doripenem / Generic mfg. - LARVOL DELTA

Retrospective Analysis of Carbapenem Antibiotic Use Expenditures and Market Patterns in Medicaid (1991-2023) (ISPOR-EU 2025) - "This study evaluated longitudinal patterns in carbapenem use, market dynamics, and economic impact within the U.S. Medicaid program from 1991 to 2023.We conducted a retrospective analysis using publicly available Medicaid State Drug Utilization data, focusing on four carbapenems: Imipenem/Cilastatin, Meropenem, Ertapenem, and Doripenem. This study highlights evolving patterns in carbapenem prescribing, influenced by clinical practices, stewardship, and policy interventions. Continued surveillance is essential to balance appropriate antibiotic use with resistance prevention and cost control. Further research should assess the long-term impact of stewardship and the role of new therapies in guiding future trends."

Medicaid • Reimbursement • Retrospective data • US reimbursement • Infectious Disease

Development of two methods for detecting Streptococcus mitis/oralis-related species with meropenem-non-susceptibility. (PubMed, J Infect Chemother) - "Media containing 2 μg/mL oxacillin, 4-16 μg/mL cefoxitin, 2 μg/mL cefdinir, 2-4 μg/mL flomoxef, 0.06-0.25 μg/mL meropenem, and 0.06-0.12 μg/mL doripenem allowed selective culture of meropenem-non-susceptible S. mitis/oralis group strains. The disk-diffusion method using six β-lactam-containing disks and selective culture agar medium are the first-reported simple and accurate methods of detecting meropenem-non-susceptible S. mitis/oralis group suitable for use in clinical microbiology laboratories."

Journal

Salivary gland tissue chip screening identifies candidate radioprotective drugs. (PubMed, Commun Med (Lond)) - "This body of work demonstrates the development and validation of assays using a tissue chip platform for high-content drug screening and the successful discovery and in vivo validation of candidate radioprotective drugs with non-antioxidant primary modes of action. These results point to possible unknown mechanisms of radioprotection. These drugs can be developed to improve radioprotection efficacy and clinical administration without adverse side-effects."

Journal • Dental Disorders • Head and Neck Cancer • Infectious Disease • Oncology • Solid Tumor • Xerostomia

Clinical Pharmacological Research Aiming to Optimize Therapeutic Strategies in Specific Populations (PubMed, Yakugaku Zasshi) - "In our study of patients admitted to intensive care unit (ICU), the pharmacokinetic parameters of doripenem differed from those in non-ICU patients, with higher pharmacokinetic/pharmacodynamic breakpoints in ICU patients...In patients with hematological malignancies, inflammatory markers such as C-reactive protein (CRP) significantly affected the intra-individual pharmacokinetic variability of voriconazole, highlighting the need for dose titration according to CRP levels. Furthermore, febrile neutropenia (FN) significantly increased vancomycin clearance in children, requiring higher daily doses than in children without FN. In contrast, augmented renal clearance, but not FN, significantly affected teicoplanin clearance in adults...These findings underscore the importance of personalized pharmacokinetic assessments to improve individualized therapeutic strategies in specific populations, and to aim for optimizing efficacy while minimizing adverse effects. Future research..."

Journal • Review • Critical care • Febrile Neutropenia • Hematological Disorders • Hematological Malignancies • Neutropenia • Oncology • Pediatrics • CRP

A hospital-based epidemiological study of the genes coding for carbapenemase production among carbapenem resistant Acinetobacter isolates in India. (PubMed, Indian J Med Microbiol) - "The major carbapenemase genetic determinants circulating especially in the hospital intensive care unit during the period of the study were blaNDM, blaOXA-23 like, blaOXA-51 like and blaVIM."

Journal • Critical care

Phenotypic and genotypic profiles of clinical isolates of various Nocardia species to carbapenems and fluoroquinolones. (PubMed, J Antimicrob Chemother) - "Nocardia spp. exhibited varying patterns of susceptibility to carbapenems and fluoroquinolones respectively. Importantly, different Nocardia spp. exhibited different patterns of susceptibility to carbapenems and fluoroquinolones, respectively."

Journal

Detection and Genomic Characteristics of NDM-19- and QnrS11-Producing O101:H5 Escherichia coli Strain Phylogroup A: ST167 from a Poultry Farm in Egypt. (PubMed, Microorganisms) - "M2-13-1 is classified under ST167, serotype O101:H5, phylogroup A, and shows an MDR phenotype, having minimum inhibitory concentrations (MICs) of 64 mg/L for both meropenem and doripenem...M2-13-1 harbors genes that impart resistance to sulfonamides (sul1), trimethoprim (dfrA14), β-lactams (blaTEM-1B), aminoglycosides (aph(6)-Id, aph(3')-Ia, aph(3″)-Ib, aac(3)-IV, and aph(4)-Ia), tetracycline (tet(A)), and chloramphenicol (floR). It was susceptible to aztreonam, colistin, fosfomycin, and tigecycline...Plasmids of the IncX3 group and the insertion sequence (ISAba125) are critical vehicles for the dissemination of blaNDM and its related variants. To our knowledge, this is the first genomic report of a blaNDM-19/IncX3-carrying E. coli isolate of animal origin globally."

Journal

Trends in carbapenem antibiotics utilization, costs, and market dynamics in Medicaid: a retrospective analysis from 1991 to 2023. (PubMed, Front Med (Lausanne)) - "Four carbapenems; imipenem/cilastatin, meropenem, ertapenem, and doripenem were examined. Continuous monitoring of antibiotic use is essential to balance effective infection management with the containment of antimicrobial resistance and healthcare costs. Further research is needed to evaluate the long-term effects of stewardship programs and the introduction of novel therapeutic options on carbapenem utilization."

Journal • Reimbursement • Retrospective data • US reimbursement • Infectious Disease • Novel Coronavirus Disease

Marine outfall discharges contribute to coastal microplastic pollution and the spread of antimicrobial resistance. (PubMed, PLoS One) - "Several isolates were resistant to the last resort of antibiotics, (doripenem and imipenem; 9% to 27%) and some of these isolates were resistant to up to ten of the antibiotics...Bacterial infections caused by Carbapenem-resistant Enterobacteriaceae have become a global concern in the fight against bacterial infections. Our findings highlight the need for more data to challenge existing marine outfall policies and the outdated notion stating that dilution alone can solve pollution problems."

Journal • Infectious Disease

Specific variants in ftsI reduce carbapenem susceptibility in Pseudomonas aeruginosa. (PubMed, Microbiol Spectr) - "By contrast, the introduction of penicillin-binding (PB) domain mutations (Met460Thr, Val471Gly, Arg504Cys, Pro527Thr, Pro527Ser, Phe533Leu, or Val537Leu) reduced the susceptibility to meropenem and doripenem by two- to eightfold in MIC. Arg504Cys, the most common mutation encountered clinically, reduced susceptibility to cefepime by fourfold. Growth parameter analysis revealed that, conversely, these PB domain mutations generally increase the susceptibility to cefiderocol and piperacillin...This key finding will facilitate the development of therapeutic options for carbapenem-resistant P. aeruginosa-associated infections. Furthermore, this study contributes to the development of a reliable database collating resistance-associated point mutations, which would aid the interpretation of genomic data on P. aeruginosa clinical isolates."

Journal • Infectious Disease

Carbapenem-resistant Enterobacterales among patients with bloodstream infections in South Africa: Consolidated surveillance data, 2015-2021. (PubMed, PLoS One) - "Periodic surveillance for CRE should be performed on regular basis to support infection prevention and stewardship program at each facility."

Journal • Infectious Disease • Pneumonia

Stability of four carbapenem antibiotics in discs used for antimicrobial susceptibility testing. (PubMed, J Appl Microbiol) - "Imipenem in discs for AST showed to be the most stable carbapenem under unfavourable conditions."

Journal

Description of Two Resistance-Nodulation-Cell Division Efflux Systems Involved in Acquired Antibiotic Resistance: AxySUV in Achromobacter xylosoxidans and AinCDJ in Achromobacter insuavis. (PubMed, Antibiotics (Basel)) - "This study demonstrated that AinCDJ overproduction is involved in the acquired resistance of A. insuavis to cefepime, meropenem, doripenem, fluoroquinolones, minocycline, doxycycline, tigecycline, and chloramphenicol and that AxySUV overproduction is involved in the acquired resistance of A. xylosoxidans to meropenem, fluoroquinolones, minocycline, doxycycline, and chloramphenicol."

Journal

Differing Rates of Carbapenem Resistance in Gram-Negative Bacteria Within Lower and Higher Socioeconomic Classes in Eastern India. (PubMed, Cureus) - "GNCB exhibited lower resistance, with six (14.3%) resistant to imipenem, eight (19.0%) to meropenem, and seven (16.7%) to doripenem. Both groups showed similar levels of resistance, highlighting that antibiotic misuse, overprescription, and inadequate stewardship are pervasive issues transcending economic boundaries. The study emphasizes the need for enhanced healthcare provider training, public education on antibiotic misuse, and policy interventions to improve sanitation and waste management. Effective antibiotic stewardship and public health measures are crucial for combating resistance and ensuring equitable health outcomes."

Journal • Infectious Disease • Pneumonia

Phage-antibiotic synergy to combat multidrug resistant strains of Gram-negative ESKAPE pathogens. (PubMed, Sci Rep) - "PAS analysis showed that the combination of ciprofloxacin (CIP) and levofloxacin (LEV) with PAW33 resulted in the synergistic eradication of all tested P. aeruginosa strains. Similarly, the combined use of doripenem (DOR) and LEV with KPW17 resulted in the synergistic eradication of the environmental and clinical K. pneumoniae strains, while the combined use of DOR and gentamicin (CN) with ECSR5 was synergistic against the clinical E. cloacae NCTC 13406. Gentamicin with ECSR5, however, only exhibited an additive effect for E. cloacae 4L, while ABTW1 with piperacillin-tazobactam (TZP) and imipenem (IPM) resulted in an indifferent interaction between the bacteriophage and tested antibiotics against the clinical A. baumannii AB3, i.e., the activity of the combination is equal to the activity of most active agent. Thus, while the observed PAS may offer an opportunity for the re-introduction or more efficient application of certain antibiotics to..."

Journal • Infectious Disease • Pneumonia

Antimicrobial susceptibility surveillance of bacterial isolates recovered in Japan from odontogenic infections in 2018. (PubMed, J Infect Chemother) - "The findings of the present study indicate that the resistance to the combination of penicillins and β-lactamase inhibitors, the first-line antimicrobial agents for odontogenic infections and oral infections caused by anaerobic flora, are low."

Journal • Dental Disorders • Infectious Disease • Inflammation • Periodontitis

Phenotypic and genotypic characterization of carbapenemase-producing Escherichia coli clinical isolates in Thi-Qar, Iraq. (PubMed, Iran J Microbiol) - "No bla KPC, bla NMC, bla IMI, bla GES, bla SPM, bla GIM, or bla SIM was detected. The high prevalence of carbapenem resistance and the corresponding encoding genes in E. coli in Thi-Qar province pose a concerning challenge for managing serious infections caused by this pathogen."

Journal • Infectious Disease

Phenotypic and genotypic characterization of carbapenemase-producing Escherichia coli clinical isolates in Thi-Qar, Iraq. (PubMed, Iran J Microbiol) - "No bla KPC, bla NMC, bla IMI, bla GES, bla SPM, bla GIM, or bla SIM was detected. The high prevalence of carbapenem resistance and the corresponding encoding genes in E. coli in Thi-Qar province pose a concerning challenge for managing serious infections caused by this pathogen."

Journal • Infectious Disease

Evolution of carbapenemase activity in the class C β-lactamase ADC-1. (PubMed, mBio) - "In this study, we selected a triple mutant of the intrinsic class C Acinetobacter-derived cephalosporinase ADC-1 (ADC-1TM) that confers high-level resistance to the carbapenems meropenem, ertapenem, and doripenem. Here, we demonstrate that the intrinsic ADC-1 β-lactamase of the clinically important pathogen Acinetobacter baumannii can evolve high-level resistance to carbapenems by just three amino acid substitutions and disclose the molecular mechanisms of its carbapenemase activity. This study demonstrates the potential for the evolution of carbapenemase activity in class C β-lactamases."

Journal • Infectious Disease

Clinical burden of Acinetobacter baumannii, including carbapenem-resistant A. baumannii, in hospitalized adult patients in the USA between 2018 and 2022. (PubMed, BMC Infect Dis) - "Presence of A. baumannii was identified on a clinical culture in 1% of adult hospitalizations in this multicenter US study. Over a third of A. baumannii hospitalization encounters were CRAB, with the highest incidence rates per 100 hospitalization encounters observed in the most central US regions. Clinicians should consider A. baumannii as a potential pathogen in patients in regions with an increasing incidence rate of A. baumannii."

Journal • Retrospective data • Infectious Disease

Evaluation of Biofilm Production and Antibiotic Resistance/Susceptibility Profiles of Pseudomonas spp. Isolated from Milk and Dairy Products. (PubMed, Foods) - "All strains were susceptible to amikacin and tobramycin; however, 73% of the strains were resistant to aztreonam, 28% to imipenem and doripenem, 19% to ceftazidime, 13% to meropenem, and 7% to cefepime. These findings highlight Pseudomonas spp. as persistent contaminants and antibiotic resistance reservoirs in dairy environments and products, posing public health risks and economic implications for the dairy industry."

Journal

Enhancing colistin efficacy with combination therapies for multidrug-resistant P. aeruginosa and A. baumannii isolates. (PubMed, Future Microbiol) - "This study evaluated the in vitro efficacy of colistin in combination with doxycycline, doripenem, and rifampicin against multidrug-resistant clinical isolates of P. aeruginosa (n = 23) and A. baumannii (n = 26). TKCs also confirmed the bactericidal activities of combinations that achieved ≥3-log10 reductions in initial bacterial counts. Colistin-based combination therapies, especially colistin-doripenem, may be promising approaches for combating multidrug-resistant pathogens while potentially reducing nephrotoxicity risk."

Journal

Evaluating the Efficacy of Doripenem against Staphylococcus aureus in Vancomycin-Resistant Strains. (PubMed, Microb Pathog) - "Additionally, the antimicrobial activity of doripenem, both alone and in combination with amoxiclav against VRSA showed consistent biofilm inhibition within 48 and 24 hours, respectively. Furthermore, these results demonstrate that doripenem maintains its high efficacy against VRSA and the combination of amoxiclav with doripenem presents a potential option for managing these resistant infections."

Journal • Infectious Disease

Impact of hospital formulary intervention on carbapenem use: a segmented time-series analysis of consumption and a propensity score-matched non-inferiority study of treatment efficacy. (PubMed, J Pharm Health Care Sci) - "The introduction of an antibiotic formulary at Yokohama City University Hospital effectively reduced the use of doripenem without compromising the effectiveness of treatment of intra-abdominal infections. These findings suggest that formulary management can be a valuable strategy for optimizing antibiotic use while maintaining clinical outcomes and contributing to improved antimicrobial stewardship in healthcare settings. Further research is warranted to explore the broader implications of formulary implementation in Japanese healthcare practices."

Head-to-Head • Journal • Infectious Disease • Oncology

Leaky Gut Syndrome Along With Clostridium perfringens Bacteremia in a Neurodegenerative Disease Patient: A Case Report. (PubMed, Cureus) - "Treatment was initiated with doripenem (DRPM) for sepsis of unknown focus...We speculate that the LGS in this case may have developed from dopaminergic neuronal decrease and impaired amino acid metabolism caused by chronic hypo-inflammation due to neurodegenerative disease (Alzheimer's disease). We report the first known case of LGS along with C. perfringens bacteremia in a neurodegenerative disease patient."

Journal • Alzheimer's Disease • CNS Disorders • Colorectal Cancer • Constipation • Diabetes • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Metabolic Disorders • Psychiatry • Septic Shock • CRP