tetracycline / Generic mfg. - LARVOL DELTA

Machine-Learning and Gene-Synergy Networks Reveal Interpretable Drivers of Antibiotic Resistance in Staphylococcus aureus. (PubMed, Int J Antimicrob Agents) - "Our findings indicate that antibiotic resistance in S. aureus involves distinct genetic network architectures depending on the antibiotic, highlighting the diverse regulatory pathways bacteria employ to acquire resistance. This discovery-oriented framework prioritizes interpretable determinants and generates testable mechanistic hypotheses, with prospective standardized evaluations aimed at assessing its translatability to clinical settings."

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Janibacter melonis bacteremia following autologous stem cell mobilization in lymphoma: a case report and literature review. (PubMed, BMC Infect Dis) - "This case highlights the importance of considering rare infections in immunocompromised patients, especially those with hematologic malignancies. Prompt microbiological and molecular diagnosis, combined with targeted therapy, is essential for good outcomes. This report also provides useful insights for managing Janibacter melonis infections."

Journal • B Cell Lymphoma • Diffuse Large B Cell Lymphoma • Hematological Disorders • Hematological Malignancies • Infectious Disease • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology

Identification and validation of small molecules with mucin-selective regiospecific binding in the gastrointestinal tract. (PubMed, Biomaterials) - "Additionally, we observe up to a 9-fold increase in budesonide concentration in the small intestine and a 25-fold increase in tetracycline concentration in the stomach. These results show that we have developed a versatile platform capable of sequestering a variety of drugs in certain GI tract organs."

Journal • Gastrointestinal Disorder

Microplastics inhibit oxytetracycline degradation in soils: Insights into biofilm-enhanced adsorption and microbial community shifts. (PubMed, J Hazard Mater) - "These microbial shifts further suppressed OTC degradation in soil. Collectively, our findings demonstrate that MPs hinder OTC degradation in paddy soils and may intensify environmental risks by enhancing antibiotic adsorption and reshaping soil microbial communities."

Journal • Infectious Disease

Tetracycline removal from an aqueous solution using bimetallic-impregnated activated carbon synthesized via one-step dry-pyrolysis of hawthorn kernels. (PubMed, Sci Rep) - "The primary mechanisms of adsorption included Hydrogen bonding, surface complexation with metal functional groups (M-π), Lewis acid-base interactions, π-π interactions, and pore filling. Continuous mode experiments in five cycles confirm the high adsorption capacity of the Fe: Mn: AC adsorbent for effectively removing pharmaceutical contaminants from aqueous media (27.5% reduction in adsorption ability)."

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Ziyuglycoside II potentiates the antibacterial activity of tetracycline against multidrug-resistant Staphylococcus aureus. (PubMed, Biomed Pharmacother) - "In vivo, the combination outperformed monotherapy by improving host survival, reducing uterine bacterial burden, and alleviating inflammatory responses. Together, these findings establish ziyuglycoside II as a safe and effective tetracycline potentiator, providing a promising strategy to combat MDR S. aureus infections."

Journal • Endometriosis • Hematological Disorders • Infectious Disease • Inflammation

Magnetic flower-like Bi5O7I/CuFe2O4 photocatalyst for doxycycline degradation: Combined experimental, density functional theory and antibacterial study. (PubMed, J Environ Manage) - "Finally, the possible doxycycline degradation pathways were speculated by analyzing the corresponding degradation intermediates with LC-MS method, and the toxicity evolution of the doxycycline degradation products was valuated by using density functional theoretical method. This research is anticipated to furnish valuable insights into the designing of photocatalysts characterized by superior recyclability S-Scheme Heterojunction Photocatalyst."

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Gravity-driven removal of tetracycline from water using a hierarchically porous adsorptive nanofibrous membrane system functionalized with metal-organic framework. (PubMed, Water Res) - "The developed membrane showed high TC removal efficiency (>99 %), strong anti-interference performance across various real water conditions, and exhibited minimal performance loss after eight GDM cycles and a total processing volume of 4000 L m-2. Its advanced material design incorporates practical water purification technologies to reduce the antibiotic contamination in engineered water systems."

Journal • PIM1

Synergistic Fe-N3 and Fe2O3 structures for high-valent metal-oxo species generation and enhanced tetracycline degradation in Fe-N-C/PMS systems. (PubMed, J Hazard Mater) - "Moreover, the Fe-N-C/PMS system exhibits effective detoxification capability, preferential selectivity for electron-rich pollutants, strong anti-interference ability, and excellent stability, underscoring its application potential. This study identifies a turning point for mechanistic switching based on the synergistic Fe-N3/Fe2O3 structures, which provides new inspiration for the design of HVMO-dominated catalysts."

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Eravacycline in allogeneic stem cell transplant recipients: A real-world study of drug-drug interactions with cyclosporine/tacrolimus and anti-infective efficacy (ASH 2025) - "Eravacycline, a novel synthetic tetracycline, shares the Cytochrome P450 3A4 (CYP3A4) metabolic pathway with CNIs, yet comprehensive data on their potential pharmacokinetic interactions are scarce...Subgroup analysis revealed that when co-administered azoles and letermovir, no significant changes in C/D ratio were observed between pre-treatment and during treatment both in cyclosporine group (n=18) and tacrolimus group (n=7)... This study presented the first clinical evidence of drug-drug interaction between eravacycline with CNIs in allo-HSCT, characterized by increased CNI exposure during eravacycline administration and delayed post-cessation exposure elevation. Intensified CNI monitoring and stepwise dose adjustments are recommended throughout and after eravacycline therapy."

Clinical • Real-world • Real-world evidence • Acute Graft versus Host Disease • Bone Marrow Transplantation • Cardiovascular • Graft versus Host Disease • Hematological Disorders • Hypertension • Immunology • Infectious Disease • Transplantation • CYP3A4

Potential confounding factors in currently used antibiotic susceptibility assays for the honey bee pathogen Melissococcus plutonius. (PubMed, J Med Microbiol) - "Only one antibiotic, oxytetracycline (OTC), is approved for EFB management, and there have been reports of recalcitrance.Gap Statement...To standardize antibiotic susceptibility testing for M. plutonius, we recommend the use of M110 media due to stability and speed of growth. However, all strains of M. plutonius persist on M110 beyond the window of OTC efficacy, complicating assay results and interpretation, and additional research is needed to determine the clinical implications of these findings."

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Antibiotics mechanism of action (PubMed, Med Sci (Paris)) - "They act by inhibiting peptidoglycan synthesis (β-lactams, glycopeptides and fosfomycin); protein synthesis (aminoglycosides, macrolides lincosamides and streptogramins -tetracyclines, tetracyclines, chloramphenicol, fusidic acid, oxazolidinones-); or nucleic acid synthesis (quinolones/ fluoroquinolones and rifamycins) or interfering with key metabolic pathways such as folate biosynthesis (cotrimoxazole). However, the extensive and sometimes inappropriate use of antibiotics has led to the emergence of resistance, progressively reducing their efficacy and highlighting the need for the development of new antibacterial agents. This review presents the origin, structure, mechanism of action, main clinical agents, and spectrum of activity of each class of antibiotic."

Journal • Review

Novel mechanistic insights for IRAK1 and IRAK4 signaling provide a framework for the development of dual IRAK1 and IRAK4 protacs for MYD88 mutated lymphomas. (ASH 2025) - P2 | "However, the relative impact of scaffold vs. kinasefunction on pro-survival signaling for either IRAK1 or IRAK4 remains unclear and is critical tounderstanding the development of kinase inhibitors vs. PROTACs for development of therapeuticstargeting MYD88 mutated lymphomas. We performed knockdown (KD) experiments using an inducible lentiviral short hairpin RNAexpression vector tet-pLKO-puro containing a tetracycline-regulated expression cassette targeting IRAK1or IRAK4 in MYD88 mutated BCWM.1 and TMD8 cells with puromycin selection...Unexpectedly, p-ERK signaling was greatly augmented following KD ofeither IRAK1 or IRAK4 which could be blocked by the BTK-inhibitor ibrutinib... Both IRAK1 and IRAK4 contribute to NFKB pro-survival signaling in MYD88 mutatedlymphoma cells which is dependent on their respective kinase activity. Loss of IRAK1 or IRAK4 scaffoldtriggered BTK mediated ERK activation consistent with a previously unrecognized stress response toblocking IRAK1..."

B Cell Lymphoma • Chronic Lymphocytic Leukemia • CNS Lymphoma • Diffuse Large B Cell Lymphoma • Hematological Malignancies • Leukemia • Lymphoma • Lymphoplasmacytic Lymphoma • Marginal Zone Lymphoma • Non-Hodgkin’s Lymphoma • Primary Central Nervous System Lymphoma • Targeted Protein Degradation • Waldenstrom Macroglobulinemia • ANXA5 • IRAK4 • MYD88 • NFKBIA

Inhibition of Drp1, a mitochondrial fission GTPase disrupts mitochondrial quality control and impairs stem-like properties in Acute Myeloid Leukemia (ASH 2025) - "Drp1 was conditionally knocked down viadoxycycline/tetracycline inducible system...The LSC like cluster, was refractory to induction treatment with decitabine-venetoclax, and showed significantly higher Drp1 (DNM1L) expression than healthy HSCs (FC=1.46,adjusted p = 0.02)... Our study demonstrates that Drp1 is critical for maintaining mitochondrial quality controland stemness in AML via regulation of mitochondrial fission and mitophagy. scRNA-seq revealed elevatedDrp1 expression in an LSC-like blast cluster associated with refractory AML. Functional experimentsconfirmed that Drp1 knockdown disrupts mitochondrial fission, impairs mitophagy, increasesmitochondrial ROS, and compromises clonogenic capacity."

Acute Myelogenous Leukemia • Hematological Malignancies • Leukemia • DNM1L

Temporal control of CAR expression enables thymic generation of autoreactive T cells targeting tumor-associated antigens (ASH 2025) - "Constructs that were tested included CARs with decreasedcostimulation, CARs under the control of a distal LCK promoter (distal LCK activity is restricted to the laterstages of thymic T cell development), and a Cre-dependent tamoxifen-inducible CAR. We demonstrate that CD19 CAR expression can be successfully induced months afterintrathymic delivery of Cre-dependent, CAR-transduced HSPCs; however, as anticipated, thymic negativeselection eliminates a subset of CAR-expressing single positive thymocytes. Future directions will focus ondeveloping clinically translatable strategies for thymic CAR T cell generation, including the use oftetracycline-inducible expression systems or the design of CARs specific for truly tumor-restricted, non-self-antigens, thereby circumventing central tolerance barriers imposed by autoreactivity."

IO biomarker • Oncology • CD19

Characterizing the biological function FOXO3 and its role as a predictive biomarker in HTLV-1 related adult T-cell leukemia-lymphoma (ASH 2025) - "More recently, our ATL cell lines were engineered to overexpress FOXO3 via moreefficient transduction of tetracycline-inducible pRetroX vectors demonstrating FOXO3 slow theproliferation of ATL cells in vitro...Our current studies aim to confirm and define the functional role ofFOXO3 in ATL and to evaluate the clinical implications of altered FOXO3 in this disease. Given ourpreliminary findings, we are investigating FOXO3 as a predictive biomarker in prospective ATL samplesand characterizing its functional using our preclinical models."

Biomarker • Clinical • Adult T-Cell Leukemia-Lymphoma • Hematological Malignancies • Leukemia • Lymphoma • Non-Hodgkin’s Lymphoma • FASLG • FOXO3

Differential impacts of Lama4 deficient microenvironment on fitness of BCR::ABL1-expressing cells during chronic myeloid leukemia initiation and progression (ASH 2025) - "To decipher the effect ofLama4-/- niche on CML clone fitness (growth/survival), we evaluated cell cycle status of hematopoieticstem and progenitor cells (HSPC, LIN-SCA1+KIT+) in the mice by simultaneous staining of KI67 and DNA at2 weeks post-tetracycline withdrawal...Surprisingly, treatment with recombinant LAMA4 peptides inhibited CML patientBM CD34+CD38- cell growth in CAFC assay (p=0.001, N=4), and even more strikingly (about 80%inhibition) in LTC-IC stem cell assay while imatinib did not show any clear inhibition... Our data suggested differential impacts of Lama4 deficiency on the fitness of BCR::ABL1-expressing cells during CML initiation and therapy response. We observed a suppressive effect on CMLclone growth of Lama4 deficient niche during CML initiation, while better fitness of the CML stem cells inin vitro environment with reduced LAMA4 levels. Together, our work suggested opposing roles of Lama4deficient niche for CML cell fitness during CML initiation and..."

IO biomarker • Acute Myelogenous Leukemia • Chronic Myeloid Leukemia • Hematological Malignancies • Leukemia • ABL1 • CD34 • CD38

A novel presentation of minocycline-induced nail discoloration: A case report. (PubMed, Exp Ther Med) - "Minocycline, a tetracycline antibiotic used to treat acne and rosacea, is known to cause nail discoloration, typically as blue-gray pigmentation. This case expands the understanding of minocycline-induced nail discoloration, emphasizing the importance of early recognition and management of this side effect to minimize its cosmetic and psychological impact. The present findings offer new insights into its pathogenesis and diagnostic significance."

Journal • Acne Vulgaris • Dermatology • Inflammation • Rosacea

PA43 An infrequently diagnosed cause of pruritus. (PubMed, Br J Dermatol) - "Treatment with tetracycline antibiotics or dapsone has been shown to reduce the duration of the inflammatory phase. The residual hyperpigmentation usually persists for many months. This case is presented to enhance awareness, and facilitate early identification and appropriate treatment of this characteristic inflammatory dermatosis."

Journal • Anorexia • Bulimia • Dermatology • Diabetes • Inflammation • Metabolic Disorders • Pruritus

BG13 Pemphigoid vegetans of the buttocks. (PubMed, Br J Dermatol) - "A variety of treatment modalities have been reported in the literature, including topical corticosteroids, dapsone, tetracyclines and systemic steroids (Kim J, Chavel S, Girardi M, McNiff JM. J Cutan Pathol 2008; 35: 1144-7). However, the rarity of this condition necessitates further discussion to optimize management strategies."

Journal • Bullous Pemphigoid • CNS Disorders • Dermatology • Dermatopathology • Eosinophilia • Immunology • Inflammation

BH04 Growing interest: a survey of low-dose oral minoxidil prescribing for hair loss. (PubMed, Br J Dermatol) - "For female pattern hair loss, 90% (n = 26) would prescribe LDOM as monotherapy and 66% (n = 19) would use it with spironolactone. For FFP/LPP, 79% (n = 23) would not prescribe LDOM as monotherapy, but would use it as an adjunct, most commonly with hydroxychloroquine (n = 20), followed by tetracyclines (n = 19)...Our study highlights the variation in LDOM prescribing within the UK and Ireland. It demonstrates the wide use of LDOM by dermatologists both as an adjunct and as monotherapy for a wide range of hair loss conditions."

Journal • Alopecia • Fibrosis • Immunology • Lichen Planus

A Vanadium-Based Polyoxometalate Nanozyme for 2-Mercaptobenzothiazole Colorimetric Detection and Visible-Light-Driven Degradation in Water. (PubMed, Inorg Chem) - "Besides MBTZ, it also takes effect on other organic pollutants, such as sulfamethoxazole, 2,6-dichloro-4-nitroaniline, methotrexate hydrate, p-nitrophenol, and tetracycline. We expect that this research on the MBTZ detection and degradation properties of V4O10 will provide a valuable reference for practical MBTZ control in an aquatic environment."

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Enhanced Molecular Surveillance for Gonococcal Resistance During Doxycycline Post-Exposure Prophylaxis Implementation. (PubMed, Int J Antimicrob Agents) - "The introduction of doxycycline post-exposure prophylaxis (doxy-PEP) as a strategy to reduce the risk of bacterial sexually transmitted infections has raised concerns about the potential for rapid selection of tetracycline resistance and the emergence of ceftriaxone-resistant strains. Clinical sample testing revealed 100% sensitivity and specificity for identifying NG infection, tracking ceftriaxone-resistant FC428-like strains, and detecting tetM associated with tetracycline resistance. The HRM-doxyPEP assay offers an accurate, affordable, and scalable tool for enhanced molecular surveillance of AMR in NG during doxy-PEP implementation."

Journal • Infectious Disease

Prevalence and Molecular Epidemiology of Extended-Spectrum β-Lactamase-Producing Escherichia coli and Effects of Antimicrobial Use in Multiple Pig Industry Sectors in Korea. (PubMed, Ann Lab Med) - "Pig-derived E. coli isolates had antimicrobial resistance (AMR) rates of 80.4%, 47.2%, 32.6%, 36.7%, 43.4%, 62.4%, and 72.1% to ampicillin, piperacillin, cefazoline, ciprofloxacin, cotrimoxazole, chloramphenicol, and tetracycline, respectively. The findings highlight the significance of elucidating AMR networks among humans, animals, and the environment. Prudent antimicrobial usage and continuous AMR monitoring in the pig industry are crucial to safeguard food safety."

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Ultrasonic cavitation-induced radical processes for tetracycline degradation and Cr(VI) reduction: Highlighting the pivotal role of Cr(V) intermediates. (PubMed, Ultrason Sonochem) - "Complementary DFT calculations confirmed that the coexistence of TC and ·H markedly lowered the energy barrier of Cr(VI) reduction. Overall, this work provides new mechanistic insight into radical transformation and metal-organic coupling under ultrasonic cavitation, and highlights its potential as a sustainable strategy for treating waters co-contaminated with metals and antibiotics."

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