NUC-101 / Nucorion, Ligand - LARVOL DELTA

Transcriptomic Profiling of Autosomal Dominant Polycystic Kidney Disease by Single-Nucleus RNA Sequencing (ERA 2026) - "Method SnRNA-seq was performed on kidneys from two male Pax8-rtTA; TetO-Cre mice with induced polycystic kidney disease and two male littermate controls without doxycycline induction...Nuclei were isolated using Nuclei EZ Lysis Buffer (Sigma, NUC101), and libraries were prepared using the Chromium GEM-X Single Cell 3′ Reagent Kits v4...(A)UMAP of cell clustering and annotation; (B)Dot plot of canonical marker genes expression; (C)Pie chart shows relative contribution of each renal cell population; (D)Immunofluorescence stain of distal convoluted tubule–derived proliferative cyst epithelium. Scale bar=10 µm."

Autosomal Dominant Polycystic Kidney Disease • Cardiovascular • Genetic Disorders • Hypertension • Nephrology • Polycystic Kidney Disease • Renal Disease • CCND1 • GPC3 • NCAM1 • PAX8 • SLC2A3 • SMAD4 • TGFB1 • TOP2A

Screening of a potential probiotic Lactiplantibacillus plantarum NUC08 and its synergistic effects with yogurt starter. (PubMed, J Dairy Sci) - "Following acid and bile salt tolerance tests, Lactiplantibacillus plantarum (NUC08 and NUC101), Lacticaseibacillus rhamnosus (NUC55 and NUC201), and Lacticaseibacillus paracasei (NUC159, NUC216 and NUC351) were shortlisted based on intraspecies distribution for further evaluation...Importantly, LAB viable counts were significantly higher in yogurt co-fermented with L. plantarum NUC08, consistently throughout the storage period. In conclusion, the study demonstrates that the probiotic strain L. plantarum NUC08 can be employed in synergy with yogurt starter strains, affirming its potential for use in the development of functional fermented dairy products."

Journal • Gastrointestinal Disorder