Betadine (povidone iodine) / Egis - LARVOL DELTA

A Novel Surgical Irrigation Solution in Post-Mastectomy Reconstruction: Evaluating Xperience™ (clinicaltrials.gov) - P=N/A | N=224 | Recruiting | Sponsor: University of North Carolina, Chapel Hill | Not yet recruiting ➔ Recruiting | Trial completion date: Dec 2027 ➔ Jun 2028 | Trial primary completion date: Dec 2027 ➔ Jun 2028

Enrollment open • Trial completion date • Trial primary completion date • Infectious Disease

Robotic arm-assisted, FDG-PET/CT guided percutaneous core-needle biopsies: Initial experience with inclusion of a subgroup of Pyrexia of unknown origin (PUO). (SNMMI 2025) - "The planned needle insertion site was cleaned with betadine and spirit followed by administration of local anaesthetic (lidocaine 1%)... A total of 69 patients (47.6 + 19 years, 39 males and 30 females) were included (including 9 patients with previous negative biopsy). We obtained good cores from nearly all target lesions in one attempt. The indications for biopsy were broadly categorised into four groups (Table below)."

Biopsy • FDG PET • Anesthesia • Biliary Cancer • Cholangiocarcinoma • Hematological Malignancies • Hepatology • Infectious Disease • Lung Cancer • Lymphoma • Non Small Cell Lung Cancer • Oncology • Renal Cell Carcinoma • Richter's Syndrome • Solid Tumor

Closed Expander Salvage With Dual-port Tissue Expander in Implant-based Breast Reconstruction for High Body Mass Index and Ptotic Patients. (PubMed, Plast Reconstr Surg Glob Open) - "Using the dual port, a closed washout protocol with a Betadine solution was initiated for suspected infections...The dual-port expander shows promise in enhancing salvage outcomes and decreasing reoperations for postoperative infections, providing a valuable addition to IB breast reconstruction strategies. The results suggest potential benefits of the dual-port expander in infection treatment."

Journal • Infectious Disease

A Randomised Comparative Study of 3% Hypertonic Saline Versus 0.5% Diluted Betadine Nasal Irrigation in the Post Operative Cases Of Functional Endoscopic Sinus Surgery. (PubMed, Indian J Otolaryngol Head Neck Surg) - "The study showed significant difference at the end of 1st week and 1st month in both groups proving betadine solution to be slightly better whereas in the 3rd month the hypertonic saline showed better results. This study concludes that that both 0.5% betadine solution and 3% hypertonic saline are equally significant with 3% hypertonic saline having slightly better results, where 0.5% diluted betadine solution has proven to be slightly better in the short-term treatment up to 1 month, and 3% hypertonic saline proved to be better in a long-term treatment upto 3 months."

Journal • Immunology • Inflammation • Nasal Polyps • Otorhinolaryngology • Respiratory Diseases • Sinusitis

SSI Stuff: Bowel Prep Practices, Antibiotic Sutures, antibiotic irrigation washouts, nasal swabs / decontamination for MRSA, Probiotics, postop antibiotic duration (if spillage), irrigating wound protectors, betadine to stapler before use / to incision (ASCRS 2025) - No abstract available

Use of Hyaluronidase with Local Anesthetic in the Treatment of Grade IV Internal Hemorrhoids (ASCRS 2025) - "The perianal region was then prepped with Betadine and draped. A 30 ml solution of 0.25% Marcaine with epinephrine 1:100,000 was mixed with 1 ml of hyaluronidase (150 TR units)...This allows resolution of perianal edema and reduction of hemorrhoids. Patients can then proceed to elective office-based interventions (i.e. sclerotherapy, rubber band ligation) or operative interventions.Figure 1Patient A with incarcerated prolapsed hemorrhoids in Figure 1a(left) and after hyaluronidase injection in Figure 1b (right).Figure 2 Patient B with incarcerated prolapsed hemorrhoids in Figure 2a(left), after hyaluronidase injection in Figure 2b (right)"

Anesthesia • Gastroenterology • Gastrointestinal Disorder • Pain

Robotic sigmoid colectomy with transvaginal specimen extraction (ASCRS 2025) - "We prepped both the rectum and the vagina with betadine...We introduced an anvil through the colpotomy prior to closure of the vagina in 2 layers using 2-0 barbed locking suture, and a Baker colorectal anastomosis was performed.Results/Outcomes: There were no intraoperative complications and the post-operative course was unremarkable. Final pathology revealed chronic diverticulitis.Conclusion/ With adherence to proper technique, transvaginal retrieval of the sigmoid colon following robotic resection for diverticular disease is feasible and safe in carefully selected patients."

Gastroenterology • Gastrointestinal Disorder • Obesity

Process Mapping as a Key Tool in Identifying Waste in Dermatologic Procedures to Improve Cost-Effectiveness and Sustainability: An Interventional Case Study. (PubMed, Dermatol Surg) - "Process mapping is an effective tool to identify consumable waste in dermatologic surgeries and results in significant cost savings."

HEOR • Journal • Dermatology

Ready, Set, Consent: Video-Assisted Consent for Neonatal Lumbar Punctures - A Randomized Controlled Trial (PAS 2025) - "Groups had comparable demographics; average neonatal ages were 27.4 days (standard) and 18.6 days (video). Both groups included Spanish-speaking participants, with a higher proportion in the standard group. Parental education was slightly higher in the standard group."

Clinical • Video • CNS Disorders • Infectious Disease • Mood Disorders • Psychiatry

Povidone-iodine and Silver Nitrate are Equally Effective in Eradicating Staphylococcal Biofilm Grown on a Titanium Surface: An in vitro Analysis (AAOS 2025) - "Antibacterial solutions were povidone-iodine, rifampicin, silver nitrate, copper sulphate, chlorhexidine; for which the minimum inhibitory concentration and the minimum biofilm eradication concentration (MBEC) were determined per bacterial strain. Povidone-iodine and silver nitrate were the only irrigating solutions capable of eradicating at least 99% of 24-hour-biofilm on titanium discs. The concentration of betadine necessary to eradicate 99% of biofilm (0.8-1.6%) seems to be higher than the suggested prophylactic 0.3% concentration."

Preclinical • Infectious Disease • Orthopedics • KEAP1

Evaluating the Efficacy of Disinfecting Agents on External Fixator Devices. (AAOS 2025) - "After incubation, the device was treated with one of either Isopropyl Alcohol (IPA), Chlorhexidine Gluconate Scrub (CHG)+IPA, Betadine (PI)+IPA, or a ChloraPrep stick. All disinfectant groups were successful at removing S. aureus from external fixators . CHG+IPA was the most effective disinfectant group. While this difference was not statistically significant, it is clinically meaningful."

Clinical • Mood Disorders

Evaluating Soaking Duration: Ex Vivo vs In Vitro Comparison for Determining the Efficacy of Dilute Povidone-Iodine Irrigation Solution (AAOS 2025) - "This study reveals significant differences in the efficacy of povidone-iodine (PVP-I) when employing ex vivo and in vitro methodologies. The lipid-rich ex vivo environment, which more accurately reflects clinical conditions, consumes iodine, thus diminishing the antimicrobial properties of the currently available dilute betadine. Based on these findings, we strongly recommend that surgeons extend the duration of dilute betadine irrigation to at least three minutes."

Preclinical • Infectious Disease • Orthopedics

MRSAD-PVP-I: Evaluation of the Decolonization Rate and Acceptance of a Complete Nasal Decolonization Kit With Povidone Iodine for MRSA Patients (clinicaltrials.gov) - P2 | N=50 | Recruiting | Sponsor: Nantes University Hospital | Not yet recruiting ➔ Recruiting | Trial completion date: Feb 2025 ➔ Nov 2026 | Trial primary completion date: Feb 2025 ➔ Nov 2026

Enrollment open • Trial completion date • Trial primary completion date • Infectious Disease

Concentration of Povidone-Iodine Pocket Irrigation in Implant-Based Breast Surgery: A Scoping Review. (PubMed, Aesthetic Plast Surg) - "While PVP-I irrigation is extensively used in implant surgeries, the current evidence base is insufficient to determine the optimal concentration and application techniques. This review underscores the need for further detailed research to establish evidence-based guidelines for PVP-I use, aiming to improve patient care and surgical outcomes in breast surgery."

Journal • Review • Aesthetic Medicine • Infectious Disease

Durable Engraftment of Cryopreserved CD3+/CD19+ Depleted Cadaveric Vertebral Bone Marrow Grafts in Primary Immunodeficiency Patients Undergoing Sequential Bilateral Orthotopic Lung Transplant (BOLT) and Bone Marrow Transplant (BMT) (TCT-ASTCT-CIBMTR 2025) - P1/2 | "RIC regimen is based on Ritux/ATG/Campath, Thiotepa and TBI 200-250cGy. Patient #4 with WAS mutation and MDS/RAEB received 500cGY TBI in 2 fractions + Fludarabine...In 2017 we introduced a cavity wash saline-betadine mix and scrubbing T9/11-L4VB logs with chlora-prep that has eliminated bacterial contamination... Engraftment with donor cells was achieved in 6/7 transplanted patients (ANC >500 @ D+12) and (PLT>50K @ D+20), however, patient #5 had immune rejection -after multiple lung rejections- while 5 of 7 patients had mixed chimerism at Day +100. For 30- and 100-day chimerism details, see Table. We have developed a complex sequence of procedures exceeding 2E+06 CD34/kg pre-cryo dose (mean: 5.06E+06) leading to prompt and multilineage engraftment in 5 of the first 7 analyzable patients and 3 of our patients are maintaining full or mixed donor chimerism 19 months, 6 and 8 years post-BMT."

Clinical • Bone Marrow Transplantation • Graft versus Host Disease • Hematological Disorders • Immunology • Primary Immunodeficiency • Respiratory Diseases • Transplantation

Letter to Editor on "Efficacy of modified vacuum-assisted dressing versus conventional betadine dressing in wound healing of open fractures". (PubMed, J Clin Orthop Trauma) - No abstract available

Journal • Musculoskeletal Diseases • Orthopedics

Safety and Efficacy of Subdermal Betadine During Posterior Spinal Fusion (clinicaltrials.gov) - P4 | N=60 | Recruiting | Sponsor: Akron Children's Hospital

New P4 trial

Povidone-iodine-induced scalp lesions in pediatric neurosurgery patients: a case series. (PubMed, Childs Nerv Syst) - "Careful preparation of the surgical site is an essential step in the prevention of surgical site infections. However, caution should be exercised during skin preparation to avoid pooling of povidone-iodine around dependent regions. Additional steps, such as scheduled head elevations and pressure dispersion, should be taken to mitigate factors contributing to these lesions."

Journal • Retrospective data • Surgery • Addiction (Opioid and Alcohol) • Contact Dermatitis • Dermatitis • Dermatology • Immunology • Infectious Disease • Pediatrics • Thermal Injury

Comparison of Conjunctival Antimicrobial Activity and Patient Comfort Between Topical Hypochlorous Acid (Avenova) and Betadine (clinicaltrials.gov) - P4 | N=230 | Recruiting | Sponsor: University of Miami | Trial completion date: Dec 2024 ➔ Dec 2025 | Trial primary completion date: Dec 2024 ➔ Dec 2025

Trial completion date • Trial primary completion date • Infectious Disease • Ocular Infections • Ophthalmology

Development of a Clinically Relevant Preclinical Animal Model to Mimic Suburethral Implantation of Support Materials for Stress Urinary Incontinence. (PubMed, Neurourol Urodyn) - "This is the first large animal model which has been designed for suburethral implantation. and which can be effectively used for the preoperative evaluation of novel materials designed for suburethral implantation. We believe that this technique in this large animal model accurately reproduces the surgical technique used to treat stress urinary incontinence in women. It provides a new and effective in vivo model for the objective evaluation of new materials to treat female stress incontinence."

Journal • Preclinical • Anesthesia • Pain • Urinary Incontinence • Urology

Nasal Iodine Swab Versus Oral Antibiotic to Prevent Surgical Site Infection After Undergoing Mohs Micrographic Surgery (clinicaltrials.gov) - P=N/A | N=0 | Withdrawn | Sponsor: Mayo Clinic | N=1532 ➔ 0 | Not yet recruiting ➔ Withdrawn

Enrollment change • Surgery • Trial withdrawal • Genetic Disorders • Infectious Disease • Oncology • Skin Cancer

Analysis of adolescent idiopathic scoliosis population for Surgical Site Infection Risk Factors. (PubMed, J Orthop) - "Chlorhexidine wipes or some other antimicrobial preparation was used on 197 patients and betadine solution was used on 321.185 patients were recorded to have received either antibiotic-loaded allograft or antibiotic powder and 326 patients were recorded to have received intraoperative antibiotics. The long term clinical follow up of our study and low incidence of infection provide additional evidence for the benefit of antimicrobial techniques and risk factor mitigation previously suggested in the literature for the prevention of SSI in AIS. Level III."

Journal • Infectious Disease • Musculoskeletal Diseases • Orthopedics

Use of Commercial Bacon to Extract Maggots from an Infested Chronic Wound. (PubMed, Adv Skin Wound Care) - "Current recommendations include the use of hypochlorous acid, sodium hypochlorite solutions, isopropyl alcohol, betadine, and hydrogen peroxide for wound cleansing. This case report focuses on a unique utilization of commercial bacon strips for the extraction of maggots in an infested necrotic wound. The use of commercial bacon strips in selective patients as a noninvasive technique for the removal of maggots from necrotic wounds can be an additional tool for medical providers."

Journal

Vaginal Prep Solutions to Reduce Bacteria Colony Counts in Patients Having a Vaginal Surgery (clinicaltrials.gov) - P=N/A | N=35 | Terminated | Sponsor: Wright State University | Trial completion date: Jul 2024 ➔ Jan 2024 | Suspended ➔ Terminated; COVID impact on recruitment; challenges with enrollment

Surgery • Trial completion date • Trial termination • Infectious Disease • Vaginitis

One-time low concentration betadine eye wash: A novel treatment for epidemic viral conjunctivitis for accelerated recovery. (PubMed, Rom J Ophthalmol) - "Group A (664 patients) underwent a 1% betadine wash in addition to the standard treatment protocol (Eye Lubricant + Moxifloxacin 0.5% eyedrops), while Group B (664 patients) followed the standard protocol alone. A single low-concentration betadine wash expedites recovery and reduces complications in acute infective conjunctivitis. This approach significantly enhances patient outcomes and alleviates the socioeconomic impact of the condition."

Journal • Conjunctivitis • Hematological Disorders • Infectious Disease • Inflammation • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology