Betadine (povidone iodine) / Egis - LARVOL DELTA

Preclinical safety and burn wound healing activity of "Novostron", a novel topical iodine-based therapeutic. (PubMed, PLoS One) - "In a murine burn model, Novostron accelerated wound contraction (25.95% at day 10), increased epidermal thickness, and enhanced collagen deposition (~44%), outperforming controls and matching or exceeding betadine...Overall, Novostron demonstrated a favourable preclinical safety and efficacy profile, and its polymer-iodine composition, which enables controlled release and localized activity highlights its potential as a promising topical therapeutic. However, the study was limited to animal models and short-term observation; further long-term and clinical investigations are needed to confirm its translational potential in human wound healing."

Journal • Preclinical • Inflammation

Use of Povidone-Iodine Solution for Intraoperative Antisepsis: A Systematic Review. (PubMed, Cureus) - "Keywords used included the following: ("Povidone-iodine" OR "Betadine") AND ("Conjunctiva" OR "Ocular surgery")...These studies compared povidone-iodine 5% to other concentrations or antibiotic agents such as povidone-iodine 1%, chloramphenicol 5%, netilmicin, commercial ozonized antiseptic solution (ozone), moxifloxacin 0.5%, and gatifloxacin...Povidone-iodine remains a highly effective and safe antiseptic agent for intraoperative use in ocular surgery, while a need exists for additional high-quality independently conducted RCTs to confirm the observed effects and expand the evidence base. Its broad antimicrobial spectrum and favorable safety profile support its continued and widespread application for conjunctival antisepsis, outperforming several commonly used alternatives."

Journal • Review • Infectious Disease • Ocular Infections • Ophthalmology

Effect of Implementing Oral Care With Betadine Wash on Mechanically Ventilated Patients' Outcomes. (PubMed, Crit Care Nurs Q) - "However, these differences were not statistically significant. Comprehensive oral care intervention with betadine wash is effective in improving oral health status and reducing the occurrence of ventilator-associated pneumonia."

Journal • Critical care • Infectious Disease • Pneumonia • Respiratory Diseases

Comparison of the efficacy of two hand decontamination methods: Alcoholic septicidine and povidone-iodine solutions. (PubMed, PLoS One) - "Both Septicidine and Betadine were effective in reducing hand bacterial load, although neither achieved complete sterilization. Alcohol-based solutions such as Septicidine may offer benefits in terms of ease of use and skin compatibility. Improving iodine-based solutions such as Betadine application techniques may enhance its efficacy. Further research is warranted to optimize hand hygiene protocols in surgical environments."

Clinical • Journal • Infectious Disease • Ophthalmology

RISK FACTORS, PREVENTION, AND TREATMENT OF INFECTIONS RELATED TO TOTAL HIP ARTHROPLASTY: SYNTHESIS OF CLINICAL EVIDENCE. (PubMed, Acta Ortop Bras) - "Although some interventions, such as collagen sponges with gentamicin and triclosan-coated sutures, have not significantly reduced the incidence of infections, others, such as closed incisional negative pressure therapy (ciNPWT) and washing with diluted betadine, have shown promise in certain contexts. Thus, despite advances, the prevention and management of infections in THA still require improvement, and interventions must be carefully evaluated to ensure the effectiveness and safety of the procedure. Level of Evidence IV; Evidence from Descriptive (non-experimental) or Qualitative Studies ."

Journal • Review • Immunology • Infectious Disease • Musculoskeletal Diseases • Orthopedics • Osteoarthritis • Pain • Rheumatoid Arthritis • Rheumatology

Patient Reported Experiences and Comfort Associated with Intravitreal Injection Technique: A Cross-Sectional Survey Approach. (PubMed, J Vitreoretin Dis) - "Lidocaine pledgets were associated with the most discomfort (P < .05). Surveyed patients preferred topical gel or subconjunctival injections, manual lid retraction, and Betadine-soaked cotton tips. Future studies may consider the safety associated with each technique."

Journal • Age-related Macular Degeneration • Anesthesia • Diabetic Macular Edema • Diabetic Retinopathy • Hematological Disorders • Ophthalmology • Retinal Disorders • Wet Age-related Macular Degeneration

Extended Pleurectomy, Decortication, and Bilobectomy for Localized Pleural Mesothelioma (IMIG 2025) - "The patient recovered uneventfully and was discharged on postoperative day six. This case highlights the feasibility of aggressive surgical management for localized pleural mesothelioma and suggests potential benefits of adjunctive techniques such as nerve cryoablation and betadine irrigation.Link to Video: https://youtu.be/MmlPxZcBJ3k?si=qcPsn48ElqxAYc8Y"

Epithelioid Mesothelioma • Malignant Pleural Mesothelioma • Mesothelioma • Pleural Mesothelioma • Solid Tumor

Robotic arm-assisted, FDG-PET/CT guided percutaneous core-needle biopsies: Initial experience with inclusion of Pyrexia of unknown origin (PUO) patients. (EANM 2025) - "Planned needle insertion site was cleaned with betadine and spirit followed by administration of local anesthetic.The Biopsy needle was placed in a needle adaptor in the robotic arm and navigated to the target lesion along the planned path following which the needle-tip position was confirmed using regional low-dose CT...No other complications were noted during any procedure. Table 1: Indication of biopsy and histopathology results Indication Number of patients Definite HP (Diagnostic success rate %) Results Lymphoma residual/ recurrent Disease 05 5/5 (100%) Residual/Reccurrence=2, Richters transformation=1, No recurrence =1, TB=1 Known solid organ malignancy ?metastasis 09 8/9 (88.8%) Left paravertebral metastasis (treated vulva primary)=1, Second primary RCC=1 (PTC treated), New lung nodule in carcinoma rectum/breast(treated)=1/1, Liver lesion-metastatic adenocarcinoma (CUPS)=1, Left iliopsoas mass-metastatic adenocarcinoma (CUPS)=1, Lytic sternal lesion in carcinoma..."

Biopsy • Clinical • FDG PET • Anesthesia • Biliary Cancer • Burkitt Lymphoma • Cervical Cancer • Cholangiocarcinoma • Colorectal Cancer • Diffuse Large B Cell Lymphoma • Hematological Malignancies • Hepatology • Hodgkin Lymphoma • Human Immunodeficiency Virus • Infectious Disease • Lung Adenocarcinoma • Lung Cancer • Lymphoma • Non Small Cell Lung Cancer • Renal Cell Carcinoma • Richter's Syndrome • Solid Tumor

Technique Matters: Factors Affecting Wound Healing in Necrotizing Soft Tissue Infection Patients Undergoing Delayed Primary Closure (ACS-CLINCON 2025) - "69.61% had multilayered closure, 24.48% had granulation tissue excision, undermining (22.63%), utilizing high-volume fluid irrigation (32.26%), betadine-antiseptic scrub (7.36%), and tissue expansion via vessel loops (7.13%)... This study demonstrates various operative factors commonly utilized in DPC for NSTI patients undergoing SSA as potentially detrimental to wound healing outcomes and signals the need for further investigation."

Clinical • Infectious Disease

Negative Pressure Wound Therapy: Significant Improvement in Definitive Fascial Closure With Reduced Theatre Episodes and Complications in Patients With Encapsulating Peritoneal Sclerosis. (PubMed, Cureus) - "43 (43%) patients were managed with NPWT and 56 (57%) patients with static mechanisms (betadine-soaked gauze.) Patients who were managed with NPWTwere more likely to achieve fascial closure (n=27 vs n=7, p<0.0001), required less total theatre episodes (n=2.27 vs 4.78, p<0.0001), and reported less failure to close episodes (p=0.002)...This study demonstrates that NPWT is associated with increased likelihood of fascial closure with a reduced complication profile in patients with EPS, representing a chronically malnourished, high-risk surgical cohort. NPWTshould be within the armamentarium of the general surgeon faced with a complex open abdomen and can be safely used in high-risk surgical patients."

Journal • Gastroenterology • Gastrointestinal Disorder

Allergic contact dermatitis in a patient with metallic implant: think about other allergens not just metals! (EADV 2025) - "Patch testing was performed using the Chemotechnique European Baseline Series, the Dental Series and the patient's topical treatments (Betadin"

Clinical • Contact Dermatitis • Dermatitis • Dermatology • Immunology • Orthopedics

Advancing Pneumothorax Surgery: The Role of Multiportal and Uniportal VATS (ERS 2025) - "Surgery involved apex resection with one or two 60-mm EndoGIA staplers, combined with Betadine (76.5%) or sterile talc (23.5%) and pleurodesis under direct vision... Multiportal and uniportal videothoracoscopy are safe, effective techniques for minimally invasive PSP treatment, offering low morbidity, shorter hospital stays, and improved postoperative comfort."

Surgery • Respiratory Diseases

Effects of Satureja montana L. and Origanum vulgare L. Hydrolates in Rabbit Burn Wound Model: Evaluation of Inflammatory, Antioxidant Activity, and Pro-Regenerative Properties in the Skin. (PubMed, Int J Mol Sci) - "Male rabbits (n = 5 per group) received full-thickness burns and were assigned to control, untreated, conventional treatment (Levomekol liniment, boric acid, and Betadine-soaked gauze dressings), Satureja montana L. hydrolate, and Origanum vulgare L. hydrolate groups...An assessment of local cellular immunity showed the most prominent decrease in CD45+ cell counts in groups treated with Satureja montana L. and Origanum vulgare L. hydrolates. This study provides promising evidence that Satureja montana L. and Origanum vulgare L. hydrolates offer promise as topical therapies for burn wounds by modulating ROS production and local inflammatory status and by improving wound healing, with Satureja montana L. hydrolate exhibiting the most pronounced therapeutic effect."

Journal • Preclinical • Inflammation • Thermal Injury • IL10 • PTPRC • TNFA

A Novel and Standardized Perioperative Protocol to Reduce Infections Related to Immediate Implant-Based Reconstruction (PSTM 2025) - "The breast pocket preparation involved rinsing with normal saline (NS) followed by dilute betadine and/or vancomycin irrigation per side, or triple antibiotic solution with Ancef/Vancomycin/Tobramycin. This study describes the largest cohort of a standardized perioperative protocol used for immediate IBBR with a largely successfully infectious outcomes rate of only 3.27%. We demonstrate that implementation of our institution's protocol using a quality improvement approach is associated with a significant reduction in implant infections."

Clinical • Breast Cancer • Hormone Receptor Breast Cancer • Infectious Disease • Oncology • Solid Tumor • ER

Wound Healing Properties of Nymphaea alba (Nymphaeaceae) Flower Extract: Evidence from In Vivo, In Vitro, and In Silico Network Analysis. (PubMed, Curr Comput Aided Drug Des) - "Nymphaea alba flower extract exhibits promising wound-healing activity through multiple mechanisms, including enhancement of cell migration and regulation of key proteins involved in tissue regeneration. These results support its potential as a natural therapeutic agent in wound management."

Journal • Preclinical • AKT1 • EGFR • ER

Effectiveness of laser ablation in minimally invasive treatment of pilonidal sinus (ESCP 2025) - "The first stage involved 11W laser power with a 1470 nm wavelength, followed by NaCl cleaning and Betadine sterilization...Conclusion This laser ablation, combined with the innovative three-incision technique, proved to be an effective, safe, and minimally invasive treatment option for SP disease. This procedure offers minimal complications and positive postoperative outcomes, making it a highly effective treatment option for both patients and clinicians."

Infectious Disease

Evaluating the inoculating bacterial communities within the bovine neonatal respiratory tract after applying an ablation technique to the dam vaginal microbiota prior to parturition. (PubMed, J Anim Sci) - "Betadine lavages (BL) are commonly used to control reproductive tract infections but can induce microbial dysbiosis...Together, these results are indicative of microbial dysbiosis prior to parturition leading to an increased immune response in BLG dams which altered colostrum IgG. Thus, dam colostrum composition could drive immune responses against neonatal inoculating bacteria resulting in differing nasal microbial communities between BLG and CON calves."

Journal • Infectious Disease

Comparative evaluation of propolis and Persea americana creams for epidermal wound healing in rats. (PubMed, Sci Rep) - "All wounds were sterilized daily using Betadine...The analysis revealed that the Persea americana cream contained a higher concentration of bioactive compounds, which likely contributed to the enhanced healing observed. Overall, the formulations were designed to utilize the bioactive components to accelerate wound repair effectively."

Journal • Preclinical

The Efficacy of Ultraviolet Radiation in Decontaminating Dropped Bone Fragments in Orthopedic Surgery. (PubMed, Cureus) - "Treatment in a UV chamber for five minutes was effective in restoring sterility to bone fragments dropped on the floor, but its effects on viability are not known. Future studies are needed to explore the role of UV radiation in the decontamination of bone and its maintenance of vitality."

Journal • Orthopedics

Comparison of Conjunctival Antimicrobial Activity and Patient Comfort Between Topical Hypochlorous Acid (Avenova) and Betadine (clinicaltrials.gov) - P4 | N=230 | Suspended | Sponsor: University of Miami | Recruiting ➔ Suspended

Trial suspension • Infectious Disease • Ocular Infections • Ophthalmology

Reuse or replacement of incidentally dropped craniotomy bone flap: An institutional perspective and literature review. (PubMed, Surg Neurol Int) - "Subsequently, the flaps were immersed in 10% betadine solution for another 15 min. Finally, they were soaked in normal saline containing gentamicin...Patients require meticulous monitoring to identify early or late surgical site infections. Nevertheless, prevention remains the most effective strategy."

Journal • Infectious Disease

Antimicrobial Efficacy of Impregnated Human Acellular Dermal Substitutes in Burn Wound Models. (PubMed, Antibiotics (Basel)) - "Compared with agents such as Betadine®, Octenilin®, and colistin, which showed cytotoxicity, and Prontosan®, which showed low efficacy, 1% AA uniquely combined potent antibacterial effects with minimal toxicity. Among the seven antimicrobial agents impregnated into ADMs, 1% AA demonstrated a unique efficacy and safety profile, supporting its potential for clinical application in integrated wound dressings and implantable biomaterials for infection control in burn care."

Journal • Infectious Disease • Septic Shock

A Novel Surgical Technique in a Sheep Model for Suburethral Graft Implantation. (PubMed, J Vis Exp) - "The incision was closed, and a betadine vaginal pack was placed after 24 h. Two animals received transvaginal polypropylene mesh using similar surgical steps but no fixation sutures...No animals showed signs of vaginal erosion or graft infection during the three-month follow-up. This large animal model accurately reproduces the surgical technique used in women, thereby providing a valuable platform for evaluating new materials for stress urinary incontinence treatment."

Journal • Infectious Disease • Urinary Incontinence • Urology

Intracameral Povidone-Iodine for Multidrug-Resistant Pseudomonas aeruginosa Exogenous Endophthalmitis: A Case Report and Literature Review. (PubMed, Case Rep Ophthalmol) - "The patient had anterior chamber washout, along with aqueous and vitreous tapping with intravitreal vancomycin, ceftazidime, and intravenous ciprofloxacin...Intracameral PI may offer a solution for endophthalmitis cases where standard antibiotics are ineffective. This case supports the potential role of PI in managing resistant intraocular infections."

Journal • Cataract • Infectious Disease • Ocular Infections • Ocular Inflammation • Ophthalmology • Pain • Retinal Disorders

Betadine vs Sterile Water for Periurethral Preparation (clinicaltrials.gov) - P4 | N=148 | Not yet recruiting | Sponsor: University of Louisville

New P4 trial • Infectious Disease • Nephrology