Betadine (povidone iodine) / Egis - LARVOL DELTA

Early Outcomes After Discontinuing Routine Gentamicin Irrigation During AMS 800 Artificial Urinary Sphincter Implantation: A Single-Centre Retrospective Before-After Cohort Study. (PubMed, Antibiotics (Basel)) - "Saline device immersion and Betadine-containing intraoperative irrigation of the operative field and both wounds continued in both periods. No statistically significant between-period difference was detected in SSI, exploratory device-related explantation, or broad all-cause complications. Sparse events, wide confidence intervals and calendar-defined exposure amid concurrent era changes preclude conclusions regarding equivalence or absence of clinically relevant benefit or harm."

Journal • Retrospective data • Infectious Disease

PIES: Povidone Iodine Efficacy Study (clinicaltrials.gov) - P2 | N=202 | Active, not recruiting | Sponsor: University of Rochester | Recruiting ➔ Active, not recruiting

Enrollment closed

Properties of novel PBC/κ-carrageenan hydrogels: probiotic bacterial cellulose synthesized by co-culture of K. xylinus with L. plantarum or P. pentosaceus. (PubMed, Front Bioeng Biotechnol) - "Furthermore, the hydrogels exhibited efficient uptake and a biphasic release profile for Betadine and Gentian Violet, with crosslinked systems showing a more controlled release profile...The PBC/κ-Carrageenan hydrogels developed in this study exhibit a combination of advantageous structural, biological, rheological, antimicrobial, and controlled-release properties. This underscores their potential as multifunctional wound-healing and antimicrobial-delivery systems, making the hydrogel a potential candidate for tissue-engineering and wound-healing applications after in vivo and clinical studies in future work."

Journal

Comparative evaluation of metal ion release and corrosion resistance of orthodontic archwires in different mouthwashes : From rinse to reactivity. (PubMed, J Orofac Orthop) - "Both material composition and mouthwash formulation critically affect corrosion and ion release. β‑Ti exhibits optimal biocompatibility, whereas chlorhexidine significantly accelerates corrosion."

Journal

Evaluating the efficacy of disinfecting agents against Staphylococcus aureus on external fixator devices. (PubMed, Injury) - "All disinfectants significantly reduced the bacterial load on the external fixators, supporting their safety in the sterile field. While there was no statistically significant difference in CFUs between disinfectants, the CHG + IPA group had the highest frequency of zero CFU data. In contrast, the Betadine + IPA group had the highest frequency of non-zero CFUs and the widest IQR of 0-3.8 × 102 CFUs."

Journal • Orthopedics

Postpartum compositional changes in bovine calf nasal and dam vaginal microbiota and concurrent D2Dx immune responses following prepartum betadine lavages. (PubMed, J Anim Sci) - "Systemic immune responses, measured via D2Dx scores, fluctuated postpartum in dams (day effect: P < 0.001) and calves (day effect: P < 0.001), with BLG calves tending toward decreased immune response compared with CON (P = 0.08). Prepartum betadine lavage minimally influenced neonatal nasal microbial diversity at birth and did not alter postpartum dam vaginal community structure, while calf nasal microbiota and D2Dx immune responses changed markedly over the first 60 days of life."

Journal

Effect of Betadine Vaginal Cleansing Before Cesarean Section to Reduce Postoperative Infectious Morbidity (clinicaltrials.gov) - P=N/A | N=600 | Not yet recruiting | Sponsor: Mohamed Mousa Mohamed Mousa

New trial • Endometriosis • Infectious Disease

Intraoperative Irrigation in Inflatable Penile Prosthesis Surgery: Past Lessons, Current Evidence, and Future Directions. (PubMed, Eur Urol Focus) - "Though specific recommendations regarding optimal irrigation selection remain undefined, contemporary evidence suggests that some historic irrigation components, including hydrogen peroxide and high-concentration betadine, should be avoided. Large multi-institutional cohort studies provide a unique avenue for implanters to compare intraoperative irrigation protocols to optimize patient outcomes."

Journal • Review • Infectious Disease

Comparative efficacy of single and double povidone-iodine soaking protocols combined with draping sequence in donor cornea disinfection. (PubMed, Indian J Ophthalmol) - "Double-soaking significantly reduced conjunctival microbial load and showed a favorable trend toward reducing rim contamination. These findings support its use as a simple, low-risk strategy to lower ocular surface bioburden and enhance graft safety, while confirming the effectiveness of current disinfection and storage practices."

Journal • Infectious Disease • Ocular Infections • Transplantation

A Trial to Study the Influence of Ultrasound Guidance on the Complications of Central Catheter (clinicaltrials.gov) - P=N/A | N=264 | Terminated | Sponsor: Centre Hospitalier Universitaire, Amiens | Unknown status ➔ Terminated; Recruitment difficulties

Trial termination • Critical care • Genetic Disorders • Obesity

Residual bacterial presence cultured during revision penile implant surgery for any reason has drastically reduced from 67.6% to 2.9% over the past 40 years as surgeons and manufacturers have altered the disciplines of infection control (AUA 2026) - "The distinguishing factors among the groups were as follows: Group A: Traditional skin prep with Betadine and non-coated PP... Over a timeline spanning more than four decades, the rate of organisms cultured incidentally during revision surgery has drastically decreased. For the first time in the literature, the impact of these infection-control advancements demonstrates a major decline in bacterial load cultured during revision surgery."

Surgery • Infectious Disease

Betadine vs Sterile Water for Periurethral Preparation (clinicaltrials.gov) - P4 | N=148 | Recruiting | Sponsor: University of Louisville | Not yet recruiting ➔ Recruiting

Enrollment open • Infectious Disease • Nephrology

Multimodality Treatment Of Complex Fistula In Ano Extended Up To Sacrum (ASCRS 2026) - "Grade 5 recurrent complex fistula extended up to sacrum, was completely cured with multimodality treatment.Multimodality Treatment Of Complex Fistula In Ano Extended Up To Sacrum Multimodality Treatment Of Complex Fistula In Ano Extended Up To Sacrum"

Asthma • Immunology • Respiratory Diseases

The Otto Aufranc Award: Iodine-Containing Products Are Safe in Allergy-Labeled Patients Undergoing Total Joint Arthroplasty: A Prospective Observational Study. (PubMed, J Arthroplasty) - "Iodophors are safe in iodine-allergic patients undergoing TJA. No allergic reactions were observed in this study. These findings challenge routine iodophor avoidance, supporting standardized antiseptic protocols to minimize PJI."

Journal • Observational data • Allergy • Immunology • Infectious Disease • Orthopedics • Pain

Evidence-Based Steps to Mitigate Bacterial Contamination. (PubMed, Clin Plast Surg) - "Evidence-based strategies-most notably the 14 point plan, betadine-based antimicrobial irrigations, meticulous surgical technique, and structured postoperative care-have reduced contracture rates from up to 50% historically to under 1% in modern practice. Comprehensive management with capsulectomy, site change, and adjuncts further optimizes long-term outcomes and patient satisfaction."

Journal • Review • Hematological Malignancies • Infectious Disease • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology

SYMBOL CLINICAL : Treatment of severe ocular chemical burns by subconjunctival injection of allogeneic mesenchymal stem cells:na multicentre, single-arm, open-label phase II trial (clinicaltrialsregister.eu) - P1/2 | N=21 | Not yet recruiting | Sponsor: Hopital Fondation Adolphe De Rothschild

New P1/2 trial • Thermal Injury

Revision Total Knee Arthroplasty with Concurrent Extensor Mechanism Allograft Reconstruction (AAOS 2026) - "Case Presentation: A 67-year-old male with a history of atrial fibrillation on apixaban, COPD, and obstructive sleep apnea presented with bilateral knee pain refractory to conservative treatment...The graft was soaked in a dilute betadine solution prior to implantation... Revision TKA with concurrent extensor mechanism allograft reconstruction can restore extensor function and improve stability in patients with complex extensor mechanism failure. Success depends on careful patient selection, precise surgical technique, and diligent postoperative management. This video provides a comprehensive demonstration of the operative workflow, graft handling, fixation strategies, and postoperative protocols, serving as an educational reference for orthopedic surgeons managing challenging TKA revisions."

Atrial Fibrillation • Cardiovascular • Chronic Obstructive Pulmonary Disease • Immunology • Infectious Disease • Musculoskeletal Diseases • Musculoskeletal Pain • Obstructive Sleep Apnea • Orthopedics • Pain • Respiratory Diseases • Sleep Disorder

Conversion Distal Femur Replacement with Telescoping Tibial Allograft (AAOS 2026) - "The wound was thoroughly irrigated with a betadine solution, and the wound was closed in a layered fashion...Telescoping tibial allografts can provide additional bone stock proximally for fixation with an 80% survivorship at 7 years. Operative planning including implant selection, availability of fluoroscopy, and prophylactic fixation are essential to successfully performing a distal femoral replacement in a patient with limited proximal femoral bone."

CNS Disorders • Osteoporosis • Osteosarcoma • Sarcoma • Solid Tumor

Validating the Use of Next Generation Sequencing in Open/Ballistic Fracture Management (AAOS 2026) - "Preoperatively, fractures underwent bedside irrigation with a betadine and saline solution... In this study, we demonstrated that NGS is a feasible tool for detecting bacterial DNA contamination in open and ballistic injuries, with a higher detection rate than traditional broth culture. In cases where both culture and NGS were positive, the NGS was able to detect the same organism isolated in culture. Additionally, NGS was more likely to detect polymicrobial contamination compared to traditional culture."

Biomarker • Next-generation sequencing • Infectious Disease • Musculoskeletal Diseases • Orthopedics

Impact of Positive Culture Findings on Clinical Outcomes in Primary Lumbar Fusion Surgery (AAOS 2026) - "All patients received preoperative Cefazolin and standard skin antiseptics (ChloraPrep or Betadine). Occult bacterial colonization was detected in one-third of patients undergoing primary lumbar fusion, with higher prevalence in deeper tissue layers. Culture- positive patients had delayed fusion and a higher long-term revision rate, suggesting that standard preoperative skin antisepsis and prophylaxis may not fully eliminate bacterial burden. The higher culture positivity in males and Betadine- prepped patients underscores the need for improved intraoperative antiseptic strategies."

Clinical data • Surgery • Infectious Disease

Impact of a Standardized Surgical Protocol on Outcomes Following DAIR Surgery for Acute Postoperative and Acute Hematogenous Periprosthetic Joint Infection (AAOS 2026) - "The standardized protocol included tissue debridement, complete synovectomy, and serial soaking with a betadine solution and an anti-biofilm solution... Our findings indicate that a structured surgical approach to DAIR has promising short term outcomes in acute PJI. Further studies are required to refine surgical technique and to continue prospective observation."

Clinical • Surgery • Infectious Disease

Are We Getting Better with Time? Trends in Treatment Success of Two-Stage Revisions for PJI (AAOS 2026) - "The "modern era" 2014-2023 time interval was determined by adoption of tranexamic acid, articulating spacers and dilute betadine. Study results suggest that treatment success in the modern era of treatment for PJI may be improving with modern techniques, protocols and implants. The authors urge caution before widespread adoption of the single-stage treatment of chronic PJI outside of academic centers who are carefully studying these two techniques."

Infectious Disease • Orthopedics

Outcomes of salvage procedures with malleable implants for penile prosthesis infections in the Veterans Affairs National Medical System: a real-world, multi-surgeon retrospective analysis over a decade. (PubMed, J Sex Med) - "Salvage with malleable prostheses is a safe and effective strategy following penile prosthesis infection, with high rates of long-term device retention and functional satisfaction."

Journal • Real-world evidence • Retrospective data • Diabetes • Erectile Dysfunction • Fibrosis • Immunology • Infectious Disease • Metabolic Disorders

The Impact of Irrigating Solutions on the Tensile Strength of Silicone Breast Implants: A Comparative In Vitro Analysis for Intraoperative use. (PubMed, Plast Surg (Oakv)) - " Silicone breast implant shells from Mentor and Allergan Natrelle were sectioned into 2.5 × 2.5 cm samples and randomly allocated to 5 irrigant groups: 0.9% normal saline, triple antibiotic solution (clindamycin, cefazolin, gentamicin), 0.05% chlorhexidine gluconate (Irrisept®), 10% povidone-iodine (Betadine®), and Poloxamer 188 (SAF-Clens® AF). Poloxamer 188, however, showed a trend toward greater reduction in tensile strength and should be thoroughly rinsed prior to implant placement. These findings support the safe use of conventional antiseptic and antibiotic irrigants with minimal impact on implant mechanical integrity."

Journal • Preclinical • Infectious Disease

Subconjunctival povidone-iodine in the treatment of bleb-associated endophthalmitis. (PubMed, Retin Cases Brief Rep) - "Subconjunctival PI may represent a useful option in treating cases of bleb-associated endophthalmitis."

Journal • Ocular Infections • Ocular Inflammation • Ophthalmology • Pain