ramipril / Generic mfg. - LARVOL DELTA

Cardioprotection without risk? meta-analysis of prophylactic agents in low-risk cancer patients on anthracyclines (ASH 2025) - "We included randomized controlled trials (RCTs) of prophylactic ACE inhibitors, ARBs, beta-blockers, statins, dexrazoxane, or SGLT2 inhibitors in adults without pre-existing cardiovascular risk factors...Agents studied included beta-blockers (nebivolol, carvedilol, bisoprolol), ACE inhibitors (ramipril), ARBs (telmisartan), and spironolactone. Treatment duration ranged from 4 months to 1 year; anthracycline doses reached up to 689 mg/m² (epirubicin) or 536 mg/m² (doxorubicin)...The protective benefit was greater in contexts involving higher cumulative anthracycline doses and concurrent cardiotoxic therapies such as trastuzumab...However, high heterogeneity limits firm conclusions. Given the moderate effect size and heterogeneity, further large-scale, well-formulated trials are essential to identify optimal cardioprotective agents and precise patient selection criteria."

Retrospective data • Breast Cancer • Congestive Heart Failure • Heart Failure • Oncology • Solid Tumor

DS27 Checking blood pressure of patients having Mohs surgery: a survey of practice of UK- and Australasia-based Mohs surgeons. (PubMed, Br J Dermatol) - "'Other' open comment themes included determining signs of malignant hypertension, checking what their baseline BP was with the patient and/or general practitioner, refer to an emergency department or give a benzodiazepine (e.g. low-dose sublingual diazepam 2 mg)...From ANZ, glyceryl trinitrate, ramipril and sublingual nifedipine were given as antihypertensives...The results confirm a range of practice and no consensus. Further discussion and an evidence-based guideline would be helpful to develop more consistent practice."

Journal • Cardiovascular • Hypertension

A systematic review of commencing full dose antihypertensives in newly diagnosed hypertension. (PubMed, Blood Press) - "The review assessed commonly used antihypertensive drugs (perindopril 8 mg, ramipril 10 mg, amlodipine 10 mg, losartan 100 mg, irbesartan 300 mg, candesartan 16 mg and candesartan 32 mg) compared to low starting doses or placebo RCTs. The review indicates that initiating full dose antihypertensives for essential hypertension may be beneficial and safe. The available data are limited and further RCTs are required to assess this in specific patient groups to assess safety and efficacy."

Journal • Review • Alzheimer's Disease • Cardiovascular • CNS Disorders • Cognitive Disorders • Dementia • Hypertension • Nephrology • Renal Disease

A novel in vivo phenotypic assay to evaluate kinase inhibitor induced cardiotoxicity and strategies for cardioprotection. (PubMed, Food Chem Toxicol) - "Heart function was rescued by discontinuation of treatment with axitinib and ponatinib but not with the sorafenib. Co-treatment with ramipril or telmisartan reduced the extent of sorafenib-induced heart failure. Thus, the embryos of L. stagnalis serve as a valuable invertebrate model of cardiotoxicity not just for the high-throughput pre-clinical phenotypic screening of chemotherapeutics but also for testing of harmful chemicals and environmental pollutants. Further, this novel model is amenable for the testing of cardioprotection strategies such as treatment discontinuation as well as the identification of additional treatment options that can be combined with cancer therapeutics to prevent cardiotoxicity."

Journal • Preclinical • Cardiovascular • Congestive Heart Failure • Heart Failure • Oncology

Single and Twice-daily Dosing of Ramipril on Renal Function in Chronic Kidney Disease Patients With Reduced Ejection Fraction Heart Failure (clinicaltrials.gov) - P4 | N=80 | Recruiting | Sponsor: Evi Liliek Wulandari

New P4 trial • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Heart Failure • Nephrology • Renal Disease • CST3

High adherence to angiotensin-converting enzyme inhibitor in children and adolescents with Alport syndrome: objective verification using liquid chromatography-mass spectrometry. (PubMed, Pediatr Nephrol) - "This study demonstrated that children with chronic kidney disease, when treated with ACEi within a clinical trial, show high adherence to the prescribed medication."

Journal • Chronic Kidney Disease • Genetic Disorders • Nephrology • Renal Disease

Renal Infarction in a Young Woman: A Diagnostic Window into Systemic Disease (KIDNEY WEEK 2025) - "She was anticoagulated with heparin, then transitioned to warfarin. Her proteinuria improved with a decrease in protein-to-creatinine ratio from 4.66 to 0.20 while on ramipril...Though she did not meet full Systemic Lupus erythematosus (SLE) criteria, hydroxychloroquine was initiated due to evolving features. Discussion This case highlights renal infarction as the initial presentation of antiphospholipid syndrome. Antiphospholipid syndrome and SLE should part of the differential diagnosis in a young woman with renal infarction."

Clinical • Genetic Disorders • Gynecology • Hematological Disorders • Immunology • Inflammatory Arthritis • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Renal Disease • Systemic Lupus Erythematosus

Unveiling novel bladder cancer associations from multicentred primary and secondary care electronic health records by machine learning: a case-control study. (PubMed, J Biomed Inform) - "The PanSPICE enables efficient high-dimensional EHR analysis, revealing under-recognised potential BC risk profiles and protective comorbidities. Gender-specific differences in BC associations highlight the importance of gender-stratified analyses, while computational advances provide a template for EHR-based clinical discovery. Findings warrant further mechanistic research into neurological protective pathways."

Journal • Alzheimer's Disease • Bladder Cancer • Cardiovascular • CNS Disorders • Dementia • Genito-urinary Cancer • Infectious Disease • Nephrology • Oncology • Solid Tumor

Drug-associated hypertensive crisis: a disproportionality analysis of the FAERS database. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "Ramipril (282 cases) and valsartan (192 cases) ranked as the second and third medications, respectively. The top 5 drugs associated with the risk of hypertensive crisis under the ROR algorithm were amlodipine perindopril (ROR = 136.64), methyl aminolevulinate (ROR = 122.78), tranylcypromine (ROR = 105.15), rifapentine (ROR = 39.46), and amiloride hydrochlorothiazide (ROR = 39.36)...Our study showed that numerous medications carry potential risks for drug-associated hypertensive crisis. Further investigation is required to establish causality and inform clinical decision-making."

Journal

High Adherence to Angiotensin-Converting Enzyme Inhibitor in Children with Alport Syndrome: Objective Verification Using Liquid Chromatography Mass Spectrometry (KIDNEY WEEK 2025) - "A LCMS based method was established and validated to simultaneously screen and quantify both ramipril and ramiprilat in urine samples...Donut graphs show the proportion of (A) the overall cohort of 107 measurements, including 13 negative controls (B) correctly identified negative controls (n=13, 100%). (C) adherence and non-adherence at both time points of the study (n=94; 98% adherence), (D) adherence and non-adherence at first adherence measurement (n=49; 98% adherence), (E) adherence and non-adherence at the second adherence measurement (n=45; 98% adherence)"

Adherence • Clinical • Chronic Kidney Disease • Genetic Disorders • Nephrology • Renal Disease

Effect of Pregnancy on Kidney Lifespan in Alport Nephropathy: Triple Therapy Offers Limited Protection (KIDNEY WEEK 2025) - "Methods Female Col4a3-deficient mice with established Alport nephropathy were randomized into four groups: 1) vehicle only (nil), 2) late treatment starting at 6 weeks of age, 3) early treatment starting at 3 weeks of age, and 4) early treatment with one pregnancy, all with food admixtures of ramipril (10 mg/kg), empagliflozin (30 mg/kg), and finerenone (10 mg/kg). These findings highlight the long-term benefits of triple therapy and the impact of pregnancy on diseased kidneys, underscoring the need for careful counseling of women with CKD. Figure"

Chronic Kidney Disease • Gynecology • Nephrology • Renal Disease

In Silico, In Vitro, and In Vivo Evaluation of Woodfordia Fruticosa for Cardio Protection against Doxorubicin-Induced Cardiomyopathy. (PubMed, Chem Biodivers) - "Molecular docking studies revealed that hecogenin, β-sitosterol, and pulmatin exhibited strong binding affinities against human protein kinase ZAK, with Dock scores of -12.07, -11.42, and -11.04, respectively, surpassing the standard drug ramipril (-9.32). fruticosa flower extract exhibited significant cardioprotective potential via the human protein kinase ZAK pathway against doxorubicin-induced cardiomyopathy through in silico, in vitro, and in vivo evaluations. These findings suggest W. fruticosa as a promising natural agent for cardiomyopathy management, warranting further studies to elucidate its mechanisms, optimize dosing, and validate long-term safety and efficacy."

Journal • Preclinical • Cardiomyopathy • Cardiovascular • Fibrosis • Immunology • TNNI3

Artificial Intelligence to Adjudicate Major Adverse Cardiovascular Events in Clinical Trials (AHA 2025) - "The estimated effect of sacubitril/valsartan vs ramipril on composite MACE was similar with Auto-MACE adjudication (HR 0.91 [95% CI 0.78-1.07]) and CEC adjudication (HR 0.90 [95% CI 0.77-1.05]).ConclusionAI-based adjudication of MACE showed high agreement with gold-standard CEC adjudication, especially for CV death and stroke, and for events in which the model was confident. A strategy of initial AI-based adjudication with human review of uncertain events may reduce adjudication workload while maintaining accuracy."

Adverse events • Clinical • Cardiovascular • Myocardial Infarction

DIAGNOSIS CONUNDRUM: MULTIPLE INTRACEREBRAL HAEMORRHAGES SECONDARY TO HYPERTENSION (WSC 2025) - "Blood pressure was managed with amlodipine, ramipril, and Bendroflumethiazide. The patient responded well to antihypertensive therapy and was discharged with restored baseline mobility and no new neurological deficits. Multifocal ICH in the context of uncontrolled hypertension presents significant diagnostic and therapeutic challenges. A comprehensive evaluation is essential to exclude other causes and confirm primary hypertension as the underlying aetiology."

Cardiovascular • Hypertension • Vasculitis

Efficacy and safety of Ambrisentan on idiopathic membranous nephropathy----a prospective, multi-center, randomized and controlled study (ChiCTR) - P=N/A | N=80 | Not yet recruiting | Sponsor: The Second Affiliated Hospital of Army Medical University; Army Medical University

New trial • Glomerulonephritis • Renal Disease

Glucagon-like peptide-1 agonists alleviate adenine-induced nephrotoxicity in rats: interaction with the renin-angiotensin system and role of NLRP-3 inflammasome, nephrin and KIM-1. (PubMed, Biochem Pharmacol) - "For validation, twenty-five male Wistar rats were divided as follows: normal, CKD, and CKD treated with ramipril, liraglutide, or both. Nevertheless, the combination of both treatments consistently showed superior effects to either treatment alone, supporting the possibility that GLP-1RA might affect more than one target in the RAS cascade. The present results warrant future investigation of the possible therapeutic effect of GLP-1RA in the context of CKD or CKD risk conditions associated with increased RAS activity."

Journal • Preclinical • Chronic Kidney Disease • Diabetes • Inflammation • Metabolic Disorders • Nephrology • Renal Disease • Type 2 Diabetes Mellitus • KIM1

A diagnostic and therapeutic odyssey in advanced HIV: disseminated tuberculosis with hematologic and renal involvement (EACS 2025) - "Antiretroviral therapy (tenofovir alafenamide/emtricitabine/bictegravir) and trimethoprim-sulfamethoxazole prophylaxis were initiated...Quadruple anti-TB therapy was started, and ART was adjusted to tenofovir disoproxil fumarate, emtricitabine, and twice-daily dolutegravir due to rifampicin interaction...ART was modified to lamivudine and double-dose dolutegravir; ramipril was added... This case underscores the high risk of disseminated TB and adverse outcomes in patients with late HIV diagnosis. Early screening and timely management are critical in high-burden settings such as Türkiye."

Metastases • Human Immunodeficiency Virus • Infectious Disease • Septic Shock • Tuberculosis • CD4

STEROID – RESISTANT NEPHROTIC SYNDROME AND FOCAL SEGMENTAL GLOMERULOSCLEROSIS: THE GREATEST HYPOCRITES (ESPN 2025) - "Supportive treatment with the ACE inhibitor ramipril was initiated as a diagnosis of type IV collagen-related nephropathy was established... This case highlights the diagnostic value of genetic testing in children with steroid-resistant nephrotic syndrome, even when renal biopsy is suggestive of FCGS. Diagnosis of AS based in genetic analysis test including new pathogenic variants, such as and COL4A3–c.1022G > A, (p.Arg341His), must be approached with critical thinking especially when phenotype is atypical. Although a genotypic relevance of nephrotic syndrome to AS is obvious, we strongly believe that our findings are not fully satisfactory to document "classic" AS."

Chronic Kidney Disease • Focal Segmental Glomerulosclerosis • Genetic Disorders • Glomerulonephritis • Nephrology • Renal Disease

RECALCITRANT IGA VASCULITIS NEPHRITIS REQUIRING COMBINATION OF IMMUNOSUPPRESSIVE AGENTS IN A 10-YEAR-OLD GIRL (ESPN 2025) - "A 10-day course of ampicillin was administered...The patient was subsequently treated with five pulses of methylprednisolone (1gr/1.73m2/24h), followed by two doses of cyclophosphamide within a 15-day interval...Disease control was achieved on combined treatment after 3 doses of rituximab (375mg/m2/dose). The patient was discharged after 9 weeks of hospitalization with proteinuria range of 20mg/m2/24h, without hematuria, on cyclosporine, ramipril and tapering steroid therapy... IgAV may be associated with difficult-to-treat nephropathy, requiring multiple immunosuppressive drugs to achieve disease control. Further reports are needed to identify optimal therapeutic strategies. In this patient the nephritogenic M2 serotype Streptococcus pyogenes as a potential trigger as well as the presence of C1q and C4d renal deposits may be associated with the disease progression."

IgA Nephropathy • Musculoskeletal Pain • Nephrology • Otorhinolaryngology • Renal Disease • Vasculitis

PRIMARY HYPEROXALURIA TYPE 3 AND SEVERE HYPERTENSION IN AN 11-YEAR-OLD GIRL (ESPN 2025) - "She was treated with Labetalol and Nicardipine infusions and later with Amlodipine and Ramipril, as well as Potassium Citrate, which are still given. This is the first report of severe hypertension in a child with PH3. Despite thorough workup, we found no cause of the hypertension other than kidney scars, caused by infections and obstruction related to nephrolithiasis, as a result of PH3."

Cardiovascular • Chronic Kidney Disease • Endocrine Disorders • Hypertension • Infectious Disease • Nephrology • Pediatrics • Renal Calculi • Renal Disease • Retinal Disorders • Solid Tumor

INCREASED ANTI-PROTEINURIC EFFECT OF LISINOPRIL VERSUS RAMIPRIL IN CHILDREN WITH CHRONIC KIDNEY DISEASE (ESPN 2025) - "Lisinopril should be preferred to Ramipril in patients with CKD on renoprotective treatment given its greater and longer lasting antiproteinuric effect, in particular if long-term follow up on lisinopril will confirm similar frequency and severity of adverse events."

Clinical • Alstrom Syndrome • Chronic Kidney Disease • Complement-mediated Rare Disorders • Focal Segmental Glomerulosclerosis • Genetic Disorders • Glomerulonephritis • Hepatology • IgA Nephropathy • Liver Failure • Nephrology • Polycystic Kidney Disease • Renal Disease

ASSESSMENT OF THE QUALITY OF LIFE IN PATIENTS WITH NON-ALCOHOLIC STEATOHEPATITIS IN COMBINATION WITH CORONARY HEART DISEASE WITH STABLE ANGINA PECTORIS AFTER TREATMENT WITH USING COMPLEX THERAPY (UEGW 2025) - "Aims & The aim: To evaluate the indicators of QoL in patients with non-alcoholic steatohepatitis with coronary heart disease with stable angina pectoris in combination after complex therapy including ezetimibe and ursodeoxycholic acid.Materials and The prospective study included 145 patients with a verified diagnosis of CHD with stable angina pectoris II functional class combined with nonalcoholic steatohepatitis (NASH) and 100 patients with CHD without NASH. All 245 patients received basic CHD therapy: acetylsalicylic acid 100 mg once a day, ramipril 2.5 mg once a day, bisoprolol 2.5 mg once a day, and rosuvastatin - 20 mg once a day... Complex therapy including ezetimibe and UDCA in patients with CHD combined with NASH is more effective compared to basic CHD therapy, as it reliably reduces the frequency of attacks of stable angina and the need for nitroglycerin. The effectiveness of the treatment of CHD combined with NASH is increased by the inclusion of..."

Clinical • Combination therapy • HEOR • Cardiovascular • Coronary Artery Disease • Dyslipidemia • Genetic Disorders • Heart Failure • Hepatology • Metabolic Dysfunction-Associated Steatohepatitis • Obesity • Pulmonary Arterial Hypertension

Venoarterial Extracorporeal Life Support in Circulatory Shock Secondary to Severe Vasoplegia from Ramipril Overdose. (PubMed, Ann Card Anaesth) - "This represents a novel mechanism of treatment. Further, the pharmacology of ACEI overdose is reviewed in the context of treatment with venoarterial extracorporeal life support."

Journal

Comparative protective effects of rosuvastatin and ramipril against doxorubicin-induced testicular toxicity in rats: A multimodal evaluation of oxidative stress and reproductive parameters. (PubMed, Vet World) - "These findings highlight its potential as a fertility-protective agent during chemotherapy. Further long-term and mechanistic studies are warranted."

Journal • Preclinical

Pilot study on the effects of dapagliflozin on echocardiographic parameters in dogs with symptomatic myxomatous mitral valve disease. (PubMed, Vet Anim Sci) - "In a prospective, randomized, single-blind study, five dogs with stage C MMVD received dapagliflozin (0.31 mg/kg, PO, q24h) alongside pimobendan, furosemide, and ramipril. These findings suggest that dapagliflozin, when added to conventional therapy, may promote reverse remodeling and improve cardiac function in dogs with stage C MMVD. Further studies with larger sample sizes and longer follow-up are warranted to validate the cardioprotective effects of dapagliflozin in veterinary patients."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure