Cubicin (daptomycin) / Merck (MSD) - LARVOL DELTA

A RARE CAUSE OF VERTEBRAL OSTEOMYELITIS CAUSED BY STREPTOCOCCUS SALIVARIUS (WRMC 2026) - "A 51-year-old male with history of splenectomy after trauma, cervical epidural abscess due to MRSA treated with decompressive laminectomy and prolonged daptomycin, and eventual recovery of his neurological deficits one year prior, presented with three months of progressive back pain, two months of fatigue, bilateral lower extremity weakness associated with bowel incontinence, and a 10-lb weight loss...The patient was treated with IV ceftriaxone for 6 weeks via PICC, with clinical improvement...This underscores the importance of incorporating a thorough dental history and oral examination into the evaluation of patients with VO. By broadening the differential to include oral flora, clinicians may improve diagnostic accuracy and guide more tailored management strategies."

Back Pain • CNS Disorders • Infectious Disease • Inflammation • Mood Disorders • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics

INFECTIOUS KERATITIS ISOLATES AND SUSCEPTIBILITY IN SEATTLE, WASHINGTON (WRMC 2026) - "All Staphylococcusisolates were susceptible to daptomycin and vancomycin, but 50% were resistant to erythromycin, and over 30% were resistant to both moxifloxacin and ofloxacin. At the largest tertiary referral center in the Pacific Northwest, Streptococcusspp. was the most common cause of infectious keratitis. Clinicians should exercise caution when prescribing erythromycin for Staphylococcusinfections, given resistance observed in 50% of cases."

Infectious Disease • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

A Rare Case of Spondylodiscitis Due to Actinotignum schaalii in a Patient With Crohn's Disease. (PubMed, J Community Hosp Intern Med Perspect) - "He underwent interventional radiology disc biopsy and open surgical biopsy with culture. He was successfully treated with a six-week course of IV daptomycin and ceftriaxone."

Journal • Back Pain • Crohn's disease • Gastroenterology • Immunology • Infectious Disease • Inflammatory Bowel Disease • Musculoskeletal Pain • Myositis • Nephrology • Pain

DAPTOMYCIN ENHANCES ANTI-LEUKEMIA EFFICACY OF CAR-T CELLS BY INHIBITING GLYCOLYSIS PATHWAY (EBMT 2026) - "Our findings establish antibiotic-driven metabolic reprogramming as a strategy to overcome CAR-T exhaustion, evaluating DAP-adjuvanted CD19 CAR-T therapy in relapsed/refractory B-cell leukemia."

CAR T-Cell Therapy • Clinical • IO biomarker • Acute Lymphocytic Leukemia • Hematological Malignancies • Leukemia • CD69 • GZMB • HAVCR2 • IL2 • IL2RA • LAG3 • PD-1 • SELL

Aztreonam/avibactam (Emblaveo) for complicated intra-abdominal infections. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Infectious Disease

Preserving the Antimycobacterial Drug Arsenal: A Case Report of Disseminated Mycobacterium Avium Disease (IWLH 2026) - "The patient was treated with clarithromycin, ethambutol, rifabutin, moxifloxacin, and cycloserine for two years, with amikacin added for the first six months, inducing ototoxicity...A salvage regimen was initiated, including amikacin, tedizolid, clofazimine, ceftazidime/avibactam, isoniazid, delamanide, and ethambutol, as well as antiepileptic treatment and IFNγ administration...Intravenous dexamethasone was administered with intensified NTM treatment, but blood cell counts continued to decline, and inflammatory markers (CRP, PCT) remained high. Due to previous Gram-negative infections, his regimen was modified to include daptomycin, meropenem/vaborbactam, and colistimethate. Candida glabrata was identified in port cultures, necessitating port removal and initiation of isavuconazole. He was placed on dual beta-lactam therapy (meropenem and ceftriaxone) combined with clofazimine, isoniazid, linezolid, cycloserine, bedaquiline, and pretomanid...Conclusions This case..."

Case report • Clinical • CNS Disorders • Epilepsy • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hemophagocytic lymphohistiocytosis • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Pulmonary Disease • Respiratory Diseases • Septic Shock • IFNG • IL12A

Leveraging patient data to detect systematic shifts in daptomycin susceptibility testing associated with reduced prescribing. (PubMed, J Clin Microbiol) - "More broadly, this study underscores the opportunity to incorporate additional modalities, such as clinical patient results, into a comprehensive quality assurance plan to ensure high-quality antimicrobial susceptibility testing results. Given the dynamic spread of multidrug resistance in bacteria, accurate susceptibility testing results are critical to identify and respond to shifts in local epidemiology."

Journal • Infectious Disease

Post-dengue disseminated methicillin-resistant Staphylococcus aureus infection with vancomycin failure successfully managed with daptomycin/linezolid salvage therapy: a case report (ESCMID Global 2026) - No abstract available

Case report • Clinical • Dengue Fever • Infectious Disease

Ceftaroline-daptomycin as salvage combination therapy for persistent MRSA bacteraemia with metastatic foci and MIC creep (ESCMID Global 2026) - No abstract available

Combination therapy • Metastases

Genomic decoding of tigecycline resistance and daptomycin non-susceptibility in Enterococcus faecium (ESCMID Global 2026) - No abstract available

Creeping pattern of daptomycin minimum inhibitory concentration in Staphylococcus aureus: a single-centre ten-year retrospective review (ESCMID Global 2026) - No abstract available

Retrospective data • Review

Phenotypic and genetic characterisation of daptomycin non-susceptible Staphylococcus aureus strains selected by adaptive laboratory evolution (ESCMID Global 2026) - No abstract available

Detection of daptomycin susceptibility and research on resistance mechanisms in methicillin-resistant Staphylococcus capitis (ESCMID Global 2026) - No abstract available

Genomic determinants of emerging daptomycin resistance in community-associated methicillin-resistant Staphylococcus aureus: insights from a genome-wide association study (ESCMID Global 2026) - No abstract available

Infectious Disease

Evaluation of clinical outcomes associated with the use of commercially available daptomycin preparations vs weight-based dosing regimens (ESCMID Global 2026) - No abstract available

Clinical • Clinical data

Exploring cannabidiol as a resistance-modifying agent in daptomycin-non-susceptible MRSA (ESCMID Global 2026) - No abstract available

Population pharmacokinetics modelling of daptomycin in paediatric patients (ESCMID Global 2026) - No abstract available

Clinical • PK/PD data • Pediatrics

Daptomycin monotherapy vs combination therapy for MRSA bacteraemia (ESCMID Global 2026) - No abstract available

Combination therapy • Monotherapy • Cardiovascular • Infectious Disease • Septic Shock

Daptomycin levels in vancomycin-resistant Enterococcus bloodstream infections (DELIVRE-BSI) (ESCMID Global 2026) - No abstract available

Infectious Disease

Reducing CoNStant testing: Impact of a diagnostic stewardship intervention targeting coagulase-negative staphylococci in blood cultures on vancomycin, daptomycin and linezolid consumption (ESCMID Global 2026) - No abstract available

Addition of daptomycin in the treatment of pneumococcal meningitis in adults: results of the phase II AddaMap trial (ESCMID Global 2026) - No abstract available

Clinical • P2 data • CNS Disorders • Infectious Disease • Pneumococcal Infections

Exploring the opportunity for therapeutic drug monitoring (TDM) and precision dose antimicrobials in an outpatient antimicrobial therapy (OPAT) service: a prospective observational study. (PubMed, J Antimicrob Chemother) - "We have demonstrated that drug monitoring is practicable in the OPAT setting of a large institution with no on-site analytical capability. Current dosage regimens result in acceptable PK-PD target attainment. Our findings provide an initial step towards supporting TDM in OPAT."

Journal • Observational data • Cardiovascular

Proportion and antibiogram of methicillin-resistant Staphylococcus aureus (MRSA) in Africa: a systematic review and meta-analysis. (PubMed, Antimicrob Resist Infect Control) - "The proportion of MRSA in Africa remains high at 42.2%, with marked regional disparities. Although resistance rates for linezolid and vancomycin are relatively low, they surpass global averages, raising concerns about emerging resistance. Alarmingly high resistance rates to several other antibiotics further underscore the urgent need for targeted interventions and continuous surveillance."

Journal • Retrospective data • Infectious Disease

Population pharmacokinetic model and dosing nomogram for daptomycin in adult patients with serious Gram-positive infections: emphasizing the role of loading doses and renal function-based adjustment. (PubMed, Antimicrob Agents Chemother) - "An eGFR-guided dosing nomogram was proposed, and simulation results demonstrated that this approach outperformed conventional weight-based dosing in achieving the PK/PD target. These findings support the use of an initial loading dose and individualized maintenance dosing based on eGFR to improve the efficacy and safety of daptomycin therapy."

Journal • PK/PD data • Infectious Disease

Real-World Daptomycin Use with a focus on muscle toxicity: A multicentric retrospective study. (PubMed, Int J Antimicrob Agents) - "Despite widespread use of high-dose daptomycin, safety monitoring was inconsistent. Systematic CK testing and careful review of myotoxic co-medications are essential to mitigate adverse events in clinical practice."

Clinical • Journal • Real-world evidence • Retrospective data • Genetic Disorders • Infectious Disease • Obesity