Dynastat (parecoxib) / Pfizer - LARVOL DELTA

Blocking PCSK9 suppresses hepatocellular carcinoma immune escape by decreasing FLI1-mediated SPP1 and PD-L1 expression. (PubMed, J Immunother Cancer) - "PCSK9 promoted HCC immune escape by upregulating SPP1 and PD-L1 via NOTCH3/FLI1 signaling. CRISPR ABE-mediated PCSK9 deficiency and PCSK9 inhibitor parecoxib may serve as effective strategies to inhibit HCC."

IO biomarker • Journal • Hematological Malignancies • Hepatocellular Cancer • Leukemia • Oncology • Solid Tumor • CD8 • FLI1 • NOTCH3 • PCSK9 • PD-L1 • SPP1

The Effect of Intravenous Parecoxib on Early Ambulation After Elective Lumbar Spinal Surgery: A Propensity Score Matching Analysis. (PubMed, J Clin Med) - " The administration of intravenous parecoxib after lumbar spine surgery demonstrated encouraging effects on early ambulation, with patients able to get out of bed and walk within 24 h after surgery. To endorse intravenous parecoxib as a standard postoperative pain protocol for spine surgery, further investigation in randomized controlled trials should be conducted."

Journal • Orthopedics • Pain

Cyclooxygenase 2 (COX-2) expression is elevated in prefrontal cortex neurons, not microglia, following methamphetamine self-administration in male and female rats. (PubMed, Neuropharmacology) - "We also showed that medial prefrontal cortex (mPFC) mediated behavioral flexibility deficits observed at this timepoint are attenuated by the COX-2 inhibitor parecoxib. COX-2 immunoreactivity was frequently absent from the infralimbic and cingulate cortices and was therefore not analyzed. Paired with our prior findings that COX-2 inhibition attenuates METH-induced behavioral deficits known to be mediated by the mPFC, these results suggest that altered neuronal COX-2 expression should be investigated for its influence on METH-induced deficits in mPFC function."

Journal • Preclinical • Inflammation • PTGS2

Ultrasound-Guided Transversus Abdominis Plane Block with Dexmedetomidine Combined with Ropivacaine Plus Diclofenac Sodium Suppository for Post-Cesarean Section Analgesia: A Non-Inferiority Randomized Controlled Trial (ChiCTR) - P=N/A | N=120 | Not yet recruiting | Sponsor: Hanzhong Central Hospital; Hanzhong Central Hospital

Head-to-Head • New trial • Pain

Scalp block versus intravenous parecoxib for post-operative cranioplasty surgery pain: A comparison of pain scores and morphine requirements. (PubMed, Surg Neurol Int) - "However, no difference in time to first commencement of PCA and total morphine dose was noted between the two groups. The scalp block reduced pain scores at the 1st, 2nd, 4th, and 6th h and morphine requirement postoperatively compared to IV parecoxib."

Journal • Anesthesia • Pain

Perfusion Enhancement via Continuous Brachial Plexus Block to Prevent Vascular Insufficiency in Replanted Digits: A Prospective, Randomized Controlled Trial. (PubMed, J Clin Med) - " After screening 113 patients, 55 patients (71 digits) were ultimately randomized and analyzed: the CBPB group (n = 27, 36 digits) received 0.2% ropivacaine infusion at 5 mL/h; the SIVA group (n = 28, 35 digits) received intravenous parecoxib 20 mg twice daily with supplemental tramadol for visual analog scale (VAS) scores > 3. No significant difference was observed in seven-day survival rates between groups (97% vs. 91%; p = 0.329). CBPB significantly enhanced perfusion in replanted digits and reduced the incidence of vascular insufficiency, despite not conferring additional survival benefits."

Journal • Cardiovascular • Hematological Disorders • Pain • Thrombosis

Prophylactic administration of parecoxib sodium for postoperative delirium in hip surgery of the elderly: a prospective, randomized, placebo-controlled trial. (PubMed, Rev Assoc Med Bras (1992)) - "Preoperative prophylactic administration of parecoxib sodium significantly reduced the incidence of postoperative delirium in elderly orthopedic patients but did not improve long-term functional recovery."

Clinical • Journal • CNS Disorders • Geriatric Disorders • Orthopedics • Pain

PCA – Patient controlled anaesthesia in thoracic surgery; offering a multifactorial approach (ERS 2025) - "Correlation with clinical and patient reported outcomes.850 cases (2019-2024)underwent thoracotomies and received intravenous PCA (paracetamol,parecoxib)for 48hours post operatively... PCA is a safe method for patients who underwent thoracotomy. It provides positive patient reported outcomes, it reduces postoperative complications in high risk patients with minimal side effects"

Clinical • Surgery • Anesthesia • Chronic Obstructive Pulmonary Disease • Immunology • Respiratory Diseases

The Analgesic Efficacy of Therapies Used for Complex Regional Pain Syndrome: A Systematic Review. (PubMed, Cureus) - "Combinations of local anesthetics and other medications (e.g., lidocaine with citalopram or parecoxib) were especially effective in acute CRPS...RCT evidence supports the use of bisphosphonates, ketamine, and early use of mirror or motor imagery therapies...However, many studies were limited by small size, short follow-up, or methodological flaws. There is an urgent need for large, high-quality, and mechanistically informed RCTs to guide long-term CRPS management."

Journal • Review • Anesthesia • Cardiovascular • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain

PANDA: Study Comparing Dynastat and Parestat Pain Relief Medications for Patients After Breast Surgery (clinicaltrials.gov) - P4 | N=60 | Not yet recruiting | Sponsor: University of Malaya

Head-to-Head • New P4 trial • Pain

Effect of parecoxib and dexamethasone on the temporomandibular joint of orchiectomized rats: Morphological and immunological analysis. (PubMed, Arch Oral Biol) - "Testosterone deficiency enhanced TMJ inflammation and impaired cartilage structure. While both dexamethasone and parecoxib modulated these effects, their actions differed: dexamethasone promoted cartilage-to-bone differentiation, potentially unfavorable long term, whereas parecoxib preserved cartilage integrity. These findings underscore hormonal influence and support selective anti-inflammatory strategies for TMJ preservation under androgen deficiency."

Journal • Preclinical • Inflammation • IL1B • IL6 • TNFA

Additive with Multinary Interactions to Perovskite Precursor Species for Catalyzed Crystallization of Antisolvent-Free α-FAPbI3 Solar Cells. (PubMed, Adv Mater) - "In this work, a novel additive, parecoxib (Pr), is proposed, which catalyzes the direct crystallization of α-FAPbI3 through multinary interactions with the solvate perovskite precursor...As a result, high-performance antisolvent-free α-FAPbI3 PSCs are achieved with the PCE reaching 25.38% and 19.64% for mini-modules (93 cm2). The unencapsulated device maintains 91.08% of the initial PCE for 1000 h at 85 °C, and 90.62% after 1000 h of maximum power point tracking."

Journal

Multiple benefits of parecoxib sodium in perioperative applications. (PubMed, Int J Surg) - No abstract available

Journal

Author's Reply to the Comment on "Pain control and adverse effects of parecoxib after wisdom teeth surgery: a quantitative systematic review". (PubMed, Oral Maxillofac Surg) - No abstract available

Adverse events • Journal • Pain

Comment on "Pain control and adverse effects of parecoxib after wisdom teeth surgery: a quantitative systematic review". (PubMed, Oral Maxillofac Surg) - No abstract available

Adverse events • Journal • Pain

Comparative Efficacy of IV Parecoxib vs Lidocaine in Reducing Propofol Injection Pain (clinicaltrials.gov) - P=N/A | N=30 | Not yet recruiting | Sponsor: Oman Medical Speciality Board

New trial • Pain

Feasibility Study of Enhanced Recovery After Surgery (ERAS) Concept in Endoscopic Submucosal Dissection (ESD) for Upper Gastrointestinal Lesions <= 2 cm: A Prospective, Randomized, Single-Center, Non-Inferiority Study (ChiCTR) - P=N/A | N=183 | Not yet recruiting | Sponsor: General Hospital of Northern Theater Command; General Hospital of Northern Theater Command

Head-to-Head • New trial

Comparing the Effects of Fentanyl, Sufentanil, and Butorphanol Combined With Flurbiprofen Axetil on Postoperative Intravenous Patient-controlled Analgesia Post Cesarean Delivery. (PubMed, Pain Physician) - "The analgesic effect in patients who underwent cesarean delivery is similar when using different postoperative PCIA formulae. Although butorphanol displayed no analgesic advantage over fentanyl and sufentanil postoperatively, it caused fewer postoperative nausea and vomiting incidences than fentanyl and sufentanil."

Clinical • Journal • Retrospective data • Anesthesia • Pain

Effect of Parecoxib and transversus abdominis plane block on postoperative anxiety and cognition: A randomized controlled-trial. (PubMed, J Pak Med Assoc) - P=N/A | "A single transversus abdominis plane block did not have a significant effect on postoperative anxiety and cognition, while parecoxib could alleviate postoperative anxiety in elderly patients undergoing laparoscopic intestinal surgery."

Clinical • Journal • Oncology • Psychiatry

Electroacupuncture and Parecoxib Reduce Inflammatory Injury in a Primary Dysmenorrhea Rat Model: Investigating the Role of the COX-2/NF-κB/NLRP3 Pathway. (PubMed, J Pain Res) - "The following pain management interventions were administered to a PDM rat model: saline (control), EA, parecoxib, EA + parecoxib, or ibuprofen. Furthermore, EA markedly improved pain symptoms and pathological damage in PDM rats and downregulated the expression of COX-2/NF-κB/NLRP3 signaling pathway proteins in uterine tissue. Our findings demonstrated superior anti-inflammatory effects of EA + parecoxib on COX-2/NF-κB/NLRP3 signaling pathway-related proteins compared with that of EA alone or single-drug administration."

Journal • Preclinical • Pain • Women's Health • IL18 • IL1B • NLRC5 • NLRP3 • PTGS2

Methamphetamine produces behavioral flexibility deficits that are attenuated by COX-2 inhibition in both male and female rats. (PubMed, Addict Neurosci) - "The current study sought to investigate the ability of an anti-inflammatory cyclooxygenase-2 (COX-2) inhibitor, parecoxib (PXB), to attenuate METH-induced deficits in behavioral flexibility in male and female rats. Sex differences in the simple discrimination (SD) part of the task were also observed, with METH-saline females exhibiting deficits that were attenuated by PXB. These findings reinforce the argument that pharmacologically targeting neuroimmune responses to METH may facilitate recovery from MUD."

Journal • Preclinical • Cognitive Disorders • Inflammation • Tobacco Addiction

MANAGEMENT OF POST-OPERATIVE ACUTE (MODERATE TO SEVERE) PAIN IN CANCER PATIENTS - A REVIEW OF THE LATEST EVIDENCE (MASCC-ISOO 2025) - "Thoracic (12%) and colorectal procedures (11%) demonstrated no consistent pain management strategies, with varying approaches including gabapentinoids and nefopam respectively...4 gastric procedures (5%) and 4 hepatic procedures (5%) found analgesics including parecoxib to be optimal...Further studies are needed to implement standardized pain management protocols, particularly for less common procedures and cancers where evidence is limited. Furthermore, long-term follow-up studies are crucial to evaluate if pain relief was sustainable and its impact on recovery."

Clinical • Review • Oncology • Pain

Pain control and adverse effects of parecoxib after wisdom teeth surgery: a quantitative systematic review. (PubMed, Oral Maxillofac Surg) - No abstract available

Adverse events • Journal • Review • Pain

Letter to editor: effect of parecoxib on postoperative delirium in patients with hyperlipidemia: a randomized, double-blind, single-center, superiority trial. (PubMed, Int J Surg) - No abstract available

Clinical • Head-to-Head • Journal • CNS Disorders • Dyslipidemia

Behavioral Flexibility Deficits Following Methamphetamine Use are Attenuated by COX-2 and PGE2 Inhibition in Male and Female Rats; Potential Role of PFC Neurons (CPDD 2025) - "Additionally, behavioral flexibility deficits were attenuated by COX-2 inhibition by parecoxib (PXB) and by PGE2 synthesis inhibition by UT-11. This may indicate that METH-induced alterations of COX-2 expression may influence PFC imbalances of GABA/glutamate signaling that underlie behavioral deficits, and that COX-2 inhibition may help restore behavioral control in MUD. 2"

Preclinical • CNS Disorders • Cognitive Disorders • Psychiatry • PTGS2