azithromycin / Generic mfg. - LARVOL DELTA

Infection Characteristics in Patients Treated With Axatilimab for Chronic Graft-Versus-Host Disease in the AGAVE-201 Trial (HOPA 2026) - P2 | "Among 7 patients receiving cyclosporine and 11 receiving tacrolimus, 1 (14.3%) and 3 (27.3%), respectively, completed tapering within 6 cycles. Among 241 randomized patients, 192 (79.7%) had severe cGVHD with a median of 4 prior cGVHD therapies; 130 (53.9%) had ≥4 organs involved. Concomitant medications included antivirals, most commonly acyclovir (60.6%); antibacterials, including sulfamethoxazole/trimethoprim (63.9%) and azithromycin (32.4%); and antifungals, including posaconazole (24.1%) and fluconazole (11.6%). Concomitant corticosteroid use at baseline was reported in 156/239 (65.3%) patients; mean daily dose was 19.4 mg."

Clinical • Chronic Graft versus Host Disease • Cytomegalovirus Infection • Epstein-Barr Virus Infections • Graft versus Host Disease • Immunology • Infectious Disease • Novel Coronavirus Disease • Pneumonia • Respiratory Diseases

Promising Drug Repurposing Candidates Targeting Free-Living Amoebae: A Systematic and Critical Review of Laboratory-Based Evidence. (PubMed, Pathogens) - "In in vivo studies, sulfadiazine and rifampicin were effective as preventive or early monotherapies for GAE. For AK, the combination of polyhexamethylene biguanide, neomycin, and atropine, as well as voriconazole and nitazoxanide monotherapies, showed the greatest promise. In PAM, azithromycin alone or in combination with amphotericin B emerged as the most promising therapeutic options. Further studies are required to advance the clinical translatability of these findings. To the best of our knowledge, this work provides the first comprehensive and integrated synthesis of repurposable drug candidates against FLA infections."

Journal • Review • CNS Disorders • Infectious Disease • Keratitis • Ocular Inflammation • Ophthalmology

Antimicrobial Susceptibility and Distribution Characteristics of Mycoplasma pneumoniae Isolates in Beijing, China, from 2017 to 2025. (PubMed, Pharmaceuticals (Basel)) - "We used the broth microdilution method to determine the minimum inhibitory concentrations (MICs) of erythromycin, azithromycin, tetracycline, levofloxacin, and moxifloxacin against these isolates. Erythromycin is no longer suitable as an empirical therapy for MP infections during epidemic periods, whereas azithromycin can be cautiously administered in young children according to age stratification and MIC detection results. Meanwhile, it is imperative to strengthen the prevention and control of cluster MP infections during epidemic phases to reduce the transmission of drug-resistant MP strains."

Journal • Infectious Disease • Pneumonia • Respiratory Diseases

Trends and risk factors of antimicrobial resistance of Neisseria gonorrhoeae in Catalonia, Spain, 2022-2023. (PubMed, Eur J Clin Microbiol Infect Dis) - No abstract available

Journal • Infectious Disease

Temporal trends in treatment strategies and outcomes of newly diagnosed Mycobacterium avium complex pulmonary disease. (PubMed, Int J Tuberc Lung Dis) - "While the use of rifampicin declined, the use of azithromycin, inhaled or intravenous amikacin, and clofazimine increased over time. The probability of culture conversion progressively improved (Tarone-Ware test, P CONCLUSIONSince 2011, treatment strategies for MAC-PD have evolved toward a more proactive approach, accompanied by a gradual improvement in treatment outcomes.."

Journal • Retrospective data • Pulmonary Disease • Respiratory Diseases

Double-dose azithromycin mass drug administration, facial cleanliness, and fly control measures for trachoma control in Oromia, Ethiopia (Stronger SAFE): a cluster-randomised controlled trial. (PubMed, Lancet Infect Dis) - "Enhanced A, F, and E (Stronger SAFE) had no additional effect compared with standard of care on reducing the prevalence of conjunctival C trachomatis at 3 years in this setting. It is therefore unlikely that these enhanced intervention measures will accelerate trachoma elimination beyond well implemented, high coverage of single-dose MDA as part of standard SAFE."

Journal • Infectious Disease • Ophthalmology • Pain

Drug-associated torsades de pointes and QT prolongation in infants: A focused real-world disproportionality analysis pharmacovigilance study. (PubMed, Pediatr Neonatol) - "This study highlights critical drug safety signals for TdP and QT prolongation in infants, emphasizing the need for vigilant monitoring and cautious drug use in this vulnerable population. Further research is essential to elucidate risk factors and improve pharmacovigilance strategies in pediatric care."

Adverse events • Journal • Real-world evidence • Anesthesia • Cardiovascular • Pediatrics • Ventricular Tachycardia

Concurrent Mold, Mycobacterial, and Viral Infections in a Hematopoietic Stem Cell Transplant Recipient Undergoing Lung Transplantation for Graft-Versus-Host Disease. (PubMed, Curr Oncol) - "Despite partial response, recurrent fungal infection necessitated prolonged antifungal therapy, including adjunctive inhaled amphotericin B and terbinafine...Post-transplant prophylaxis with voriconazole, rifabutin, azithromycin, and inhaled amikacin prevented recurrence, and the patient remained clinically stable at 6-month follow-up. This case illustrates the complexity of managing overlapping mold and NTM infections in HSCT recipients, highlighting the need for individualized, multidisciplinary care. Therapeutic drug monitoring, careful adjustment for drug-drug interactions, and the use of adjunctive inhaled antifungals were critical to achieving a favorable outcome."

Journal • Acute Myelogenous Leukemia • Bone Marrow Transplantation • Graft versus Host Disease • Hematological Malignancies • Immunology • Infectious Disease • Leukemia • Nontuberculous Mycobacterial Disease • Oncology • Pulmonary Disease • Respiratory Diseases • Respiratory Syncytial Virus Infections • Transplantation

Severe Pertussis During Early Infancy from a High-Altitude Region: Two Clinical Cases and Literature Review. (PubMed, J Clin Med) - " Case 1 had macrolide-resistant Bordetella pertussis (MRBP, 23S rRNA A2047G) with peak WBC 52.25 × 109/L, and received cefoperazone-sulbactam, piperacillin-tazobactam and azithromycin, and was successfully treated with trimethoprim-sulfamethoxazole combined with exchange transfusion. High altitude is an independent risk modifier in infantile pertussis, demanding heightened vigilance and proactive interventions: early non-invasive ventilation, prophylactic anticoagulation, and timely exchange transfusion before pulmonary hypertension develops. This is the first high-altitude case series that provides essential insights for clinicians in similar environments globally, guiding early recognition and proactive management strategies to improve outcomes in this vulnerable population."

Journal • Cardiovascular • Hypertension • Infectious Disease • Pertussis • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

Effects of the COVID-19 pandemic on antibiotic use and resistance in French hospitals, 2019-22: a retrospective ecological analysis of national surveillance data. (PubMed, Lancet Digit Health) - "Our results highlight alterations in antibiotic use and pathogen-specific effects of the pandemic on antibiotic resistance in hospitals. Although the biological mechanisms underlying between-species differences remain unclear, these results provide insights into the potential effects of a viral pandemic on antibiotic resistance and support the need for pandemic preparedness in health-care facilities."

Journal • Retrospective data • Critical care • Infectious Disease • Novel Coronavirus Disease • Pneumonia

Occurrence of Pharmaceuticals in the Seawater Samples of the Port of Cartagena (Murcia, Spain): A Pilot Study. (PubMed, Toxics) - "Diclofenac and several antibiotics (erythromycin, azithromycin, clindamycin, and trimethoprim) were the most frequently detected compounds, reaching maximum concentrations of up to 12,294.1 ng/L. Most detected concentrations exceeded established environmental-quality or risk-threshold values, indicating a potential threat to marine ecosystems. These findings highlight the vulnerability of port environments to pharmaceutical pollution and underscore the need for continuous monitoring programs to support effective environmental management and biodiversity protection in coastal port areas."

Journal

ICARIA: Improving Care Through Azithromycin Research for Infants in Africa (clinicaltrials.gov) - P3 | N=20560 | Active, not recruiting | Sponsor: Barcelona Institute for Global Health | Trial completion date: Dec 2025 ➔ Apr 2026

Trial completion date

Safety, colonisation kinetics, transmissibility, and immune correlates of protection in healthy adults inoculated with Bordetella pertussis in England: a single-centre, open-label, phase 1, controlled human infection study. (PubMed, Lancet Microbe) - P=N/A | "Our findings suggest that controlled human infection with B pertussis in an outpatient setting is safe. Higher humoral and CD4+ T-cell responses with specificity to acellular pertussis vaccine antigens are associated with protection against colonisation by B pertussis after experimental challenge. This technique could enable the testing of potential novel vaccines or formulations for sustained protection against infection and transmission."

Journal • P1 data • Cough • Infectious Disease • Pertussis • Respiratory Diseases • CD4

Efficacy of Azithromycin 1% in the Clinical Management of Bacterial Conjunctivitis. (PubMed, J Pharm Bioallied Sci) - "High clinical cure rates were observed with minimal adverse effects, indicating good efficacy and tolerability. Topical azithromycin 1% is a safe and effective treatment option for bacterial conjunctivitis in routine clinical practice."

Journal • Conjunctivitis • Ocular Infections • Ocular Inflammation • Ophthalmology

Rickettsial Encephalitis Presenting as Status Epilepticus in a 30-year-old Male: A Diagnostic Challenge. (PubMed, Ann Afr Med) - "The patient responded to doxycycline and azithromycin and was eventually extubated and discharged in a conscious and oriented state. Early empirical doxycycline can be lifesaving. A high index of suspicion and thorough evaluation are essential in such atypical presentations."

Journal • CNS Disorders • Epilepsy • Herpes Simplex • Immunology • Infectious Disease

Nationwide assessment of community pharmacists' practices and atorvastatin-drug interactions in Egypt. (PubMed, Sci Rep) - "High-frequency encounters were reported for major DDIs with cyclosporine (49.3%) and clarithromycin (45.8%) and for moderate DDIs with digoxin (42.2%), phenytoin (41.0%), and azithromycin (40.5%). Regional variation showed higher interaction frequencies in Upper Egypt and the Delta. Strengthening pharmacist stewardship programs and expanding standardized DDI screening approaches may improve ATV safety."

Journal • Cardiovascular

Severe pulmonary Mycobacterium genavense infection in an immunocompetent adult : Diagnostic challenges and successful macrolide-based combination therapy (PubMed, Inn Med (Heidelb)) - "Molecular diagnostics identified M. genavense as the causative pathogen. A 15-month regimen of rifampicin, azithromycin, and ethambutol led to complete clinical and radiological remission."

Journal • Infectious Disease • Nontuberculous Mycobacterial Disease • Oncology • Respiratory Diseases

PETAL Study: Preventing recurrent acute lower respiratory infections in young First Nations and Timorese children using long-term, once-weekly azithromycin: a multicentre randomised controlled trial (ANZCTR) - P3 | N=160 | Active, not recruiting | Sponsor: Menzies School of Health Research | Recruiting ➔ Active, not recruiting

Enrollment closed • Infectious Disease • Respiratory Diseases

PARROT-Junior: Effect of prophylactic azithromycin on chest infections in children with neurological and neuromuscular impairment (ANZCTR) - P3/4 | N=94 | Completed | Sponsor: Menzies School of Health Research | Recruiting ➔ Completed

Trial completion • Infectious Disease • Respiratory Diseases

BENEFITS OF A MULTIDISCIPLINARY COMMITTEE FOR THE TREATMENT OF CHRONIC GVHD: CASE REPORTS AS A PARADIGM FOR COLLABORATIVE CARE (EBMT 2026) - "Together with the Dermatology Department, tocilizumab was initiated—monthly at first and later every three months—with clinical improvement beginning after the second dose...She was re-evaluated, and recovery was optimized through respiratory physiotherapy, FAM therapy, optimization of bronchodilator therapy with closed triple therapy (LABA/LAMA/ICS), and temporarily increasing azithromycin to 600 mg for six days, followed by a return to the previous dose of 250 mg three days per week. Prednisone was gradually discontinued, and immunoglobulins were administered every three weeks... The GVHD committee at our hospital reflects a collaborative effort among various specialists focused on the management of patients with this condition. We believe that this kind of multidisciplinary approach provides clear clinical benefit among patients with GVHD, particularly in cases with several organs involved."

Case report • Clinical • Asthma • Bone Marrow Transplantation • Chronic Graft versus Host Disease • Graft versus Host Disease • Hematological Disorders • Immunology • Infectious Disease • Inflammation • Neutropenia • Ophthalmology • Respiratory Diseases

BUSULFAN ASSOCIATED PULMONARY TOXICITY AND INFECTIOUS COMPLICATIONS FOLLOWING AUTOLOGOUS SCT IN A 3-YEAR-OLD CHILD WITH NEUROBLASTOMA (EBMT 2026) - "Background: High-dose busulfan/melphalan (Bu/Mel) remains a standard conditioning regimen for autologous stem cell transplantation in high-risk neuroblastoma but is associated with significant organ toxicity, particularly hepatic and pulmonary injury...A treatment with Defibrotide, Ganciclovir and Azithromycin was initiated...We started a treatment with Sildenafil, Macitentan, Epoprostenol in addition to Methylprednisolone pulse therapy and antifibrotic treatment with Nintedanib, Hydroxychloroquin and Azithromycin... This case illustrates the complex interplay between infectious complications, post-transplant inflammation and busulfan-induced pulmonary toxicity in a young neuroblastoma patient undergoing Bu/Mel conditioning and autologous SCT. Consideration of busulfan toxicities, especially when presenting with nonspecific early symptoms is important even when alternative explanations such as severe infection may appear equally plausible after autologous SCT. Early..."

Clinical • Acute Respiratory Distress Syndrome • Cardiovascular • Cystic Fibrosis • Cytomegalovirus Infection • Gastroenterology • Genetic Disorders • Hepatology • Immunology • Infectious Disease • Inflammation • Interstitial Lung Disease • Neuroblastoma • Pneumonia • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Septic Shock • Solid Tumor

MYCOBACTERIUM ABSCESSUS AS A COMPLICATION OF IMMUNOSUPPRESSION AFTER ALLOGENEIC STEM CELL TRANSPLANTATION FOR CONGENITAL NEUTROPENIA (EBMT 2026) - "Despite treatment with systemic corticosteroids, ruxolitinib, ibrutinib, antiviral agents, and antifungal therapy for a probable invasive pulmonary aspergillosis infection, respiratory status continued to decline.By day +190, the patient presented with septic shock, for which invasive mechanical ventilation (IMV), fluid expansion and vasopressor therapy were required...BAL and blood cultures were positive for M. abscessus massiliense, confirming invasive pulmonary disease with bacteremia.Treatment consisted of intravenous amikacin, tigecycline, imipenem, and TDM guided azithromycin and clofazimine, in addition to ongoing antifungal therapy... This case illustrates how Mabs can emerge insidiously in pediatric alloSCT recipients, mimicking more common post-transplant complications and progressing rapidly to severe invasive infection. The patient's gradual recovery underscores the importance of early recognition, aggressive multidrug therapy, and careful reassessment of..."

Graft versus Host Disease • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Inflammation • Neutropenia • Nontuberculous Mycobacterial Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases • Septic Shock • Transplantation • CSF3R

BENEFITS OF A MULTIDISCIPLINARY COMMITTEE FOR THE TREATMENT OF CHRONIC GVHD: CASE REPORTS AS A PARADIGM FOR COLLABORATIVE CARE (EBMT 2026) - "Together with the Dermatology Department, tocilizumab was initiated—monthly at first and later every three months—with clinical improvement beginning after the second dose...She was re-evaluated, and recovery was optimized through respiratory physiotherapy, FAM therapy, optimization of bronchodilator therapy with closed triple therapy (LABA/LAMA/ICS), and temporarily increasing azithromycin to 600 mg for six days, followed by a return to the previous dose of 250 mg three days per week. Prednisone was gradually discontinued, and immunoglobulins were administered every three weeks... The GVHD committee at our hospital reflects a collaborative effort among various specialists focused on the management of patients with this condition. We believe that this kind of multidisciplinary approach provides clear clinical benefit among patients with GVHD, particularly in cases with several organs involved."

Case report • Clinical • Asthma • Bone Marrow Transplantation • Chronic Graft versus Host Disease • Graft versus Host Disease • Hematological Disorders • Immunology • Infectious Disease • Inflammation • Neutropenia • Ophthalmology • Respiratory Diseases

Sutimlimab as a bridge to recovery in a life-threatening case of secondary cold agglutinin syndrome​​​​ (OeGHO-AHOP 2026) - "Despite azithromycin therapy, hemolysis worsened, and the patient developed renal failure (creatinine 8.7 mg/dL) and respiratory compromise. Supportive therapy and treatment of the underlying cause are standard for secondary CAS. However, the rapid and sustained improvement following Sutimlimab strongly suggests that complement inhibition effectively halted intravascular hemolysis, prevented organ dysfunction, and promoted full recovery, indicating potential benefit of Sutimlimab in infection-associated CAS."

Clinical • Autoimmune Hemolytic Anemia • Complement-mediated Rare Disorders • Hematological Disorders • Immunology • Infectious Disease • Pneumonia • Renal Disease • HP

ARRET: Azithromycin Reduction to Reach Elimination of Trachoma (clinicaltrials.gov) - P4 | N=3931 | Completed | Sponsor: University of California, San Francisco | N=74920 ➔ 3931

Enrollment change • Ophthalmology