FP-100 / Flightpath Biosci - LARVOL DELTA

Impact of Long-Term Alkaline Cleaning on Ultrafiltration Tubular PVDF Membrane Performances. (PubMed, Membranes (Basel)) - "The installation included an industrial module with FP100 tubular membranes made of polyvinylidene fluoride (PVDF)...As a result of the repeated chemical cleaning, the pore size increased, resulting in a more than 50% increase in permeate flux. However, the quality of the recovered wash water did not deteriorate, as an additional separation layer was formed on the membrane surface due to the fouling phenomenon."

Journal

A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of FP-100 in Healthy Adults (ANZCTR) - P1 | N=72 | Completed | Sponsor: Flightpath Biosciences Australia Pty Ltd | Recruiting ➔ Completed

Trial completion • Infectious Disease • Inflammatory Arthritis • Lyme Disease

Changes in Tubular PVDF Membrane Performance During Initial Period of Pilot Plant Operation. (PubMed, Membranes (Basel)) - "The module was equipped with tubular FP100 (100 kDa) polyvinylidene fluoride (PVDF) membranes used to separate carwash wastewater. The effect of membrane compaction during the first few days of the process on changes in permeate flux and dextran (40-500 kDa) separation rate was investigated. The effect of fouling, membrane washing with P3 Ultrasill 11 solution (pH = 12) and maintenance with sodium metabisulfite solution on the stabilisation of the technological performance of the plant was determined."

Journal

Changes in the Separation Properties of Aged PVDF Ultrafiltration Membranes During Long-Term Treatment of Car Wash Wastewater. (PubMed, Membranes (Basel)) - "Therefore, the main aim of the current study was to provide a comprehensive investigation on the changes in the separation properties of aged FP100 ultrafiltration membranes made of polyvinylidene fluoride (PVDF) with respect to their application for long-term treatment of CWW...Likewise, with regard to the separation of E. coli, the aged PVDF membranes ensured the high process efficiency and over 99.99% bacterial retention. In the interest of the growing potential of PVDF membrane in CWW treatment, the results obtained in the current work complement the findings made in this field."

Journal

A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of FP-100 in Healthy Adults (ANZCTR) - P1 | N=72 | Recruiting | Sponsor: Flightpath Biosciences Australia Pty Ltd | Not yet recruiting ➔ Recruiting | Initiation date: May 2024

Enrollment open • Trial initiation date • Infectious Disease • Inflammatory Arthritis • Lyme Disease

Targeted elimination of Fusobacterium nucleatum alleviates periodontitis. (PubMed, J Oral Microbiol) - "Alveolar bone loss was significantly reduced in the FP-100 group (p = 0.018), with concurrent decreases in gingival IL-1β and TNF-α expression (p = 0.052 and 0.018, respectively). FP-100 effectively eliminates F. nucleatum from oral microbiota and significantly reduces bone loss in a mouse periodontitis model, demonstrating its potential as a targeted therapeutic agent for periodontal disease."

Journal • Dental Disorders • Osteoporosis • Periodontitis • IL1B • TNFA

Prevalence of Fast Progressors of Infarct Growth in Anterior Circulation Large Vessel Occlusions <6 Hours From Onset (ISC 2024) - "FP was defined at 2 levels: as "FP70" with IGR >11.7mL/h (which would result in an ICV >70mL by 6h) and had >=70mL of overall hypoperfusion present; and as "FP100" with IGR >16.7mL/h (which would result in an ICV >100mL by 6h) and had >=100mL of overall hypoperfusion present. 108 patients were included with median (IQR) age of 75.5 (67-85), NIHSS of 20 (12-24), onset time of 2h (1.5-4), median ICV of 11mL (0-40), hypoperfusion volume of 122mL (70-164), and mismatch volume of 86.5mL (58-130)... In a cohort of acute anterior circulation LVO strokes <6h from onset, the vast majority were good candidates for EVT with small to medium size core volumes. However, ~25% were fast progressors that may require more caution in selection, with ICV at or on pace to reach 70-100mL thresholds by 6h."

Cardiovascular