Budenofalk granules (budesonide gastro-resistant granules) / Dr Falk - LARVOL DELTA

Effect of Yanghe Pingchuan granules combined with inhaled western medication on clinical efficacy and serum inflammatory cytokine levels in patients with kidney deficiency and phlegm-turbid-type COPD in the stable phase. (PubMed, Medicine (Baltimore)) - "After the treatment, the TCM syndrome score, pulmonary functions (FEV1, FVC, FEV1/FVC, 6MWT), CAT score, and changes in serum inflammatory cytokines (IL-6, IL-10, IL-17, LTB4) levels in the 2 groups decreased compared with those before treatment (P < .01), and all of the above indexes, except the pulmonary function FEV1/FVC ratio, in the combined group were better than those in the control group (P < .05). Yanghe Pingchuan granules combined with inhaled Western medication has better clinical efficacy than single inhaled Western medication in patients with kidney deficiency and phlegm-turbid-type COPD in the stable phase, by significantly improving clinical symptoms, enhancing the pulmonary functions, and reducing the inflammation level."

Journal • Retrospective data • Chronic Obstructive Pulmonary Disease • Immunology • Inflammation • Pulmonary Disease • Respiratory Diseases • IL10 • IL17A • IL6

Analysis of the effects of azithromycin combined with budesonide and children's Chaiqiao Qingre granules on the efficacy and improvement of clinical symptoms of mycoplasma pneumonia in children. (PubMed, Medicine (Baltimore)) - "There was no significant difference in the incidence of adverse reactions between the 2 groups of children (P > .05). Azithromycin combined with budesonide and children's Chaiqiao Qingre granules can effectively improve the clinical symptoms of children with mycoplasma pneumonia, enhance immune function, improve pulmonary function, reduce inflammatory response, and reduce the incidence of adverse reactions, which is worthy of clinical promotion and application."

Journal • Retrospective data • Cough • Infectious Disease • Inflammation • Pediatrics • Pneumonia • Respiratory Diseases • CRP

Novel desensitization therapy of mesalamine intolerance in patients with ulcerative colitis. (PubMed, Gastroenterol Hepatol) - "This retrospective study reports a successful and safe desensitization method for UC patients with mesalamine intolerance."

Journal • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammatory Bowel Disease • Ulcerative Colitis

COMBINED ORAL MESALAMINE AND BUDESONIDE SUPPOSITORIES YIELD FASTER SYMPTOM RESOLUTION IN ACTIVE ULCERATIVE COLITIS THAN ORAL MESALAMINE MONOTHERAPY. A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED ADD-ON STUDY. (DDW 2024) - "Both once daily oral mesalamine monotherapy (MES) and the combination of once daily oral mesalamine and rectal budesonide suppository (MES/BUS) are effective treatments for active UC but resolution of symptoms and clinical improvement is accomplished more rapidly with the combination therapy."

Clinical • Monotherapy • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammatory Bowel Disease • Ulcerative Colitis

Effect of Biyanning Granules on local symptoms and immune function of chronic rhinosinusitis (PubMed, Zhongguo Zhong Yao Za Zhi) - "It significantly improved the curative effect, regulated immune imbalance, accele-rated the recovery of immune function, reduced the recurrence rate of inflammatory reaction, and improved the quality of life. The combination of Chinese and western treatment is more effective than glucocorticoid alone and warrants further clinical study in large sample size."

Journal • Chronic Rhinosinusitis With Nasal Polyps • Immunology • Nasal Polyps • Otorhinolaryngology • Respiratory Diseases • Sinusitis • CD4 • FOXP3 • IL21 • IL2RA

The Efficacy and Safety of Xinjia Xuanbai Chengqi Granules in Acute Exacerbation of COPD: A Multicentre, Randomised, Double-Blind, Controlled Trial. (PubMed, Evid Based Complement Alternat Med) - "XJXBCQ is beneficial and safe for AECOPD treatment and could be considered an adjunctive therapy for promoting the relief of clinical symptoms. This trial is registered with ChiCTR1800016915."

Journal • Chronic Obstructive Pulmonary Disease • Constipation • Critical care • Gastroenterology • Gastrointestinal Disorder • Immunology • Pulmonary Disease • Respiratory Diseases

The PDE4 Inhibitor Tanimilast Restrains the Tissue-Damaging Properties of Human Neutrophils. (PubMed, Int J Mol Sci) - "In contrast, it promoted neutrophil survival by decreasing both spontaneous apoptosis and cell death in the presence of pro-survival factors. The present work suggests that tanimilast can alleviate the severe tissue damage caused by massive recruitment and activation of neutrophils in inflammatory diseases such as COPD."

Journal • Chronic Obstructive Pulmonary Disease • Immunology • Inflammation • Oncology • Pulmonary Disease • Respiratory Diseases

"Budesonide MMX - is it Budenofalk granules or Cortiment tablets? Sorry, only such budesonide preparations are available to us" (@al1506UA)

Efficacy and safety of prolonged release budesonide granules in mesalazine-refractory ulcerative colitis: A multi-centre Phase IIa study (TOPICAL-1). (PubMed, United European Gastroenterol J) - P2a | "Treatment with prolonged release budesonide granules for 8 weeks was associated with clinical, endoscopic and histological remission and demonstrated a favourable safety profile in patients with mesalazine-refractory ulcerative colitis. These results warrant further investigation into the potential of prolonged release budesonide granules as an alternative treatment for this patient population."

Clinical • Journal • P2a data • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammatory Bowel Disease • Ulcerative Colitis

Budesonide for Induction of Remission in Incomplete Microscopic Colitis (clinicaltrials.gov) - P3; N=44; Completed; Sponsor: Dr. Falk Pharma GmbH; Active, not recruiting ➔ Completed

Clinical • Trial completion • Gastrointestinal Disorder

"Thanks for the tag Alison! Yep the budesonide capsules can be opened and granules can be mixed into applesauce if unable to swallow capsule whole. MMX technology is intended to extend drug's release to distal part of colonic mucosa so essential to swallow these tabs whole." (@GI_PharmD)

Yiqi Huoxue Huatan Granule for Reducing Mortality in COPD With Chronic Respiratory Failure (clinicaltrials.gov) - P3; N=372; Enrolling by invitation; Sponsor: Peking University People's Hospital; Not yet recruiting ➔ Enrolling by invitation

Clinical • Enrollment open

Yiqi Huoxue Huatan Granule for Reducing Mortality in COPD With Chronic Respiratory Failure (clinicaltrials.gov) - P3; N=372; Not yet recruiting; Sponsor: Peking University People's Hospital

Clinical • New P3 trial

Esophageal Actinomycetoma Masquerading as Cancer in an Immunocompetent Patient (ACG 2019) - "Medications included Budesonide-Formoterol and Albuterol inhalers...An initial course of IV penicillin G or Ceftriaxone for 4-6 weeks is followed by oral penicillin V or amoxicillin for 6-12 months...We believe that inhaled corticosteroids may have created the milieu for the growth of Actinomyces and Candida in the esophagus by impairing local defenses. 43% of inhaled corticosteroid is deposited in the esophagus according to Gamma scintigraphic studies."

Clinical

Budesonide for Induction of Remission in Incomplete Microscopic Colitis (clinicaltrials.gov) - P3; N=44; Active, not recruiting; Sponsor: Dr. Falk Pharma GmbH; Recruiting ➔ Active, not recruiting; N=106 ➔ 44

Enrollment change • Enrollment closed

DRUG UTILIZATION OF PATIENTS WITH RESPIRATORY DISEASE AT COMMUNITY PHARMACIES IN CHINA- AN ANALYSIS OF CHEMICAL DRUGS (2014-2017) (ISPOR 2019) - "The nature of prescriptions and indication of the Top 10 chemical drugs in 2017 were: (1)Pediatric paracetamol, atificial cow-bezoar and chlorphenamine maleate granules(OTC, cold); (2)Compound paracetamol capsule(OTC, cold); (3) Compound paracetamol tablets(OTC, cold); (4)Pediatric paracetamol granules(OTC, cold); (5)Loratadine tablets(OTC, allergic rhinitis); (6)Salmeterol xinafoate and fluticasone propionate powder for inhalation(prescription ,asthma); (7)Montelukast sodium chewable tablets(prescription, asthma); (8) Ambroxol hydrochloride and clenbuterol hydrochloride oral solution(prescription, bronchitis); (9)Ibuprofen suspension(OTC, cold), (10)Budesonide formoterol powder inhalation(prescription, asthma). CONCLUSIONS At community pharmacies in China, the chemical drugs for patients with respiratory disease, especially the OTC, are mainly used to treat colds, and the prescription drugs for asthma treatment increase rapidly. More interventions are needed to enhance..."

Clinical

DRUG UTILIZATION OF PATIENTS WITH RESPIRATORY DISEASE AT COMMUNITY PHARMACIES IN CHINA- AN ANALYSIS OF LEADING PRESCRIPTION AND OVER-THE-COUNTER DRUGS (ISPOR 2019) - "The nature and indication of the 10 leading prescription drugs were: (1) Pudilan Xiaoyan oral liquid (CPM, pharyngitis); (2) Salmeterol xinafoate and fluticasone propionate powder for inhalation (chemical drug, asthma); (3) Montelukast sodium chewable tablets (chemical drug, asthma); (4) Budesonide formoterol powder inhalation (chemical drug, asthma); (5) Xiao'er Chiqiao Qingre granules (CPM, cold); (6) Ambroxol hydrochloride and clenbuterol hydrochloride oral solution (chemical drug, bronchitis); (7) Bailing capsule (CPM, bronchitis); (8) Xiao’er Feire Kechuan granules (CPM, cold); (9) Suhuang Zhike granule (CPM, pharyngitis); (10) Montelukast sodium tablets (chemical drug, asthma). CONCLUSIONS Complex interventions are needed to improve drug therapy management of the leading prescription and OTC drugs for patients with respiratory disease at community pharmacies in China. Community pharmacists should pay special attention to the use of chemical drugs and CPM by..."

Clinical

Phase 2a, AMP Challenge, Dose Escalation Study to Assess the Dose Response for Topical Efficacy and Systemic Activity in Asthmatic Subjects (clinicaltrials.gov) - P2a; N=56; Completed; Sponsor: GlaxoSmithKline; Recruiting ➔ Completed

Trial completion