Betadine (povidone iodine) / Egis - LARVOL DELTA

Evidence-Based Steps to Mitigate Bacterial Contamination. (PubMed, Clin Plast Surg) - "Evidence-based strategies-most notably the 14 point plan, betadine-based antimicrobial irrigations, meticulous surgical technique, and structured postoperative care-have reduced contracture rates from up to 50% historically to under 1% in modern practice. Comprehensive management with capsulectomy, site change, and adjuncts further optimizes long-term outcomes and patient satisfaction."

Journal • Review • Hematological Malignancies • Infectious Disease • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology

SYMBOL CLINICAL : Treatment of severe ocular chemical burns by subconjunctival injection of allogeneic mesenchymal stem cells:na multicentre, single-arm, open-label phase II trial (clinicaltrialsregister.eu) - P1/2 | N=21 | Not yet recruiting | Sponsor: Hopital Fondation Adolphe De Rothschild

New P1/2 trial • Thermal Injury

Revision Total Knee Arthroplasty with Concurrent Extensor Mechanism Allograft Reconstruction (AAOS 2026) - "Case Presentation: A 67-year-old male with a history of atrial fibrillation on apixaban, COPD, and obstructive sleep apnea presented with bilateral knee pain refractory to conservative treatment...The graft was soaked in a dilute betadine solution prior to implantation... Revision TKA with concurrent extensor mechanism allograft reconstruction can restore extensor function and improve stability in patients with complex extensor mechanism failure. Success depends on careful patient selection, precise surgical technique, and diligent postoperative management. This video provides a comprehensive demonstration of the operative workflow, graft handling, fixation strategies, and postoperative protocols, serving as an educational reference for orthopedic surgeons managing challenging TKA revisions."

Atrial Fibrillation • Cardiovascular • Chronic Obstructive Pulmonary Disease • Immunology • Infectious Disease • Musculoskeletal Diseases • Musculoskeletal Pain • Obstructive Sleep Apnea • Orthopedics • Pain • Respiratory Diseases • Sleep Disorder

Conversion Distal Femur Replacement with Telescoping Tibial Allograft (AAOS 2026) - "The wound was thoroughly irrigated with a betadine solution, and the wound was closed in a layered fashion...Telescoping tibial allografts can provide additional bone stock proximally for fixation with an 80% survivorship at 7 years. Operative planning including implant selection, availability of fluoroscopy, and prophylactic fixation are essential to successfully performing a distal femoral replacement in a patient with limited proximal femoral bone."

CNS Disorders • Osteoporosis • Osteosarcoma • Sarcoma • Solid Tumor

Validating the Use of Next Generation Sequencing in Open/Ballistic Fracture Management (AAOS 2026) - "Preoperatively, fractures underwent bedside irrigation with a betadine and saline solution... In this study, we demonstrated that NGS is a feasible tool for detecting bacterial DNA contamination in open and ballistic injuries, with a higher detection rate than traditional broth culture. In cases where both culture and NGS were positive, the NGS was able to detect the same organism isolated in culture. Additionally, NGS was more likely to detect polymicrobial contamination compared to traditional culture."

Biomarker • Next-generation sequencing • Infectious Disease • Musculoskeletal Diseases • Orthopedics

Impact of Positive Culture Findings on Clinical Outcomes in Primary Lumbar Fusion Surgery (AAOS 2026) - "All patients received preoperative Cefazolin and standard skin antiseptics (ChloraPrep or Betadine). Occult bacterial colonization was detected in one-third of patients undergoing primary lumbar fusion, with higher prevalence in deeper tissue layers. Culture- positive patients had delayed fusion and a higher long-term revision rate, suggesting that standard preoperative skin antisepsis and prophylaxis may not fully eliminate bacterial burden. The higher culture positivity in males and Betadine- prepped patients underscores the need for improved intraoperative antiseptic strategies."

Clinical data • Surgery • Infectious Disease

Impact of a Standardized Surgical Protocol on Outcomes Following DAIR Surgery for Acute Postoperative and Acute Hematogenous Periprosthetic Joint Infection (AAOS 2026) - "The standardized protocol included tissue debridement, complete synovectomy, and serial soaking with a betadine solution and an anti-biofilm solution... Our findings indicate that a structured surgical approach to DAIR has promising short term outcomes in acute PJI. Further studies are required to refine surgical technique and to continue prospective observation."

Clinical • Surgery • Infectious Disease

Are We Getting Better with Time? Trends in Treatment Success of Two-Stage Revisions for PJI (AAOS 2026) - "The "modern era" 2014-2023 time interval was determined by adoption of tranexamic acid, articulating spacers and dilute betadine. Study results suggest that treatment success in the modern era of treatment for PJI may be improving with modern techniques, protocols and implants. The authors urge caution before widespread adoption of the single-stage treatment of chronic PJI outside of academic centers who are carefully studying these two techniques."

Infectious Disease • Orthopedics

Outcomes of salvage procedures with malleable implants for penile prosthesis infections in the Veterans Affairs National Medical System: a real-world, multi-surgeon retrospective analysis over a decade. (PubMed, J Sex Med) - "Salvage with malleable prostheses is a safe and effective strategy following penile prosthesis infection, with high rates of long-term device retention and functional satisfaction."

Journal • Real-world evidence • Retrospective data • Diabetes • Erectile Dysfunction • Fibrosis • Immunology • Infectious Disease • Metabolic Disorders

The Impact of Irrigating Solutions on the Tensile Strength of Silicone Breast Implants: A Comparative In Vitro Analysis for Intraoperative use. (PubMed, Plast Surg (Oakv)) - " Silicone breast implant shells from Mentor and Allergan Natrelle were sectioned into 2.5 × 2.5 cm samples and randomly allocated to 5 irrigant groups: 0.9% normal saline, triple antibiotic solution (clindamycin, cefazolin, gentamicin), 0.05% chlorhexidine gluconate (Irrisept®), 10% povidone-iodine (Betadine®), and Poloxamer 188 (SAF-Clens® AF). Poloxamer 188, however, showed a trend toward greater reduction in tensile strength and should be thoroughly rinsed prior to implant placement. These findings support the safe use of conventional antiseptic and antibiotic irrigants with minimal impact on implant mechanical integrity."

Journal • Preclinical • Infectious Disease

Subconjunctival povidone-iodine in the treatment of bleb-associated endophthalmitis. (PubMed, Retin Cases Brief Rep) - "Subconjunctival PI may represent a useful option in treating cases of bleb-associated endophthalmitis."

Journal • Ocular Infections • Ocular Inflammation • Ophthalmology • Pain

Re-sterilization Prior to Implant Insertion in Prosthetic Breast Reconstruction: Is It Necessary? (PubMed, Surg Infect (Larchmt)) - "Residual contamination may persist despite the initial surgical site sterilization. The re-application of antiseptics and re-draping immediately before implant insertion may help reduce post-operative infections and should be considered an adjunct to comprehensive peri-operative protocols. Some infections may be more closely related to post-operative management than pre-implant field contamination, underscoring the need for meticulous post-operative care. Definitive causal relationships should be tested using rigorously designed and adequately powered studies."

Journal • Infectious Disease

Optimizing Infection Prevention in Primary Shoulder Arthroplasty: Evidence-Based Strategies and Best Practices. (PubMed, JBJS Rev) - "Management of biologic and targeted immunosuppressive therapies should be coordinated with medical specialists and tailored to the specific agent's pharmacokinetics and surgical risk.» Preoperative skin preparation with agents such as benzoyl peroxide or chlorhexidine gluconate may decrease bacterial colonization. Antibiotic prophylaxis with a single preoperative dose of cefazolin administered within one hour of incision reduces infection risk, and in patients with true beta-lactam allergy, fully infused vancomycin prior to incision is an effective alternative. Intraoperatively, measures such as dilute betadine lavage, vancomycin powder, chlorhexidine wash, and antibiotic irrigation can reduce bacterial contamination. Additional intraoperative techniques including electrocautery after skin incision may further decrease bacterial burden, although higher level evidence for these latter interventions remains limited or conflicting."

Journal • Review • Allergy • Hematological Disorders • Immunology • Infectious Disease • Orthopedics • Tobacco Cessation

Wound healing potential of methanolic extract of Wrightia tinctoria fresh leaf. (PubMed, Naturwissenschaften) - "In vivo studies revealed that ointment prepared from methanolic extract of W. tinctoria fresh leaf healed the wound faster (100%) than betadine-treated on 13th day. Hence, methanolic extract of fresh leaves of W. tinctoria could be explored as potential candidate for the development of green and safe wound healing drug."

Journal

Wound Healing Activity of Uncaria callophylla Stem Methanol Extract in Diabetic Rats and Its Phytochemical Profile. (PubMed, Res Sq) - " Diabetic excision wound models were established and animals were divided into six groups: non-diabetic untreated wounds, diabetic untreated wounds, diabetic wounds treated with UCSME ointment at concentrations of 5%, 10%, and 20%, and diabetic wounds treated with betadine ointment...LC-MS/MS and GC-MS analyses identified several bioactive compounds associated with wound healing and antioxidant effects. Topical UCSME effectively promotes wound healing in diabetic rats and represents a promising natural therapeutic candidate for diabetic wound management."

Journal • Preclinical • Inflammation • Metabolic Disorders

Clinical Practice Changes Reduce Resorbable Plate-Associated Wound Complications in Cranial Vault Reconstructive Surgery: A Single Institution Experience. (PubMed, J Craniofac Surg) - "In conclusion, 4 changes in our clinical practice introduced at our institution in 2018 with the aim of reducing our wound complication rates post-CVR have resulted in a significant reduction in wound complications requiring readmission among patients with craniosynostosis."

Journal • Pediatrics

Preventing Surgical Site Infections: A Narrative Review of Antiseptic Solutions in the Operating Theatre. (PubMed, Cureus) - "Surgeons and scrub nurses use a variety of antiseptic agents to prepare their hands and patients' skin on the surgical site pre-operatively to help minimise the risk of infections. The objective of this narrative review was to retrieve and create a summary of existing evidence in the literature about the antiseptics used in surgery to prevent surgical site infections and highlight any possible limitations noted in the literature."

Journal • Review • Infectious Disease

MRSAD-PVP-I: Evaluation of the Decolonization Rate and Acceptance of a Complete Nasal Decolonization Kit With Povidone Iodine for MRSA Patients (clinicaltrials.gov) - P2 | N=1 | Terminated | Sponsor: Nantes University Hospital | N=50 ➔ 1 | Trial completion date: Nov 2026 ➔ Dec 2025 | Recruiting ➔ Terminated | Trial primary completion date: Nov 2026 ➔ Dec 2025; Recruitment difficulties

Enrollment change • Trial completion date • Trial primary completion date • Trial termination • Infectious Disease

Preclinical safety and burn wound healing activity of "Novostron", a novel topical iodine-based therapeutic. (PubMed, PLoS One) - "In a murine burn model, Novostron accelerated wound contraction (25.95% at day 10), increased epidermal thickness, and enhanced collagen deposition (~44%), outperforming controls and matching or exceeding betadine...Overall, Novostron demonstrated a favourable preclinical safety and efficacy profile, and its polymer-iodine composition, which enables controlled release and localized activity highlights its potential as a promising topical therapeutic. However, the study was limited to animal models and short-term observation; further long-term and clinical investigations are needed to confirm its translational potential in human wound healing."

Journal • Preclinical • Inflammation

Use of Povidone-Iodine Solution for Intraoperative Antisepsis: A Systematic Review. (PubMed, Cureus) - "Keywords used included the following: ("Povidone-iodine" OR "Betadine") AND ("Conjunctiva" OR "Ocular surgery")...These studies compared povidone-iodine 5% to other concentrations or antibiotic agents such as povidone-iodine 1%, chloramphenicol 5%, netilmicin, commercial ozonized antiseptic solution (ozone), moxifloxacin 0.5%, and gatifloxacin...Povidone-iodine remains a highly effective and safe antiseptic agent for intraoperative use in ocular surgery, while a need exists for additional high-quality independently conducted RCTs to confirm the observed effects and expand the evidence base. Its broad antimicrobial spectrum and favorable safety profile support its continued and widespread application for conjunctival antisepsis, outperforming several commonly used alternatives."

Journal • Review • Infectious Disease • Ocular Infections • Ophthalmology

Effect of Implementing Oral Care With Betadine Wash on Mechanically Ventilated Patients' Outcomes. (PubMed, Crit Care Nurs Q) - "However, these differences were not statistically significant. Comprehensive oral care intervention with betadine wash is effective in improving oral health status and reducing the occurrence of ventilator-associated pneumonia."

Journal • Critical care • Infectious Disease • Pneumonia • Respiratory Diseases

Comparison of the efficacy of two hand decontamination methods: Alcoholic septicidine and povidone-iodine solutions. (PubMed, PLoS One) - "Both Septicidine and Betadine were effective in reducing hand bacterial load, although neither achieved complete sterilization. Alcohol-based solutions such as Septicidine may offer benefits in terms of ease of use and skin compatibility. Improving iodine-based solutions such as Betadine application techniques may enhance its efficacy. Further research is warranted to optimize hand hygiene protocols in surgical environments."

Clinical • Journal • Infectious Disease • Ophthalmology

RISK FACTORS, PREVENTION, AND TREATMENT OF INFECTIONS RELATED TO TOTAL HIP ARTHROPLASTY: SYNTHESIS OF CLINICAL EVIDENCE. (PubMed, Acta Ortop Bras) - "Although some interventions, such as collagen sponges with gentamicin and triclosan-coated sutures, have not significantly reduced the incidence of infections, others, such as closed incisional negative pressure therapy (ciNPWT) and washing with diluted betadine, have shown promise in certain contexts. Thus, despite advances, the prevention and management of infections in THA still require improvement, and interventions must be carefully evaluated to ensure the effectiveness and safety of the procedure. Level of Evidence IV; Evidence from Descriptive (non-experimental) or Qualitative Studies ."

Journal • Review • Immunology • Infectious Disease • Musculoskeletal Diseases • Orthopedics • Osteoarthritis • Pain • Rheumatoid Arthritis • Rheumatology

Patient Reported Experiences and Comfort Associated with Intravitreal Injection Technique: A Cross-Sectional Survey Approach. (PubMed, J Vitreoretin Dis) - "Lidocaine pledgets were associated with the most discomfort (P < .05). Surveyed patients preferred topical gel or subconjunctival injections, manual lid retraction, and Betadine-soaked cotton tips. Future studies may consider the safety associated with each technique."

Journal • Age-related Macular Degeneration • Anesthesia • Diabetic Macular Edema • Diabetic Retinopathy • Hematological Disorders • Ophthalmology • Retinal Disorders • Wet Age-related Macular Degeneration

Extended Pleurectomy, Decortication, and Bilobectomy for Localized Pleural Mesothelioma (IMIG 2025) - "The patient recovered uneventfully and was discharged on postoperative day six. This case highlights the feasibility of aggressive surgical management for localized pleural mesothelioma and suggests potential benefits of adjunctive techniques such as nerve cryoablation and betadine irrigation.Link to Video: https://youtu.be/MmlPxZcBJ3k?si=qcPsn48ElqxAYc8Y"

Epithelioid Mesothelioma • Malignant Pleural Mesothelioma • Mesothelioma • Pleural Mesothelioma • Solid Tumor