doripenem / Generic mfg. - LARVOL DELTA

Exploring the evolution of multidrug resistance patterns in ESKAPEE pathogens using association mining: Key to antibiotic stewardship? (PubMed, Wellcome Open Res) - "Time trend analysis revealed a decline in meropenem and piperacillin-tazobactam resistance to Enterococcus faecium and doripenem for Pseudomonas aeruginosa, while resistance to imipenem ( Klebsiella pneumoniae, Acinetobacter baumannii, and Enterobacter species) and meropenem ( Staphylococcus aureus, A. baumannii, and Enterobacter species) increased. Association rule mining identified sMDR patterns, such as meropenem and levofloxacin resistance, in S. aureus, K. pneumoniae, P. aeruginosa and A. baumannii. Thus, our findings from the data challenge represents hypothesis driven patterns intended to promote further investigation and clinical validation which potentially supports antibiotic stewardship efforts."

Journal • Gene Therapies • Infectious Disease • Pneumonia

Carbapenem-Associated Hepatitis and Hepatic Failure: A FDA Adverse Event Reporting System (FAERS) Pharmacovigilance Analysis (ACG 2026) - "Future investigations should aim to confirm causality and elucidate the underlying pathophysiology, while also evaluating combination drugs like meropenem-vaborbactam. ADRs for both hepatitis and hepatic failure were analyzed. Doripenem had no relevant ADRs and was excluded from the data analysis. Meropenem, imipenem, and ertapenem all showed statistically significant RORs with hepatitis and hepatic failure."

Adverse events • Hepatology • Infectious Disease • Inflammation • Liver Failure

Impact of pathophysiologically relevant underlying disease burden on pathogen distribution and antimicrobial resistance in patients with device-associated urinary tract infections. (PubMed, Front Cell Infect Microbiol) - "Antimicrobial resistance analysis revealed a significant correlation between underlying disease burden and the resistance of Escherichia coli to fluoroquinolones: Group C had a significantly increased risk of ciprofloxacin resistance (P = 0.009), while Group B had a higher resistance risk to levofloxacin (P = 0.018) and norfloxacin (P = 0.019). For Klebsiella pneumoniae, the resistance risks to cefotetan (P = 0.029), doripenem (P = 0.036), and amikacin (P = 0.026) were significantly elevated in Group B. Carbapenems, aminoglycosides, and polymyxins maintained high susceptibility across all groups...Routine use of fluoroquinolones should be avoided in such high-risk patients for clinical empirical therapy. The initial treatment regimen should be optimized and etiological testing should be strengthened based on local antimicrobial resistance surveillance data and the patient's comorbidity status."

Journal • Retrospective data • Critical care • Diabetes • Infectious Disease • Metabolic Disorders • Nephrology • Pneumonia • Renal Disease • Urolithiasis • Urology

Polymersome-Enabled Multimodal Delivery of Tobramycin and Doripenem for Targeted Eradication of Pseudomonas aeruginosa Biofilms in Chronic Rhinosinusitis. (PubMed, Small) - "Notably, co-dosing with pH-responsive polymersomes and DOR-loaded inert polymersomes resulted in the most effective biofilm eradication. Overall, the results demonstrate that the pH-responsive polymersome carrier contributes substantially to antibiofilm activity, while sustained DOR delivery may further enhance therapeutic efficacy against biofilm-associated infections."

Journal • Infectious Disease • Otorhinolaryngology • Respiratory Diseases • Sinusitis

Sustainable adsorption-photodegradation of doripenem using MIL-100(Fe)@TiO2 metal-organic framework composite. (PubMed, Environ Sci Pollut Res Int) - "Five-cycle reusability tests showed higher stability of MIL-100(Fe)@TiO2 (efficiency decreased from ~ 95 to 88%), compared to pure MIL-100(Fe) (~ 84 to 70%). These results confirmed that the MIL-100(Fe)@TiO2 composite has the potential to serve as a sustainable, multifunctional material for the remediation of pharmaceutical waste containing antibiotics."

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Stepwise within-host evolution of a blaCTX-M-27-positive Klebsiella pneumoniae clone under changing antimicrobial pressures leading to enhancement of β-lactam resistance. (PubMed, Int J Antimicrob Agents) - "We reveal stepwise within-host evolution of a K. pneumoniae clone enabling its survival under changing antimicrobial pressures."

Journal • Hematological Malignancies • Infectious Disease • Leukemia • Oncology • Pneumonia

Antimicrobial Resistant Bacteria among Community Deaths in Children Aged <5 Years in the Child Health and Mortality Prevention Services (CHAMPS) Network (PAS 2026) - "We examined 509 CHAMPS deaths that underwent AST for priority pathogens; 364 (71.5%) occurred in a healthcare facility and 145 (28.5%) occurred in the community. The median age at death was 294 days (interquartile range 97-631 days) and 54.8% were male (Table 1). Of community deaths, 25.5% had AMR to a priority pathogen compared to 73.6% of healthcare facility deaths (P < 0.001)."

Clinical • Infectious Disease • Pneumonia

A multi-stage computational pipeline for repurposing FDA-approved drugs: application to EGFR C797S-mutant NSCLC. (PubMed, Front Chem) - "Among the evaluated compounds, doripenem, norgestrel, oxymetholone, norethisterone, and ertapenem exhibited high docking scores and consistent interactions with crucial hinge-region residues, such as MET-793 and mutant SER-797, within the ATP-binding site. These findings suggest that ertapenem and oxymetholone are promising structurally unique scaffolds for targeting osimertinib-resistant EGFR C797S-driven NSCLC. While experimental validation is necessary, this study provides a computational framework for swift drug repurposing and lays a rational foundation for future biochemical evaluation and structure-guided optimization of next-generation EGFR inhibitors."

FDA event • Journal • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • EGFR

Quinolone Resistance and Virulence Genes Prevalence of Uropathogenic Escherichia coli Isolated from Kidney Transplant Recipients with Urinary Tract Infections in Tehran, Iran. (PubMed, Res Rep Urol) - "The resistance rates for the following antibiotics were as follows: ampicillin (94%), amoxicillin-clavulanate (54%), ampicillin-sulbactam (64%), piperacillin-tazobactam (54%), cefazolin (88%), cefepime (70%), cefotaxime (80%), cefoxitin (48%), cefpodoxime (80%), doripenem (16%), ertapenem (20%), meropenem (72%), imipenem (18%), gentamicin (34%), tobramycin (44%), amikacin (28%), ciprofloxacin (62%), trimethoprim/sulfamethoxazole (70%), nitrofurantoin (20%), and fosfomycin (86%). The rising resistance rates to ciprofloxacin, combined with the higher prevalence of a specific virulence gene in E. coli isolates from kidney transplant recipients with UTIs, underscore the need for phenotypic and molecular antimicrobial susceptibility testing. Additionally, analyzing virulence genes is crucial for developing effective treatment strategies and preventing E. coli infections in UTI patients."

Journal • Chronic Kidney Disease • Infectious Disease • Nephrology • Renal Disease • Transplantation

Adsorption of doripenem and meropenem antibiotics on activated carbon derived from snake fruit seeds: single-compound and binary mechanism via experiments and modelling. (PubMed, Sci Rep) - "Comparatively, it was demonstrated that our adsorbent is an efficient material for various pharmaceuticals removal. In summary, the activated carbon indicated promising performance to remove various pharmaceuticals including MER and DOR."

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A pharmacovigilance analysis of carbapenem-related utilizing the FDA adverse event reporting system (FAERS) database from 2013 to 2025. (PubMed, J Antimicrob Chemother) - "Significant differences exist in haematologic safety profiles among carbapenems. Meropenem shows the broadest spectrum of severe toxicity, while other carbapenems demonstrate fewer reports. demonstrates fewer reported haematologic safety signals and not a most favourable haematologic safety profile. These differential safety profiles should inform further studies on carbapenem selection, including patients with baseline haematologic disorders."

Adverse events • Journal • Agranulocytosis • Aplastic Anemia • Eosinophilia • Granulocytopenia • Hematological Disorders • Infectious Disease • Leukopenia • Neutropenia • Thrombocytopenia • Thrombocytosis

Association between antimicrobial use and the detection rates of carbapenem-resistant Enterobacterales: long-term surveillance results from a single centre. (PubMed, Infect Prev Pract) - "Overall, AUD and DOT increased, notably for piperacillin/tazobactam (TZP), cefmetazole, ceftriaxone (CRO) and cefepime. Conversely, AUD and DOT for flomoxef, cefoperazone/sulbactam, cefozopran, ciprofloxacin, levofloxacin, doripenem, aztreonam and fosfomycin decreased. AUD of meropenem (MEM) increased, but its overall proportion decreased...Carbapenemase-producing carbapenem-non-susceptible Enterobacterales (CP-CNSE) detection was associated with TZP usage, and non-carbapenemase-producing (NCP)-CNSE detection correlated with overall AUD, TZP, and CRO use. Reducing TZP and cephalosporin usage, in addition to carbapenems, is crucial for preventing resistant strains."

Journal • Infectious Disease

Retrospective Analysis of Carbapenem Antibiotic Use Expenditures and Market Patterns in Medicaid (1991-2023) (ISPOR-EU 2025) - "This study evaluated longitudinal patterns in carbapenem use, market dynamics, and economic impact within the U.S. Medicaid program from 1991 to 2023.We conducted a retrospective analysis using publicly available Medicaid State Drug Utilization data, focusing on four carbapenems: Imipenem/Cilastatin, Meropenem, Ertapenem, and Doripenem. This study highlights evolving patterns in carbapenem prescribing, influenced by clinical practices, stewardship, and policy interventions. Continued surveillance is essential to balance appropriate antibiotic use with resistance prevention and cost control. Further research should assess the long-term impact of stewardship and the role of new therapies in guiding future trends."

Medicaid • Reimbursement • Retrospective data • US reimbursement • Infectious Disease

Development of two methods for detecting Streptococcus mitis/oralis-related species with meropenem-non-susceptibility. (PubMed, J Infect Chemother) - "Media containing 2 μg/mL oxacillin, 4-16 μg/mL cefoxitin, 2 μg/mL cefdinir, 2-4 μg/mL flomoxef, 0.06-0.25 μg/mL meropenem, and 0.06-0.12 μg/mL doripenem allowed selective culture of meropenem-non-susceptible S. mitis/oralis group strains. The disk-diffusion method using six β-lactam-containing disks and selective culture agar medium are the first-reported simple and accurate methods of detecting meropenem-non-susceptible S. mitis/oralis group suitable for use in clinical microbiology laboratories."

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Salivary gland tissue chip screening identifies candidate radioprotective drugs. (PubMed, Commun Med (Lond)) - "This body of work demonstrates the development and validation of assays using a tissue chip platform for high-content drug screening and the successful discovery and in vivo validation of candidate radioprotective drugs with non-antioxidant primary modes of action. These results point to possible unknown mechanisms of radioprotection. These drugs can be developed to improve radioprotection efficacy and clinical administration without adverse side-effects."

Journal • Dental Disorders • Head and Neck Cancer • Infectious Disease • Oncology • Solid Tumor • Xerostomia

Clinical Pharmacological Research Aiming to Optimize Therapeutic Strategies in Specific Populations (PubMed, Yakugaku Zasshi) - "In our study of patients admitted to intensive care unit (ICU), the pharmacokinetic parameters of doripenem differed from those in non-ICU patients, with higher pharmacokinetic/pharmacodynamic breakpoints in ICU patients...In patients with hematological malignancies, inflammatory markers such as C-reactive protein (CRP) significantly affected the intra-individual pharmacokinetic variability of voriconazole, highlighting the need for dose titration according to CRP levels. Furthermore, febrile neutropenia (FN) significantly increased vancomycin clearance in children, requiring higher daily doses than in children without FN. In contrast, augmented renal clearance, but not FN, significantly affected teicoplanin clearance in adults...These findings underscore the importance of personalized pharmacokinetic assessments to improve individualized therapeutic strategies in specific populations, and to aim for optimizing efficacy while minimizing adverse effects. Future research..."

Journal • Review • Critical care • Febrile Neutropenia • Hematological Disorders • Hematological Malignancies • Neutropenia • Oncology • Pediatrics • CRP

A hospital-based epidemiological study of the genes coding for carbapenemase production among carbapenem resistant Acinetobacter isolates in India. (PubMed, Indian J Med Microbiol) - "The major carbapenemase genetic determinants circulating especially in the hospital intensive care unit during the period of the study were blaNDM, blaOXA-23 like, blaOXA-51 like and blaVIM."

Journal • Critical care

Phenotypic and genotypic profiles of clinical isolates of various Nocardia species to carbapenems and fluoroquinolones. (PubMed, J Antimicrob Chemother) - "Nocardia spp. exhibited varying patterns of susceptibility to carbapenems and fluoroquinolones respectively. Importantly, different Nocardia spp. exhibited different patterns of susceptibility to carbapenems and fluoroquinolones, respectively."

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Detection and Genomic Characteristics of NDM-19- and QnrS11-Producing O101:H5 Escherichia coli Strain Phylogroup A: ST167 from a Poultry Farm in Egypt. (PubMed, Microorganisms) - "M2-13-1 is classified under ST167, serotype O101:H5, phylogroup A, and shows an MDR phenotype, having minimum inhibitory concentrations (MICs) of 64 mg/L for both meropenem and doripenem...M2-13-1 harbors genes that impart resistance to sulfonamides (sul1), trimethoprim (dfrA14), β-lactams (blaTEM-1B), aminoglycosides (aph(6)-Id, aph(3')-Ia, aph(3″)-Ib, aac(3)-IV, and aph(4)-Ia), tetracycline (tet(A)), and chloramphenicol (floR). It was susceptible to aztreonam, colistin, fosfomycin, and tigecycline...Plasmids of the IncX3 group and the insertion sequence (ISAba125) are critical vehicles for the dissemination of blaNDM and its related variants. To our knowledge, this is the first genomic report of a blaNDM-19/IncX3-carrying E. coli isolate of animal origin globally."

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Trends in carbapenem antibiotics utilization, costs, and market dynamics in Medicaid: a retrospective analysis from 1991 to 2023. (PubMed, Front Med (Lausanne)) - "Four carbapenems; imipenem/cilastatin, meropenem, ertapenem, and doripenem were examined. Continuous monitoring of antibiotic use is essential to balance effective infection management with the containment of antimicrobial resistance and healthcare costs. Further research is needed to evaluate the long-term effects of stewardship programs and the introduction of novel therapeutic options on carbapenem utilization."

Journal • Reimbursement • Retrospective data • US reimbursement • Infectious Disease • Novel Coronavirus Disease

Marine outfall discharges contribute to coastal microplastic pollution and the spread of antimicrobial resistance. (PubMed, PLoS One) - "Several isolates were resistant to the last resort of antibiotics, (doripenem and imipenem; 9% to 27%) and some of these isolates were resistant to up to ten of the antibiotics...Bacterial infections caused by Carbapenem-resistant Enterobacteriaceae have become a global concern in the fight against bacterial infections. Our findings highlight the need for more data to challenge existing marine outfall policies and the outdated notion stating that dilution alone can solve pollution problems."

Journal • Infectious Disease

Specific variants in ftsI reduce carbapenem susceptibility in Pseudomonas aeruginosa. (PubMed, Microbiol Spectr) - "By contrast, the introduction of penicillin-binding (PB) domain mutations (Met460Thr, Val471Gly, Arg504Cys, Pro527Thr, Pro527Ser, Phe533Leu, or Val537Leu) reduced the susceptibility to meropenem and doripenem by two- to eightfold in MIC. Arg504Cys, the most common mutation encountered clinically, reduced susceptibility to cefepime by fourfold. Growth parameter analysis revealed that, conversely, these PB domain mutations generally increase the susceptibility to cefiderocol and piperacillin...This key finding will facilitate the development of therapeutic options for carbapenem-resistant P. aeruginosa-associated infections. Furthermore, this study contributes to the development of a reliable database collating resistance-associated point mutations, which would aid the interpretation of genomic data on P. aeruginosa clinical isolates."

Journal • Infectious Disease

Carbapenem-resistant Enterobacterales among patients with bloodstream infections in South Africa: Consolidated surveillance data, 2015-2021. (PubMed, PLoS One) - "Periodic surveillance for CRE should be performed on regular basis to support infection prevention and stewardship program at each facility."

Journal • Infectious Disease • Pneumonia

Stability of four carbapenem antibiotics in discs used for antimicrobial susceptibility testing. (PubMed, J Appl Microbiol) - "Imipenem in discs for AST showed to be the most stable carbapenem under unfavourable conditions."

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Description of Two Resistance-Nodulation-Cell Division Efflux Systems Involved in Acquired Antibiotic Resistance: AxySUV in Achromobacter xylosoxidans and AinCDJ in Achromobacter insuavis. (PubMed, Antibiotics (Basel)) - "This study demonstrated that AinCDJ overproduction is involved in the acquired resistance of A. insuavis to cefepime, meropenem, doripenem, fluoroquinolones, minocycline, doxycycline, tigecycline, and chloramphenicol and that AxySUV overproduction is involved in the acquired resistance of A. xylosoxidans to meropenem, fluoroquinolones, minocycline, doxycycline, and chloramphenicol."

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