clotrimazole oral / Generic mfg. - LARVOL DELTA

Low Incidence of Oral Squamous Cell Carcinoma in Patients With Oral Lichen Planus on Sustained Anti-Inflammatory Therapy: A Single-Centre Retrospective Study of 273 Patients. (PubMed, J Cutan Med Surg) - "OSCC incidence was low in OLP patients on sustained anti-inflammatory therapy, occurring exclusively in those with EOLP. Males and patients with dysphagia more often developed OSCC."

Journal • Retrospective data • Dermatology • Dermatopathology • Gastrointestinal Disorder • Lichen Planus • Oncology • Oral Cancer • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck

Low incidence of oral squamous cell carcinoma in patients with oral lichen planus on sustained anti-inflammatory therapy: A single-center retrospective study of 273 patients (AAD 2025) - "Tacrolimus swish-and-spit was the most frequently prescribed treatment (100%), followed by 10 mg clotrimazole troches (89.4%) and topical corticosteroids (85%)... OSCC incidence was low in OLP patients on sustained anti-inflammatory therapy, occurring exclusively in those with EOLP. Males and patients with dysphagia more often developed OSCC."

Retrospective data • Dermatology • Dermatopathology • Gastrointestinal Disorder • Lichen Planus • Oncology • Oral Cancer • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck

Evaluation of clotrimazole prophylaxis on tacrolimus trough concentrations in kidney transplant recipients. (PubMed, Transpl Infect Dis) - "Our study provides further evidence of a significant drug-drug interaction between tacrolimus and clotrimazole among kidney transplant recipients that can potentially lead to negative allograft outcomes."

Journal • Candidiasis • Transplantation

Less common bacterial, fungal and viral infections: review of management in the pregnant patient. (PubMed, Drugs Context) - "Liposomal amphotericin B is the preferred therapy for cryptococcosis, histoplasmosis, oesophageal candidiasis, and coccidioidomycosis, especially during the first trimester due to teratogenic concerns with azole antifungals. For oral candidiasis, clotrimazole troches or miconazole mucoadhesive buccal tablets are recommended. A β-lactam antimicrobial is preferred over doxycycline for various manifestations of Lyme disease and the drug of choice for Pneumocystis pneumonia is trimethoprim/sulfamethoxazole. Acyclovir is the preferred antiviral for varicella zoster virus...This population lacks definitive recommendations in many clinical practice guidelines. The key to optimizing therapy is a comprehensive review of the available evidence and a careful balance of risks and benefits before final treatment decisions."

Clinical • Journal • Review • Candidiasis • Herpes Zoster • Infectious Disease • Inflammatory Arthritis • Lyme Disease • Pneumonia • Respiratory Diseases • Varicella Zoster

Impact of Clotrimazole Fungal Prophylaxis on Tacrolimus Exposure in Kidney Transplant Recipients: A Retrospective Study. (PubMed, Transplant Proc) - "Clotrimazole troches, prescribed to posttransplant recipients immediately for the first 30 days for oral candidiasis prevention, are considered nonsystemic...When assessing the effect of race and sex, no influence was found on the degree of change in tacrolimus level after clotrimazole discontinuation. In conclusion, clotrimazole exerts a significant interaction on tacrolimus where close monitoring of tacrolimus trough levels after discontinuation of clotrimazole is warranted."

Journal • Retrospective data • Candidiasis • Transplantation

Prevalence and antifungal susceptibility of gastrointestinal candidiasis among diabetic patients: A cross-sectional study. (PubMed, Afr J Lab Med) - "Resistance was observed with miconazole (48.65%), clotrimazole (18.92%) and fluconazole (8.11%). No resistance to itraconazole and nystatin was observed. Gastrointestinal candidiasis was associated with poor glucose control (p ≤ 0.001), prior use of antibiotics (p ≤ 0.001), antifungals (p ≤ 0.001) and corticosteroids (p ≤ 0.001) and was more common among female patients (p = 0.01). Occurrence of gastrointestinal candidiasis was relatively low among our participants, and infection was associated with poor glucose control, female sex and use of antifungals, antibiotics and corticosteroids."

Clinical • Journal • Observational data • Candidiasis • Dermatology • Diabetes • Gastrointestinal Disorder • Metabolic Disorders • Solid Tumor

Molecular Modeling Studies of Halogenated Imidazoles against 14α-Demethylase from Candida albicans for treating Fungal Infections. (PubMed, Infect Disord Drug Targets) - "Halogenated imidazole analogues may be used as potential lead molecules as 14α- demethylase inhibitors."

Journal • Infectious Disease

Antimicrobial activity of novel 5-benzylidene-3-(3-phenylallylideneamino)imidazolidine-2,4-dione derivatives causing clinical pathogens: Synthesis and molecular docking studies. (PubMed, J Infect Public Health) - "A novel set of imidazolidine-2,4-dione compounds 3a-h have synthesized and characterized successfully. The screening of antimicrobial activity shows that all compounds possess antimicrobial activities. In addition, the objective of the study was succeeded with a few of the promising molecules, which are proving to be a potential treatment of bacterial infection candidates."

Clinical • Journal • Infectious Disease • Pneumonia

Physicochemical and Antifungal Properties of Clotrimazole in Combination with High-Molecular Weight Chitosan as a Multifunctional Excipient. (PubMed, Mar Drugs) - "The inhibition of C. glabrata growth reached at least 90%, regardless of the drug/excipient weight ratio, and even at half of the minimal inhibitory concentrations of clotrimazole. Our results demonstrate that clotrimazole and high-molecular weight chitosan could be an effective combination in a topical antifungal formulation, as chitosan acts synergistically with clotrimazole against non-albicans candida strains."

Combination therapy • Journal

CAPTURE: Clotrimazole Enemas for Pouchitis in Children and Adults (clinicaltrials.gov) - P1/2; N=18; Terminated; Sponsor: Paul Rufo; N=40 ➔ 18; Trial completion date: Jun 2020 ➔ Dec 2020; Suspended ➔ Terminated; Trial primary completion date: Jun 2020 ➔ Dec 2020; Funding Horizon

Clinical • Enrollment change • Trial completion date • Trial primary completion date • Trial termination • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis

Short communication: Tissue-specific transcript expression of P-glycoprotein isoforms abcb1a and abcb1b in rainbow trout (Oncorhynchus mykiss) following induction with clotrimazole. (PubMed, Comp Biochem Physiol B Biochem Mol Biol) - "To determine if P-gp induction alters transcript responses, the antifungal mammalian Pregnane-X-Receptor (PXR) agonist clotrimazole (CTZ) was used. CTZ-treated rainbow trout showed significantly increased abcb1b transcript expression in the optic lobe and distal intestine, providing evidence that trout PXR exhibits a similar substrate base as mammalian PXR, albeit selectively in regions of the brain and intestine."

Journal

A multicenter, randomized, open and positive parallel controlled clinical study of clotrimazole vaginal expansion suppository and vaginal tablet in the treatment of mild and moderate vulvovaginal candidiasis (PubMed, Zhonghua Fu Chan Ke Za Zhi) - " In the treatment of mild and moderate vulvovaginal candidiasis, clotrimazole vaginal expansion suppository is no less effective than clotrimazole vaginal tablet, and there is no significant difference in the recurrence rate between the two. In terms of patient satisfaction, clotrimazole vaginal expansion suppository is superior to clotrimazole vaginal tablet."

Clinical • Journal • Candidiasis • Pruritus • Vaginitis

[VIRTUAL] COVID-19 ASSOCIATED EOSINOPHILIC LICHEN PLANUS (ACAAI 2020) - "A clotrimazole-betamethasone regimen proved ineffective. This is particularly true in the context of preclinical studies arguing that eosinophils have antiviral functions. A possible association between LP and COVID-19 would also be an important addition to diagnostic differentials, especially among multiple reports of painful yet non-pruritic chilblain eruptions in the same location."

Asthma • Atopic Dermatitis • Dermatology • Dermatopathology • Eosinophilia • Hematological Disorders • Immunology • Infectious Disease • Lichen Planus • Novel Coronavirus Disease • Pain • Pruritus • Respiratory Diseases

[VIRTUAL] UNRAVELING THE MYSTERY OF A PRURITIC RASH (ACAAI 2020) - "Initial diagnosis was scrotal contact dermatitis and treatment with topical Triamcinolone0.1% cream without improvement. Subsequently diagnosed with scrotal candidiasis and treated with clotrimazole/betamethasone without improvement...Urology diagnosed Red Scrotum Syndrome and doxycycline given without improvement...After washing his hands with soap and water after use of tretinoin, scrotal dermatitis resolved within 5 days.Discussion The patient was diagnosed with “Indirect contact dermatitis.” The scrotum has significant permeability and is extremely susceptible to irritating agents resulting in irritant contact dermatitis. Therefore, to successfully manage recalcitrant CD clinicians should continue to explore the clinical history to ultimately unravel the real trigger to appropriately treat the patient."

Candidiasis • Contact Dermatitis • Dermatitis • Dermatology • Immunology • Pruritus • Urology

Comparison of in vitro activities of 11 antifungal agents against Trichophyton verrucosum isolates associated with a variety hosts and geographic origin. (PubMed, Mycoses) - "Our study has shown that drugs of different chemical origin have satisfactory antifungal activity and can be promising candidates for the treatment of T. verrucosum dermatophytosis. Moreover, no significant disparity in drug sensitivity between isolates obtained from different hosts and geographical regions have been demonstrated."

Journal • Preclinical • Dermatology

Prevalence of dermatophytosis in animals and antifungal susceptibility testing of isolated Trichophyton and Microsporum species. (PubMed, Trop Anim Health Prod) - "Only T. mentagrophytes, T. rubrum, T. verrucosum, and T. tonsurans were able to show optimum growth at 37 °C. Maximum inhibition of fungal growth was exhibited by clotrimazole and least by fluconazole."

Journal • Dermatology

In-vitro assessment of first-line antifungal drugs against Aspergillus spp. caused human keratomycoses. (PubMed, J Infect Public Health) - "Five different species of aspergilli, A. flavus (n=53), A. fumigatus (n=14), A. terreus (n=9), A. tamarii (n=6) and A. niger (n=3) were identified based on morphological features. Minimum inhibitory concentration analyses indicated that, voriconazole, natamycin, itraconazole, clotrimazole, econazole followed by ketoconazole shall be the order of choices for the effective treatment for Aspergillus keratitis."

Journal • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

Synthesis and biological evaluation of substituted phenyl azetidine-2-one sulphonyl derivatives as potential antimicrobial and antiviral agents. (PubMed, Bioorg Chem) - "Moreover, compounds 5h, 5i, 5j, and 5q showed good inhibitory activity against fungal strains whereas other derivatives had mild or diminished activity in comparison with standard drug clotrimazole...Interestingly, these tested compounds showed weak antiviral activity against Vaccinia virus, Human Coronavirus (229E), Reovirus-1, Herpes simplex virus, Sindbis virus, Coxsackievirus B4, Yellow Fever virus, and Influenza B virus in HEL cell, Vero cell, and MDCK cell cultures. The findings of the present study might open new avenues to target human disease-causing deadly microbes and viruses."

Journal • Herpes Simplex • Infectious Disease • Novel Coronavirus Disease

Epidemiological pattern of Malassezia, its phenotypic identification and antifungal susceptibility profile to azoles by broth microdilution method. (PubMed, Indian J Med Microbiol) - "The systemic antifungal of choice was itraconazole with the lowest minimum inhibitory concentration (MIC) of 0.125-1 μg/ml. The best topical drug with the lowest MIC value was clotrimazole 0.03-0.5 μg/ml. AFST is important as it will help the dermatologist to choose the appropriate antifungal agents for the patient and thereby reduce the chronicity of the disease with good patient compliance."

Clinical • Journal • Dermatology

Synthesis, Cytotoxic Analysis, and Molecular Docking Studies of Tetrazole Derivatives via N-Mannich Base Condensation as Potential Antimicrobials. (PubMed, Drug Des Devel Ther) - "The exact binding mode between the most active tetrazole derivatives (ie, 1b, 2a, and 2b) and the proteins (ie, 4OR7, 1AI9, and 4FM9) was established using Autodock Vina 1.1.2 software and compared to the binding mode of the reference compounds (ie, cefazolin, clotrimazole, and fluorouracil). Generally, 1b, 2a, and 2b exhibited impressive inhibitory capabilities in antibacterial, antifungal, and cytotoxic screenings relative to the reference compounds. The results of the molecular docking studies and both the microbial and anticancer screenings indicate that these novel derivatives could be developed into potential therapeutic agents for medical applications."

Journal • Breast Cancer • Oncology

Green synthesis of selenium-N-heterocyclic carbene compounds: Evaluation of antimicrobial and anticancer potential. (PubMed, Bioorg Chem) - "Selected salts and respective selenium N-Heterocyclic carbenes (selenium-NHC) adducts were tested in vitro against Cervical Cancer Cell line (Hela), Breast Adenocarcinoma cell line (MCF-7), Retinal Ganglion Cell line (RGC-5) and Mouse Melanoma Cell line (B16F10) using MTT assay and the results were compared with standard drug 5-Fluorouracil. In addition, compounds III-VIII were screened for their antibacterial and antifungal potential. Adduct VI was found to be potent anti-fungal agent against A. Niger with zone of inhibition (ZI) value 27.01 ± 0.251 mm which is better than standard drug Clotrimazole tested in parallel."

Journal • Breast Cancer • Cervical Cancer • Gynecologic Cancers • Melanoma • Oncology • Solid Tumor

Successful treatment of erythematous-squamous disorders of the external auditory canal with tacrolimus and clotrimazole in otic oil: our experience in 25 patients. (PubMed, Dermatol Ther) - "Retreatment showed an equal efficacy observed during the first treatment period. The efficacy and the absence of side effects with the treatment make this magistral formula an adequate therapeutic option for these dermatoses."

Clinical • Journal • Atopic Dermatitis • Contact Dermatitis • Cutaneous Lupus Erythematosus • Dermatitis • Dermatology • Immunology • Inflammatory Arthritis • Lupus • Otorhinolaryngology • Pruritus • Psoriasis • Seborrheic Dermatitis

Carvacrol essential oil stimulates growth performance, immune response, and tolerance of Nile tilapia to Cryptococcus uniguttulatus infection. (PubMed, Dis Aquat Organ) - "Thymoquinone, thymol, carvacrol, eugenol, and cinnamon were first tested in vitro against 20 clinical yeast strains in comparison with antifungal drugs (fluconazole, ketoconazole, itraconazole, amphotericin B, nystatin, and clotrimazole) using disc diffusion and broth microdilution methods...This unique experimental model indicates that carvacrol seems promising not only for enhancing immunity and promoting fish growth, but also for controlling emerging fungal infections. Future studies should investigate different concentrations of carvacrol as well as its antifungal activity in different fish species."

Journal • Infectious Disease

Remdesivir-COVID-19: drug interactions in dentistry. (PubMed, Eur Rev Med Pharmacol Sci) - "It is clinically necessary for oral health professionals to be aware of possible drug interactions that may occur between remdesivir and drugs commonly prescribed in dentistry in order to prevent adverse reactions that may even endanger the life of a patient with COVID-19."

Journal • Infectious Disease • Novel Coronavirus Disease

Novel 4,6-Disubstituted s-Triazin-2-yl Amino Acid Derivatives as Promising Antifungal Agents. (PubMed, J Fungi (Basel)) - "Most of them showed antifungal activity against Candida albicans compared to clotrimazole (standard drug)...In addition, docking studies revealed that all the compounds accommodated well in the active site residues of N-myristoltransferase (NMT) and exhibited complementarity, which explains the observed antifungal activity. Interestingly, none of these compounds showed antibacterial activity."

Journal