Estrofem (estradiol oral) / Novo Nordisk - LARVOL DELTA

Bilateral Ovarian Agenesis and Bone Modeling Disease in Pre-puberty Girl With Primary Amenorrhea. (PubMed, Cureus) - "Treatment included hormonal therapy with progyluton and estrofem, transitioning to marvilon, alongside physical therapy, nutritional support, and psychological counseling. This is the first reported case of bilateral ovarian agenesis with chromosome X translocation presenting with phenotypic amenorrhea and bone deformities, demonstrating the value of tailored therapeutic approaches. Ongoing monitoring remains essential to ensure continued progress and mitigate long-term risks."

Journal • Musculoskeletal Diseases • Orthopedics • Osteoporosis • Pain • Rheumatology • Women's Health

Determining Dose Equivalence Between Oral and Transdermal Estrogen Treatment in Women With Turner Syndrome (clinicaltrials.gov) - P4 | N=50 | Recruiting | Sponsor: Aarhus University Hospital

New P4 trial • Endocrine Disorders • Genetic Disorders • Turners Syndrome

Evaluation of 28-day estradiol and progesterone vaginal rings in a phase 1 clinical pharmacokinetic study. (PubMed, Menopause) - "The 80/4 IVR and 160/8 IVR gave similar steady-state concentrations of E2 as seen with drug products approved by the US Food and Drug Administration for treatment of VMS and genitourinary symptoms of menopause. The E2 concentrations of this study support the potential of DARE-HRT1, a promising new option for hormone therapy for treatment of VMS and vaginal symptoms associated with menopause."

Journal • P1 data • PK/PD data • Women's Health

"Hiçbir eczanede bulunmayan, depolarda olmayan ilacı var sayamazsınız. Lütfen artık ilaçları verin. @novonordisk #estrofem #novonordiks" (@lisandlis)

"We can't find Estrofem in Turkey @novonordisk #NovoNordisk" (@justag_rill)

Progesterone and estrogen levels are associated with live birth rates following artificial cycle frozen embryo transfers. (PubMed, J Assist Reprod Genet) - "Serum progesterone and estradiol levels impact live birth rate in AC-FET."

Journal

"A difference in availability is the current estradiol shortage in Australia. @novonordisk Estrofem would cost a cis woman on menopausal HRT (mHRT) $6.60 for two weeks' worth. It costs me, a trans woman on feminising HRT (fHRT) ~$32.00 for two weeks' worth." (@epistemophagy)

Pricing

Safety of oral micronized progesterone versus norethisterone acetate in continuous combination with oral estrogen as menopausal hormone therapy – a double-blind randomized study- PROBES study (Progesterone Breast Endometrial Safety study) Säkerhet med oralt mikroniserat progesteron jämfört med noretisteronacetat i kontinuerlig kombination med oralt östrogen som menopausal hormo (clinicaltrialsregister.eu) - P3; N=520; Ongoing; Sponsor: Karolinska University Hospital

New P3 trial

Gonadotropin Releasing Hormone Agonist (GnRHa) Versus Estrogen and Progesterone for Luteal Support in High Responders (clinicaltrials.gov) - P4; N=100; Recruiting; Sponsor: Assaf-Harofeh Medical Center

Clinical • New P4 trial

The Temporo-spatial Dynamics of Genital Tract Microbiota (clinicaltrials.gov) - P=N/A; N=27; Completed; Sponsor: Peter Humaidan; Active, not recruiting ➔ Completed

Clinical • Trial completion • Infertility • Sexual Disorders

"Bende bulamıyorm =( bir ara çok tehlikeli olmasına rağmen Diana35 kullandım şimdi aldactone + estrofem e geçicem =[" (@asln_irm)

"Casodex + estrofeme başladım. Diane çok tehlike. Casodex nonstereoid testo reseptör inhibitörü." (@AnarkoTatbikat)