Cubicin (daptomycin) / Merck (MSD) - LARVOL DELTA

Janibacter melonis bacteremia following autologous stem cell mobilization in lymphoma: a case report and literature review. (PubMed, BMC Infect Dis) - "This case highlights the importance of considering rare infections in immunocompromised patients, especially those with hematologic malignancies. Prompt microbiological and molecular diagnosis, combined with targeted therapy, is essential for good outcomes. This report also provides useful insights for managing Janibacter melonis infections."

Journal • B Cell Lymphoma • Diffuse Large B Cell Lymphoma • Hematological Disorders • Hematological Malignancies • Infectious Disease • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology

Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus Causing Healthcare-Associated Bloodstream Infections in Brazil: Results from A Prospective Countrywide Multicenter Study. (PubMed, Infect Dis Ther) - "The recently reported ST105(CC5)-SCCmecII-t002 clone has disseminated in hospitals from different Brazilian regions, together with other lineages that have been previously associated with community-associated infections, composed a new molecular landscape of MRSA causing HA BSIs in Brazil."

Clinical • Journal • Infectious Disease

GD04 (P064) A study of multidrug resistance pattern in scabies-associated infections in endemic communities. (PubMed, Br J Dermatol) - "High resistance was noted for erythromycin (91.6%) and ciprofloxacin (53.7%). Gentamicin and clindamycin had moderate susceptibility rates of 57.4% and 51.9%, respectively. Nitrofurantoin and rifampicin maintained high susceptibility (98.1% and 92.6%). Among bacterial strains, methicillin-resistant S. aureus (MRSA) was most prevalent (46.3%), followed by coagulase-negative staphylococci (5.6%) and vancomycin-resistant S. aureus (5.6%)...The high prevalence of MRSA highlights the urgent need for improved infection control measures and the judicious use of antibiotics. While newer drugs like tigecycline, linezolid and daptomycin offer alternative treatment options, robust surveillance and targeted antibiotic stewardship programmes are crucial to address this growing challenge and ensure effective patient care.TableBacteria isolated from 55 patients with scabiesOrganism isolatedn (%)Staphylococcus aureus47 (97)Staphylococcus haemolyticus2 (4)Staphylococcus epidermidis2..."

Journal • Infectious Disease

P064 A study of multidrug resistance pattern in scabies-associated infections in endemic communities. (PubMed, Br J Dermatol) - "High resistance was noted for erythromycin (91.6%) and ciprofloxacin (53.7%). Gentamicin and clindamycin had moderate susceptibility rates of 57.4% and 51.9%, respectively. Nitrofurantoin and rifampicin maintained high susceptibility (98.1% and 92.6%). Among bacterial strains, methicillin-resistant S. aureus (MRSA) was most prevalent (46.3%), followed by coagulase-negative staphylococci (5.6%) and vancomycin-resistant S. aureus (5.6%)...The high prevalence of MRSA highlights the urgent need for improved infection control measures and the judicious use of antibiotics. While newer drugs like tigecycline, linezolid and daptomycin offer alternative treatment options, robust surveillance and targeted antibiotic stewardship programmes are crucial to address this growing challenge and ensure effective patient care.TableBacteria isolated from 55 patients with scabiesOrganism isolatedn (%)Staphylococcus aureus47 (97)Staphylococcus haemolyticus2 (4)Staphylococcus epidermidis2..."

Journal • Infectious Disease

P012 Metastatic Staphylococcus aureus bacteraemia in atopic dermatitis: a case series. (PubMed, Br J Dermatol) - "IV, intravenousPatientClinical manifestationsComplications of SABTreatment of metastatic SABOutcome1Diaphoresis, rigors, nausea, fatigueMitral/aortic valve IE8 weeks IV flucloxacillinRecommenced on methotrexate; good control of AD2ErythrodermaMitral valve IE6 weeks IV flucloxacillinCommenced on dupilumab; excellent control of AD3Pyrexia and rigors following abscess development at footMitral/aortic valve IE6 weeks IV cefazolinMitral valve repair for mitral regurgitation. Recent commencement of dupilumab; AD improving4Erythroderma, subjective fevers, fatigueMRSA bacteraemia with mitral valve IETotal duration 6 weeks 6 days: IV vancomycin → IV daptomycin → IV ceftaroline + vancomycin → oral linezolidRecent recommencement of tralokinumab; AD improving5Right shoulder painSeptic arthritis of right shoulderIV flucloxacillin + vancomycin → 8 weeks daptomycin + rifampicin → 6 weeks doxycyclineCommenced on dupilumab; excellent control of ADAD, atopic dermatitis; IE, infective..."

Journal • Atopic Dermatitis • Cardiovascular • Cognitive Disorders • Dermatitis • Dermatology • Dermatopathology • Immunology • Infectious Disease • Inflammation • Musculoskeletal Pain • Pain • Rheumatology

Pharmacokinetics of daptomycin during low-flow continuous renal replacement therapy in critically ill Japanese patients. (PubMed, J Infect Chemother) - "These results help to define the pharmacokinetics of daptomycin during low-flow CRRT, while also helping to consider dosing regimens for critically ill Japanese patients receiving CRRT."

Journal • PK/PD data • Infectious Disease

Phospholipid composition changes in bacterial membranes: A molecular mechanism of antibiotic resistance. (PubMed, Adv Colloid Interface Sci) - "The bacterial cell membrane is a structurally essential and relatively accessible target for several antimicrobial agents, including daptomycin, polymyxins, antimicrobial peptides, and polymers...In this review, we outline membrane remodeling strategies associated with resistance in both Gram-positive and Gram-negative bacteria and provide an overview of analytical methods commonly employed to study these changes. These insights highlight the growing relevance of membrane-level adaptations in antimicrobial resistance and underscore the need for further research using modern lipidomic and biophysical tools."

Journal • Review • Infectious Disease

Allele-specific effects of mutations in the rifampin resistance-determining region (RRDR) of RpoB on physiology and antibiotic resistance in Enterococcus faecium. (PubMed, mSphere) - "In a local population of 710 E. faecium clinical isolates collected from patients at a single hospital, we found significant associations between the presence of RRDR mutations and prior exposure to rifamycin antibiotics, as well as associations between RRDR mutations and altered daptomycin susceptibility. Some of these collateral effects appear to promote E. faecium resistance to antibiotics and survival in the hospital environment, raising questions about the selective pressures driving their emergence. Overall, our study underscores the importance of examining the collateral effects of resistance-associated mutations in multidrug-resistant pathogens, which could help mitigate their persistence and spread among vulnerable patients."

Journal • Infectious Disease

Overcoming the drug resistance barrier: progress in fosfomycin combination therapy against multidrug-resistant pathogens. (PubMed, Front Microbiol) - "The preclinical and clinical evidence of key combination regimens (including β-lactams, aminoglycosides, fluoroquinolones, polymyxins, and daptomycin) has been comprehensively evaluated, with detailed discussions of the mechanistic foundations for the observed synergistic effects. Although in vitro and animal models show substantial promise, we critically examine the translational gap between positive preclinical results and clinical realities, discussing major barriers to clinical advancement. Finally, we outline a prospective research agenda, encompassing pharmacokinetic/pharmacodynamic (PK/PD)-guided precision dosing, exploring non-antibiotic adjuvants, and developing more predictive preclinical models to unlock the full potential of fosfomycin-based combinations against MDR infections."

Journal • Review • Infectious Disease

In vitro exebacase (CF-301) activity against methicillin-susceptible or methicillin-resistant Staphylococcus aureus and coagulase-negative staphylococci strains isolated from patients with infective endocarditis. (PubMed, J Antimicrob Chemother) - "Exebacase activity was independent of methicillin resistance and consistently higher against S. aureus than S. epidermidis. Further research is warranted to explore lysins in combination against staphylococcal infections."

Journal • Preclinical • Cardiovascular • Infectious Disease

Analytical Methods for Daptomycin Determination: Applications in Biological Matrices and Pharmaceutical Formulations. (PubMed, Crit Rev Anal Chem) - "protein precipitation and solid-phase extraction, have also been systematically discussed. By offering a comparative perspective grounded in experimental evidence, this review aims to guide researchers and laboratory professionals in selecting appropriate DAP quantification strategies for both clinical and pharmaceutical applications."

Journal • Review • Cardiovascular • Infectious Disease

Adverse events leading to discontinuation of daptomycin versus vancomycin in outpatient parenteral antimicrobial therapy: a retrospective cohort study. (PubMed, JAC Antimicrob Resist) - "These findings suggest that either agent may be considered in the OPAT setting depending on patient-specific factors. Dosing of vancomycin using Bayesian model dosing software may have led to a reduction of adverse events in the vancomycin group."

Adverse events • Journal • Retrospective data

Giants in Infectious Diseases: Prof. Jose M. Miro's translational research in infective endocarditis. (PubMed, Clin Microbiol Infect) - No abstract available

Journal • Cardiovascular • Colon Cancer • Colorectal Cancer • Infectious Disease • Oncology • Solid Tumor

Daptomycin Plasma and Subcutaneous Pharmacokinetics in Critically Ill Patients: Implications for Target Attainment in Skin and Soft Tissue Infections (ISDS 2025) - "According to EUCAST, Staphylococcus aureus (MIC90 = 0.5 mg/L) and Enterococcus faecalis (MIC90 = 2 mg/L) fall within the range of plasma target attainment; however, poor tissue penetration raises concerns regarding efficacy in skin and soft tissue infections in critically ill patients. These findings suggest that adequate plasma exposure does not guarantee therapeutic tissue levels and highlight the need for individualised dosing and therapeutic drug monitoring in this population."

Clinical • PK/PD data • Infectious Disease

Loss of LafB activity reverses daptomycin resistance in E. faecium. (PubMed, mBio) - "Infections caused by multidrug-resistant enterococci, particularly vancomycin-resistant Enterococcus (VRE), present significant therapeutic challenges. Furthermore, we show that loss of function mutation of the lafB gene in daptomycin-resistant clinical isolates renders them more susceptible to daptomycin than wild-type Enterococcus faecium. This indicates that an effective small molecule inhibitor of LafB activity or lafB gene expression would be a useful adjunctive for extending and restoring the therapeutic utility of daptomycin."

Journal • Infectious Disease

Daptomycin is associated with higher treatment failure rates than alternatives for Enterococcus faecium bloodstream infections in critically ill patients: a multicentric retrospective cohort. (PubMed, Crit Care) - "In this multicenter retrospective cohort of critically ill patients with monomicrobial E. faecium bloodstream infections, use of daptomycin as the definitive antibiotic regimen was associated with a higher rate of treatment failure. Further prospective studies are needed."

Clinical • Journal • Retrospective data • Critical care • Infectious Disease

Antimicrobial resistance, genomic, and public health insights into Enterococcus spp. from Australian cattle. (PubMed, Vet Microbiol) - "Antimicrobial resistance among enterococci from Australian cattle is low. These strains are genetically distinct from vancomycin-resistant E. faecium circulating in hospitals, suggesting that cattle are not a significant source of clinically relevant AMR enterococci in Australia."

Journal • Infectious Disease • Septic Shock

A Retrospective Study on the Use of Daptomycin and Linezolid in Singapore General Hospital. (PubMed, Antibiotics (Basel)) - "The primary reason for inappropriate linezolid use was overly broad empirical therapy where first-line options like cefazolin and vancomycin could have been prescribed. Nevertheless, our findings suggest the need to re-evaluate the empirical treatment strategies especially in VRE-colonized patients. Implementation of robust risk-based criteria as well as in-house hospital guidelines or protocols on the initiation of VRE-active agents may help support more judicious prescribing practices of these agents."

Journal • Retrospective data • Infectious Disease

Influence of heparin-based anticoagulants on antibiotic therapy. (PubMed, Front Immunol) - "Given the prevalence of negatively charged anticoagulants in clinical settings, we aimed to explore the effects of unfractionated heparin, low molecular weight heparin, and fondaparinux on the antibacterial activity of AMCs and antibiotics (colistin, daptomycin, gentamicin, imipenem, ofloxacin, and vancomycin). These findings support our hypothesis that specific heparin-based anticoagulants interfere with the activity of blood-derived AMCs and positively charged antibiotics, reducing their efficacy in vitro. Our research aims to provide a foundation for future studies focused on optimizing anticoagulant use in clinical settings, ultimately improving patient outcomes in the ongoing fight against multidrug-resistant bacteria."

Journal • Infectious Disease

Molecular mechanisms of resistance and tolerance of Staphylococcus aureus to daptomycin. (PubMed, Int J Antimicrob Agents) - "Furthermore, the pathways in daptomycin resistance appear to overlap with tolerance which is understudied in S. aureus. In this review, we explore the current understanding of the complex interplay of molecular mechanisms involved in daptomycin resistance and tolerance in S. aureus."

Journal • Review • Infectious Disease

[18F]Fluorodeoxyglucose Positron Emission Tomography for diagnosis and monitoring of acute Staphylococcus aureus vascular graft infection in a rat model. (PubMed, J Infect Dis) - "FDG-PET differentiated untreated S. aureus-infected rats from uninfected ones but failed to monitor infection progression, as SUVmax declined over time despite a constant bacterial load.FDG-PET could not distinguish between uninfected rats and those with suppressed infection, likely due to reduced inflammation and encapsulation of the infection."

Journal • Preclinical • Cardiovascular • Infectious Disease • Inflammation • IL10

Clinico Microbiological Profile of Diabetic Foot Ulcers: A Retrospective Study. (PubMed, Cureus) - "This study has enhanced our understanding of the epidemiology of diabetic foot ulcers by identifying common pathogens. The antibiotic susceptibility pattern of the pathogens will help clinicians provide better empirical therapy, thereby promoting faster wound healing."

Journal • Retrospective data • Diabetes • Infectious Disease • Metabolic Disorders • Pneumonia

The last resort antibiotic daptomycin exhibits two independent antibacterial mechanisms of action. (PubMed, Nat Commun) - "This dual mechanism of action provides an explanation for the frequently disagreeing findings obtained through in vivo and in vitro studies and explains why resistance development towards daptomycin is slow and multifactorial. In a broader context, this demonstrates that dual mechanism antibiotics can be clinically successful and exhibit favourable characteristics in terms of real-world, clinically relevant resistance development."

Journal • Infectious Disease

A Six-Year Surveillance of Nasal Methicillin-Resistant Staphylococcus aureus Colonization on Intensive Care Unit Admission: Do We Need Screening? (PubMed, Infect Dis Rep) - "All 29 strains were susceptible to vancomycin, linezolid, and daptomycin, while one strain was resistant to teicoplanin (3.5%). Screening should be performed because MRSA colonization may be a risk factor for invasive infections; however, screening all patients would be prohibitively expensive and labor-intensive. Instead, it may be more appropriate to identify risk factors and then screen select patients."

Journal • Chronic Kidney Disease • Critical care • Infectious Disease • Pneumonia • Renal Disease • Respiratory Diseases

Peptide-based antibiotics: structure-driven strategies to tackle toxicity and resistance of antimicrobial peptides. (PubMed, Bioorg Med Chem) - "This review focuses on five representative AMPs: daptomycin, pexiganan (MSI-78), murepavadin (POL7080), iseganan (IB-367), and omiganan (MBI-226), and involves an analysis of their clinical development, mechanisms of resistance, toxicity profiles, and resultant outcomes. Furthermore, we discuss prospective peptide design strategies that may effectively address these challenges. Notably, we underscore the potential of structure-based strategies, including amino acid substitutions and conjugation with diverse molecular entities (such as small functional groups, synthetic polymers, peptides, and antibiotics), as promising pathways to mitigate these barriers and advance the development of clinically viable AMP therapeutics."

Journal • Review