tetracycline / Generic mfg. - LARVOL DELTA

Optimization of Minocycline for Helicobacter Pylori Rescue Treatment (clinicaltrials.gov) - P4 | N=480 | Completed | Sponsor: Shanghai Jiao Tong University School of Medicine | Recruiting ➔ Completed | Trial completion date: Aug 2026 ➔ Feb 2026 | Trial primary completion date: Aug 2026 ➔ Feb 2026

Trial completion • Trial completion date • Trial primary completion date • Infectious Disease

ARRET: Azithromycin Reduction to Reach Elimination of Trachoma (clinicaltrials.gov) - P4 | N=3931 | Completed | Sponsor: University of California, San Francisco | N=74920 ➔ 3931

Enrollment change • Ophthalmology

BEYOND CATHETERS: A MULTISOURCE MICROBIAL AND RESISTANCE LANDSCAPE AMONG DIALYSIS PATIENTS (ISN-WCN 2026) - "We observed very high resistance to 3rd-generation cephalosporins and fluoroquinolones (≈90–100%) but remained fully susceptible to carbapenems and amikacin in E. coli. While K. pneumoniae shows moderate–high resistance to ceftriaxone (58.3%) and aztreonam (66.7%), but lower aminoglycoside resistance (16.7%). Half of S. aureus was MRSA (oxacillin/cefoxitin 50%) with vancomycin still susceptible and low clindamycin(9.1%) and erythromycin(18.2%) resistance.Download: Download high-res image (252KB)Download: Download full-size imageIn exploratory modeling, organism type was the principal driver of resistance, though most organisms–antibiotic effects had wide confidence intervals. The most reliable association was lower tetracycline resistance in S. epidermidis (OR 0.012, 95% CI 0.0003–0.49; p=0.020)...Organism type showed significant relations to resistance rather than dialysis modality or specimen source. The importance of empirical therapy based on organisms are..."

Clinical • Chronic Kidney Disease • Infectious Disease • Nephrology • Pneumonia • Renal Disease

Hexahydroacridine Derivatives as Novel Anti-Salmonella Agents: In Vitro, In Vivo, and In Silico Studies. (PubMed, Microb Pathog) - "Synergistic interactions with ciprofloxacin and tetracycline were observed for both derivatives. Molecular docking studies further supported strong binding of D01 and D04 to the S. enterica InvA protein. Collectively, these results identify D01 and D04 as promising antibacterial and anti-virulence candidates with low resistance potential and favorable host compatibility."

Journal • Preclinical • Immunology

Pangenome-GWAS analysis of Clostridioides difficile resistant traits from healthcare and non-healthcare associated settings. (PubMed, Can J Microbiol) - "Antibiotics commonly used in agriculture such as aminoglycosides or tetracyclines also presented associations with non-healthcare environments. Our work offers a comprehensive exploration of C. difficile AMR gene repertoire across healthcare and non-healthcare related settings shedding light on the selection pressures present in each environment, enhancing our understanding of C. difficile resistome and its influence on the bacterium's opportunistic colonization nature."

Journal • Infectious Disease

LaFeO3/g-C3N4 heterostructure nanozyme with enhanced peroxidase-like activity for colorimetric detection of tetracycline. (PubMed, Spectrochim Acta A Mol Biomol Spectrosc) - "Based on this effect, a colorimetric sensor was constructed, exhibiting a linear response to TC from 0.25 to 2.50 μg/mL, with a low detection limit of 0.076 μg/mL, and achieving recoveries of 93.9%-108.2% in spiked egg samples. These findings highlight the potential of LaFeO3/g-C3N4 nanozymes for the sensitive and selective detection of tetracycline, offering a practical approach for ensuring food safety."

Journal

A Flow-Through Solar Evaporator Integrating Photothermal Evaporation and Photo-Fenton Catalysis for Seawater Desalination and Pollutant Degradation. (PubMed, Langmuir) - "Under a light intensity of 1 kW m-2 (1 sun), the flow-through evaporator based on this photothermal catalytic fabric exhibited excellent catalytic performance in degrading various organic pollutants including 97.7% removal of methylene blue and effective elimination of tetracycline antibiotics. Meanwhile, a high evaporation rate of 1.862 kg m-2 h-1 is obtained for pure water and stable evaporation is maintained for 10 h of operation with 15 wt % brine, without salt accumulation. This integrated system provides a promising strategy for long-term, pollution-resistant solar desalination and advanced wastewater purification."

Journal

A magnetic MOFs-based multifunctional molecularly imprinted fluorescence nanosensor for ultra-rapid and sensitive detection of tetracycline in food. (PubMed, Mikrochim Acta) - No abstract available

Journal

Before and after the bottleneck: pediatric group A streptococcal infections in Houston, TX, from 2013 to 2023. (PubMed, Microbiol Spectr) - "All isolates were emm typed, and nonsusceptibility (NS) to tetracycline, erythromycin, and clindamycin was determined using standard methods. These changes likely reflect how pandemic-related disruptions altered bacterial spread. By examining both mild and severe infections over more than a decade, this work demonstrates how large-scale changes in human behavior can reshape bacterial disease patterns and highlights the importance of continued monitoring to protect child health."

Journal • Infectious Disease • Novel Coronavirus Disease • Pediatrics

Molecular insights into antimicrobial resistance and virulence in hospital-associated of vancomycin-resistant Enterococcus faecium isolates in a tertiary hospital in Bangkok Thailand. (PubMed, PLoS One) - "All isolates exhibited resistance to penicillin, ampicillin, vancomycin, levofloxacin, ciprofloxacin, and rifampin. Resistance to erythromycin, high-level streptomycin, teicoplanin, and tetracycline occurred in 98.1%, 53.8%, 51.9%, and 17.3% of isolates, respectively. Chloramphenicol, linezolid, and high-level gentamicin remained effective against all isolates...Genome analysis reveals antibiotic resistance genes, virulence factors, and mobile genetic elements that may drive antimicrobial resistance, increase diversity, and support adaptation in hospital settings. Ongoing infection control and active surveillance are essential."

Journal • Infectious Disease

Effect of Penicillin Allergy Label on Antibiotic Treatment Outcomes in Adult Patients with Rhinosinusitis. (PubMed, Otolaryngol Head Neck Surg) - "In patients with RS, PAL often leads to the prescription of a second-line antibiotic, which has decreased benefit-to-risk ratio compared to first-line treatment. This emphasizes the need for additional efforts to remove PALs from patients without true penicillin allergy."

Journal • Allergy • Immunology • Otorhinolaryngology • Respiratory Diseases • Sinusitis

Bimetallic urchin-like Au@Pt/SiO2 hybrid interface realizing a reversed positive signal strategy for electrochemical immunosensing of tetracycline. (PubMed, Mikrochim Acta) - No abstract available

Journal

Variables Associated With Poor Clinical Outcomes in Patients With Serious Fluconazole Non-Susceptible Candida Species Infections. (PubMed, Ann Pharmacother) - "Several host-derived physiological markers and recent exposure to protein synthesis inhibitor antibiotics were independent variables associated with 30-day mortality in patients with non-susceptible serious Candida sp."

Clinical data • Journal • Candidiasis • Hematological Disorders • Infectious Disease • Thrombocytopenia

Joint effects of contaminants of emerging concern (CECs) on sleep quality in Chinese elderly: A Bayesian kernel machine regression and quantile g-computation analysis. (PubMed, Ecotoxicol Environ Saf) - "In the multivariable logistic analysis, azithromycin, sulfamonomethoxine, lincosamides, and N, N-diethyl-m-toluamide (DEET) were positively linked with reduced sleep quality, with odds ratios (ORs) varying from 1.17 to 1.38...DEET, tetracyclines, lincosamides, acetaminophen and metformin exhibited positive risk trends, whereas other CECs showed flat or modest inverse risk trends...Exposure to certain CECs-particularly DEET, tetracyclines, and acetaminophen-was associated with sleep disturbances in an elderly Chinese population. Public health interventions targeting environmental CECs and medication management are warranted."

Journal • CNS Disorders • Sleep Disorder

Diverse dif module content and configurations in the r3-T5 group of Rep_3/OrfX plasmids from Acinetobacter species reveal extensive dif module shuffling. (PubMed, Microbiol Spectr) - "pMSHR_A204 consists of a 3.27 kbp backbone C module and five accessory dif modules (two C and three D modules), including the tet39 tetracycline resistance module and a large fusion module carrying higBA2 toxin-antitoxin genes...To investigate the dynamics of dif module movement, here, the properties and configurations of one group of plasmids with identical or closely related backbones that carry different dif modules or the same modules in different configurations have been examined. This will increase understanding of the global distribution and diversity of plasmids that carry dif modules, as well as provide insight into the way dif modules relocate."

Journal • Infectious Disease

Two-week course of minocycline therapy for early syphilis compared with benzathine penicillin G: a single-centre retrospective cohort study. (PubMed, Sex Transm Infect) - No abstract available

Journal • Retrospective data • Infectious Disease

Epidemiology and Antibiotic Resistance of Foodborne Diseases Among Children in Shanghai: A Four-Year Surveillance Study, 2021-2024. (PubMed, Infect Drug Resist) - "Salmonella resistance rates were high, at 74.5% for ampicillin and 24.5% for multi-drug resistance. Campylobacter exhibited over 80% resistance to ciprofloxacin and tetracycline; 18.9% of isolates were resistant to all three tested antibiotics. Food-borne pathogens are widely prevalent among children with suspected food-borne illnesses in Shanghai, and the high levels of antibiotic resistance observed in Salmonella and Campylobacter highlight a critical public health concern. These findings underscore the necessity for strengthened surveillance of pediatric food-borne diseases, rational clinical use of antibiotics, and implementation of targeted preventive strategies to reduce the burden of drug-resistant infections in this vulnerable population."

Journal • Infectious Disease • Pediatrics

Systematic evaluation of phage cocktail-ciprofloxacin combination therapy against multidrug-resistant Salmonella Typhimurium induced gut dysbiosis. (PubMed, Microbiol Spectr) - "In addition, the susceptibility of S. Typhimurium to β-lactams, quinolones, and observed four- to eightfold reduction in tetracycline minimal inhibitory concentration (MIC) demonstrated effective restoration of antibacterial activity after therapeutic intervention. Crucially, it prevents systemic inflammation and preserves intestinal barrier function. This ecologically sustainable paradigm provides a dual-defense mechanism against infections and microbiome dysbiosis, positioning phage-antibiotic synergy as a transformative tool for containing foodborne disease threats."

Journal • Infectious Disease • Inflammation • Inflammatory Bowel Disease • CD4 • CD8

Synthesis of symmetrical bis(indolyl)methanes via Sc(OTf)3 catalyzed tandem CO and CC bond breaking reaction and their anti-bacterial studies. (PubMed, Bioorg Med Chem Lett) - "Most of the tested BIMs exhibited anti-bacterial activity with quantitative values. Notably, BIM 3l showed the highest anti-bacterial activity among all tested BIMs, with a zone of inhibition (ZI) value of 18.33 ± 1.52 mm, as compared to the standard antibiotics ciprofloxacin (25 ± 0.57) and tetracycline (28 ± 0.57)."

Journal

Serotype Distribution, Antibiotic Resistance Characteristics, and Virulence Factor Analysis of Group B Streptococcus Isolates in Guangzhou Based on Whole-Genome Sequencing. (PubMed, Infect Drug Resist) - "The high carriage of tetM and ermB suggests sustained selective pressure for tetracycline and macrolide resistance, while the near-ubiquitous virulence repertoire-including lmb, bca, cpsJ, and hlyB-and frequent PI-1/PI-2a may support colonization and invasiveness. These findings highlight the need for ongoing, region-specific genomic surveillance to track serotype/lineage shifts and resistance trends and to inform prophylaxis, empiric therapy, and future vaccine coverage in South China."

Journal • Infectious Disease

Real-world use of eravacycline for the treatment of mono- and polymicrobial infections involving Enterobacterales. (PubMed, Microbiol Spectr) - "Eravacycline (ERV) is a promising non-β-lactam antibiotic with a broad spectrum of activity, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococci, and carbapenem-resistant Enterobacterales...In this study, we assessed the safety and effectiveness of eravacycline for the treatment of Enterobacterales infections in a real-world setting. These findings suggest that eravacycline may be a viable therapeutic agent for these infections, expanding our treatment options for multidrug-resistant (MDR) pathogens."

Journal • Real-world evidence • Infectious Disease • Pneumonia • Respiratory Diseases

Rational Design of Helical Peptoids for Tetracycline Conjugation: Insights into Molecular Complexation Mechanisms. (PubMed, Bioconjug Chem) - "Additionally, circular dichroism revealed that the peptoid sequence influences the complexation. Our findings demonstrate the potential for rationally designed peptoids as capture probes for sensing applications."

Journal

Capsular polysaccharides of Acinetobacter baumannii modulate antimicrobial resistance and innate immune response. (PubMed, Sci Rep) - "CPS-deficient mutant (∆galU) displayed increased susceptibility to gentamicin, tetracycline, colistin, and sodium dodecyl sulfate (SDS). Moreover, purified CPS induced pro-inflammatory cytokine expression in sterile infection and promoted neutrophil chemotaxis. Altogether, this study demonstrates that CPS not only mask A. baumannii virulence surface structures, but also actively modulate host immune response and antimicrobial resistance."

Journal • Infectious Disease • Inflammation • CASP3

Prevalence, Antimicrobial Resistance, and Genomic Characterization of Salmonella Typhimurium Isolated in Hengyang, China (2020-2023). (PubMed, Foodborne Pathog Dis) - "Salmonella Typhimurium ST34 is the dominant multidrug-resistant lineage in Hengyang, characterized by a larger resistome and unique virulence factors. Its close phylogenetic relationship with strains from southern and eastern China, combined with active mobile genetic elements, underscores its role in regional dissemination and adaptive evolution."

Journal

Foreign Body-Associated Eikenella corrodens Aspiration Pneumonia in an Elderly Immunocompetent Adult: A Case Report. (PubMed, Int Med Case Rep J) - "The isolate was susceptible to all tested beta-lactams, fluoroquinolones, tetracycline, and co-trimoxazole, and resistant to azithromycin. Susceptibility-guided therapy based on susceptibility testing resulted in clinical and radiological improvement. This case highlights the diagnostic value of bronchoscopy in persistent focal pneumonia and underscores that isolation of E. corrodens in pure culture from appropriately collected lower respiratory specimens should prompt careful evaluation for aspiration or airway obstruction."

Journal • Cough • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases