Vantas (histrelin acetate) / Orion Corp, Endo, Takeda - LARVOL DELTA

Proteomics reveals COX7B as a prognostically relevant oxphos-linked protein in pediatric AML (ASH 2025) - "Despite improvements in supportive care, the standardtreatment for AML has remained largely unchanged since the 1970s through use of cytarabine incombination with anthracyclines. This study represents one of the first and most comprehensive global proteome profiling ofdiagnostic bone marrow samples from pediatric AML patients. We report several metabolic enzymes thatare predictive of poor outcome and specifically COX7B and its role in OXPHOS pathway is highly relevantas LSC survival is dependent on OXPHOS highlighting its therapeutic potential. Understanding themolecular mechanisms behind these distinct protein patterns may guide the development of precisiontherapies as well as identify novel drug targets in AML."

Clinical • Acute Myelogenous Leukemia • Hematological Malignancies • Leukemia • Pediatrics • FH

Mallinckrodt and Endo to Combine to Create a Global, Scaled, Diversified Pharmaceuticals Leader (PRNewswire) - "Mallinckrodt plc...and Endo, Inc...today announced that they have entered into a definitive agreement to combine in a stock and cash transaction to create a global, scaled, diversified pharmaceuticals leader...Mallinckrodt and Endo plan to combine their generic pharmaceuticals businesses and Endo's sterile injectables business after the close of the transaction and intend to separate that business from the combined company at a later date. Such a separation would be subject to approval by the combined company's Board of Directors and other conditions...The combined company's brands portfolio will comprise leading pharmaceutical brands across a range of therapeutic areas, including XIAFLEX (collagenase clostridium histolyticum), Acthar Gel (repository corticotropin injection), Terlivaz (terlipressin), SUPPRELIN LA (histrelin acetate) and AVEED (testosterone undecanoate)."

M&A • Ankylosing Spondylitis • Diabetic Nephropathy • Fibrosis • Immunology • Lupus • Multiple Sclerosis • Ocular Inflammation • Prostate Cancer • Psoriatic Arthritis • Renal Disease • Rheumatoid Arthritis • Sarcoidosis • Systemic Lupus Erythematosus • Uterine Leiomyoma

Endo Reports Third-Quarter 2024 Financial Results and Reaffirms 2024 Financial Expectations (Endo Pharmaceuticals Press Release) - "Specialty Products revenues were $159 million in third-quarter 2024, representing a 6% increase compared to $150 million in third-quarter 2023...This increase was partially offset by decreased SUPPRELIN LA revenues resulting from lower volumes..."

Commercial • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor

Fertility preservation in transfeminine adolescents using TESE at the time of Histrelin Acetate subcutaneous implant placement: A Case Series. (PubMed, J Pediatr Urol) - "Performing TESE for FP is feasible for transgender youth undergoing Histrelin implant placement, leading to short delays in starting GAT. Testicular volume and endocrine markers can provide preoperative insight into likelihood of successful sperm retrieval during TESE, are needed to identify which patients will have successful sperm retrieval to ensure optimal counseling and informed decision making for providers, patients and families."

Journal

"Congratulations @bvantassell on a tremendous (and deserved) honor. Cheers!" (@wbaker0621)

Histrelin Implants for Suppression of Puberty in Youth with Gender Dysphoria: A Comparison of 50 mcg/Day (Vantas) and 65 mcg/Day (SupprelinLA). (PubMed, Transgend Health) - " These results indicate that both implants are effective in suppressing puberty in early-to-mid pubertal youth with gender dysphoria. These data may inform decisions about insurance coverage of Supprelin and/or Vantas for youth with gender dysphoria."

Journal • CNS Disorders • Pediatrics

Episode 3: Learning About Advanced Prostate Cancer (Cure Today) - "Dr. Charles Ryan: Metastatic, when applied to a cancer, implies that the cancer cells started in the organ of origin, which in this case is the prostate. The most common site of cancer prostate cancer spreading or metastasizing is to the bone or to the lymph nodes. Less commonly, it can go to the liver or the lung."

Video

Comparative Efficacy of Histrelin Acetate and hCG for Inducing Ovulation in Brazilian Northeastern Jennies (Equus africanus asinus). (PubMed, J Equine Vet Sci) - "All jennies from G1 and G2 ovulated up to 48 hours after ovulation induction, whereas 100% of jennies in the control cycle ovulated later (>48 hours from the administration of saline). In conclusion, both histrelin acetate and hCG at the used dose are efficient ovulation-inducing agents in jennies promoting ovulation up to 48 hours after administration."

Clinical • Journal

"The Pediatric Endocrine Society lists these medications for puberty suppression.... Leuprolide acetate depot/Lupron Depot Triptorelin/Triptodur Histrelin acetate/Supprelin LA and Vantas https://t.co/AMkOO1M63D" (@notworthmessing)

Clinical

A Case of a Forgotten Histrelin Acetate Implant: Can Histrelin Acetate Implants Be Used for More Than a Year? (ENDO 2019) - "Abstracts presented at a news conference are embargoed until the date and time of the news conference. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO.*"

Clinical