KK4277
/ SBI Biotech, Kyowa Kirin
- LARVOL DELTA
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September 15, 2025
Safety, Pharmacodynamics, and Efficacy of a Novel Plasmacytoid Dendritic Cells Targeting Antibody in Healthy Adults and Patients with SLE or Cutaneous Lupus Erythematosus with Active Skin Lesions: A First-In-Human Study of KK4277
(ACR Convergence 2025)
- P1 | "Multiple doses of 100 mg/body IV were tolerable. KK4277 greatly depleted pDC in blood and skin and reduced type I IFN. A proof of pharmacological action was obtained."
Clinical • First-in-human • P1 data • PK/PD data • Cutaneous Lupus Erythematosus • Immunology • Inflammation • Inflammatory Arthritis • Lupus
September 20, 2025
A Study of KK4277 in Healthy Volunteers and Patients With Systemic Lupus Erythematosus and Cutaneous Lupus Erythematosus
(clinicaltrials.gov)
- P1 | N=157 | Active, not recruiting | Sponsor: Kyowa Kirin Co., Ltd. | Recruiting ➔ Active, not recruiting
Enrollment closed • Cutaneous Lupus Erythematosus • Immunology • Inflammatory Arthritis • Lupus • Systemic Lupus Erythematosus
September 19, 2024
A Study of KK4277 in Healthy Volunteers and Patients With Systemic Lupus Erythematosus and Cutaneous Lupus Erythematosus
(clinicaltrials.gov)
- P1 | N=157 | Recruiting | Sponsor: Kyowa Kirin Co., Ltd. | N=116 ➔ 157 | Trial completion date: Mar 2025 ➔ Dec 2025
Enrollment change • Trial completion date • Cutaneous Lupus Erythematosus • Immunology • Inflammatory Arthritis • Lupus • Systemic Lupus Erythematosus
August 08, 2023
A Study of KK4277 in Healthy Volunteers and Patients With Systemic Lupus Erythematosus and Cutaneous Lupus Erythematosus
(clinicaltrials.gov)
- P1 | N=116 | Recruiting | Sponsor: Kyowa Kirin Co., Ltd. | Not yet recruiting ➔ Recruiting | Trial completion date: Sep 2024 ➔ Mar 2025 | Trial primary completion date: Sep 2023 ➔ Dec 2024
Enrollment open • Trial completion date • Trial primary completion date • Cutaneous Lupus Erythematosus • Immunology • Inflammatory Arthritis • Lupus • Systemic Lupus Erythematosus
October 04, 2017
Newly added pipeline product: SBI-9674
(SBI Biotech Press Release)
Pipeline update • Lupus
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