Dynastat (parecoxib) / Pfizer - LARVOL DELTA

Parecoxib sequential with imrecoxib for occurrence and remission of severe acute pancreatitis: a multicentre, double-blind, randomised, placebo-controlled trial. (PubMed, Gut) - "Parecoxib sequential with imrecoxib was effective and well tolerated in reducing the occurrence and duration of SAP and local complications through suppression of systemic inflammatory response, leading to decreased morbidity."

Journal • Immunology • Inflammation • Pancreatitis • Systemic Inflammatory Response Syndrome

Novel multimodal analgesic regimen for perioperative pain management after hepatic artery infusion chemotherapy in patients with advanced hepatocellular carcinoma. (PubMed, World J Gastrointest Surg) - "Our study demonstrates that multimodal analgesia is effective in reducing postoperative pain, minimizing adverse reactions, and improving patient satisfaction in HCC patients undergoing HAIC. This approach provides valuable clinical strategies for optimizing pain management in this patient population."

Clinical • Journal • Hepatocellular Cancer • Hepatology • Oncology • Pain • Solid Tumor

Effect of mini-open rotator cuff repair combined with intraoperative cocktail therapy in the treatment of rotator cuff injury: a prospective comparative study between the cocktail therapy and the control group. (PubMed, Arch Orthop Trauma Surg) - "The mini-open rotator cuff repair has satisfactory curative effect in the treatment of rotator cuff injury, and intraoperative cocktail therapy can alleviate postoperative pain and speed up postoperative functional rehabilitation and improvement of joint range of motion."

Clinical • Journal • Infectious Disease • Pain

The impact of external oblique intercostal block on early postoperative pain and recovery in patients undergoing J-shaped incisions for upper abdominal surgery: a single-center prospective randomized controlled study. (PubMed, BMC Anesthesiol) - P=N/A | "EOIB significantly enhances postoperative analgesia in patients undergoing upper abdominal J-shaped incision surgery, reducing opioid consumption and analgesic requirements, and improving the quality of recovery. It may be considered as part of a multimodal analgesic regimen following upper abdominal surgery."

Clinical • Journal • Anesthesia • Pain

A Comparative Study on the Effects of Repeated Subacromial Injections of Parecoxib and Triamcinolone in a Rat Model of Normal Rotator Cuff. (PubMed, Clin Orthop Surg) - "The PEG2 level in the subacromial bursa was significantly different among the 3 groups at the third, fifth, and sixth injections (p = 0.019, p = 0.004, and p = 0.004, respectively). In the rat model of normal rotator cuff, repeated local injections of the cyclooxygenase-2 inhibitor showed fewer negative effects on the biomechanical and histological properties of the normal tendon than triamcinolone."

Clinical • Journal • Preclinical

PASC: Analgesic Effect of Parecoxib Versus Morphine in SCD Patients Presenting to the Emergency Department (clinicaltrials.gov) - P3 | N=226 | Not yet recruiting | Sponsor: Oman Medical Speciality Board | Trial completion date: Jul 2026 ➔ Jul 2028 | Trial primary completion date: May 2026 ➔ May 2028

Trial completion date • Trial primary completion date • Genetic Disorders • Hematological Disorders • Pain • Sickle Cell Disease

Non-Opioid Analgesics for Postoperative Pain Management Following Total Joint Arthroplasty: A Systematic Review and Meta-Analysis. (PubMed, J Arthroplasty) - "This review found that postoperative administration of non-opioid co-analgesia may alleviate the need for opioids and have modest protective effects on postoperative pain. The effects of these analgesics, however, may be clinically non-meaningful for reducing pain. These results may further implicate a need to implement non-opioid co-analgesia in postoperative patient care. Future research may include an updated investigation of this research question as more medication-granular research becomes available."

Journal • Retrospective data • Orthopedics • Pain

Nonsteroidal anti-inflammatory drugs (NSAIDs) for acute renal colic. (PubMed, Cochrane Database Syst Rev) - "NSAIDs may reduce pain in adult patients with renal colic compared to placebo. Comparing one NSAID against another, IV ketorolac may be less effective than IV ibuprofen, and pirprofen may result in less need for rescue medication than indomethacin. The intravenous route of administration is probably similar to the intramuscular route but may be better than the rectal route. The evidence is uncertain regarding the potential harms of NSAIDs. We were not able to perform subgroup analysis based on our predefined criteria because there were no eligible studies."

Clinical • Journal • Review • Inflammation • Pain • Renal Calculi • Urolithiasis

Synergistic therapeutic effect of parecoxib and ilomastat combination in osteoarthritis via inhibition of IL-17/PI3K/AKT/NF-κB activity. (PubMed, Mol Immunol) - "The combined administration of parecoxib and ilomastat to inhibit IL-17/PI3K/AKT/NF-κB transduction is beneficial to reduce the infiltration of inflammatory factors and matrix metalloproteinases in osteoarthritis."

Journal • Immunology • Osteoarthritis • Pain • Rheumatology • IL17A • IL1B

Effect of parecoxib on postoperative delirium in patients with hyperlipidemia: a randomized, double-blind, single-center, superiority trial. (PubMed, Int J Surg) - "Parecoxib may help in reducing the hyperlipidemia-related postoperative delirium incidence. The effective anti-inflammatory activity of prostaglandin endoperoxide synthase-2 inhibition by parecoxib and postoperative pain control may be important mechanisms for preventing postoperative delirium."

Clinical • Head-to-Head • Journal • Anesthesia • CNS Disorders • Dyslipidemia • Pain • PTGS2

Effect of parecoxib on postoperative cognitive function (delirium) in patients with hyperlipidemia: a single-center, randomized, double-blind controlled trial (ChiCTR) - P4 | N=442 | Completed | Sponsor: Affiliated Hospital of Southwest Medical University; Affiliated Hospital of Southwest Medical University | Not yet recruiting ➔ Completed

Trial completion • CNS Disorders • Dyslipidemia • PACERR • PTGS2 • TNFA

Effect of esketamine combined with parecoxib sodium on postoperative analgesia and inflammatory response in patients with thoracoscopic pulmonary resection (ChiCTR) - P=N/A | N=80 | Sponsor: Yongchuan Hospital affiliated to Chongqing Medical University; Yongchuan Hospital affiliated to Chongqing Medical University

New trial • Inflammation • Lung Cancer • Oncology • Solid Tumor • IL6

Bioengineered NanoAid synergistically targets inflammatory pro-tumor processes to advance glioblastoma chemotherapy. (PubMed, Nanoscale) - "NanoAid employs macrophage-membrane-liposome hybrids to optimize the delivery of COX-2 inhibitor parecoxib and paclitaxel. This results in substantial tumor growth inhibition and extends the median survival of tumor-bearing mice. Thus, our study bridges clinical insights with fundamental research, potentially revolutionizing tumor therapy paradigms."

Journal • Brain Cancer • CNS Tumor • Glioblastoma • Oncology • Solid Tumor

Identification of novel fructose 1,6-bisphosphate aldolase inhibitors against tuberculosis: QSAR, molecular docking, and molecular dynamics simulation-based analysis of DrugBank compounds. (PubMed, J Biomol Struct Dyn) - "REPTree, chosen for further screening, led to the identification of four promising preclinical anti-TB drug candidates from DrugBank-Serdemetan, Parecoxib, N, N-Diethyl-2-[(2-Thienylcarbonyl) amino], and Visnadine.All screened ligands show stable binding behaviour during a 200-ns molecular dynamics simulation. Density functional theory (DFT) analysis was also employed for the analysis HOMO (highest occupied molecular orbital)/LUMO (lowest unoccupied molecular orbital) gap, and both screened hits showed efficient results. This study presents a potential avenue for effective TB therapeutics development from compounds with proven druggability in other contexts."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

AOPC: Effect of Preventive Analgesia with Oxycodone and Parecoxib Sodium on the Chronification of Acute Post-operative Pain (clinicaltrials.gov) - P=N/A | N=1316 | Not yet recruiting | Sponsor: Ailin Luo

New trial • Surgery • Pain

Preemptive Analgesic Efficacy of Parecoxib for Reducing Postoperative Pain in Gynecological Surgery (clinicaltrials.gov) - P4 | N=178 | Completed | Sponsor: Rajavithi Hospital | Recruiting ➔ Completed

Trial completion • Gynecology • Pain

Effect of Parecoxib sodium combined with esketamine and incision infiltration on postoperative analgesia and postoperative delirium (ChiCTR) - P4 | N=44 | Completed | Sponsor: Taian City Central Hospital; Taian City Central Hospital

New P4 trial • CNS Disorders • Pain • IL6

Contractive function of mesenteric lymph nodes in obese rats (PubMed, Vopr Pitan) - "Before the end of the experiment, four groups of HFD rats were formed: obesity resistant animals (HFD-OR, n=11), without additional interventions (HFD, n=10), rats which were administered dexamethasone three days before the study (HFD+Dexa, n=9), HFD followed by 8-week diet restriction (HFD+DR, n=9). At the end of the experiment, mesenteric lymph nodes (LNs) were taken from rats under anesthesia and their contractile function was studied in a myograph using 1400W, dynastat and Tempol...The reason for inhibition of LN contractile function is obesity, but not consumption of food high in fat. Transferring obese rats to a calorie-restricted diet results in a decrease in body weight and visceral fat mass and an improvement in LN contractile function."

Journal • Preclinical • Anesthesia • Genetic Disorders • Inflammation • Obesity

Sustained methamphetamine-induced impairment of cognitive flexibility in rats: the behavioral effects of prostaglandin E2 (PGE2) synthase inhibition (Neuroscience 2024) - "We found that administration of parecoxib (PXB), a cyclooxygenase-2 (COX-2) inhibitor, attenuated deficits in the extradimensional shift (ED) phase of the ASST following abstinence in rats given binge-like access to self-administered METH. Further work could investigate if a higher dose of UT-11 would result in greater attenuation of deficits or analyze the effect of inhibiting the synthesis of other prostaglandins. These results reinforce the notion that pharmacological therapeutics may promote cognitive recovery and facilitate behavioral treatment for MUD patients."

Preclinical • Alzheimer's Disease • CNS Disorders • Cognitive Disorders

Methamphetamine-induced behavioral deficits are not associated with prefrontal microglia: potential role of COX-2 signaling in cortical neurons (Neuroscience 2024) - "Behavioral flexibility deficits in attentional set shifting were observed at the same time point, which were attenuated by the COX-2 inhibitor, parecoxib (PXB) in both sexes (n = 9-13/group). Colocalization of COX-2 with specific neuronal cell subtypes is on-going. Outside of its inflammatory function, COX-2 is expressed constitutively in neurons following glutamatergic activation, providing a potential alternative explanation for our behavioral findings and a novel avenue for investigation."

CNS Disorders • Cognitive Disorders • CCL2 • CX3CL1 • IFNG • IL18 • IL6 • LEP • PTGS2

PRECISE: Efficacy and Safety of Parecoxib vs. Indomethacin in Preventing Post-ERCP Pancreatitis (clinicaltrials.gov) - P2 | N=100 | Not yet recruiting | Sponsor: Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

New P2 trial • Pancreatitis

Transdermal buprenorphine patch as an adjunct to multimodal analgesia after total joint arthroplasty: a retrospective cohort study. (PubMed, Front Pharmacol) - "Three postoperative analgesic regimens were selected: Group A (flurbiprofen 50 mg and tramadol 37.5 mg/acetaminophen 325 mg), Group B (flurbiprofen 50 mg and TDB 5 mg), and Group C (Parecoxib 40 mg and TDB 5 mg). Rate of adverse reactions among three groups for THA and TKA was not statistically different (P > 0.05). This study suggests that the combination of TDB patch and NSAIDs is safe and effective for postoperative analgesia after THA/TKA."

Journal • Retrospective data • CNS Disorders • Musculoskeletal Pain • Orthopedics • Pain • Sleep Disorder

Increased levels of Escherichia-Shigella and Klebsiella in the gut contribute to the responsivity of placebo analgesia. (PubMed, Neuropharmacology) - "Here, we conducted a conditioning training model with chronic inflammatory pain induced by complete Freund's adjuvant (CFA) in mice, associating parecoxib with different cues...Notably, levels of Escherichia Shigella and Klebsiella in the gut were increased considerably in the placebo analgesia responders as compared to both control and non-responders groups. In conclusion, placebo analgesia responders demonstrated marked analgesia, reduced anxiety-like behaviors, and increased levels of Escherichia-Shigella and Klebsiella, implying a potential linkage between gut microbiota and placebo analgesia."

Journal • Mood Disorders • Pain • Psychiatry

Peripheral inflammation suppresses striatal dopamine signaling via prostaglandin-dependent mechanisms (ECNP 2024) - "Subsequent administration of a combined cyclooxygenase (COX)-1 and -2 inhibitor, indomethacin (10 mg/kg), effectively blocked the decrease in dopamine after LPS administration, indicating a prostaglandin-dependent mechanism. Further investigation with selective COX-1 and COX-2 inhibitors, SC-560 (30 mg/kg) and Parecoxib (10 mg/kg), respectively, demonstrated that the decrease in dopamine transmission was specifically mediated by cyclooxygenase-1 (COX-1)...Future research will delve deeper into the molecular mechanisms underlying inflammation-induced reductions in dopamine release, utilizing cell type-specific gene deletions and optogenetics to elucidate the cascade of events from peripheral inflammation to striatal dopamine release. This comprehensive investigation holds promise for deepening our understanding of the intricate interplay between inflammation and neurotransmitter modulation in affective states."

CNS Disorders • Depression • Mood Disorders • Psychiatry

Comparison of postoperative pain in robotic and laparoscopic myomectomy: a retrospective cohort study. (PubMed, J Robot Surg) - "However, there were no significantly different in the postoperative visual analog scale pain scores, use and dosage of ketorolac and opioid, and use of Dynastat and nerve block between the groups. Hospitalization duration and intraoperative blood loss were similar between the groups. RM and LM offer comparable postoperative pain outcomes, emphasizing the importance of patient-specific factors in decision-making regarding myomectomy techniques."

Clinical • Journal • Retrospective data • Gynecology • Pain • Uterine Leiomyoma