Diastat (diazepam rectal gel) / Bausch Health - LARVOL DELTA

Safety and Local Tolerability of Diazepam Nasal Spray for Children With Epilepsy Aged 2-5 Years: Final Results of a Phase 1/2a Trial. (PubMed, J Child Neurol) - P1/2 | "A long-term safety study in patients aged 6-65 years found a safety profile similar to diazepam rectal gel. No serious treatment-related TEAEs or TEAEs leading to discontinuation/death occurred. The safety profile aligns with patients aged ≥6 years, supporting use in this population.(ClinicalTrials.gov identifier: NCT05076838)."

Journal • P1/2 data • CNS Disorders • Epilepsy

Complete genome sequence of Streptomyces diastaticus strain GN02 and analysis of its biosynthetic gene clusters. (PubMed, Microbiol Resour Announc) - "The genome comprises a 6.8 Mb linear chromosome with a GC content of 73.5%. Genome analysis identified 23 biosynthetic gene clusters."

Journal

Rapid Assessment of Honey Physicochemical Properties by Mid-Infrared Spectroscopy and Chemometric Modeling. (PubMed, ACS Omega) - "A total of 97 samples of honey from Apis melliferabees from different botanical and geographical origins in Brazil were subjected to physicochemical analyses of pH, moisture, total soluble solids, free acidity, lactonic acidity, total acidity, proline, diastatic activity, hydroxymethylfurfural, and MIR...The models presented statistical validation parameters, including correlation coefficients ranging from 0.81 to 0.97, performance ratios for deviation from 1.7 to 4.4, and interval error ratios between 5.7 and 16.3. The results demonstrate the potential of using MIR spectroscopy in conjunction with iPLS for the simultaneous, fast, and nondestructive quantification of physicochemical parameters of honey."

Journal

Replicative age differentially predicts metabolic competence across industrial yeasts at single-cell resolution. (PubMed, FEMS Yeast Res) - "diastaticus BE-134, S. cerevisiae var...Among S. cerevisiae variants, age-dependent gradients were weaker and strain-specific, while in K. phaffii reliable discrimination required exponential growth. Replicative age is thus a strain-dependent predictor of metabolic competence rather than a universally conserved one, and the workflow offers brewers and bioprocess developers a practical tool for age-resolved fermentation monitoring and pitching-yeast assessment."

Journal

Description of last instar nymph of Zoraena sarracenia (Abbott & Hibbitts, 2011) (Odonata: Cordulegastridae) with notes on its life history. (PubMed, Zootaxa) - "Laboratory rearings suggest a minimum nymphal development time of approximately two years, with some individuals requiring three years. This description completes knowledge of nymphal morphology within the diastatops species group and facilitates identification and conservation assessment of this geographically restricted species."

Journal

Rate and risk factors of diastasis recti abdominis developed during the postpartum period: a cross-sectional study. (PubMed, BMC Musculoskelet Disord) - "Cesarean section is the independently contributing factors to develop the diastasis recti abdominis besides other socio-demographic and obstetric variables, suggesting that controlling cesarean section has a unique advantage in this regard. The widest separation distance occurs most frequently at the level of the umbilicus, and the percentage of which increases with increasing diastasis recti abdominis severity."

Journal • Observational data • Obstetrics

Rapid Assessment of Italian Honey Chemical Composition and Botanical Origin Using NIR Spectroscopy Coupled with Chemometric Analysis. (PubMed, Sensors (Basel)) - "Hydroxymethylfurfural and diastatic activity were poorly predicted (R2 up to 0.49), likely due to their low concentrations. Summarising, the main outcomes suggested that tested portable NIR settings are also suitable for rapid quantitative screening of chemical traits, whereas the benchtop system provide higher precision for botanical qualitative authentication."

Journal

Rational construction of rpsL or/and rpoB merodiploids affects biosynthesis of secondary metabolite in Streptomyces. (PubMed, Mol Biol Rep) - "Constructing a diploid by directly introducing the rpsL and rpoB genes carrying "beneficial mutations" is an effective strategy to enhance the synthesis level of secondary metabolites, whether for the model strain S. coelicolor M145 or the industrial strain S. diastatochromogenes 1628."

Journal

Field scale evaluation of agronomic and malting quality traits in hybrid barley. (PubMed, BMC Plant Biol) - No abstract available

Journal

Natural food-derived antimicrobials against beer spoilage microorganisms. (PubMed, Appl Microbiol Biotechnol) - "diastaticus. These findings provide insight into the potential role of natural food-derived antimicrobials in controlling beer spoilage microorganisms, pending further validation in real beverage systems."

Journal

Natural Strategies to Preserve Alcohol-Free Beer: Phenolamide Dimers with Anti-Yeast Potential. (PubMed, J Agric Food Chem) - "diastaticus...Notably, the newly synthesized agmatine amide of poacic acid, a stilbenoid dimer of ferulic acid, showed increased antiyeast activity compared to its monomeric precursors. These results demonstrate that amidation and oxidative coupling can increase the antiyeast activity of hydroxycinnamic acid derivatives, and that hydroxycinnamoylagmatine dimers possess potential as preservatives against wild yeast spoilage in beer."

Journal

Growing skull fracture presenting with late-onset seizures: a case report. (PubMed, Childs Nerv Syst) - "Neglected cases of GSF can lead to long-term neurological impairments, underscoring the importance of early recognition and intervention. This case highlights seizures as an important presentation of GSF and emphasizes the need for timely treatment."

Journal • CNS Disorders • Epilepsy • Musculoskeletal Diseases • Orthopedics • Pediatrics

Impact of germination and kilning parameters on Eleusine coracana malting for industrial brewing applications. (PubMed, Sci Rep) - "The malts were characterized by germination energy, enzyme activity, protein and tannin content, as well as brewing performance indicators including diastatic power and hot water extract...Wort analysis yielded hot water extract values of 77.7-90.7% (dry basis), with upper values surpassing EBC standards, suggesting possible over-modification under certain treatments. These findings demonstrate finger millet's suitability as an alternative brewing raw material and support its potential for commercial millet-based beer production in Ethiopia and beyond."

Journal

Final, Long-Term Safety Results for Diazepam Nasal Spray in Patients Aged 2-5 Years From a Phase 1/2a Study (AES 2025) - P1/2 | "Diazepam nasal spray does not require positioning the patient, needs fewer steps to administer than diazepam rectal gel, and has an established safety profile in patients aged 6-17 y that is consistent with rectal diazepam in children ≥6 y and adults. The safety profile of diazepam nasal spray was generally consistent with that of older patients and confirms the safety profile of diazepam nasal spray and age- and weight-based dosing in this younger age group of patients aged 2-5 y."

Clinical • P1/2 data • CNS Disorders • Depression • Epilepsy • Psychiatry • Respiratory Diseases

Caregiver Perceptions of Diazepam Nasal Spray Treatment in Children Aged 2-5 Years (AES 2025) - "Two diazepam formulations are approved by the US Food and Drug Administration for the treatment of SCs in patients with epilepsy aged ≥2 y: diazepam rectal gel and diazepam nasal spray. At the end of the 180-day period, caregivers reported that most patients recovered quickly and that SCs did not affect other responsibilities, were not stressful to the family, and were milder and fewer and that recovery improved with treatment. These insights into caregiver perceptions reinforce the value of appropriate SC management."

Clinical • CNS Disorders • Epilepsy

Examining Nasal and Respiratory Safety of Diazepam Nasal Spray and Device Suitability for Children With Epilepsy Aged 2-5 Years (AES 2025) - "Rationale: Diazepam nasal spray (Valtoco®) is approved for the treatment of seizure clusters in patients with epilepsy aged ≥2 y. In patients aged 6-65 y, a safety profile consistent with that of diazepam rectal gel has been demonstrated. Diazepam nasal spray demonstrated favorable local safety and tolerability profile in children aged 2-5 years, with no serious treatment-related TEAE (including respiratory depression), and a low rate of dosing errors comparable to that seen in studies in older children and adults. These findings support the dosing paradigm and the device's suitability in treating seizure clusters for this age group."

Clinical • CNS Disorders • Depression • Dermatology • Epilepsy • Psychiatry • Respiratory Diseases

Chemical composition, aroma profile, antioxidant activity, and sensory attributes of beer according to roasting degree and malt type. (PubMed, Food Chem ) - "Roasting increased carbohydrate content, diastatic power, and Maillard products such as melanoidins and Amadori compounds, contributing to deeper color and enhanced antioxidant activity...These changes aligned with antioxidant capacity, as melanoidin- and pyrazine-rich profiles enhanced radical scavenging. Overall, roasting modulated sensory and antioxidant properties through Maillard-derived transformations, underscoring their impact on beer quality."

Journal

SILENT PERFORATION: LIFE-THREATENING PNEUMO-MEDIASTINUM FROM NASOGASTRIC TUBE PLACEMENT IN AN ELDERLY PATIENT (CHEST 2025) - " Elderly patients are at high risk for complications during nasogastric tube (NGT) insertion due to factors like decreased pharyngeal reflexes and altered levels of consciousness [1]• Caution is essential when performing NGT insertion in elderly patients, with the use of multiple confirmation methods to ensure accurate placement.• Reported causes of cervical emphysema and pneumo-mediastinum include dental surgery, mastoid fractures, diastatic cecum rupture, and acute perforated diverticulitis, often treated with prophylactic antibiotics. • This case underscores the potential dangers of NG tube insertion, particularly in elderly patients, whose anatomical or functional vulnerabilities may heighten the risk of complications."

Clinical • Cardiovascular • Coronary Artery Disease • Diabetes • Endocrine Disorders • Gastrointestinal Disorder • Gout • Hypertension • Infectious Disease • Inflammatory Arthritis • Metabolic Disorders • Musculoskeletal Diseases • Nephrology • Orthopedics • Pulmonary Disease • Respiratory Diseases • Rheumatology • Type 2 Diabetes Mellitus

Diastatotropis elegans (Coleoptera: Anthribidae) from Madagascar: nomenclatural status, redescription and ecological notes. (PubMed, Zootaxa) - "Based on the available distributional data, D. elegans seems to be endemic to the Montagne dAmbre massif, northern Madagascar. A checklist of valid species of Diastatotropis Lacordaire, 1865 is provided."

Journal

Epidemiology of complex colon cancer entities and patterns of locoregional recurrence entities: A nationwide retrospective cohort study (ESCP 2025) - "Aim Despite the high incidence of colon cancer, there is a lack of data concerning complex colon cancer (CCC) entities, including uncomplicated cT4 tumors, peritumoral abscess (PACC), tumor perforation (TPCC) and diastatic proximal perforation (DPCC), as well as patterns of locoregional recurrences (LRR)...PACC and cT4 stage were independently associated with isolated LRR. The observed LRR incidence was 7.7% and peritoneal localization was most frequently observed (4.0%)."

Retrospective data • Colon Cancer • Colorectal Cancer • Oncology • Solid Tumor

Enhancement or Activation of Agricultural Antibiotic Production in Streptomyces by an Identified Strong Promoter P30S. (PubMed, J Agric Food Chem) - "The higher expression level and utility of P30S were further confirmed in three different host strains, including the industrial strain Streptomyces diastatochromogenes 1628...Similarly, in S. rimosus M527, P30S was superior to permE* in increasing rimocidin production through the overexpression of the accsr gene, which encodes acetyl-CoA carboxylase. Moreover, P30S successfully activated a cryptic gene cluster responsible for TM biosynthesis in S. rimosus M527 via CRISPR/Cas9-mediated knock-in."

Journal

A new antifungal compound from Streptomyces diastatochromogenes. (PubMed, BMC Biotechnol) - "Compound 1 exhibited potent inhibitory activity against the hyphal growth of R. solani, F. oxysporum, and B. cinerea, with IC50 values of 0.20, 1.28, and 1.53 µg/mL, respectively. These fundings underscore S. diastatochromogenes as a promising microbial source for the discovery of natural antifungal agents."

Journal

Superior thermostability and divalent cation sensitivity of isoamylase CMI294C from Cyanidioschyzon merolae. (PubMed, Plant Mol Biol) - "Our results indicate that CMI294C can be potentially used for industrial maltose production due to its enzymatic properties. Overall, our findings provide molecular insights into the isoamylase in glucan structure modulation and enhance our understanding of glucan metabolism in C. merolae."

Journal

Genetic pre-adaptations in Saccharomyces cerevisiae Andean chicha isolates facilitate industrial brewery application. (PubMed, Food Microbiol) - "These outperformed commercial reference brewing strains and had fermentation profiles and alcohol yields similar to those of diastatic S. cerevisiae strains of the Mosaic/Beer 2 group...Apart from 4-vinylguaiacol, which is considered an essential flavour compound in wheat beers, no off-flavours were detected in test beers. Results highlight the value of assessing industrial brewing potential of non-European strains associated with traditional cereal-based fermentations."

Journal

Pharmacokinetics and 180-day safety of diazepam nasal spray in pediatric patients with epilepsy aged 2-5 years. (PubMed, Epilepsia) - "This study characterizes the PK of diazepam in patients 2-5 years of age and reports a safety profile consistent with older patients. Results demonstrate that the diazepam nasal spray drug-device combination is appropriate for drug delivery and absorption in these patients."

Journal • PK/PD data • CNS Disorders • Depression • Epilepsy • Pediatrics • Psychiatry