VX-993 oral / Vertex - LARVOL DELTA

A Study to Evaluate How the Body Processes 14C-VX-993 After a Single Oral Dose (clinicaltrials.gov) - P1 | N=8 | Recruiting | Sponsor: Vertex Pharmaceuticals Incorporated | Not yet recruiting ➔ Recruiting

Enrollment open • Pain

A Microneurography Study of NaV1.8 Inhibition in Healthy Adults (clinicaltrials.gov) - P1 | N=92 | Completed | Sponsor: Vertex Pharmaceuticals Incorporated | Recruiting ➔ Completed

Trial completion • Pain

A Study to Evaluate How the Body Processes 14C-VX-993 After a Single Oral Dose (clinicaltrials.gov) - P1 | N=8 | Not yet recruiting | Sponsor: Vertex Pharmaceuticals Incorporated

New P1 trial • Pain

Evaluation of the Pharmacokinetic Drug-drug Interactions Between VX-993 and Metformin in Healthy Adults (clinicaltrials.gov) - P1 | N=31 | Completed | Sponsor: Vertex Pharmaceuticals Incorporated | Active, not recruiting ➔ Completed

Trial completion • Pain

A Microneurography Study of NaV1.8 Inhibition in Healthy Adults (clinicaltrials.gov) - P1 | N=92 | Recruiting | Sponsor: Vertex Pharmaceuticals Incorporated | Completed ➔ Recruiting | N=40 ➔ 92 | Trial completion date: Jul 2024 ➔ Apr 2025 | Trial primary completion date: Jul 2024 ➔ Mar 2025

Enrollment change • Enrollment open • Trial completion date • Trial primary completion date • Pain

Evaluation of the Pharmacokinetic Drug-drug Interactions Between VX-993 and Metformin in Healthy Adults (clinicaltrials.gov) - P1 | N=31 | Active, not recruiting | Sponsor: Vertex Pharmaceuticals Incorporated | Recruiting ➔ Active, not recruiting

Enrollment closed • Pain

A Study Evaluating Efficacy and Safety of VX-993 for Acute Pain After a Bunionectomy (clinicaltrials.gov) - P2 | N=355 | Recruiting | Sponsor: Vertex Pharmaceuticals Incorporated | Not yet recruiting ➔ Recruiting

Enrollment open • Pain

Evaluation of the Pharmacokinetic Drug-drug Interactions Between VX-993 and Metformin in Healthy Adults (clinicaltrials.gov) - P1 | N=32 | Recruiting | Sponsor: Vertex Pharmaceuticals Incorporated | Trial completion date: Sep 2024 ➔ Dec 2024 | Trial primary completion date: Sep 2024 ➔ Dec 2024

Trial completion date • Trial primary completion date • Pain

Evaluation of Efficacy and Safety of VX-993 for Pain Associated With Diabetic Peripheral Neuropathy (clinicaltrials.gov) - P2 | N=300 | Recruiting | Sponsor: Vertex Pharmaceuticals Incorporated | Not yet recruiting ➔ Recruiting

Enrollment open • Diabetic Neuropathy • Neuralgia • Pain • Peripheral Neuropathic Pain

A Study to Evaluate the Relative Bioavailability and Food Effect of a New Tablet Formulation of VX-993 (clinicaltrials.gov) - P1 | N=24 | Completed | Sponsor: Vertex Pharmaceuticals Incorporated | Active, not recruiting ➔ Completed

Trial completion • Pain

A Study Evaluating Efficacy and Safety of VX-993 for Acute Pain After a Bunionectomy (clinicaltrials.gov) - P2 | N=355 | Not yet recruiting | Sponsor: Vertex Pharmaceuticals Incorporated

New P2 trial • Pain

Evaluation of Efficacy and Safety of VX-993 for Pain Associated With Diabetic Peripheral Neuropathy (clinicaltrials.gov) - P2 | N=300 | Not yet recruiting | Sponsor: Vertex Pharmaceuticals Incorporated

New P2 trial • Diabetic Neuropathy • Neuralgia • Pain • Peripheral Neuropathic Pain

A Study to Evaluate the Relative Bioavailability and Food Effect of a New Tablet Formulation of VX-993 (clinicaltrials.gov) - P1 | N=24 | Active, not recruiting | Sponsor: Vertex Pharmaceuticals Incorporated | Recruiting ➔ Active, not recruiting

Enrollment closed • Pain

Evaluation of the Pharmacokinetic Drug-drug Interactions Between VX-993 and Metformin in Healthy Adults (clinicaltrials.gov) - P1 | N=32 | Recruiting | Sponsor: Vertex Pharmaceuticals Incorporated | Not yet recruiting ➔ Recruiting

Enrollment open • Pain

A Study to Evaluate the Relative Bioavailability and Food Effect of a New Tablet Formulation of VX-993 (clinicaltrials.gov) - P1 | N=24 | Recruiting | Sponsor: Vertex Pharmaceuticals Incorporated | Not yet recruiting ➔ Recruiting

Enrollment open • Pain

A Phase 1, Open-label Study Evaluating the Pharmacokinetics and Drug-drug Interaction of VX-993 in Healthy Adults (clinicaltrials.gov) - P1 | N=42 | Completed | Sponsor: Vertex Pharmaceuticals Incorporated | Active, not recruiting ➔ Completed

Trial completion • Pain

Evaluation of the Pharmacokinetic Drug-drug Interactions Between VX-993 and Metformin in Healthy Adults (clinicaltrials.gov) - P1 | N=32 | Not yet recruiting | Sponsor: Vertex Pharmaceuticals Incorporated

New P1 trial • Pain

A Study to Evaluate the Relative Bioavailability and Food Effect of a New Tablet Formulation of VX-993 (clinicaltrials.gov) - P1 | N=24 | Not yet recruiting | Sponsor: Vertex Pharmaceuticals Incorporated

New P1 trial • Pain

A Phase 1 Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics, of VX-993 (clinicaltrials.gov) - P1 | N=39 | Completed | Sponsor: Vertex Pharmaceuticals Incorporated | Active, not recruiting ➔ Completed

Trial completion • Pain

A Phase 1, Open-label Study Evaluating the Pharmacokinetics and Drug-drug Interaction of VX-993 in Healthy Adults (clinicaltrials.gov) - P1 | N=42 | Active, not recruiting | Sponsor: Vertex Pharmaceuticals Incorporated | Recruiting ➔ Active, not recruiting

Enrollment closed • Pain

A Phase 1, Open-label Study Evaluating the Pharmacokinetics and Drug-drug Interaction of VX-993 in Healthy Adults (clinicaltrials.gov) - P1 | N=42 | Recruiting | Sponsor: Vertex Pharmaceuticals Incorporated | Not yet recruiting ➔ Recruiting

Enrollment open • Pain

A Phase 1 Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics, of VX-993 (clinicaltrials.gov) - P1 | N=39 | Active, not recruiting | Sponsor: Vertex Pharmaceuticals Incorporated | Recruiting ➔ Active, not recruiting

Enrollment closed • Pain

A Phase 1 Dose Escalation Study of Intravenous VX-993 in Healthy Adults (clinicaltrials.gov) - P1 | N=110 | Not yet recruiting | Sponsor: Vertex Pharmaceuticals Incorporated

New P1 trial • Pain

A Phase 1, Open-label Study Evaluating the Pharmacokinetics and Drug-drug Interaction of VX-993 in Healthy Adults (clinicaltrials.gov) - P1 | N=42 | Not yet recruiting | Sponsor: Vertex Pharmaceuticals Incorporated

New P1 trial • Pain

A Phase 1 Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics, of VX-993 (clinicaltrials.gov) - P1 | N=40 | Recruiting | Sponsor: Vertex Pharmaceuticals Incorporated

New P1 trial • Pain