionally, the GGBS-incorporated series demonstrated higher susceptibility to sulfuric acid attack compared to the WC-incorporated series."

Journal • Musculoskeletal Diseases • Orthopedics

Habitat Suitability and Glacial Refugia of the Turbid-Water Coral Turbinaria peltata Across the Indo-West Pacific Ocean Based on MaxEnt Modeling. (PubMed, Biology (Basel)) - "These refugia may have maintained coral populations through glaciation and contributed to the present-day biogeographic patterns of this species. Our findings provide quantitative spatial evidence for targeted conservation of nearshore stress-resistant corals under climate warming."

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Machine Learning-Guided Design of MQ Silicone Resin Reinforced Addition-Curing Silicone Rubber: From Literature Data Mining to Experimental Validation. (PubMed, Polymers (Basel)) - "An RF model trained on 55 curated literature points spanning RTV and LSR systems, using four physically motivated descriptors (MQ content, M/Q ratio, curing system and vinyl content), yielded leave-one-out coefficient of determination (R2) values of 0.741 for tensile strength (TS) and 0.730 for Shore A hardness (HA), with mean absolute errors of 0.63 MPa and 8.95 ShA, respectively...Guided by the model, seven LSR formulations (vinyl content 4 wt%, M/Q = 0.8, loading 5-35 wt%) were designed and fully characterised: the model reproduced the measured TS and HA for all seven formulations within the corresponding training mean-absolute-error tolerance, whereas elongation at break (EB), whose prediction is substantially weaker (LOO R2 ≈ 0), was captured only as a qualitative trend with respect to MQ loading. This workflow demonstrates that a modest, curated literature dataset, mined by an interpretable ML model, can support formulation design and independent experimental..."

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Comparative Motor Outcomes and Programming Timelines After Deep Brain Stimulation for Parkinson's Disease With Abbott Infinity™ Versus Medtronic Percept™ Systems. (PubMed, Cureus) - "Methods We performed an exploratory retrospective cohort study of patients with Parkinson's disease who underwent primary DBS implantation with either the Abbott Infinity or Medtronic Percept systems between October 2021 and November 2024 at Jersey Shore University Medical Center, New Jersey, United States...Given the small and imbalanced cohort, these findings should not be interpreted as demonstrating equivalence between devices. Larger, longer-term prospective multi-center studies are needed to determine whether clinically meaningful device-specific differences exist."

Journal • Alzheimer's Disease • CNS Disorders • Dementia • Movement Disorders • Parkinson's Disease

On the Larval Sensory Organs and Central Nervous System of the Zoea 1 of the Asian Shore Crab Hemigrapsus sanguineus (Decapoda, Brachyura). (PubMed, J Comp Neurol) - "These are, for example, the lateral protocerebrum (which in adult crabs will house the mushroom bodies) and the median protocerebrum that includes the central body. The discussion of our findings is framed against the knowledge of the larval behavioral performance and, considering the larval investment in higher order neuropils, the possibility of complex behavioral decisions that integrate aspects of learning and memory."

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Influence of Watershed Land Use on Contamination of the Sediments of Lake Victoria, Africa: A Case Study of Pesticides, Alkylphenols, and Antimicrobial Agents. (PubMed, ACS Environ Au) - "Spatially, elevated contaminant loads along the northern and northeastern shores of the lake coincided with catchments dominated by croplands and built-up areas, indicating the influence of agricultural runoff, urban wastewater, and riverine inputs on sediment contamination. Ecological risk assessment identified five priority compounds with risk scores >1 (4-tert-octylphenol, 2-phenylphenol, 4-phenylphenol, β-HCH, and 4-n-octylphenol) that pose potential aquatic ecotoxic risks to aquatic organisms. This study demonstrates that activities related to agriculture, industrialization, and urban development are the main drivers of sediment contamination in the lake, highlighting the need for targeted catchment management and monitoring."

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Water-mass structuring and vertical segregation of protist communities in the Korea Strait during late spring. (PubMed, Mar Environ Res) - "Interannual phosphate limitation in 2025 modulated taxonomic composition by slightly increasing the relative abundances of small-sized taxa, such as cryptophytes and picochlorophytes, yet coastal-offshore water-mass-influenced dynamics remained the primary driver of spatial structure. Collectively, our findings demonstrate that during the late spring transition, the Korea Strait is a functionally heterogeneous boundary system in which physical forcing, stratification, and benthic-pelagic linkages jointly regulate protist community organization, underscoring the importance of integrating molecular and morphological approaches in resolving microbial ecosystem dynamics."

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The marine otter (Lontra felina) as a bioindicator for mercury pollution along the South Pacific coast of Chile. (PubMed, Environ Pollut) - "The marine otter, or chungungo (Lontra felina), possesses a narrow home range and a clear dietary overlap with humans in coastal settlements, and thus presents as a critical sentinel species for biomonitoring pollution along the Southeast Pacific shoreline...Northern Marine otters usually show the highest THg levels consistent with high mining pressure and a marked piscivorous diet, however southern otters may be subjected to an unexpectedly high risk of long-term bioaccumulation, as revealed by high fur THg. These findings establish a vital baseline for the Minamata Convention in the Southeastern Pacific, and showcase the marine otter as a useful bioindicator."

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Marine waste-derived soil amendments via combined biological treatments and mineral enrichment: Process characterisation and potential for ecological restoration. (PubMed, Waste Manag) - "Posidonia oceanica litter accumulates along shorelines forming deposits with important ecological functions but also challenging management requirements...It also selectively removed ammonium from the soluble fraction, markedly reducing phytoinhibition. Overall, the combination of anaerobic digestion, composting, vermicomposting, and zeolite enrichment proved to be an effective approach for the stabilisation and valorisation of marine organic wastes, leading to the production of mature soil amendments with high potential for use in ecological restoration strategies for degraded substrates."

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Offshore Wind Energy in India: Foundation Design and Challenges. (PubMed, Indian Geotech J) - "It will be shown based on centrifuge test data that the monopile response in liquefiable soils is significantly altered in the presence of operational wind/wave loading. The online version contains supplementary material available at https://doi.org/10.1007/s40098-026-01515-4."

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Numerical simulation of oil spill dispersion and weathering in the Alboran Sea: A case study of its North-Eastern Coast. (PubMed, PLoS One) - "This study applies the OpenOil module of the OpenDrift Lagrangian framework to simulate a hypothetical release of 100 tons of heavy fuel oil (Generic Bunker C) offshore the Driouch coast (35.45° N, 2.95° W) over a seven-day (168 h) period, beginning on 02 July 2024 at 12:00 UTC...The revised analysis indicates that high viscosity and density lower than seawater explain the long surface residence time of fresh Bunker C, while sedimentation risk becomes critical mainly in shallow, sediment-rich environments through oil-mineral aggregation. The study identifies priority coastal exposure pathways and provides management-relevant guidance for preparedness planning, including pre-positioning of response equipment adapted to viscous oils, rapid protection of lagoon inlets where feasible, and transboundary coordination between Morocco and Algeria."

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Incorporating Phylogeography and SDM Projection to Inform Conservation Efforts of the Foundation Seaweed Gloiopeltis furcata sensu lato in the North Pacific Under Climate Change. (PubMed, Evol Appl) - "We further applied projection-based species distribution models (SDMs) and detected consistent habitat suitability contraction in low latitude regions (20°N-40°N) (e.g., the Bohai Sea, the southern East China Sea, the southern Japan-Pacific coastline) and expansion in high latitude regions (40°N-60°N) (e.g., the southern Sakhalin Island, the northern Sea of Japan, the southern Kamchatka Peninsula and the Alaska Peninsula) under future moderate (SSP2-4.5) and high (SSP5-8.5) emission scenarios. These results demonstrate that integrating phylogeographic information (e.g., the identification of ancestral persistence areas and unique populations harboring rare allelic variation or high endemism) with SDMs-based assessments of climate change impacts, offers a powerful framework for prioritizing conservation units in marine benthic ecosystems under future climate change."

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