ECC4703
/ Eccogene
- LARVOL DELTA
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October 08, 2025
SYNERGISTIC EFFECTS OF ECC4703, A LIVER-TARGETING THRΒ FULL AGONIST, IN COMBINATION WITH ECC0509, A SELECTIVE SSAO INHIBITOR, OR SEMAGLUTIDE IN A MASH ANIMAL MODEL
(AASLD 2025)
- "ECC4703 has the potential to be the corner stone for combination with other mechanisms to treat MASH in humans."
Combination therapy • Preclinical • Diabetes • Fibrosis • Genetic Disorders • Hepatology • Immunology • Inflammation • Liver Cirrhosis • Metabolic Disorders • Metabolic Dysfunction-Associated Steatohepatitis • Metabolic Dysfunction-Associated Steatotic Liver Disease • Obesity
October 06, 2025
Eccogene Receives U.S. FDA Clearance to Initiate Phase 2a MOSAIC Trial of ECC4703 and ECC0509 for MASH
(GlobeNewswire)
- "The MOSAIC trial is a U.S.-based, multicenter, randomized, double-blind, placebo-controlled Phase 2a trial that will evaluate the efficacy and safety of ECC4703, ECC0509, and the combination of the two in adults with presumed MASH. The 12-week study is expected to enroll approximately 160 participants."
IND • New P2a trial • Metabolic Dysfunction-Associated Steatohepatitis
May 17, 2025
Metabolic Effects of ECC4703, a Liver Targeting Full THRb Agonist, in Combination with Semaglutide and Tirzepatide in Diet-Induced Obese Mice
(ADA 2025)
- "These results suggest that ECC4703 in combination with GLP-1R agonists holds potential therapeutic merits to treat obesity and related comorbidities."
Combination therapy • Late-breaking abstract • Preclinical • Metabolic Disorders • Obesity
June 17, 2025
Eccogene to Report Preclinical Data with ECC4703, Showcasing Impact on Lean Muscle Sparing and Fat Loss in Combination with Semaglutide and Tirzepatide
(GlobeNewswire)
- "The combination therapy of ECC4703 and semaglutide or tirzepatide resulted in significantly greater weight loss compared to semaglutide or tirzepatide alone. The body composition indicated the additional weight loss was mainly contributed by fat mass loss, with preservation of lean mass."
Preclinical • Obesity
July 05, 2024
FTIH of ECC4703 in Healthy Volunteers
(clinicaltrials.gov)
- P1 | N=75 | Completed | Sponsor: Eccogene | Recruiting ➔ Completed | N=54 ➔ 75 | Trial completion date: Jul 2023 ➔ Oct 2023 | Trial primary completion date: Jul 2023 ➔ Oct 2023
Enrollment change • Trial completion • Trial completion date • Trial primary completion date • Hepatology • Metabolic Dysfunction-Associated Steatohepatitis
September 23, 2022
FTIH of ECC4703 in Healthy Volunteers
(clinicaltrials.gov)
- P1 | N=54 | Recruiting | Sponsor: Eccogene
New P1 trial • Hepatology • Non-alcoholic Steatohepatitis • APOB
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