tetracycline / Generic mfg. - LARVOL DELTA

Helicobacter heilmannii Gastritis Identified on Random Gastric Biopsy in a Patient With Nondysplastic Barrett's Esophagus (ACG 2026) - "He was treated with 14 days of bismuth-based quadruple therapy using pantoprazole, metronidazole, tetracycline, and bismuth subsalicylate. Random gastric biopsies should be considered when symptoms persist, even when the gastric mucosa appears normal. Figure: Endoscopic images showing an irregular Z-line with otherwise grossly normal gastric and duodenal mucosa."

Biopsy • Clinical • Barrett Esophagus • Celiac Disease • Extranodal Marginal Zone Lymphoma • Gastric Cancer • Gastroenterology • Gastrointestinal Disorder • Hematological Malignancies • Immunology • Infectious Disease • Lymphoma • Marginal Zone Lymphoma • Peptic Ulcer • Solid Tumor

When Cannabis Hyperemesis Is Not the Whole Story: Refractory Multidrug-Resistant Helicobacter pylori Masquerading as Cannabis Hyperemesis Syndrome (ACG 2026) - "Gastric culture with susceptibility testing demonstrated resistance to amoxicillin, clarithromycin, metronidazole, levofloxacin, and rifampin, with susceptibility only to tetracycline. In patients with presumed CHS and recurrent or refractory symptoms, clinicians should maintain a broad differential and pursue endoscopic evaluation when appropriate. Early susceptibility-guided therapy is essential after multiple eradication failures to avoid delayed diagnosis and repeated ineffective treatment."

Gastrointestinal Disorder • Genetic Disorders • Infectious Disease • Obesity

The Other Helicobacter : Gastritis Caused by Helicobacter heilmannii (ACG 2026) - "Quadruple therapy of proton pump inhibitor, bismuth subsalicylate, tetracycline, and metronidazole was prescribed...Increased awareness among clinicians and pathologists is important to avoid misclassification and ensure appropriate treatment. Figure: Histology Identification of Helicobacter heilmannii in Gastric Biopsy"

Extranodal Marginal Zone Lymphoma • Gastroenterology • Gastrointestinal Disorder • Hematological Malignancies • Infectious Disease • Lymphoma • Marginal Zone Lymphoma

Simplified Vonoprazan Rescue Regimens for Persistent/Refractory Helicobacter pylori : A Rescue-Specific Meta-Analysis of Randomized Trials (ACG 2026) - "Additional prespecified comparisons were supported by only one eligible RCT each and were summarized without pooling: vonoprazan-amoxicillin had fewer adverse reactions than susceptibility-guided therapy (RR 0.29, 95% CI 0.16-0.54), adding Saccharomyces boulardii improved ITT eradication versus vonoprazan-amoxicillin alone (RR 1.16, 95% CI 1.03-1.30), and rifabutin-based vonoprazan triple therapy achieved comparable ITT eradication to quadruple therapy (RR 0.99, 95% CI 0.91-1.08). Six rescue-relevant RCTs were eligible; 3 RCTs (n=1,278) formed the main meta-analysis (vonoprazan-amoxicillin in 2 trials; vonoprazan-tetracycline in 1 trial). Dual therapy did not show a clear intention-to-treat (ITT) eradication advantage versus quadruple therapy (RR 0.94, 95% CI 0.85-1.05; I²=74.3%). Modified ITT (RR 0.93, 95% CI 0.84-1.04; I²=82.2%) and per-protocol analyses (RR 0.93, 95% CI 0.85-1.02; I²=76.3%) were concordant."

Retrospective data • Infectious Disease

Scleroderma, Stasis, and Sarcina: A Rare Gastric Infection in Systemic Sclerosis (ACG 2026) - "Case Description/ A 70-year-old woman with systemic sclerosis complicated by esophageal aperistalsis, and chronic use of methadone and trazodone presented with progressive dysphagia and reflux...She was treated with amoxicillin-clavulanate, high-dose proton pump inhibitor, and prucalopride as a prokinetic agent...Although ciprofloxacin plus metronidazole is the most commonly reported regimen, no formal treatment guidelines exist. In vitro susceptibility data suggest efficacy of penicillins, fluoroquinolones, macrolides, and tetracyclines. Our use of amoxicillin-clavulanate to avoid QT prolongation risk represents a novel therapeutic approach. This case highlights the importance of evaluating for underlying causes of delayed gastric emptying when S. ventriculi is detected, the variable clinical spectrum of this organism, and the role of individualized antibiotic selection when standard regimens are contraindicated."

Gastrointestinal Disorder • Immunology • Infectious Disease • Respiratory Diseases • Scleroderma • Systemic Sclerosis

Rifabutin Induced Febrile Neutropenia in Salvage Therapy for Refractory H. pylori Infection (ACG 2026) - "Case Description/ A 32âyearâold woman with recurrent dyspepsia, reflux, and bloating was found to have persistent H. pylori infection despite multiple eradication attempts, including clarithromycinâbased triple therapy, metronidazoleâbased therapy, and tetracyclineâ and levofloxacinâcontaining regimens...She was started on salvage therapy with rifabutin, doxycycline, bismuth, and pantoprazole...This case highlights the importance of baseline and interval CBC monitoring when prescribing rifabutinâcontaining salvage regimens for refractory H. pylori. Early recognition and prompt discontinuation typically result in rapid hematologic recovery."

Dyspepsia • Febrile Neutropenia • Hematological Disorders • Infectious Disease • Leukopenia • Neutropenia

Vonoprazan-Based Rescue Regimens Versus Bismuth Quadruple Therapy for Refractory Helicobacter pylori Infection: A Systematic Review and Meta-Analysis of Randomized Controlled Trials (ACG 2026) - "Three randomized controlled trials comprising 1,278 patients were included. Vonoprazan-based rescue regimens included vonoprazan-amoxicillin dual therapy, vonoprazan-tetracycline dual therapy, and vonoprazan-rifabutin-amoxicillin triple therapy, while comparator arms received BQT rescue regimens. For the primary outcome of ITT eradication, vonoprazan-based therapy demonstrated efficacy comparable to BQT (OR 0.94, 95% CI 0.71-1.25; p=0.662)."

Retrospective data • Review • Infectious Disease

First Reported Human Case of Helicobacter Felistomachi Gastritis Refractory to Standard and Salvage Eradication Therapy (ACG 2026) - "Completion of bismuth quadruple therapy with tetracycline was complicated by Clostridioides difficile colitis and treated with vancomycin...After a course of salvage rifabutin triple therapy, repeat biopsies revealed persistent chronic active non-pylori Helicobacter gastritis, and confirmatory sequencing identified Helicobacter felistomachi...Throughout this course, his concurrent uncontrolled ulcerative colitis required a prednisone taper and vedolizumab induction...Figure: Figure 2: IHC 100x Helicobacter immunohistochemical stain (100x) highlighting the elongated spiral morphology of Helicobacter felistomachi organisms within gastric glands. Species identification confirmed by 16S rRNA polymerase chain reaction sequencing."

Clinical • Dyspepsia • Extranodal Marginal Zone Lymphoma • Gastroenterology • Gastrointestinal Disorder • Hematological Malignancies • Immunology • Infectious Disease • Inflammatory Bowel Disease • Lymphoma • Marginal Zone Lymphoma • Peptic Ulcer • Ulcerative Colitis

Vonoprazan-Based Dual Therapy as a Rescue Regimen for Treatment-Experienced Helicobacter pylori Infection: A Systematic Review and Meta-Analysis (ACG 2026) - "Four studies used vonoprazan-amoxicillin; one used vonoprazan-tetracycline, sensitivity analysis was applied for this study across all outcomes and did not materially affect the results. Our search yielded 180 citations; 29 were reviewed in full text. Five studies (4 RCTs, 1 retrospective) met inclusion criteria, comprising 1,990 patients (vonoprazan dual = 866 vs. comparator = 893)."

Retrospective data • Review • Infectious Disease

Hidradenitis Suppurativa from Preconception to Lactation: Clinical Treatment Decision-Making Review. (PubMed, Dermatol Ther (Heidelb)) - "Topical clindamycin, benzoyl peroxide, chlorhexidine, and selected beta-lactam antibiotics appear to represent preferred options for mild disease or acute flares, whereas tetracyclines, retinoids, spironolactone, apremilast, Janus kinase inhibitors, and most glucagon-like peptide-1 (GLP-1) receptor agonists require avoidance or discontinuation because of fetal or neonatal safety concerns. Among biologics, tumor necrosis factor-α inhibitors remain the best-characterized agents, with certolizumab pegol offering minimal placental transfer and adalimumab or infliximab requiring individualized decisions regarding continuation and timing of discontinuation. Evidence for newer agents, including secukinumab and bimekizumab, is evolving but remains more limited. The review also highlights the importance of preconception counseling, medication transition, multidisciplinary delivery planning, postpartum flare prevention, breastfeeding-compatible therapy, and individualized..."

Journal • Review • Dermatology • Hidradenitis Suppurativa • Immunology • Oncology • Women's Health

Animal type outweighs growth stage in shaping the active antibiotic resistome in livestock manure. (PubMed, Front Microbiol) - "Metagenomic analysis identified 944 ARG subtypes, predominantly associated with tetracycline, multidrug, and macrolide-lincosamide-streptogramin (MLS) resistance...Overall, animal type was the dominant measured correlate of resistome composition, whereas growth stage was associated mainly with variation in selected ARG abundances. These observational findings require validation in multi-farm longitudinal studies before management or environmental-risk conclusions are drawn."

Journal

Slaughtered pigs as reservoirs of One Health-relevant antimicrobial resistance genes in Klebsiella pneumoniae from Brazil. (PubMed, Front Microbiol) - "Antimicrobial susceptibility was determined by disk diffusion and broth microdilution for colistin...High frequencies of non-susceptibility were observed for tetracycline (86.8%), ciprofloxacin (77.4%), and amoxicillin-clavulanate (67.9%), while 34 isolates (64.2%) were classified as MDR...These findings demonstrate a high occurrence of MDR K. pneumoniae carrying clinically important resistance determinants in pigs at slaughter and reveal the circulation of distinct genomic lineages harboring acquired virulence-associated loci. The results suggest that swine production systems may contribute to the maintenance and potential dissemination of One Health-relevant K. pneumoniae and highlight the importance of integrated genomic surveillance to support antimicrobial stewardship and food safety."

Journal • Infectious Disease • Pneumonia

Effects of PVA/TiO2 Composite Hydrogel-Modified PES Ultrafiltration Membranes on Antibiotic Removal Performance and Membrane Fouling Behavior. (PubMed, Membranes (Basel)) - "Low pH favored sulfamethoxazole, tetracycline, and ofloxacin removal, while 5 μm particles increased sulfamethoxazole and tetracycline removal by 27.0% and 22.0%, respectively. Hermia model fitting suggested predominantly standard blocking-type hydraulic behavior under the tested pH conditions and complete blocking-type behavior in the presence of HA or particles. These results show that PVA/TiO2 modification improves PES membrane hydrophilicity and antibiotic removal, although fouling under complex conditions remains important."

Journal

Antibiotics modulate activity of mouse and human dorsal root ganglia neurons. (PubMed, bioRxiv) - "We found that β-lactams, macrolides, and tetracyclines induce calcium flux in sensory neurons within minutes of application...Pharmacological manipulations further revealed that cephalexin responses depend on TRPA1 activity whereas doxycycline responses require mitochondrial reactive oxygen species (ROS) production. These findings demonstrate that clinically relevant concentrations of antibiotics directly modulate sensory neuron activity through divergent mechanisms, thus expanding our current understanding of antibiotic side effects. Clinically relevant antibiotics induce calcium flux in mouse and human sensory neurons through unique, drug-specific mechanisms."

Journal • Preclinical • TRPA1

Oncohistone inhibition reshapes tumor-microenvironment communication in Diffuse Midline Glioma (DMG). (PubMed, bioRxiv) - "We generated a tetracycline-inducible PiggyBac-based oncohistone expression cassette in patient- and murine-derived models and validated inducible and reversible H3K27M expression...Importantly, inhibition of H3K27M disrupted these tumor-associated signaling networks and partially restored neuron- immune communication within the tumor microenvironment. Together, these findings demonstrate that H3K27M extensively reshapes the tumor microenvironment in these Diffuse Midline Gliomas and provides strong rationale for directly targeting the oncohistone as a therapeutic strategy for patients with H3K27M-mutant DMG."

Biomarker • Journal • Brain Cancer • Diffuse Midline Glioma • Glioma • Oncology • Pediatrics • Solid Tumor • SLC1A3

Phylogenomic Diversity, Serotype Heterogeneity and In Vivo Virulence of Flavobacterium psychrophilum Isolates From Rainbow Trout Farms in Türkiye. (PubMed, J Fish Dis) - "Antimicrobial susceptibility testing showed a high proportion of non-wild-type phenotypes for oxytetracycline, florfenicol and enrofloxacin; however, no acquired antimicrobial resistance genes were detected by genome-based screening. Collectively, these findings demonstrate that Turkish F. psychrophilum populations are phylogenomically diverse but retain largely conserved virulence-associated loci and immunoreactive antigenic structures. This study provides the first evidence of the CC-ST90/ST108 lineage in Türkiye and highlights the value of integrating genomic, serological, phenotypic, antigenic and experimental infection data for understanding the population structure, serotype heterogeneity and pathogenic potential of F. psychrophilum in rainbow trout aquaculture."

Heterogeneity • Journal • Preclinical • Infectious Disease

Longitudinal patterns of antimicrobial use across production stages in semi-intensive broiler systems in Uganda. (PubMed, Prev Vet Med) - "Tetracyclines accounted for 43.8% of total quantified AAI mass...Biomass-normalised AMU was not associated with reported clinical signs or deaths, suggesting that AMU patterns were not explained by reported disease occurrence alone. These findings identify early production stages, frequent use of combination products and antimicrobials of particular importance to human medicine, and high-use flocks as priorities for targeted stewardship, alongside strengthened preventive flock health management."

Journal

High prevalence and multidrug resistance of Methicillin-resistant Staphylococcus aureus at a provincial referral hospital in Zambia: A 5-year retrospective study. (PubMed, PLOS Glob Public Health) - "In resource-limited settings such as Zambia, staphylococcal infections are treated empirically with clindamycin or co-trimoxazole due to limited susceptibility testing...MRSA demonstrated significantly lower susceptibility than MSSA to non-beta-lactam antibiotics: clindamycin (46.2% vs. 67.7%), erythromycin (50.0% vs. 79.5%), ciprofloxacin (58.2% vs. 91.4%), and tetracycline (58.3% vs. 81.9%)...Empirical use of clindamycin and erythromycin for suspected staphylococcal skin and soft tissue infections should be reconsidered and guided by local antimicrobial susceptibility whenever available. Continued local surveillance and multicenter studies are needed to inform empirical treatment guidelines across Zambia."

Journal • Retrospective data • Infectious Disease • CAT

Non-destructive monitoring of antibiotic action in Bacillus subtilis biofilms using dual-parameter swept-source optical coherence tomography. (PubMed, Biofouling) - "Viable counts decrease by ∼2.5 log10 CFU/mL in both treated arms (p < 0.001), confirming substantial killing; γ nonetheless declined nonlinearly with respect to viability and continued falling after CFU/mL stabilized, indicating that γ reflects progressive physical quiescence rather than viable cell numbers. SSOCT attenuation and biospeckle thus offer a non-destructive complement to conventional viability assays."

Journal

Occurrence of Stenotrophomonas carrying β-lactamase-encoding genes in a veterinary hospital environment. (PubMed, Vet Res Commun) - "Antimicrobial susceptibility testing revealed a high resistance profile to ciprofloxacin, whereas resistance to tetracyclines, chloramphenicol, levofloxacin, and trimethoprim/sulfamethoxazole was less frequent. In accordance with the reported intrinsic resistance of Stenotrophomonas to a range of antibiotic classes, the strains were resistant to meropenem, ampicillin, cefoxitin, and amoxicillin/clavulanate...Together, these findings indicate that environmental Stenotrophomonas spp. strains from veterinary settings harbor multidrug resistance determinants, efflux-mediated mechanisms, and biofilm-forming capacity, highlighting their potential role in the maintenance and dissemination of clinically relevant antimicrobial resistance."

Journal

Gentiana sino-ornata Balf. f. ethyl acetate extract alleviates high-fat diet- and tetracycline-induced liver injury in mice: insights from serum pharmacochemistry, network pharmacology, and experimental validation. (PubMed, Front Pharmacol) - "In vivo experiments showed that GSEA markedly alleviated HFD- and tetracycline-induced liver injury by suppressing the expression of inflammation- and glucolipid-metabolism-related genes, attenuating hepatic inflammation, modulating the gut microbiota, and partially regulating the PI3K/Akt/FoxO1 signaling pathway. Collectively, these findings provide mechanistic evidence supporting the potential application of GSEA as a natural therapeutic agent for the prevention or treatment of liver injury associated with metabolic dysfunction and tetracycline exposure."

Journal • Preclinical • Hepatology • Inflammation • Liver Failure • Metabolic Disorders • Metabolic Dysfunction-Associated Steatotic Liver Disease • AKT1

Antimicrobial resistance characteristics of enterococcus and analysis of intra-farm transmission associations in large-scale laying hen production. (PubMed, Poult Sci) - "The predominant resistance phenotypes were to macrolides, tetracyclines, and sulfonamides...Resistance phenotypes for enrofloxacin and sulfisoxazole were strongly associated with environmental samples, highlighting the farm environment as a critical potential control point for AMR risk mitigation. Leveraging whole-genome sequencing, this study explores the transmission risk of antimicrobial-resistant Enterococcus in layer production and provides insights for preventing AMR risks originating from layer farms."

Journal

Microbiological safety and antimicrobial resistance in cashew-based plant-based cheese analogues. (PubMed, Braz J Microbiol) - "Resistance was detected in a limited number of isolates, mainly to ciprofloxacin, tetracycline, and gentamicin, whereas C. malonaticus exhibited resistance to penicillin. A total of eight antimicrobial resistance genes were identified, four of which were located on plasmids in C. malonaticus and L. brevis. These findings suggest that microorganisms associated with plant-based cheese analogues may act as reservoirs of antimicrobial resistance determinants, highlighting the importance of safety assessment and microbiological surveillance of strains intended for technological or probiotic applications."

Journal

Bacillus Probiotics With Bismuth Quadruple Therapy for Helicobacter Pylori Infection (clinicaltrials.gov) - P=N/A | N=336 | Not yet recruiting | Sponsor: Anabio R&D

New trial • Infectious Disease

Type II Minocycline-Induced Hyperpigmentation During Long-Term Management of an Epidermal Growth Factor Receptor (EGFR) Inhibitor-Associated Acneiform Eruption. (PubMed, Cureus) - "We report the case of a 40-year-old man with hereditary leiomyomatosis and renal cell carcinoma (HLRCC) who developed an EGFR inhibitor-associated papulopustular eruption shortly after initiating erlotinib and bevacizumab. Persistent disease despite doxycycline therapy and concern for doxycycline-associated photosensitivity prompted a transition to long-term minocycline...This case highlights the importance of longitudinal dermatologic follow-up in patients receiving prolonged tetracycline therapy for EGFR inhibitor-associated cutaneous toxicities. Periodic reassessment of treatment necessity, dose optimization, and early recognition of delayed medication-related adverse effects may minimize cumulative toxicity while preserving effective oncologic therapy."

Journal • Dermatology • Genito-urinary Cancer • Nephrology • Oncology • Renal Cell Carcinoma • Solid Tumor