myoinositol trispyrophosphate (OXY111A) / NormOxys - LARVOL DELTA

Potentiation of the immune checkpoint blockade response by tumor acidosis and hypoxia modulation is predictable using molecular imaging (SITC 2022) - "To interrogate the modulation of hypoxia, we measured the correlation between oxygen saturation and immune cell infiltrate and the tumor growth kinetics of myoinositol trispyrophosphate (ITPP) in combination with αPD-1 and αCTLA-4 blockade...Conclusions AcidoCEST MRI can predict tumor control in the combination treatment of esomeprazole followed by αPD-1 and αCTLA-4 one day afterwards, with TCF-1+ effector CD4 and CD8 T cells being possible biomarkers for treatment success as well. MSOT may also indicate αPD-1 and αCTLA-4 tumor control by determining changes in tumor oxygenation by ITPP."

Checkpoint inhibition • Lung Cancer • Melanoma • Non Small Cell Lung Cancer • Oncology • Solid Tumor • CD4 • CD8