Cubicin (daptomycin) / Merck (MSD) - LARVOL DELTA

Artificial Intelligence-Driven Discovery and Optimization of Antimicrobial Peptides Targeting ESKAPE Pathogens and Multidrug-Resistant Fungi. (PubMed, Microorganisms) - "Clinically used peptide-derived antibiotics such as polymyxins and daptomycin demonstrate the therapeutic feasibility of peptide-based antimicrobials, while investigational peptides, including pexiganan, illustrate ongoing translational progress. Although no fully AI-designed AMP has yet achieved regulatory approval, the accelerating convergence of computational modeling and experimental validation suggests a rapidly evolving translational landscape. Advancing scalable, surveillance-informed AI frameworks that integrate resistance data, predictive safety modeling and delivery optimization will be essential to accelerate the clinical translation of next-generation, multi-objective AMPs against high-risk resistant pathogens."

Journal • Review

Understanding Daptomycin Resistance Mechanisms and Treatment Challenges in Enterococcus faecium Infection: A Case Series. (PubMed, Antibiotics (Basel)) - "All patients were successfully managed by escalating to combination therapy with high-dose daptomycin and ceftaroline, alongside appropriate source control. This series emphasizes the importance of periodic susceptibility reassessment during daptomycin therapy and cautions clinicians against assuming sustained susceptibility in patients with prolonged bacteremia or complex infections. Early recognition of evolving resistance and timely therapeutic adjustment may improve outcomes in this high-risk population."

Journal • Hepatology • Infectious Disease • Solid Organ Transplantation • Transplantation

Pharmacokinetic/Pharmacodynamic Analysis of High-Dose Daptomycin in Combination with Continuous Infusion Ceftobiprole in a Case Series of Documented Staphylococcal Bacteremia or Endocarditis: Is There Any Room for TDM-Guided Dosing Reduction? (PubMed, Antibiotics (Basel)) - "Targeted therapy with daptomycin plus CI ceftobiprole achieved high PK/PD target attainment and favorable clinical outcomes in staphylococcal BSI and IE. TDM and model-informed precision dosing may enable dose optimization and may improve the balance between efficacy and safety. Multicenter studies are warranted."

Journal • PK/PD data • Cardiovascular • Eosinophilia • Infectious Disease

Occurrence of Antimicrobial Resistance in Indicator Bacteria and Campylobacter spp. Isolated from Commercial Raw-Meat-Based Food for Dogs and Cats in Belgium. (PubMed, Antibiotics (Basel)) - "Among these, one E. faecalis strain with acquired resistance to vancomycin and daptomycin was isolated. Commercial RMBDs in Belgium exhibit widespread bacterial contamination with concerning AMR patterns. These findings highlight the need for improved production standards in the RMBD industry and the need to raise awareness in pet owners."

Journal

Unmasking a Rare Infectious Complication of Th2 Pathway Inhibition: A Case of Iliopsoas Abscess Post-Dupilumab. (IMMUNOLOGY 2026) - "He was treated with intravenous (IV) vancomycin and ampicillin-sulbactam for 10 days...IV vancomycin, cefepime, and metronidazole were initiated...Due to persistent fevers, antibiotics were changed to IV daptomycin, cefepime, and metronidazole.MRI of the right thigh on day 8 revealed a large multiloculated gluteal abscess (9 x 2.5 x 2.5 cm) and minimal iliopsoas involvement. As dupilumab's use expands, clinicians should remain vigilant for its rare but serious infectious complications."

Clinical • Asthma • Atopic Dermatitis • Back Pain • Immunology • Infectious Disease • Musculoskeletal Pain • Respiratory Diseases • IL13 • IL4

Research communication: Regional variation in antimicrobial resistance of Streptococcus agalactiae isolated from bovine mastitis in major dairy-producing provinces of northern China. (PubMed, J Dairy Res) - "Results showed high sensitivity to most antibiotics (e.g. 100% resistance to penicillin, ceftiofur, amoxicillin, cefquinome and vancomycin) but significant resistance to tetracycline (80.7%) and daptomycin (99.3%). Inner Mongolia isolates exhibited higher resistance and mimimum inhibitory concentrations (MIC) values, reflecting regional antibiotic usage differences, guiding mastitis treatment and antibiotic stewardship in China's dairy industry."

Journal

EFFICACY OF DAPTOMYCIN FOR VANCOMYCIN-REFRACTORY METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS SEPSIS ASSOCIATED WITH VENOUS HYPERTENSION IN VASCULAR ACCESS -A CASE REPORT- (ISN-WCN 2026) - "Therefore, the antibiotic was changed to DAP and rifampicin (RFP) was administered in combination...After switching to oral minocycline (MINO), there was no relapse, and the patient was discharged five months after admission...Venous hypertension and skin erosion in the VA were suspected as causes of MRSA sepsis. Since changes in central venous patency may occur after major vascular surgery, careful consideration is required for the location of VA creation.Conclusion These results indicate that DAP may be an effective treatment option for VCM-resistant MRSA sepsis associated with artificial materials."

Case report • Clinical • Cardiovascular • Chronic Kidney Disease • Hypertension • Infectious Disease • Inflammation • Nephrology • Pulmonary Embolism • Respiratory Diseases • Septic Shock

NALFURAFINE FOR REFRACTORY UREMIC AND CHOLESTATIC PRURITUS IN A HEMODIALYSIS PATIENT: A CASE REPORT (ISN-WCN 2026) - "During her course, she experienced recurrent spontaneous bacterial peritonitis (pathogen: vancomycin-resistant Enterococcus faecium) necessitating multiple courses of broad-spectrum antibiotics (including cefoperazone-sulbactam, meropenem, daptomycin, linezolid)...Initially suspected as a drug allergy, all potential culprit medications were discontinued, and prednisone was administered...Despite trials of various standard therapies including antihistamines, intensified hemodialysis with hemoperfusion, gabapentin, ursodeoxycholic acid, sertraline, topical tacrolimus ointment, and achieving targets for phosphate and parathyroid hormone control, the generalized pruritus remained refractory...This outcome underscores its mechanistic advantage and potential therapeutic value in challenging clinical scenarios involving mixed-origin pruritus.Conclusion In conclusion, nalfurafine presents a promising therapeutic option for refractory pruritus of mixed uremic and cholestatic..."

Case report • Clinical • Chronic Kidney Disease • Dermatology • Fibrosis • Hepatology • Immunology • Infectious Disease • Inflammation • Liver Cirrhosis • Liver Failure • Nephrology • Pruritus • Renal Disease • Urticaria

A CASE OF FLUCONAZOLE-INDUCED ARGININE VASOPRESSIN RESISTANCE (ISN-WCN 2026) - "Acquired AVP-R includes drug-induced AVP-R, and typical causative drugs are lithium, demeclocycline, amphotericin B, and rifampicin.Methods We report a rare case of fluconazole drug-induced AVP-R.Results A 52-year-old woman with type I diabetes was admitted to our hospital because of impaired consciousness. The patient had been in her usual state of health until 2 days before the admission, and her diabetic medications included dapagliflozin, insulin, and metformin...Broad spectrum antibiotics, meropenem and daptomycin, were introduced and continued to control the infection...Initially, micafungin 150 mg q12hr was introduced and then stopped due to liver dysfunction...Desmopressin administration did not increase urine osmolality or reduce urine volume, which demonstrated renal unresponsiveness...FCZ has been rarely reported to cause AVP-R, and its mechanistic is unclear. Careful continuous observation of urinary concentration and serum sodium level are important to..."

Clinical • Atherosclerosis • CNS Disorders • Dermatitis • Genetic Disorders • Hepatology • Immunology • Infectious Disease • Liver Failure • Metabolic Disorders • Obesity • Ocular Infections • Ocular Inflammation • Ophthalmology • Type 1 Diabetes Mellitus

Polygenic, cell-envelope adaptations drive high-frequency daptomycin resistance in Staphylococcus capitis NRCS-A from neonatal sepsis and NEC. (PubMed, Antimicrob Agents Chemother) - "Ten of 11 NRCS-A isolates (91%) were resistant to daptomycin, and 18% displayed decreased susceptibility to vancomycin. These results indicate that S. capitis NRCS-A rapidly evolves resistance via polygenic, cell-envelope-driven mechanisms distinct from those in S. aureus. The high prevalence and adaptive capacity of DAP-R in neonatal isolates raise concern for therapeutic failure in neonatal intensive care."

Journal • Critical care • Infectious Disease • Septic Shock

Value-Based Healthcare analysis of antibiotic administration in non-hospital settings: assessment of patient benefits and economic sustainability of the system. (PubMed, Recenti Prog Med) - "The OPAT v2.0 model demonstrates clinical and economic effectiveness, reducing hospital costs and improving quality of care. However, full implementation requires better territorial organisation, with home administration only for non-self-sufficient patients, while self-sufficient patients should be administered at district clinics in order to relieve congestion in hospital clinics."

Clinical • Journal • Infectious Disease

Coupled Hydrogen-Bond-Electrostatic Recognition of Phosphatidylglycerol Drives the Design of Resistance-Suppressing Miniature Peptidomimetics. (PubMed, J Am Chem Soc) - "It remains active in serum-containing environments, protects host cells from bacterial damage, and demonstrates excellent biocompatibility and strong therapeutic efficacy in intraperitoneal, pulmonary, and bloodstream methicillin-resistant Staphylococcus aureus infection models. As a synthetically accessible small molecule that functionally mimics and improves upon daptomycin's lipid-targeting mechanism, this work establishes a secondary-bonding-driven PG-recognition paradigm for combating MDR bacterial infections."

Journal • Infectious Disease

Pharmacovigilance and antibiotic resistance: analysis of real-world data from the Rizzoli Orthopedic Institute in the management of antibiotic-related adverse drug reactions in musculoskeletal diseases. (PubMed, Recenti Prog Med) - "Our experience confirms an under-reporting and has highlighted that the contribution to reporting by hospital doctors and nurses is closely related to the valuable work of awareness and support of hospital pharmacists. They assist clinicians in detecting phenomena that may underline the onset of adverse reactions and, consequently, carry out a reporting activity that guarantees useful information for the management of antibiotic therapy. Disseminating and discussing the results of pharmacovigilance is an aspect that motivates the healthcare professional to report. Working to increase the identification of ADRs and the consequent reporting allows us to contribute to the appropriate prescription of antibiotics, avoiding the onset of resistance and also the exposure of the individual patient to serious and disabling side effects."

Adverse drug reaction • Adverse events • Journal • Real-world evidence • Eosinophilia • Immunology • Infectious Disease • Musculoskeletal Diseases • Orthopedics

Population pharmacokinetics modelling of daptomycin in paediatric patients (ESCMID Global 2026) - No abstract available

Clinical • PK/PD data • Pediatrics

Ceftaroline-daptomycin as salvage combination therapy for persistent MRSA bacteraemia with metastatic foci and MIC creep (ESCMID Global 2026) - No abstract available

Combination therapy • Metastases

Post-dengue disseminated methicillin-resistant Staphylococcus aureus infection with vancomycin failure successfully managed with daptomycin/linezolid salvage therapy: a case report (ESCMID Global 2026) - No abstract available

Case report • Clinical • Dengue Fever • Infectious Disease

Genomic decoding of tigecycline resistance and daptomycin non-susceptibility in Enterococcus faecium (ESCMID Global 2026) - No abstract available

Phenotypic and genetic characterisation of daptomycin non-susceptible Staphylococcus aureus strains selected by adaptive laboratory evolution (ESCMID Global 2026) - No abstract available

Detection of daptomycin susceptibility and research on resistance mechanisms in methicillin-resistant Staphylococcus capitis (ESCMID Global 2026) - No abstract available

Creeping pattern of daptomycin minimum inhibitory concentration in Staphylococcus aureus: a single-centre ten-year retrospective review (ESCMID Global 2026) - No abstract available

Retrospective data • Review

Genomic determinants of emerging daptomycin resistance in community-associated methicillin-resistant Staphylococcus aureus: insights from a genome-wide association study (ESCMID Global 2026) - No abstract available

Infectious Disease

Evaluation of clinical outcomes associated with the use of commercially available daptomycin preparations vs weight-based dosing regimens (ESCMID Global 2026) - No abstract available

Clinical • Clinical data

Population pharmacokinetics modelling of daptomycin in paediatric patients (ESCMID Global 2026) - No abstract available

Clinical • PK/PD data • Pediatrics

Exploring cannabidiol as a resistance-modifying agent in daptomycin-non-susceptible MRSA (ESCMID Global 2026) - No abstract available

Daptomycin monotherapy vs combination therapy for MRSA bacteraemia (ESCMID Global 2026) - No abstract available

Combination therapy • Monotherapy • Cardiovascular • Infectious Disease • Septic Shock