tetracycline / Generic mfg. - LARVOL DELTA

Generation of two tetracycline-inducible NGN2 iN iPSC lines carrying a heterozygous floating-Harbor syndrome SRCAP truncating mutation. (PubMed, Stem Cell Res) - "Floating-Harbor syndrome (FHS) is a rare neurodevelopmental disorder caused by truncating variants in the last two exons of the gene encoding the chromatin remodeler SRCAP. We characterised two independent lines that maintained a normal karyotype, pluripotency and the ability to differentiate in vitro into all three embryonic germ layers. These lines can be rapidly differentiated into cortical neurons through the addition of doxycycline, making them a useful model for understanding the pathogenic mechanisms underlying FHS."

Journal • CNS Disorders • Developmental Disorders • Psychiatry

Antimicrobial resistance status of small marine fishes off the coastal cities of east and west coast of India: an adaptive nanopore sequencing based metagenomics raises concerns. (PubMed, Int J Biol Macromol) - "A total of 54 distinct ARGs associated with 12 classes of AMR were detected across both coasts with enhanced resistance observed towards aminoglycosides, macrolides, beta lactam, tetracycline and chloramphenicol...as putative reservoirs of ARGs indicating potential zoonotic and foodborne transmission to humans. This study offers a novel, and in-depth characterization of edible fish associated AMR contamination in east and West coast of India, providing essential data for assessing the public health hazards posed by ARGs and the pathogenic taxa."

Journal

Boosting visible-light photocatalysis with MWCNT-modified TiO2/SiO2/g-C3N4: efficient tetracycline removal in pure and hard water. (PubMed, Sci Rep) - "Furthermore, the presence of MWCNTs remarkably improved tetracycline (TC) removal in CaCO3-rich water (20 mg/L TC with 300 mg/L CaCO3). The high photocatalytic activity is attributed to the formation of abundant local junctions among g-C3N4, TiO2/SiO2, and MWCNTs, which facilitate efficient charge separation and migration through a direct Z-scheme mechanism under visible light illumination."

Journal

Activation of peroxymonosulfate by nickel-cobalt-based PBAs and their derivatives for tetracycline degradation: Degradation mechanism and toxicological evaluation. (PubMed, Environ Res) - "Using HPLC-MS and T.E.S.T., this research analyzed and predicted the intermediate substances during TC's degradation and their biological toxicity. This research provided guidance for the development of efficient, stable and economically viable catalytic materials for PMS activation to support environmental purification efforts."

Journal

In vitro activity of eravacycline compared to other antibiotics commonly used for treatment of infections involving anaerobic bacteria: a review of the literature and our own data. (PubMed, Diagn Microbiol Infect Dis) - "Eravacycline is a third-generation tetracycline, a fluorocycline agent with two modifications that distinguish it from tigecycline. So far, only the injectable eravacycline administration for complicated intraabdominal infections has been approved. However, more studies in more countries are needed to assess its usefulness for combination treatment and still not labeled indications."

Journal • Preclinical • Review • Infectious Disease

Prevalence and persistence of oxytetracycline-resistant and copper-tolerant Xanthomonas arboricola pv. pruni in peach orchards of the southeastern USA. (PubMed, Plant Dis) - "Regardless of the spray programs utilized, copper-tolerant and OTC-resistant XAP populations have been consistently recovered from the sampled trees across years. Season-long chemical spray programs are still valuable for this disease, but the prevalence and persistence of copper-tolerant and OTC-resistant XAP emphasizes the need for resistance management and development of novel disease management strategies."

Journal • NR6A1

Boron and Nitrogen Codoped Biochar for Efficient Activation of Peroxydisulfate in Oxytetracycline Degradation: Performance Study, Degradation Pathways, and Mechanism. (PubMed, Langmuir) - "Density functional theory calculations combined with liquid chromatography-mass spectrometry (LC-MS) analysis revealed that OTC underwent stepwise degradation via decarboxylation, ring-opening, and hydroxylation, ultimately forming low-molecular-weight products. This study offers a useable strategy for the valorization of waste molasses and an efficient nonmetal-based catalytic scheme , for environmental remediation."

Journal

Synergistic effects of N-vacancies and S-doping in g-C3N4 for enhanced charge separation: Achieving simultaneous antibiotic degradation and solar-driven H2O2 synthesis. (PubMed, J Environ Manage) - "The synthesized SCN-E materials exhibit excellent bifunctional photocatalytic performance: (1) photocatalytic degradation of tetracycline antibiotics-degradation rates of tetracycline hydrochloride (TC), oxytetracycline (OTC), and chlortetracycline (CTC) reach ∼100%, 92%, and 94% within 30 min under visible light irradiation; (2) photocatalytic H2O2 synthesis-a yield of 1183.54 μmol L-1·h-1 is achieved after 30 min of O2 bubbling. In addition, the biotoxicity of the catalytically degraded antibiotic solutions to E. coli DH5α was basically eliminated."

Journal

Corynebacterium Periprosthetic Joint Infections: A Single-Institution's Experience with a Virulent Organism. (PubMed, J Arthroplasty) - "Corynebacterium-associated PJIs represent a unique subset of disease that can be challenging to manage, in part due to its antibiotic resistance profile. However, with close collaboration between surgical and infectious disease teams, reasonable outcomes can be expected."

Journal • Infectious Disease • Orthopedics • Pain

Genomic characterization of Salmonella enterica serotype Saintpaul isolates from horses. (PubMed, Vet Microbiol) - "Antimicrobial susceptibility testing revealed widespread multi-drug resistance, particularly to aminoglycosides, beta-lactams, tetracyclines and sulfonamides...IncI-gamma/K1 plasmids were consistently associated with the MOBP relaxase and MPF_I mating pair formation system. The emergence of multi-drug-resistant S. Saintpaul in horses underscores the importance of continued surveillance and antimicrobial resistance monitoring to mitigate animal and zoonotic risks."

Journal • Gastrointestinal Disorder • Infectious Disease • Pneumonia • Respiratory Diseases

Fungal laccase-polycarboxylate functionalized magnetic nanoparticles enable highly efficient degradation of tetracycline antibiotics in marine aquaculture wastewater. (PubMed, Int J Biol Macromol) - "Based on the identification of intermediates, the pathways for TC removal involve dehydrogenation, demethylation, and ring-opening reactions, resulting in less toxic and readily biodegradable products. Overall, this system demonstrates strong potential for effective removal of TCs from aquaculture wastewater and for broader environmental remediation applications."

Journal

ERAVACYCLINE IN ALLOGENEIC STEM CELL TRANSPLANT RECIPIENTS: A REAL-WORLD STUDY OF DRUG-DRUG INTERACTIONS WITH CYCLOSPORINE/TACROLIMUS AND ANTI-INFECTIVE EFFICACY (EBMT 2026) - "Eravacycline, a novel synthetic tetracycline, shares the CYP3A4 metabolic pathway with CNIs, yet comprehensive data on their potential pharmacokinetic interactions are scarce...Subgroup analysis revealed that when co-administered azoles and letermovir, no significant changes in C/D ratio were observed between pre-treatment and during treatment both in cyclosporine group (n=18) and tacrolimus group (n=7)... This study provides the first clinical evidence of pharmacokinetic interaction between eravacycline with CNIs in allo-HSCT, characterized by increased CNI exposure during eravacycline administration and delayed post-cessation exposure elevation, with this effect waning within around 2 weeks. Despite its modest magnitude, Intensified CNI monitoring and stepwise dose adjustments are recommended throughout and after eravacycline therapy, particularly for tacrolimus during eravacycline administration."

Clinical • Real-world • Real-world evidence • Acute Graft versus Host Disease • Bone Marrow Transplantation • Graft versus Host Disease • Hematological Disorders • Infectious Disease • Transplantation • CYP3A4

GENERATION OF CHIMERIC ANTIGEN RECEPTORS AGAINST MURINE CD123 ALLOWS BIOLOGIC ASSESSMENTS IN IMMUNOLOGICALLY COHERENT IN VIVO SYSTEMS (EBMT 2026) - "CAR expression was regulated by a tetracycline-inducible (Tet-on) T11 promoter and linked to an IRES-driven dTomato (iTom) reporter... Antigen-display is a powerful approach for generating CARs against non-human antigens with human equivalents, enabling thorough evaluation of their biological properties in vivo. Early identification of limitations or unexpected toxicities in such models may significantly inform and improve the design of future human CAR T-cell trials."

Preclinical • Hematological Malignancies • Infectious Disease • Leukemia • CD123 • IL3RA • MYC

Albendazole-doxycycline combination therapy alleviates MRI- and pathology-evident neuroinflammation and restores IL-33/GFAP balance in mouse neuroangiostrongyliasis. (PubMed, Parasit Vectors) - "ABZ-DOX co-therapy was associated with reduced parasite recovery and multilevel improvements across pathology, MRI, and glial markers in mice neuroangiostrongyliasis. These findings support ABZ-DOX co-therapy as a candidate regimen for further investigation in the management of A. cantonensis-associated neuroinflammation."

Journal • Preclinical • CNS Disorders • Hematological Disorders • Infectious Disease • Inflammation • FAP • GFAP • IL33

Targeted gene expression and associated metabolomic insights into Bacillus subtilis LBS5-mediated suppression of Candidatus liberibacter asiaticus in acid lime (Citrus aurantiifolia (christm.) swingle). (PubMed, World J Microbiol Biotechnol) - "LBS5 inhibited the surrogates, Xanthomonas citri and Agrobacterium tumefaciens with inhibition zones of 1.15 cm and 1.06 cm, respectively, and significantly reduced CLas titres from 6.33 ± 0.04 × 10⁸ to 9.15 ± 0.05 × 10³ copies within five days, comparable to tetracycline ((2.75 ± 0.91) × 10⁴)...FTIR and ¹H NMR analyses confirmed reduced lipid oxidation and lignin deposition, along with enhanced defense-related metabolites. Collectively, LBS5 effectively suppresses CLas, activates key defense pathways, and enhances metabolite-mediated resistance, highlighting its potential as a biocontrol and plant growth-promoting agent for sustainable management of CGD."

Journal

Mycoplasma bovis isolates from Chinese dairy farms: Analysis of genomic features, antimicrobial resistance, and virulence-associated structural differences. (PubMed, Vet Microbiol) - "Antimicrobial susceptibility testing revealed that Chinese isolates were generally resistant to erythromycin (97.9 %) and tylosin (59.6 %), and all strains were non-susceptible to oxytetracycline, showing a pattern of multidrug resistance. In contrast, doxycycline and tiamulin exhibited favorable in vitro activity based on MIC testing. This study systematically elucidates the clonal dissemination patterns, virulence evolution, and antimicrobial resistance risks of M. bovis in China, providing scientific evidence for the development of control strategies and vaccine design."

Journal • Immune Modulation • Immunology

A novel 0D/2D direct Z-scheme photocatalyst constructed from ultrathin Bi2MoO6 nanosheets anchored with BiOCl0.7I0.3 quantum dots for efficient pollutant degradation. (PubMed, Nanoscale) - "Photocatalytic degradation is an eco-friendly method for decomposing tetracycline hydrochloride (TC), yet it faces challenges such as slow photogenerated carrier transfer, poor separation efficiency, and limited active sites...Moreover, the unique 0D and 2D structures provide a large specific surface area, offering abundant active sites and reducing the carrier transport distance, thereby boosting the photocatalytic performance. This study provides theoretical and experimental insights for designing and synthesizing novel visible light-responsive photocatalysts."

Journal

Molecular characterization & risk factors associated with carbapenemase-producing enterobacterales acquisition in hospitalised patients in a tertiary care setting. (PubMed, Indian J Med Res) - "CP-CRE isolates exhibited high resistance (70-90%) to fluoroquinolones, aztreonam, aminoglycosides, and tetracyclines, moderate resistance to tigecycline, and the lowest to colistin (2/58, 3.5%). Interpretation & conclusions This study revealed a high prevalence of CP-CRE, predominantly blaNDM-producing K. pneumoniae. CP-CRE infections were associated with multidrug resistance, increased mortality, and risk factors like prolonged hospitalisation, surgical procedures, and previous carbapenem exposure."

Journal • Infectious Disease • Pneumonia

Evaluation of Acute Pancreatitis in Patients Receiving Doxycycline Therapy: A Prospective Study. (PubMed, Cureus) - "Doxycycline, a widely used tetracycline antibiotic, has been infrequently implicated as a causative agent in isolated case reports, leaving the true incidence and risk factors unclear. Conclusion Doxycycline-induced acute pancreatitis, though uncommon, is a clinically relevant adverse event with favorable outcomes upon early detection and drug withdrawal. Prolonged therapy beyond 10 days may increase risk, underscoring the need for clinical vigilance and patient monitoring during treatment."

Journal • Inflammation • Pancreatitis

Self-powered decentralized water treatment clean boat with electrochemical fenton system for antibiotic remediation in natural water bodies. (PubMed, Fundam Res) - "The boat achieved a 99.4% removal rate for tetracycline (TC) at 1 mg L-1 in contaminated water within 3 h, demonstrating over 98% removal efficiency for other common antibiotics. This system integrates clean energy use, H2O2 production, Fenton reaction activation, and pollutant degradation, addressing the limitations of conventional electrochemical methods in low-conductivity waters. It offers a sustainable solution for decentralized water treatment in pilot-scale experiments with low unique energy consumption (0.43 kWh mg-1) by solar energy."

Journal

Acute Hemolytic Anemia Due to Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency Triggered by Helicobacter pylori Quadruple Therapy in a Jehovah's Witness: A Case Report. (PubMed, Cureus) - "Although some drugs like antimalarials (primaquine, tafenoquine), sulfonamides, and dapsone are well-known triggers of hemolysis, reports of this adverse effect are rare with standard bismuth-based quadruple therapy for Helicobacter pylori. In this report, we present a 65-year-old male who developed profound anemia (hemoglobin 5.8 g/dL, drop of 4.4 points from baseline) within hours of initiating metronidazole- and tetracycline-containing quadruple therapy...Regarding H. pylori treatment, the patient was initiated on triple therapy (clarithromycin, amoxicillin, proton pump inhibitor), without recurrence of hemolysis...Clinicians should maintain a high suspicion for G6PD deficiency in high-risk populations and exercise caution when prescribing oxidative regimens for H. pylori in these patients."

Journal • Anemia • Hematological Disorders • Infectious Disease • Metabolic Disorders

Conversion of a thelytokous to a stable bisexual line by non-target effect antibiotic elimination of Rickettsia in Anastatus gansuensis. (PubMed, Insect Sci) - "Thus, we investigated not only the efficacy but also the non-target effects of three antibiotics: rifampicin, tetracycline, and sulfadiazine, administered at five concentrations (0.01, 0.05, 0.1, 1, and 10 mg/mL) in Rickettsia-infected thelytokous parasitoid Anastatus gansuensis (Hymenoptera: Eupelmidae). In contrast, sulfadiazine, previously effective against Wolbachia, had minimal impact on Rickettsia removal. This study provides a validated protocol for generating genetically stable aposymbiotic lines and a framework for assessing antibiotic specificity and non-target effects, enabling future studies of host adaptation and biological control in Rickettsia-cured parasitoids."

Journal

Antimicrobial resistance in Mycoplasma genitalium and Mycoplasma hominis: a systematic review in urology. (PubMed, Arch Ital Urol Androl) - "Antimicrobial resistance in M. genitalium and M. hominis limits the effectiveness of traditional empirical therapies and requires the implementation of molecular detection and resistance testing. Resistance-guided treatment and epidemiological surveillance are essential to optimize clinical management and curb the spread of multidrug-resistant strains."

Journal • Inflammation • Urology

Long-term persistence of clonal resistant and multidrug resistant E. coli despite absence of antimicrobial use in weaned dairy heifer rearing systems in Switzerland. (PubMed, Vet Microbiol) - "The most frequent phenotype was streptomycin-tetracycline (n = 37), and sul2 and tetB were the most frequent resistance genes...Potential explanations for this finding, among others, may be that persistence of certain isolates in the cattle gut is longer than previously thought after cessation of selection pressure, or that isolates are maintained in the population through circulation via other animals or inanimate items. Therefore, also animals of livestock production categories with little AMU shall be considered when establishing One Health approaches to combat antimicrobial resistance."

Journal

Intersite differences in gut microbiome are associated with habitat quality in a limestone forest-dwelling langur. (PubMed, BMC Microbiol) - "Our study concludes that intersite differences in gut microbiome are associated with habitat quality in the François' langurs, underscoring its role in habitat adaptation and necessity for physiological indicators to elucidate the mechanisms by which wildlife responds to human disturbance and ecological variability. In addition, we recommend prioritizing the restoration of native vegetation diversity in the langurs' habitats, which leverages their gut microbiota's adaptive potential to provide a suitable fundamental environment for the langurs' long-term survival."

Journal