Dynastat (parecoxib) / Pfizer - LARVOL DELTA

PANDA: Study Comparing Dynastat and Parestat Pain Relief Medications for Patients After Breast Surgery (clinicaltrials.gov) - P4 | N=60 | Not yet recruiting | Sponsor: University of Malaya

Head-to-Head • New P4 trial • Pain

Effect of parecoxib and dexamethasone on the temporomandibular joint of orchiectomized rats: Morphological and immunological analysis. (PubMed, Arch Oral Biol) - "Testosterone deficiency enhanced TMJ inflammation and impaired cartilage structure. While both dexamethasone and parecoxib modulated these effects, their actions differed: dexamethasone promoted cartilage-to-bone differentiation, potentially unfavorable long term, whereas parecoxib preserved cartilage integrity. These findings underscore hormonal influence and support selective anti-inflammatory strategies for TMJ preservation under androgen deficiency."

Journal • Preclinical • Inflammation • IL1B • IL6 • TNFA

Additive with Multinary Interactions to Perovskite Precursor Species for Catalyzed Crystallization of Antisolvent-Free α-FAPbI3 Solar Cells. (PubMed, Adv Mater) - "In this work, a novel additive, parecoxib (Pr), is proposed, which catalyzes the direct crystallization of α-FAPbI3 through multinary interactions with the solvate perovskite precursor...As a result, high-performance antisolvent-free α-FAPbI3 PSCs are achieved with the PCE reaching 25.38% and 19.64% for mini-modules (93 cm2). The unencapsulated device maintains 91.08% of the initial PCE for 1000 h at 85 °C, and 90.62% after 1000 h of maximum power point tracking."

Journal

Multiple benefits of parecoxib sodium in perioperative applications. (PubMed, Int J Surg) - No abstract available

Journal

Author's Reply to the Comment on "Pain control and adverse effects of parecoxib after wisdom teeth surgery: a quantitative systematic review". (PubMed, Oral Maxillofac Surg) - No abstract available

Adverse events • Journal • Pain

Comment on "Pain control and adverse effects of parecoxib after wisdom teeth surgery: a quantitative systematic review". (PubMed, Oral Maxillofac Surg) - No abstract available

Adverse events • Journal • Pain

Comparative Efficacy of IV Parecoxib vs Lidocaine in Reducing Propofol Injection Pain (clinicaltrials.gov) - P=N/A | N=30 | Not yet recruiting | Sponsor: Oman Medical Speciality Board

New trial • Pain

Feasibility Study of Enhanced Recovery After Surgery (ERAS) Concept in Endoscopic Submucosal Dissection (ESD) for Upper Gastrointestinal Lesions <= 2 cm: A Prospective, Randomized, Single-Center, Non-Inferiority Study (ChiCTR) - P=N/A | N=183 | Not yet recruiting | Sponsor: General Hospital of Northern Theater Command; General Hospital of Northern Theater Command

Head-to-Head • New trial

Comparing the Effects of Fentanyl, Sufentanil, and Butorphanol Combined With Flurbiprofen Axetil on Postoperative Intravenous Patient-controlled Analgesia Post Cesarean Delivery. (PubMed, Pain Physician) - "The analgesic effect in patients who underwent cesarean delivery is similar when using different postoperative PCIA formulae. Although butorphanol displayed no analgesic advantage over fentanyl and sufentanil postoperatively, it caused fewer postoperative nausea and vomiting incidences than fentanyl and sufentanil."

Clinical • Journal • Retrospective data • Anesthesia • Pain

Effect of Parecoxib and transversus abdominis plane block on postoperative anxiety and cognition: A randomized controlled-trial. (PubMed, J Pak Med Assoc) - P=N/A | "A single transversus abdominis plane block did not have a significant effect on postoperative anxiety and cognition, while parecoxib could alleviate postoperative anxiety in elderly patients undergoing laparoscopic intestinal surgery."

Clinical • Journal • Oncology • Psychiatry

Electroacupuncture and Parecoxib Reduce Inflammatory Injury in a Primary Dysmenorrhea Rat Model: Investigating the Role of the COX-2/NF-κB/NLRP3 Pathway. (PubMed, J Pain Res) - "The following pain management interventions were administered to a PDM rat model: saline (control), EA, parecoxib, EA + parecoxib, or ibuprofen. Furthermore, EA markedly improved pain symptoms and pathological damage in PDM rats and downregulated the expression of COX-2/NF-κB/NLRP3 signaling pathway proteins in uterine tissue. Our findings demonstrated superior anti-inflammatory effects of EA + parecoxib on COX-2/NF-κB/NLRP3 signaling pathway-related proteins compared with that of EA alone or single-drug administration."

Journal • Preclinical • Pain • Women's Health • IL18 • IL1B • NLRC5 • NLRP3 • PTGS2

Methamphetamine produces behavioral flexibility deficits that are attenuated by COX-2 inhibition in both male and female rats. (PubMed, Addict Neurosci) - "The current study sought to investigate the ability of an anti-inflammatory cyclooxygenase-2 (COX-2) inhibitor, parecoxib (PXB), to attenuate METH-induced deficits in behavioral flexibility in male and female rats. Sex differences in the simple discrimination (SD) part of the task were also observed, with METH-saline females exhibiting deficits that were attenuated by PXB. These findings reinforce the argument that pharmacologically targeting neuroimmune responses to METH may facilitate recovery from MUD."

Journal • Preclinical • Cognitive Disorders • Inflammation • Tobacco Addiction

MANAGEMENT OF POST-OPERATIVE ACUTE (MODERATE TO SEVERE) PAIN IN CANCER PATIENTS - A REVIEW OF THE LATEST EVIDENCE (MASCC-ISOO 2025) - "Thoracic (12%) and colorectal procedures (11%) demonstrated no consistent pain management strategies, with varying approaches including gabapentinoids and nefopam respectively...4 gastric procedures (5%) and 4 hepatic procedures (5%) found analgesics including parecoxib to be optimal...Further studies are needed to implement standardized pain management protocols, particularly for less common procedures and cancers where evidence is limited. Furthermore, long-term follow-up studies are crucial to evaluate if pain relief was sustainable and its impact on recovery."

Clinical • Review • Oncology • Pain

Pain control and adverse effects of parecoxib after wisdom teeth surgery: a quantitative systematic review. (PubMed, Oral Maxillofac Surg) - No abstract available

Adverse events • Journal • Review • Pain

Letter to editor: effect of parecoxib on postoperative delirium in patients with hyperlipidemia: a randomized, double-blind, single-center, superiority trial. (PubMed, Int J Surg) - No abstract available

Clinical • Head-to-Head • Journal • CNS Disorders • Dyslipidemia

Behavioral Flexibility Deficits Following Methamphetamine Use are Attenuated by COX-2 and PGE2 Inhibition in Male and Female Rats; Potential Role of PFC Neurons (CPDD 2025) - "Additionally, behavioral flexibility deficits were attenuated by COX-2 inhibition by parecoxib (PXB) and by PGE2 synthesis inhibition by UT-11. This may indicate that METH-induced alterations of COX-2 expression may influence PFC imbalances of GABA/glutamate signaling that underlie behavioral deficits, and that COX-2 inhibition may help restore behavioral control in MUD. 2"

Preclinical • CNS Disorders • Cognitive Disorders • Psychiatry • PTGS2

Opioid-sparing anaesthesia in thymectomy using ultrasound-guided bilateral deep parasternal block: a case report (Euroanaesthesia 2025) - "To our knowledge, this is the first report of its preoperative application in thymectomy.Case Report: A 53-year-old male (BMI 29.1) with a history of substance use (marijuana, cocaine, alcohol abuse, 40 pack-years smoking) and psychotic disorder (on quetiapine and zopiclone) presented for elective thymectomy following a diagnosis of thymoma...The anesthesia plan included general anesthesia (GA) induction with fentanyl (0.2 mg), propofol, and rocuronium, combined with a bilateral DPB under ultrasound guidance (40 mL 0.375% ropivacaine total). GA was maintained with sevoflurane and additional analgesia consisted of paracetamol (1000 mg), dexamethasone (8 mg), magnesium sulfate (2500 mg), parecoxib (40 mg), and dexmedetomidine (100 mcg)...Postoperative analgesia included paracetamol (1000 mg every 6 hours) and rescue tramadol as needed...DPB offers a safe, effective and promising method for reducing opioid reliance and their associated side effects, for contributing to..."

Case report • Clinical • Anesthesia • CNS Disorders • Pain • Psychiatry • Solid Tumor • Thymoma • Thymus Cancer

A commentary on 'Effect of parecoxib on postoperative delirium in patients with hyperlipidemia: a randomized, double-blind, single-center, superiority trial'. (PubMed, Int J Surg) - No abstract available

Clinical • Head-to-Head • Journal • CNS Disorders • Dyslipidemia

A commentary on "Effect of parecoxib on postoperative delirium in patients with hyperlipidemia: a randomized, double-blind, single-center, superiority trial". (PubMed, Int J Surg) - No abstract available

Clinical • Head-to-Head • Journal • CNS Disorders • Dyslipidemia

Effect of parecoxib on postoperative delirium in patients with hyperlipidemia: a randomized, double-blind, single-center, superiority trial. (PubMed, Int J Surg) - No abstract available

Clinical • Head-to-Head • Journal • CNS Disorders • Dyslipidemia

Parecoxib in Total Knee Arthroplasty (clinicaltrials.gov) - P4 | N=40 | Completed | Sponsor: University of Chile | Recruiting ➔ Completed | Trial completion date: Apr 2024 ➔ Sep 2024 | Trial primary completion date: Apr 2024 ➔ Sep 2024

Trial completion • Trial completion date • Trial primary completion date • Immunology • Orthopedics • Osteoarthritis • Pain • Renal Disease • Rheumatology

The Effects of Non-Steroidal Anti-Inflammatory Drugs Used for Orthodontic Pain Management on Tooth Movement: A Comprehensive Review of the Literature. (PubMed, J Clin Med) - "Evidence shows that NSAIDs such as aspirin, ketorolac, diclofenac, and nimesulide significantly reduce OTM. The results for ibuprofen, meloxicam, and celecoxib were inconsistent with both no influence or a reduction in OTM, depending on dosage, mode, and duration of administration. Conversely, tenoxicam, nabumetone, etoricoxib, and parecoxib appear to have no effect on OTM. Among these, etoricoxib appears particularly promising due to its favorable gastrointestinal profile, high COX-2 selectivity, and negligible influence on OTM in clinical doses. However, the limited number of human trials highlights the need for further research to develop evidence-based guidelines for pain management that preserve treatment efficiency in orthodontics."

Journal • Review • Pain

Parecoxib sequential with imrecoxib for occurrence and remission of severe acute pancreatitis: a multicentre, double-blind, randomised, placebo-controlled trial. (PubMed, Gut) - "Parecoxib sequential with imrecoxib was effective and well tolerated in reducing the occurrence and duration of SAP and local complications through suppression of systemic inflammatory response, leading to decreased morbidity."

Journal • Immunology • Inflammation • Pancreatitis • Systemic Inflammatory Response Syndrome

Novel multimodal analgesic regimen for perioperative pain management after hepatic artery infusion chemotherapy in patients with advanced hepatocellular carcinoma. (PubMed, World J Gastrointest Surg) - "Our study demonstrates that multimodal analgesia is effective in reducing postoperative pain, minimizing adverse reactions, and improving patient satisfaction in HCC patients undergoing HAIC. This approach provides valuable clinical strategies for optimizing pain management in this patient population."

Clinical • Journal • Hepatocellular Cancer • Hepatology • Oncology • Pain • Solid Tumor

Effect of mini-open rotator cuff repair combined with intraoperative cocktail therapy in the treatment of rotator cuff injury: a prospective comparative study between the cocktail therapy and the control group. (PubMed, Arch Orthop Trauma Surg) - "The mini-open rotator cuff repair has satisfactory curative effect in the treatment of rotator cuff injury, and intraoperative cocktail therapy can alleviate postoperative pain and speed up postoperative functional rehabilitation and improvement of joint range of motion."

Clinical • Journal • Infectious Disease • Pain