Cubicin (daptomycin) / Merck (MSD) - LARVOL DELTA

Vaginal Probiotic Potential of Lactobacillus acidophilus: Population Genomic and Phenotypic Analysis. (PubMed, Genes (Basel)) - "Both isolates were non-hemolytic, and were susceptible to vancomycin and linezolid, resistant to clindamycin, and non-susceptible to daptomycin. These findings support combining population genomic analysis with strain-level phenotypic testing when selecting Lb. acidophilus candidates for bacterial vaginal infections."

Journal • Hematological Disorders • Infectious Disease • Vaginitis

Genomic Epidemiology, Antimicrobial Resistance, and Virulence of Clinical Enterococcus Isolates from Hat Yai, Thailand: Genomic Relatedness and Lineage Persistence. (PubMed, Antibiotics (Basel)) - " All isolates were susceptible to linezolid and oritavancin, whereas non-susceptibility to ampicillin, fosfomycin, vancomycin, and daptomycin was 60.0%, 57.5%, 12.5%, and 5.0%, respectively. High-level gentamicin resistance and MDR occurred in 37.5% and 22.5%, respectively...Three novel STs were identified, with E. faecium ST3096 exhibiting high-level ampicillin resistance, fosfomycin resistance, and reduced daptomycin susceptibility. These findings reveal emerging resistant lineages and spatiotemporal patterns of genomic relatedness, supporting continued genomic surveillance of clinical enterococci in Thailand."

Journal • Infectious Disease • LIAS

Reserve antibiotics in paediatrics: single-centre clinical experience and antimicrobial stewardship implementation. (PubMed, Eur J Pediatr) - " Reserve antibiotic use in complex paediatric populations highlights the importance of characterizing our clinical experience of prescribing in real-world practice. In this context, the development and implementation of a structured institutional antimicrobial stewardship program represents a pragmatic strategy to improve clinical governance and guide the appropriate positioning of these last-resort agents."

Journal • Observational data • Retrospective data • Hematological Disorders • Hematological Malignancies • Infectious Disease • Oncology • Pediatrics

Rare HCV-Associated IRIS Presenting as Acute Hepatitis Following ART Initiation in an HIV/HCV Coinfected Patient: A Case Report (ACG 2026) - "Case Description/ A 32-year-old ART-naïve male with advanced Human Immunodeficiency Virus (HIV) (CD4 274 cells/mm³, Viral load >10 million copies/mL) and untreated chronic Hepatitis C virus (HCV)(Viral load 15,094 IU/mL), complicated by bioprosthetic tricuspid valve endocarditis, was initiated on bictegravir/emtricitabine/tenofovir (Biktarvy) five weeks after achieving culture negativity with IV daptomycin...Prednisone 40 mg daily was initiated on day 7 without ART discontinuation, resulting in improvement in liver enzymes (AST 78, ALT 349 U/L within one week)...This case shows that HCV-IRIS does not mandate ART discontinuation and that it responds to corticosteroids, although this remains controversial. In these clinical scenarios, treating HCV before starting ART in coinfected patients may be a reasonable approach to help reduce the risk of hepatic IRIS."

Case report • Clinical • Autoimmune Hepatitis • Cardiovascular • Hepatitis B • Hepatitis C • Hepatology • Human Immunodeficiency Virus • Immunology • Infectious Disease • Inflammation • Liver Failure • CD4

Perforated Low-Grade Appendiceal Mucinous Neoplasm Incidentally Discovered During Evaluation of Pneumonia-Associated Encephalopathy (ACG 2026) - "Case Description/ A 75-year-old man with atrial fibrillation on warfarin, chronic kidney disease, diabetes, and recent prosthetic joint septic arthritis on daptomycin/ceftriaxone presented with encephalopathy, cough, dysuria, and hypoxia to 88%. Figure: Figure 1: Intraoperative findings of large volume of thick, gelatinous, mucinous material in the right lower quadrant/pelvis highly concerning for mucinous malignancy. The appendix appeared to be completely obliterated"

Appendix Cancer • Atrial Fibrillation • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Cough • Diabetes • Diabetic Nephropathy • Immunology • Infectious Disease • Metabolic Disorders • Nephrology • Pneumonia • Pulmonary Embolism • Renal Disease • Respiratory Diseases

Polymicrobial Endotipsitis in the Setting of Incarcerated Abdominal Hernia: A Case Report (ACG 2026) - "Blood cultures were positive for Achromobacter xylosoxidans and the patient was treated with piperacillin-tazobactam and daptomycin for a 6-week course. Given lack of interventional options for recanalization or source control, management transitioned to suppressive rather than curative antimicrobial therapy with Levofloxacin 500 mg oral tablet once daily...Broad spectrum antibiotic coverage is a crucial component of early management as the microbiologic profile of endotipsitis pathogens become better defined. Figure: Hepatic duplex ultrasound demonstrating TIPS occlusion Figure: Interventional radiology attempt for TIPS revision with contrast injection confirming complete TIPS occlusion"

Case report • Clinical • Cardiovascular • Fibrosis • Gastroenterology • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Portal Hypertension • Respiratory Diseases • Thrombosis

From Gut to Heart: A Rare Case of Colovesical Fistula Leading to Infective Endocarditis (ACG 2026) - "Blood cultures grew vancomycin-resistant Enterococcus faecium (VRE), and daptomycin was initiated...Antimicrobial therapy was broadened to meropenem, and VRE coverage was transitioned from daptomycin to linezolid...Figure: Contrast-enhanced CT demonstrating the fistulous connection and interval enlargement of the extramural abscess to 3.5 cm, with reactive bladder wall thickening. Figure: Transesophageal echocardiogram identified a 0.21 cm mobile vegetation on the posterior mitral leaflet and a 0.46 x 0.13 cm filamentous vegetation on the noncoronary cusp of the aortic valve."

Clinical • Cardiovascular • Chronic Obstructive Pulmonary Disease • Congestive Heart Failure • Diabetes • Gastrointestinal Disorder • Heart Failure • Immunology • Inflammation • Metabolic Disorders • Pulmonary Disease • Respiratory Diseases • Type 2 Diabetes Mellitus

Persistent Recurrent ESBL Escherichia coli Bacteremia Following Transjugular Intrahepatic Portosystemic Shunt (TIPS) Placement: Presumed EndoTIPSitis (ACG 2026) - "Within days of TIPS placement, he developed polymicrobial bacteremia with vancomycin-resistant Enterococcus (VRE) and extended-spectrum beta-lactamase (ESBL) Escherichia coli , treated with IV daptomycin and meropenem (11/27-12/10)...The patient was treated with six weeks of IV ertapenem followed by indefinite suppressive trimethoprim-sulfamethoxazole therapy, resulting in resolution of fevers and clearance of bacteremia...Recurrent bacteremia with enteric pathogens following TIPS placement â particularly with repeated relapse despite appropriate antimicrobial therapy â should prompt consideration of endoTIPSitis after alternative sources are excluded. Because TIPS removal is generally not feasible, management may require prolonged antimicrobial therapy, chronic suppressive treatment, and consideration of liver transplantation for definitive source control."

Fibrosis • Gastroenterology • Hepatology • Immunology • Infectious Disease • Thrombosis

A Rare Recurrent Pyogenic Liver Abscess Due to Gut Commensals ( Pediococcus acidilactici and Gemella morbillorum ) in an Immunocompetent Individual (ACG 2026) - "Intravenous (IV) ceftriaxone and metronidazole were started; the serology for Entamoeba histolytica & Echinococcus was negative. The pus culture showed Pediococcus acidilactici, and the patient was discharged on oral amoxicillin-clavulanate for 3 weeks...IV vancomycin and piperacillin-tazobactam were initiated, and the drainage of the abscesses was not feasible. The blood culture grew Gemella morbillorum ; antibiotics were switched to IV daptomycin and meropenem...On follow-up, the repeat CT showed interval resolution of the abscess (Figure 4), and the patient was discharged on IV daptomycin and ertapenem for a total of 6 weeks...Figure 4. Follow-up CECT abdomen (axial view) demonstrating interval improvement in the previously identified right hepatic lobe abscesses, with decreased size and surrounding inflammatory changes."

Clinical • Addiction (Opioid and Alcohol) • CNS Disorders • Diabetes • Gastroenterology • Gastrointestinal Disorder • Hepatology • Human Immunodeficiency Virus • Immunology • Infectious Disease • Inflammatory Bowel Disease • Metabolic Disorders • Pneumonia • CA 19-9 • CEACAM5 • MUC16

From Bile Duct to Heart Valve: A Case Report of Polymicrobial Infective Endocarditis Complicating Recurrent Ascending Cholangitis After Roux-en-Y Hepaticojejunostomy (ACG 2026) - "Antimicrobial stewardship involved multiple agents over several life threatening hospitilazations, including daptomycin, ciprofloxacin, ceftriaxone, metronidazole, meropenem, and cefepime. Systematic reviews have confirmed that the rate of recurrent non-stenotic cholangitis across studies is approximately 4% of all hepaticojejunostomies, with optimal treatment remaining poorly defined. The case report of this gentleman highlights core learning objectives: recognizing recurrent RYHJ-associated cholangitis as a source of IE in patients; and understanding that non-surgical management emphasizes percutaneous biliary source control, tailored antimicrobial therapy, and longitudinal cardiac surveillance."

Case report • Clinical • Cardiovascular • Gastrointestinal Disorder • Hepatology • Infectious Disease • Pneumonia • Septic Shock

Bacterial-derived cyclic lipopeptides suppress dauer arrest in C. elegans. (PubMed, bioRxiv) - "We also found that surfactin C, a cyclic lipopeptide from B. subtilis , similarly suppressed dauer formation whereas the cyclic lipopeptide antibiotic daptomycin did not, indicating that dauer suppression is shared by a subset of cyclic lipopeptides rather than being a general property of the class. Lastly, we found that massABC -dependent Massetolide F production induces the expression of the acid sphingomyelinase asm-3 in C. elegans, that asm-3 is required for Massetolide F induced dauer suppression, and that loss of Massetolide F production also leads to reduced bacterial clearance in host animals. Together, these findings identify Massetolide F as a microbiome-derived molecule that promotes animal development and reveal an unexpected function for bacterial biosurfactants in regulating animal physiology."

Journal • TGFB1

A truncated nisin variant, lipidated at its C-terminus, displays improved stability and increased antibacterial activity against methicillin-resistant Staphylococcus aureus. (PubMed, RSC Chem Biol) - "Some naturally occurring AMPs are lipidated, showing similarity with clinically used antimicrobial agents such as daptomycin and polymyxins, which are lipidated peptides...Antimicrobial activity was assessed against two Gram-positive strains: methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE)...Mode-of-action studies revealed that the lipidated construct 12 retained its ability to bind lipid II but does not induce pore formation in S. aureus. Notably, due to its short length, ring-protected structure, and lipid modification, the construct demonstrated improved proteolytic stability against chymotrypsin, trypsin and protease K. Our findings suggest that optimizing lipid-peptide combinations can lead to more effective, specific, and stable candidates for antimicrobial development."

Journal • Infectious Disease

Purine and pyrimidine analogs differentially regulate cell wall precursor biosynthesis to control β-lactam susceptibility in methicillin-resistant Staphylococcus aureus. (PubMed, mBio) - "We previously showed that the pyrimidine analogs 5-fluorouracil (5-FU) and 5-fluorouridine (5-FUrd) synergize with β-lactams...Gemcitabine (Gem) and mitomycin C (Mito), such as 5-FU and 5-FUrd, exhibited intrinsic anti-MRSA activity and potentiated β-lactams, whereas the purine analog 6-thioguanine (6-TG) showed distinct, often antagonistic effects...Consistent with this, pyrimidine analogs also suppressed GlmS expression, potentially limiting UDP-GlcNAc production required for cell wall synthesis, and synergized with fosfomycin...Additionally, glutathione-mediated attenuation of killing implicated reactive oxygen species in the bactericidal activity of cloxacillin combinations. Finally, these agents displayed strong antibiofilm activity, further enhanced in combination with daptomycin and rifampicin...These drugs altered the bacterial cell wall and other metabolic pathways linked to antibiotic susceptibility. Our findings reveal the potential to repurpose certain..."

Journal • Infectious Disease • Oncology

An in vitro comparative study of cefiderocol, siderophore-aztreonam and siderophore-daptomycin conjugates against select gram-negative bacteria. (PubMed, Bioorg Med Chem) - "Our in vitro studies demonstrated that siderophore conjugates exhibit comparable or superior antimicrobial activity to, with daptomycin conjugates notably retaining efficacy over extended periods. These findings suggest that conjugation with iron chelators that closely mimic natural siderophores can improve antibiotic delivery and activity, providing complementary options to existing therapies for multidrug-resistant Gram-negative infections."

Journal • Preclinical • Infectious Disease

Effectiveness and safety of daptomycin in pediatrics. (PubMed, Enferm Infecc Microbiol Clin (Engl Ed)) - "Daptomycin showed a high rate of clinical effectiveness. In patients for whom CK levels were available, no elevations were observed; however, the small number of patients monitored limits the interpretation of safety. Its use was largely empirical. These findings support its consideration as a therapeutic alternative in this group of patients, although prospective, controlled studies are needed to strengthen the evidence in the pediatric population."

Journal • Cardiovascular • Eosinophilia • Infectious Disease • Pediatrics

Plasma and subcutaneous tissue pharmacokinetics of daptomycin in critically ill patients (EADV 2026) - No abstract available

Clinical • PK/PD data • Infectious Disease

Evaluation of Changes in Staphylococcus and Enterococcus Resistance Following Reduced Restrictions on Daptomycin and Linezolid. (PubMed, Open Forum Infect Dis) - "Daptomycin and linezolid may have more favorable safety and efficacy profiles compared to vancomycin and require less therapeutic monitoring. The liberalization of daptomycin and linezolid did not result in clinically relevant increases in resistance. Further studies are needed to confirm the durability of these results, specifically among CoNS and VRE."

Journal • Infectious Disease

Antimicrobial Resistance in Nontyphoidal Salmonella and Clinically Relevant Enterococcus From Faecal Samples of Conservation-Priority Captive Ungulates in a United Arab Emirates Urban Zoo: A Cross-Sectional Baseline Study. (PubMed, Environ Microbiol Rep) - "Among 33 E. faecium/Enterococcus faecalis isolates tested phenotypically, resistance was generally low, with erythromycin and ciprofloxacin resistance each observed in 9.1%. One clinically important E. faecium isolate showed glycopeptide resistance and genetic markers associated with reduced daptomycin susceptibility. These single-institution cross-sectional data provide an initial regional baseline for AMR-relevant enteric bacteria in conservation-managed ungulates and identify priorities for broader longitudinal and interface-based surveillance."

Journal • Infectious Disease

Validation of an innovative tissue-cage/beads rabbit model for ex vivo determination of minimum levels of Staphylococcus aureus biofilm eradication. (PubMed, Eur J Clin Microbiol Infect Dis) - "Vancomycin, daptomycin, and rifampin MBEC90 values were 1.0, 1.5, and < 0.016 mg/L, respectively, and were significantly lower than those obtained against in vitro-formed biofilms. Compared with existing in vitro and in vivo studies, this innovative model of ex vivo determination of MBEC90 on in vivo-formed biofilm is likely to be more predictive of the in vivo anti-staphylococcal antibiofilm activity and requires a limited number of animals."

Journal • Preclinical • Infectious Disease

Methicillin resistance and antimicrobial non-susceptibility trends among Staphylococcus aureus clinical isolates in Aseer, Saudi Arabia (2013-2024): A retrospective laboratory-based surveillance study. (PubMed, PLoS One) - "In this single-center Aseer surveillance, MRSA became the majority of S. aureus during 2013-2024 and showed broad multidrug non-susceptibility, while vancomycin and daptomycin retained full in vitro activity. These local findings support sustained laboratory-based surveillance, Aseer-tailored empirical and stewardship guidance, and confirmatory testing of the emerging low-level linezolid non-susceptibility signal."

Journal • Retrospective data • Infectious Disease

Ceftazidime-avibactam in elastomeric pump for vascular graft infection: a case report. (PubMed, Infez Med) - "A subsequent isolate of K. pneumoniae demonstrated resistance to both ertapenem and ceftolozane-tazobactam.Treatment was transitioned to daptomycin (500 mg daily) and ceftazidime-avibactam (2.5 g three times a day), with oral rifampin added for anti-biofilm activity.To facilitate early discharge per the patient's request, ceftazidime-avibactam was administered off-label via an elastomeric pump. This case demonstrates that continuous 12-hour infusion of ceftazidime-avibactam via elastomeric pumps is a feasible and safe strategy for managing complex CRE infections in the OPAT setting. Such tailored approaches can enhance patient quality of life and reduce hospital stays, though further prospective studies are needed."

Journal • Cardiomyopathy • Cardiovascular • Diabetes • Infectious Disease • Metabolic Disorders • Peripheral Arterial Disease • Pneumonia

RAPID-ONSET DAPTOMYCIN-INDUCED PULMONARY TOXICITY WITHOUT EOSINOPHILIA (CHEST 2026) - No abstract available

Eosinophilia

PRONED FROM A PRESCRIPTION: A CASE OF DAPTOMYCIN-INDUCED EOSINOPHILIC PNEUMONITIS (CHEST 2026) - No abstract available

Clinical • Inflammation • Pneumonia

WHEN PNEUMONIA IS NOT PNEUMONIA: DAPTOMYCIN-INDUCED PNEUMONITIS IN A PATIENT WITH ACTIVE SPINAL INFECTION (CHEST 2026) - No abstract available

Clinical • Infectious Disease • Inflammation • Pneumonia • Respiratory Diseases

DAPTOMYCIN-INDUCED EOSINOPHILIC PNEUMONIA: A CASE REPORT (CHEST 2026) - No abstract available

Case report • Clinical • Infectious Disease • Pneumonia • Respiratory Diseases