NP-500 / Jaguar Health - LARVOL DELTA

Aggregation and deposition kinetics of polystyrene nanoplastics in lung fluids: Influence of particle property, fluid condition, and surfactant protein. (PubMed, J Hazard Mater) - "This study investigated the aggregation and deposition kinetics of six polystyrene NPs (PSNPs): NP50, NP100, NP500, A-NP50 and A-NP100 (amino-modified), and C-NP100 (carboxyl-modified), in artificial lysosomal fluid (ALF) and Gamble's solution (GMB)...For A-NP50, BSA consistently reduced aggregation. These findings provide insights into NP transport and health risks in pulmonary environments."

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Analgesic and anti-inflammatory activities of NPK500 capsules, a Cassia sieberiana DC. - based herbal analgesic medicine used to treat dysmenorrhea and peptic ulcer, is mediated through the inhibition of PGE2 and iNOS. (PubMed, J Ethnopharmacol) - "These results show that NNPK500 and ONPK500 capsules possessed potent analgesic and anti-inflammatory activities via inhibition of PGE2 and iNOS as a result of their chemical constituents. NPK500 capsules thus, relief acute pain and inflammation without causing gastrointestinal, renal or hepatic injuries, since they did not inhibit COX-1."

Journal • Gastroenterology • Gastrointestinal Disorder • Inflammation • Liver Failure • Pain • Peptic Ulcer • Women's Health

The size-dependent effects of nanoplastics in mouse primary hepatocytes from cells to molecules. (PubMed, Environ Pollut) - "The degree of inhibition of CAT activity by different sized NPs was coherent at the cellular and molecular levels, and NP-500 had the most impact...All NPs induce CAT fluorescence sensitization and make the chromophore microenvironment hydrophobic. This study provides new insights for NP risk assessment and applications."

Journal • Preclinical • CAT

Silica nanoparticles conferring resistance to bacterial wilt in peanut (Arachis hypogaea L.). (PubMed, Sci Total Environ) - "In this study, we synthesized silica nanoparticles (SiO NPs), a prospective efficient management approach to control PBW, and conducted a hydroponic experiment to investigate the effects of different SiO NPs treatments (i.e., 0, 100, and 500 mg L as NP0, NP100, and NP500, respectively) on promoting plant growth and resistance to R. solanacearum...Meanwhile, the up-regulated expression of the SA-metabolism gene, salicylate carboxymethyltransferase (SAMT), initiated SAR to promote PBW resistance. Overall, our findings revealed that SiO NPs, functioning as a plant elicitor, could effectively modulate physiological enzyme activities and enhance SA contents through the regulation of SA-metabolism genes to confer the PBW resistance in peanuts, which highlighted the potential of SiO NPs for sustainable agricultural practices."

Journal • CAT

Aggregation kinetics of polystyrene nanoplastics in gastric environments: Effects of plastic properties, solution conditions, and gastric constituents. (PubMed, Environ Int) - "This study investigated the early-stage (20 min) and long-term (1-6 h) aggregation kinetics of four commonly-found polystyrene nanoplastics (PSNPs) including NP100 (100-nm), A-NP100 (100-nm, amino-modified), C-NP100 (100-nm, carboxyl-modified), and NP500 (500-nm) under gastric conditions...Freundlich isotherm suggested that PSNPs adsorbed organic constituents following lysozyme > porcine bile > proteose-peptone > pepsin > glycine > D-glucose, inducing changes in constituent structure and PSNP properties. These findings provide insights on the transport of nanoplastics in the gastric environments."

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