Dynastat (parecoxib) / Pfizer - LARVOL DELTA

PI2025_843_0004: Evaluation of postoperative recovery when combining intravenous lidocaine with ropivacaine infiltration in laparoscopic colorectal oncologic surgery: a randomized controlled trial (clinicaltrialsregister.eu) - P4 | N=182 | Not yet recruiting | Sponsor: Centre Hospitalier Universitaire Amiens Picardie

New P4 trial • Colorectal Cancer • Oncology • Solid Tumor

Efficacy of intravenous parecoxib in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis: a randomized controlled trial. (PubMed, Surg Endosc) - "Intravenous parecoxib was effective in reducing post-ERCP abdominal pain and showed a trend toward a lower incidence of post-ERCP pancreatitis (PEP) in both unselected and high-risk patients, without any serious adverse events. Therefore, intravenous parecoxib may represent a viable alternative for PEP prevention in settings where rectal nonsteroidal anti-inflammatory drugs are unavailable."

Journal • Pain • Pancreatitis

Effect of preventive precision multimodal analgesia (PPMA) on postoperative acute pain process and rehabilitation in adult patients undergoing thoracoscopic pulmonary resection: protocol for a prospective, multicentre, randomised controlled study. (PubMed, BMJ Open) - P=N/A | "Patients in the PPMA Group will receive a regimen consisting of local anaesthetic infiltration of surgical incision (for incisional pain), intravenous injection of oxycodone (for visceral pain) and parecoxib sodium (for inflammatory pain) before surgery initiation...The results will be published in a peer-reviewed journal. Chinese Clinical Trial Registry (ChiCTR2300072176)."

Clinical protocol • Journal • Anesthesia • Pain

Effectiveness of drug interventions to prevent delirium after surgery for older adults: systematic review and network meta-analysis of randomised controlled trials. (PubMed, BMJ) - "Dexmedetomidine is effective in the prevention of postoperative delirium. This finding remains after exclusion of studies at high risk of bias. Corticosteroids, melatonin receptor agonists, parecoxib, intranasal insulin, and olanzapine have potential benefit, although evidence is of moderate to very low quality. Evidence synthesis in this area is complicated by inadequate trial registration practices and incomplete adoption of core outcome sets."

Clinical • Journal • Retrospective data • Review • Anesthesia • Cardiovascular • CNS Disorders • Hypotension • Infectious Disease

Comparison of Tegileridine and Sufentanil for Multimodal Analgesia in Gynecological Laparoscopic Surgery: A Randomized Double-blinded Controlled Trial (ChiCTR) - P=N/A | N=168 | Not yet recruiting | Sponsor: Obstetrics and Gynecology Hospital, Fudan University; Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and D

New trial • Pain

The Efficacy of Ultrasound-Guided Thoracic Paravertebral Blocks Using a Novel Analgesic Regimen for Thoracic Herpes Zoster-Associated Pain: A Randomized Controlled Trial. (PubMed, Pain Physician) - "Compared to conventional treatment, US-guided paravertebral blocks that used the novel drug combination provided more sustained analgesia and greater sleep quality enhancement without additional safety concerns. This optimized formulation represents a promising therapeutic approach for treating thoracic HZ-associated neuralgia."

Clinical • Journal • Anesthesia • CNS Disorders • Constipation • Depression • Gastroenterology • Gastrointestinal Disorder • Herpes Zoster • Neuralgia • Pain • Psychiatry • Respiratory Diseases • Varicella Zoster

The effect of intravenous patient-controlled analgesia with oxycodone or sufentanil on postoperative recovery in patients undergoing knee arthroscopic surgery: A randomized controlled clinical trial (ChiCTR) - P4 | N=120 | Not yet recruiting | Sponsor: Longhua District People's Hospital, Shenzhen; Longhua District People's Hospital, Shenzhen

New P4 trial • Orthopedics

Effect of erioperative based-AVNS nutritional trategy on accelerated recovery and long-term prognosis of hip fracture: a single-center, prospective randomized controlled trials (ChiCTR) - P=N/A | N=106 | Recruiting | Sponsor: Affiliated hospital of chengdu university; Affiliated hospital of chengdu university

New trial • Musculoskeletal Diseases • Orthopedics

Blocking PCSK9 suppresses hepatocellular carcinoma immune escape by decreasing FLI1-mediated SPP1 and PD-L1 expression. (PubMed, J Immunother Cancer) - "PCSK9 promoted HCC immune escape by upregulating SPP1 and PD-L1 via NOTCH3/FLI1 signaling. CRISPR ABE-mediated PCSK9 deficiency and PCSK9 inhibitor parecoxib may serve as effective strategies to inhibit HCC."

IO biomarker • Journal • Hematological Malignancies • Hepatocellular Cancer • Leukemia • Oncology • Solid Tumor • CD8 • FLI1 • NOTCH3 • PCSK9 • PD-L1 • SPP1

The Effect of Intravenous Parecoxib on Early Ambulation After Elective Lumbar Spinal Surgery: A Propensity Score Matching Analysis. (PubMed, J Clin Med) - " The administration of intravenous parecoxib after lumbar spine surgery demonstrated encouraging effects on early ambulation, with patients able to get out of bed and walk within 24 h after surgery. To endorse intravenous parecoxib as a standard postoperative pain protocol for spine surgery, further investigation in randomized controlled trials should be conducted."

Journal • Orthopedics • Pain

Cyclooxygenase 2 (COX-2) expression is elevated in prefrontal cortex neurons, not microglia, following methamphetamine self-administration in male and female rats. (PubMed, Neuropharmacology) - "We also showed that medial prefrontal cortex (mPFC) mediated behavioral flexibility deficits observed at this timepoint are attenuated by the COX-2 inhibitor parecoxib. COX-2 immunoreactivity was frequently absent from the infralimbic and cingulate cortices and was therefore not analyzed. Paired with our prior findings that COX-2 inhibition attenuates METH-induced behavioral deficits known to be mediated by the mPFC, these results suggest that altered neuronal COX-2 expression should be investigated for its influence on METH-induced deficits in mPFC function."

Journal • Preclinical • Inflammation • PTGS2

Ultrasound-Guided Transversus Abdominis Plane Block with Dexmedetomidine Combined with Ropivacaine Plus Diclofenac Sodium Suppository for Post-Cesarean Section Analgesia: A Non-Inferiority Randomized Controlled Trial (ChiCTR) - P=N/A | N=120 | Not yet recruiting | Sponsor: Hanzhong Central Hospital; Hanzhong Central Hospital

Head-to-Head • New trial • Pain

Scalp block versus intravenous parecoxib for post-operative cranioplasty surgery pain: A comparison of pain scores and morphine requirements. (PubMed, Surg Neurol Int) - "However, no difference in time to first commencement of PCA and total morphine dose was noted between the two groups. The scalp block reduced pain scores at the 1st, 2nd, 4th, and 6th h and morphine requirement postoperatively compared to IV parecoxib."

Journal • Anesthesia • Pain

Perfusion Enhancement via Continuous Brachial Plexus Block to Prevent Vascular Insufficiency in Replanted Digits: A Prospective, Randomized Controlled Trial. (PubMed, J Clin Med) - " After screening 113 patients, 55 patients (71 digits) were ultimately randomized and analyzed: the CBPB group (n = 27, 36 digits) received 0.2% ropivacaine infusion at 5 mL/h; the SIVA group (n = 28, 35 digits) received intravenous parecoxib 20 mg twice daily with supplemental tramadol for visual analog scale (VAS) scores > 3. No significant difference was observed in seven-day survival rates between groups (97% vs. 91%; p = 0.329). CBPB significantly enhanced perfusion in replanted digits and reduced the incidence of vascular insufficiency, despite not conferring additional survival benefits."

Journal • Cardiovascular • Hematological Disorders • Pain • Thrombosis

Prophylactic administration of parecoxib sodium for postoperative delirium in hip surgery of the elderly: a prospective, randomized, placebo-controlled trial. (PubMed, Rev Assoc Med Bras (1992)) - "Preoperative prophylactic administration of parecoxib sodium significantly reduced the incidence of postoperative delirium in elderly orthopedic patients but did not improve long-term functional recovery."

Clinical • Journal • CNS Disorders • Geriatric Disorders • Orthopedics • Pain

PCA – Patient controlled anaesthesia in thoracic surgery; offering a multifactorial approach (ERS 2025) - "Correlation with clinical and patient reported outcomes.850 cases (2019-2024)underwent thoracotomies and received intravenous PCA (paracetamol,parecoxib)for 48hours post operatively... PCA is a safe method for patients who underwent thoracotomy. It provides positive patient reported outcomes, it reduces postoperative complications in high risk patients with minimal side effects"

Clinical • Surgery • Anesthesia • Chronic Obstructive Pulmonary Disease • Immunology • Respiratory Diseases

The Analgesic Efficacy of Therapies Used for Complex Regional Pain Syndrome: A Systematic Review. (PubMed, Cureus) - "Combinations of local anesthetics and other medications (e.g., lidocaine with citalopram or parecoxib) were especially effective in acute CRPS...RCT evidence supports the use of bisphosphonates, ketamine, and early use of mirror or motor imagery therapies...However, many studies were limited by small size, short follow-up, or methodological flaws. There is an urgent need for large, high-quality, and mechanistically informed RCTs to guide long-term CRPS management."

Journal • Review • Anesthesia • Cardiovascular • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain

PANDA: Study Comparing Dynastat and Parestat Pain Relief Medications for Patients After Breast Surgery (clinicaltrials.gov) - P4 | N=60 | Not yet recruiting | Sponsor: University of Malaya

Head-to-Head • New P4 trial • Pain

Effect of parecoxib and dexamethasone on the temporomandibular joint of orchiectomized rats: Morphological and immunological analysis. (PubMed, Arch Oral Biol) - "Testosterone deficiency enhanced TMJ inflammation and impaired cartilage structure. While both dexamethasone and parecoxib modulated these effects, their actions differed: dexamethasone promoted cartilage-to-bone differentiation, potentially unfavorable long term, whereas parecoxib preserved cartilage integrity. These findings underscore hormonal influence and support selective anti-inflammatory strategies for TMJ preservation under androgen deficiency."

Journal • Preclinical • Inflammation • IL1B • IL6 • TNFA

Additive with Multinary Interactions to Perovskite Precursor Species for Catalyzed Crystallization of Antisolvent-Free α-FAPbI3 Solar Cells. (PubMed, Adv Mater) - "In this work, a novel additive, parecoxib (Pr), is proposed, which catalyzes the direct crystallization of α-FAPbI3 through multinary interactions with the solvate perovskite precursor...As a result, high-performance antisolvent-free α-FAPbI3 PSCs are achieved with the PCE reaching 25.38% and 19.64% for mini-modules (93 cm2). The unencapsulated device maintains 91.08% of the initial PCE for 1000 h at 85 °C, and 90.62% after 1000 h of maximum power point tracking."

Journal

Multiple benefits of parecoxib sodium in perioperative applications. (PubMed, Int J Surg) - No abstract available

Journal

Author's Reply to the Comment on "Pain control and adverse effects of parecoxib after wisdom teeth surgery: a quantitative systematic review". (PubMed, Oral Maxillofac Surg) - No abstract available

Adverse events • Journal • Pain

Comment on "Pain control and adverse effects of parecoxib after wisdom teeth surgery: a quantitative systematic review". (PubMed, Oral Maxillofac Surg) - No abstract available

Adverse events • Journal • Pain

Comparative Efficacy of IV Parecoxib vs Lidocaine in Reducing Propofol Injection Pain (clinicaltrials.gov) - P=N/A | N=30 | Not yet recruiting | Sponsor: Oman Medical Speciality Board

New trial • Pain

Feasibility Study of Enhanced Recovery After Surgery (ERAS) Concept in Endoscopic Submucosal Dissection (ESD) for Upper Gastrointestinal Lesions <= 2 cm: A Prospective, Randomized, Single-Center, Non-Inferiority Study (ChiCTR) - P=N/A | N=183 | Not yet recruiting | Sponsor: General Hospital of Northern Theater Command; General Hospital of Northern Theater Command

Head-to-Head • New trial