Priligy (dapoxetine) / AbbVie - LARVOL DELTA

Who should monitor antidepressant therapy for premature ejaculation? A risk-stratified shared-care approach. (PubMed, J Sex Med) - No abstract available

Journal • Sexual Disorders

Reply to Comments on Real-World Premature Ejaculation Clinical Practice Survey. (PubMed, Andrology) - No abstract available

Journal • Real-world evidence • Sexual Disorders

Serum Metabolomics Unveils Novel Biomarkers Predicting Efficacy of Dapoxetine: A Prospective Study on Premature Ejaculation. (PubMed, Andrology) - "This study revealed serum metabolites correlated with dapoxetine efficacy, paving the way for future research into novel therapeutic targets and personalized treatment strategies."

Biomarker • Journal • Sexual Disorders

Immediate-Term Dapoxetine Administration Suppressed Functional Connectivity of Subcallosal Cingulate Cortex in Premature Ejaculation: A Resting-State fMRI Study. (PubMed, Andrology) - "The therapeutic effects of immediate-term dapoxetine administration may act by downregulating FC of SCC and related circuits (promotional factors for PE), but do not enhance FC of DLPFC and related circuits (inhibition factors for PE). The latter may be achieved by long-term dapoxetine administration or other long-acting SSRI treatments."

Journal • Sexual Disorders

Randomized controlled trial comparing deep dermal glanular hyaluronic acid injection versus oral dapoxetine in management of premature ejaculation. (PubMed, Int Urol Nephrol) - "Deep dermal glanular hyaluronic acid injection is more effective than oral dapoxetine in improving ejaculatory control, sexual function, and quality of life in men with lifelong PE, with an acceptable safety profile."

Journal • Pain • Sexual Disorders • Xerostomia

Microfabricated multiplexed sensor for the determination of undisclosed aphrodisiac medications in herbal products. (PubMed, RSC Adv) - "This work presents a novel, multiplexed potentiometric sensor for the simultaneous detection of sildenafil citrate (SIL) and dapoxetine HCl (DPX) in complex herbal matrices. The sensor successfully analyzed commercial herbal products (Ginkgo biloba, Herbal Viagra, Chinese herbal medicine), detecting an undisclosed SIL contamination in one sample and demonstrating excellent accuracy (95.0-105.1% recovery) for spiked samples. Meeting key WHO "ASSURED" criteria, this user-friendly, cost-effective platform offers a robust tool for safeguarding consumer health by enabling the rapid screening of adulterated herbal supplements."

Journal

DIA-Based Plasma Proteomic Profiling Identifies Novel Biomarkers for Diagnosis of Premature Ejaculation and Their Association With Dapoxetine Treatment Outcomes. (PubMed, Andrology) - "This study successfully identifies a panel of five plasma protein biomarkers for LPE, which not only facilitate accurate noninvasive diagnosis but also may be associated with clinical outcomes after dapoxetine treatment."

Biomarker • Journal • Sexual Disorders • DDX39A • DDX39B • PPP2R2A

Premature ejaculation: A comprehensive urological review of current evidence-based management strategies. (PubMed, Urologia) - "Initial therapy is on-demand topical anesthetics and dapoxetine, with enhanced durability when combined with psychosexual therapy...The literature was systematically searched across PubMed/MEDLINE, Embase, Cochrane Library, and Web of Science (January 2005 to October 2025). Harmonized definitions, inclusive diagnostic criteria, and standardized outcome measures remain high priorities for future research."

Journal • Review • Anesthesia • Erectile Dysfunction • Sexual Disorders

Efficacy of pelvic floor muscle training in the management of premature ejaculation: a systematic review and meta-analysis of randomized controlled trials. (PubMed, J Sex Med) - "Heterogeneity was considered high in the PFMT subgroup (I2 = 75%) and null for the SCT subgroup (I2 = 0%). Dapoxetine or the combination of PFMT with an auxiliary masturbation device or diaphragmatic breathing exercises may be superior in improving IELT in men with PE compared with isolated exercise programs."

Clinical • Journal • Retrospective data • Review • Sexual Disorders

Safety and efficacy of the traditional Chinese medicine chaihu guizhi ganjiang decoction combined with wendan decoction in the treatment of premature ejaculation: an open-label retrospective cohort study on Chinese men. (PubMed, Sex Med) - "This study offers the initial clinical validation of CGGWD for PE but is limited by population selection constraints, potential information bias, and unobserved confounding factors. For Chinese men with liver depression and spleen deficiency PE, CGGWD matches dapoxetine in efficacy but offers superior safety and systemic symptom relief, serving as a safe, effective alternative."

Journal • Retrospective data • CNS Disorders • Depression • Psychiatry • Sexual Disorders

Innovative Buccal Nanofibers for Dual Delivery of Tadalafil and Dapoxetine for Erectile Dysfunction and Premature Ejaculation Conditions. (PubMed, Pharmaceuticals (Basel)) - "In vitro cytotoxicity studies on human dermal fibroblasts confirmed the safety of both medications, with cell viability exceeding 50%, at concentrations of 1.56 to 25 µg/mL for tadalafil and 4.69 to 9.38 µg/mL for dapoxetine after 24 and 48 h of incubation. These findings highlight the potential of PVP-based nanofibers as a novel buccal delivery system for the combined treatment of ED and PE."

Journal • Erectile Dysfunction • Sexual Disorders

Effectiveness of physiotherapy in male premature ejaculation. A systematic review and metaanalysis. (PubMed, J Sex Med) - "The results of the meta-analyses suggest that dapoxetine at a dose of 30 mg is significantly more effective than physiotherapy for prolonging IELT in men with lifelong PE. Physiotherapy can be considered a safe and beneficial intervention, positioning it as a promising alternative for patients who are intolerant to pharmacological treatment. Nevertheless, the qualitative review suggests that a combined therapeutic approach yields the most significant improvements in IELT."

Clinical • Journal • Retrospective data • Review • Sexual Disorders

Real-World Clinical Practices for Premature Ejaculation: A National Survey of Chinese Physicians. (PubMed, Andrology) - "Chinese physicians commonly use combined pharmacological and psychological approaches for premature ejaculation treatment, but significant challenges persist, including inappropriate treatment of non-premature ejaculation cases, unwarranted surgical interventions, and insufficient utilization of evidence-based selective serotonin reuptake inhibitors, highlighting the need for standardized diagnostic criteria and enhanced physician education on guideline-recommended therapies."

Journal • Real-world evidence • CNS Disorders • Depression • Mood Disorders • Psychiatry • Sexual Disorders

A prospective multicenter study on plasma metabolomics and machine learning for diagnosing premature ejaculation and predicting dapoxetine treatment response. (PubMed, J Sex Med) - "This study delineates distinct metabolic profiles in PPE, establishes robust machine learning-based models for diagnosis and DT-Response prediction, and reveals the involvement of neurotransmitter dysregulation in its pathophysiology."

Biomarker • Clinical • Journal • Metabolic Disorders • Sexual Disorders

Exploring lactoferrin as an innovative covalently immobilized chiral selector for the selective separation of pharmaceutical enantiomers using HPLC. (PubMed, Anal Chim Acta) - "HPLC remains the primary choice for all pharmaceutical research, as it offers higher sensitivity, reliability, and reproducibility. This work introduces LF as a novel, multifunctional CS for HPLC, covalently immobilized for the first time, expanding the toolbox of protein-based chiral stationary phases. Moreover, the study also offers a critical insight into the limitations of relying solely on computational predictions, empirically demonstrating that solvent effects can override binding affinities, a phenomenon not captured by standard docking simulations."

Journal

Screening strategy using a filamentous fungus model to repurpose drugs for mitochondrial complex I deficiencies. (PubMed, Life Sci) - "Together, our work demonstrates the usefulness of Podospora anserina as fungal model for identifying promising therapeutic candidates for complex I diseases, paving the way for future clinical trials."

Journal • Metabolic Disorders

Nose to brain delivery of dapoxetine-loaded PLGA nanoparticle for treatment of premature ejaculation distress in normal and diabetic rats with in silico targeting brain FOX and serotonin proteins. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "Our results improve PE neurobiology and pharmacology research. Expression of FOS protein in DH nanoformula IN protects normal and diabetic rats in normal and diabetic premature ejaculated rats."

Journal • Preclinical • Mood Disorders • Oncology • Psychiatry • Sexual Disorders • FOS

Comparative evaluation of safety and efficacy of dapoxetine, silodosin, and citalopram in the management of premature ejaculation: a randomized clinical trial. (PubMed, BMC Urol) - P4 | "In this direct head-to-head comparison of active treatments for lifelong PE, daily citalopram (20 mg) demonstrated superior efficacy in prolonging IELT and improving psychosocial outcomes compared to daily or on-demand dapoxetine and silodosin. The findings suggest that citalopram is a highly effective first-line option, while the dose-dependent efficacy of dapoxetine and the distinct side-effect profile of silodosin provide alternative considerations for personalized treatment strategies."

Clinical • Journal • Sexual Disorders

Combined chiral-achiral supercritical fluid chromatography method for the impurity analysis of dapoxetine reveals insights in entropy-driven retention and acid-modulated selectivity. (PubMed, J Chromatogr A) - "The neutral complexes impact retention depending on the amine substitution pattern and may suppress polar and enhance hydrophobic interactions. These results underscore the potential application of combined additive systems to enhance SFC applications in the field of ionizable analytes."

Journal

Enantiodivergent Rh-Catalyzed Reductive Hydroformylation of Alkenyl Boronic Esters. (PubMed, Angew Chem Int Ed Engl) - "The chiral γ-boryl alcohol or diol products are versatile building blocks applicable to the synthesis of a series of APIs including (S)-tolterodine, (S)-dapoxetine, and (R)-atomaxetine. DFT calculation has revealed the origin of enantiodivergence of Rh-catalyzed reductive AHF of alkenyl boronic esters with Ph-BPE as the chiral ligand. The transformation is promised to provide great synthetic potential in both academia and industry."

Journal

Frequency-Dependent Effects of Repetitive Transcranial Magnetic Stimulation on Sexual Behavior Parameters in Premature Ejaculation Rodent Models. (PubMed, Andrology) - "rTMS exhibited frequency-dependent therapeutic efficacy in rapid ejaculation rat models, with high-frequency protocols demonstrating superior benefits compared with low-frequency interventions. These effects are mediated through activation of the BDNF-TrkB pathway and enhanced serotonergic signaling, suggesting high-frequency rTMS as a promising non-pharmacological therapy for PE."

Journal • Preclinical • Sexual Disorders

Study on the efficacy and safety of rTMS combined with dapoxetine hydrochloride in the treatment of premature ejaculation (ChiCTR) - P=N/A | N=90 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Anhui Medical University; The First Affiliated Hospital of Anhui Medical University

New trial • Sexual Disorders

Amine-Borane-Promoted Rhodium-Catalyzed Asymmetric Transfer Hydrogenation of β-Chloro Ketones. (PubMed, Org Lett) - "A broad range of substrates was reduced in up to 99% yield and >99% ee, with gram-scale reactions completed within 1 h. The resulting 3-chloroalkanols serve as versatile intermediates for the synthesis of pharmaceuticals such as (S)-Nisoxetine, (S)-Fluoxetine, (S)-Tomoxetine, (S)-Duloxetine, (S)-Dapoxetine, and Ezetimibe analogues. DFT calculations reveal that C-H···π interactions and hydrogen bonding control stereoselectivity, and the effect of different amine-boranes on enantioselectivity was rationalized, providing guidance for broader application in asymmetric transfer hydrogenation."

Journal

The Inaugural Pre-Treatment Nomogram to Assess the Eight-Week Efficacy of Dapoxetine: A Prospective Multi-Center Study. (PubMed, Andrology) - "We constructed and validated the inaugural 8-week DapE-Nomo. In outpatient settings, it will enable andrologists to more accurately evaluate the efficacy and promptly adjust treatment plans for patients with scores below 153.4. Moreover, It will help patients who've taken dapoxetine for 4 weeks with poor results decide whether to stop."

Journal • Sexual Disorders

Efficacy and safety of on-demand dapoxetine combined with phosphodiesterase-5 inhibitor compared to monotherapy dapoxetine as a treatment of premature ejaculation without erectile dysfunction: a systematic review and meta-analysis. (PubMed, Arch Ital Urol Androl) - "This study demonstrates that the combination of dapoxetine and PDE-5i significantly improves post-treatment scores of IELT and sexual satisfaction compared to dapoxetine monotherapy. Despite an increased risk of certain side effects, the overall tolerability of the combination therapy remains favorable."

Clinical • Journal • Monotherapy • Retrospective data • Review • CNS Disorders • Constipation • Erectile Dysfunction • Fatigue • Gastroenterology • Gastrointestinal Disorder • Pain • Sexual Disorders • Sleep Disorder • Urology