DAT-5000A
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March 26, 2025
Discovery of a novel, selective WRN inhibitor, DAT-5000A, in the treatment of microsatellite-unstable tumors
(AACR 2025)
- "DAT-5000A exhibited single-agent activity with tumor regression on MSI-H cell-line derived xenograft (CDX) tumor models, meanwhile DAT-5000A did not cause any abnormality on these mice. Our data demonstrated that DAT5000A is a potent, selective WRN inhibitor with sufficient in vivo exposure and acceptable preliminary safety profile, which supports DAT-5000A to be further evaluated in human clinical trials."
Endometrial Cancer • Gastric Cancer • Microsatellite Instability • Oncology • Solid Tumor • MSI • WRN
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