DAT-5000A / Danatlas - LARVOL DELTA

Discovery of a novel, selective WRN inhibitor, DAT-5000A, in the treatment of microsatellite-unstable tumors (AACR 2025) - "DAT-5000A exhibited single-agent activity with tumor regression on MSI-H cell-line derived xenograft (CDX) tumor models, meanwhile DAT-5000A did not cause any abnormality on these mice. Our data demonstrated that DAT5000A is a potent, selective WRN inhibitor with sufficient in vivo exposure and acceptable preliminary safety profile, which supports DAT-5000A to be further evaluated in human clinical trials."

Endometrial Cancer • Gastric Cancer • Microsatellite Instability • Oncology • Solid Tumor • MSI • WRN