7-oxoprasterone (HL-9001) / Humanetics - LARVOL DELTA

LC-MS/MS techniques for the analysis of steroid panel in human cerebrospinal fluid. (PubMed, Neurochem Int) - "The validation of the method without derivatization was performed for ten C19- steroids (dehydroepiandrosterone (DHEA), 7α-hydroxyDHEA, 7β-hydroxyDHEA, 7-ketoDHEA, testosterone, epitestosterone, dihydrotestosterone, 11-hydroxytestosterone, 11-ketotestosterone and androstenedione), ten C21- steroids (cortisol, 11-deoxycortisol, 21-deoxycortisol, cortisone, corticosterone, 11-deoxycorticosterone, pregnenolone, progesterone, 17-hydroxyprogesterone, aldosterone) and three C18- steroids (estrone, estradiol, estriol)...17-hydroxypregnenolone, and 11-deoxycortisol were quantified for the first time, their CSF levels in NPH subjects are presented. We also observed significantly increased CSF levels of testosterone and 17-hydroxyprogesterone in men compared to women, both with NPH."

Journal • CNS Disorders • Ventriculomegaly

Neuroactive Steroids in Cerebrospinal Fluid of Patients with Normal Pressure Hydrocephalus Before and After Surgical Treatment (ENDO 2025) - "In accordance with our previous research, we found increased levels of neuroprotective 7-ketoDHEA. To the best of our knowledge, we have quantified for the first time the CSF levels of 17-hydroxypregnenolone, which were significantly increased in the 3- and 12-months follow-up. The increase was found also in 11-hydroxytestosterone, which metabolism within the nervous system is actually not fully understood."

Clinical • Alzheimer's Disease • CNS Disorders • Dementia • Movement Disorders • Parkinson's Disease • Urinary Incontinence • Urology • Ventriculomegaly

Integrative Psychiatry: Herbs Nutrients and Breath Practices for Disorders of Mood Anxiety Trauma Neurocognition Attention Sexual Function and Long Covid (APA 2025) - "They will also briefly review B Vitamins, methylfolate, S-adenosylmethionine (SAMe), N-acetyl cysteine, omega-3 fatty acids (fish oi), Hokkaido Scallop Oil, dehydroepiandrosterone (DHEA), 7-keto DHEA, melatonin, centrophenoxine, CDP choline, racetams, cilostazol, selegiline, and LUMA TC (medical food formula). Objective Three: Access information and tools to develop skills in the integration of herbs, nutrients, neurohormones, and nootropics into patient care. Objective Four: Objective Five:; Objective One: Identify herbs, nutrients, hormones, and combination products that can be integrated into treatment of anxiety, depression, PTSD, and other psychiatric disorders to improve patient outcomes.; Objective Two: List 2 herbs, 2 nutrients, and 1 nootropic that can enhance brain function for individuals being treated for cognitive impairment due to traumatic brain injury, stroke, or dementia.; Objective Three: Access information and tools to develop skills in the integration..."

Alzheimer's Disease • Cardiovascular • CNS Disorders • Cognitive Disorders • Dementia • Depression • Mental Retardation • Novel Coronavirus Disease • Post-traumatic Stress Disorder • Psychiatry • Vascular Neurology

A systematic review of the impact of 7-keto-DHEA on body weight. (PubMed, Arch Gynecol Obstet) - "Various possible mechanisms in favor of weight loss are discussed; however, with the evidence currently available, no clear answer can be given regarding 7-keto-DHEA and weight loss. Further studies need to be conducted to clarify the efficacy and safety of this drug before it can be recommended for therapeutic use."

Journal • Review • Genetic Disorders • Obesity

An LC-MS/MS method for the simultaneous quantification of 32 steroids in human plasma. (PubMed, J Chromatogr B Analyt Technol Biomed Life Sci) - "Validation demonstrated that the method was applicable for the quantitative analysis of two C- steroids (estrone, estradiol), nineteen C- steroids (testosterone, epitestosterone, dihydrotestosterone, 11-ketodihydrotestosterone, 11β-hydroxyandrostenedione, 11β-hydroxytestosterone, 11-ketotestosterone, dehydroepiandrosterone, 7α-hydroxydehydroepiandrosterone, 7β-hydroxydehydroepiandrosterone, 7-ketodehydroepiandrosterone, androsterone, epiandrosterone, androstenedione, androstenediol, 5α-androstane-3α,17β-diol, 5α-androstane-3β,17β-diol, 5β-androstane-3α,17β-diol, 5β-androstane-3β,17β-diol), and eleven C- steroids (cortisol, 21-deoxycortisol, 11-deoxycortisol, cortisone, corticosterone, 11-deoxycorticosterone, pregnenolone, 17-hydroxypregnenolone, progesterone, 17-hydroxyprogesterone, 5α-dihydroprogesterone)...The accuracy, intra- and inter-day precision values as well as stability tests were in accordance with FDA Guidelines. The method will be a useful tool in..."

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Metabolomics workflow as a driven tool for rapid detection of metabolites in doping analysis. Development and validation. (PubMed, Rapid Commun Mass Spectrom) - "The application of metabolomics tools as an investigation strategy could reduce the time and resources required to identify and characterize intake markers maximizing the information that can be extracted from the data and extending the research field by avoiding a priori bias. Therefore, metabolic fingerprinting of prohibited substance intakes could be an appropriate analytical approach to reduce the risk of false-positive/negative results, aiding in the interpretation of "abnormal" profiles and discrimination of pseudo-endogenous steroid intake in the anti-doping field."

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7-keto-DHEA metabolism in humans. Pitfalls in interpreting the analytical results in the antidoping field. (PubMed, Drug Test Anal) - "Some deoxydation reactions (including arimistane formation) were found and most probably can be linked to the sample preparation or instrumental analysis. This is important when interpreting the results after the application of the procedures to detect steroids in urine currently used in Antidoping laboratories."

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Detection of urinary metabolites of arimistane in humans by gas chromatography coupled to high accuracy mass spectrometry for antidoping analyses. (PubMed, Rapid Commun Mass Spectrom) - "Arimistane itself was not observed in the free or glucuronated fractions, but only in the sulfate fraction. The peaks showing mass spectra in agreement with hydroxylated metabolites did not match with those for 7-keto-DHEA, 7α- or 7β-hydroxy-DHEA. This suggests that the first hydroxylation did not occur on C3, but on C2. These newly described metabolites allow the specific detection of arimistane misuse in sports."

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