Stedicor (azimilide dihydrochloride) / AbbVie, Blue Ash Therap - LARVOL DELTA

Cardiac Na/Ca exchange stimulators among cardioprotective drugs. (PubMed, J Physiol Sci) - "We previously reviewed our study of the pharmacological properties of cardiac Na/Ca exchange (NCX1) inhibitors among cardioprotective drugs, such as amiodarone, bepridil, dronedarone, cibenzoline, azimilide, aprindine, and benzyl-oxyphenyl derivatives (Watanabe et al. Cardiac Na/Ca exchange current (I) was stimulated by nicorandil (a hybrid ATP-sensitive K channel opener), pinacidil (a non-selective ATP-sensitive K channel opener), flecainide (an antiarrhythmic drug), and sodium nitroprusside (SNP) (an NO donor). Sildenafil (a phosphodiesterase-5 inhibitor) further increased the pinacidil-induced augmentation of I. In paper, here I review the NCX stimulants that enhance NCX function among the cardioprotective agents we examined such as nicorandil, pinacidil, SNP, sildenafil and flecainide, in addition to atrial natriuretic (ANP) and dofetilide, which were reported by other investigators."

Journal • Review

Anti-Arrhythmic Drug Therapy in Implantable Cardioverter-Defibrillator Recipients. (PubMed, Pharmacol Res) - "Sotalol and mexiletine are the main alternatives to amiodarone with a better side effect profile though they are less efficacious at preventing ventricular arrhythmia recurrence. Dofetilide, azimilide and ranolazine are emerging as therapeutic options for secondary prevention; more studies are needed to assess efficacy and safety in comparison to currently used agents. Beta blockers and amiodarone are the mainstay of therapy in patients experiencing electrical storm; their use reduces the frequency of ventricular arrhythmias and ICD intervention as well as affording time until catheter ablation can be considered."

Journal • Review

Genome Editing of Induced Pluripotent Stem Cells to Decipher Cardiac Channelopathy Variant. (PubMed, J Am Coll Cardiol) - "The results suggest that the KCNH2 VUS may be classified as potentially pathogenic."

Journal

Antiarrhythmic Drugs or Catheter Ablation in the Management of Implantable Cardioverter-Defibrillator Interventions: A Network Meta-Analysis of Randomized Controlled Trials (ACC 2019) - "...AADs included amiodarone, sotalol, azimilide, and celivarone... Among patients with ICD, amiodarone and CA significantly reduced VT recurrence and appropriate ICD shocks without increased deaths compared with control and other AADs."

Retrospective data