AT1965 / Alyssum Therap - LARVOL DELTA

Activating a B cell immune response regresses immunologically cold tumours. (PubMed, Nat Nanotechnol) - "Our results rationalize clinical data showing that patients with high CMTR2 expression in tumours have a poor prognosis and that B cell infiltration is associated with long-term survival in multiple tumour types. The AT-1965 nanomedicine-inspired discovery of CMTR2 as a potential cancer target and B cell recruitment opens a new frontier for immuno-oncology."

IO biomarker • Journal • Oncology

AT1965, a novel mRNA cap 2′O methylation inhibitor, exerts potent antitumor activity and enhances chemotherapy efficacy (AACR 2025) - "Here, we report that AT1965, a novel mRNA cap 2′O methylation inhibitor, exhibits potent antitumor effects and significant synergy with cabazitaxel, an FDA-approved anticancer agent. These findings underscore the potential of RNA capping enzymes as therapeutic targets in cancer. Future studies should explore the application of AT1965 in other tumor models and its potential to synergize with diverse chemotherapeutics."

Clinical • Lung Cancer • Oncology • Solid Tumor

Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmocodynamics and Preliminary Antitumor Activity of AT-1965 in Patients With Advanced, Refractory or Recurrent Solid Tumors (clinicaltrials.gov) - P1/2 | N=85 | Recruiting | Sponsor: Alyssum Therapeutics | Not yet recruiting ➔ Recruiting

Enrollment open • Metastases • Oncology • Solid Tumor

Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmocodynamics and Preliminary Antitumor Activity of AT-1965 in Patients With Advanced, Refractory or Recurrent Solid Tumors (clinicaltrials.gov) - P1/2 | N=85 | Not yet recruiting | Sponsor: Alyssum Therapeutics

New P1/2 trial • Oncology • Solid Tumor

Long noncoding RNA TANCR promotes γδ T cells activation by regulating TRAIL expression in cis. (PubMed, Cell Biosci) - "Here, we identified the novel function of lncRNA NONHSAT196558.1 in isopentenyl pyrophosphate (IPP)-activated and -expanded γδ T cells using RNA-seq...Furthermore, TANCR may be involved in the cytotoxicity of γδ T cells. This study aims to further our understanding of the molecular mechanisms underlying lncRNA-mediated immune responses."

Journal

Heimlich valve: from the view of the patient (ERS 2019) - "Heimlich valve (HV) drainage system, described at 1965 from Henry Heimlich, is a oneway valve system used by thoracic surgeons in various conditions...HV system has many advantages. Even though the 48% of patients satisfied seems to be small when other benefits are also taken into account we believe that it would be wise for the practice to be included in the daily practice of thoracic surgery."

Clinical