Dynastat (parecoxib) / Pfizer - LARVOL DELTA

Methamphetamine produces behavioral flexibility deficits that are attenuated by COX-2 inhibition in both male and female rats. (PubMed, Addict Neurosci) - "The current study sought to investigate the ability of an anti-inflammatory cyclooxygenase-2 (COX-2) inhibitor, parecoxib (PXB), to attenuate METH-induced deficits in behavioral flexibility in male and female rats. Sex differences in the simple discrimination (SD) part of the task were also observed, with METH-saline females exhibiting deficits that were attenuated by PXB. These findings reinforce the argument that pharmacologically targeting neuroimmune responses to METH may facilitate recovery from MUD."

Journal • Preclinical • Cognitive Disorders • Inflammation • Tobacco Addiction

MANAGEMENT OF POST-OPERATIVE ACUTE (MODERATE TO SEVERE) PAIN IN CANCER PATIENTS - A REVIEW OF THE LATEST EVIDENCE (MASCC-ISOO 2025) - "Thoracic (12%) and colorectal procedures (11%) demonstrated no consistent pain management strategies, with varying approaches including gabapentinoids and nefopam respectively...4 gastric procedures (5%) and 4 hepatic procedures (5%) found analgesics including parecoxib to be optimal...Further studies are needed to implement standardized pain management protocols, particularly for less common procedures and cancers where evidence is limited. Furthermore, long-term follow-up studies are crucial to evaluate if pain relief was sustainable and its impact on recovery."

Clinical • Review • Oncology • Pain

Pain control and adverse effects of parecoxib after wisdom teeth surgery: a quantitative systematic review. (PubMed, Oral Maxillofac Surg) - No abstract available

Adverse events • Journal • Review • Pain

Letter to editor: effect of parecoxib on postoperative delirium in patients with hyperlipidemia: a randomized, double-blind, single-center, superiority trial. (PubMed, Int J Surg) - No abstract available

Clinical • Head-to-Head • Journal • CNS Disorders • Dyslipidemia

Behavioral Flexibility Deficits Following Methamphetamine Use are Attenuated by COX-2 and PGE2 Inhibition in Male and Female Rats; Potential Role of PFC Neurons (CPDD 2025) - "Additionally, behavioral flexibility deficits were attenuated by COX-2 inhibition by parecoxib (PXB) and by PGE2 synthesis inhibition by UT-11. This may indicate that METH-induced alterations of COX-2 expression may influence PFC imbalances of GABA/glutamate signaling that underlie behavioral deficits, and that COX-2 inhibition may help restore behavioral control in MUD. 2"

Preclinical • CNS Disorders • Cognitive Disorders • Psychiatry • PTGS2

Opioid-sparing anaesthesia in thymectomy using ultrasound-guided bilateral deep parasternal block: a case report (Euroanaesthesia 2025) - "To our knowledge, this is the first report of its preoperative application in thymectomy.Case Report: A 53-year-old male (BMI 29.1) with a history of substance use (marijuana, cocaine, alcohol abuse, 40 pack-years smoking) and psychotic disorder (on quetiapine and zopiclone) presented for elective thymectomy following a diagnosis of thymoma...The anesthesia plan included general anesthesia (GA) induction with fentanyl (0.2 mg), propofol, and rocuronium, combined with a bilateral DPB under ultrasound guidance (40 mL 0.375% ropivacaine total). GA was maintained with sevoflurane and additional analgesia consisted of paracetamol (1000 mg), dexamethasone (8 mg), magnesium sulfate (2500 mg), parecoxib (40 mg), and dexmedetomidine (100 mcg)...Postoperative analgesia included paracetamol (1000 mg every 6 hours) and rescue tramadol as needed...DPB offers a safe, effective and promising method for reducing opioid reliance and their associated side effects, for contributing to..."

Case report • Clinical • Anesthesia • CNS Disorders • Pain • Psychiatry • Solid Tumor • Thymoma • Thymus Cancer

A commentary on 'Effect of parecoxib on postoperative delirium in patients with hyperlipidemia: a randomized, double-blind, single-center, superiority trial'. (PubMed, Int J Surg) - No abstract available

Clinical • Head-to-Head • Journal • CNS Disorders • Dyslipidemia

A commentary on "Effect of parecoxib on postoperative delirium in patients with hyperlipidemia: a randomized, double-blind, single-center, superiority trial". (PubMed, Int J Surg) - No abstract available

Clinical • Head-to-Head • Journal • CNS Disorders • Dyslipidemia

Effect of parecoxib on postoperative delirium in patients with hyperlipidemia: a randomized, double-blind, single-center, superiority trial. (PubMed, Int J Surg) - No abstract available

Clinical • Head-to-Head • Journal • CNS Disorders • Dyslipidemia

Parecoxib in Total Knee Arthroplasty (clinicaltrials.gov) - P4 | N=40 | Completed | Sponsor: University of Chile | Recruiting ➔ Completed | Trial completion date: Apr 2024 ➔ Sep 2024 | Trial primary completion date: Apr 2024 ➔ Sep 2024

Trial completion • Trial completion date • Trial primary completion date • Immunology • Orthopedics • Osteoarthritis • Pain • Renal Disease • Rheumatology

The Effects of Non-Steroidal Anti-Inflammatory Drugs Used for Orthodontic Pain Management on Tooth Movement: A Comprehensive Review of the Literature. (PubMed, J Clin Med) - "Evidence shows that NSAIDs such as aspirin, ketorolac, diclofenac, and nimesulide significantly reduce OTM. The results for ibuprofen, meloxicam, and celecoxib were inconsistent with both no influence or a reduction in OTM, depending on dosage, mode, and duration of administration. Conversely, tenoxicam, nabumetone, etoricoxib, and parecoxib appear to have no effect on OTM. Among these, etoricoxib appears particularly promising due to its favorable gastrointestinal profile, high COX-2 selectivity, and negligible influence on OTM in clinical doses. However, the limited number of human trials highlights the need for further research to develop evidence-based guidelines for pain management that preserve treatment efficiency in orthodontics."

Journal • Review • Pain

Parecoxib sequential with imrecoxib for occurrence and remission of severe acute pancreatitis: a multicentre, double-blind, randomised, placebo-controlled trial. (PubMed, Gut) - "Parecoxib sequential with imrecoxib was effective and well tolerated in reducing the occurrence and duration of SAP and local complications through suppression of systemic inflammatory response, leading to decreased morbidity."

Journal • Immunology • Inflammation • Pancreatitis • Systemic Inflammatory Response Syndrome

Novel multimodal analgesic regimen for perioperative pain management after hepatic artery infusion chemotherapy in patients with advanced hepatocellular carcinoma. (PubMed, World J Gastrointest Surg) - "Our study demonstrates that multimodal analgesia is effective in reducing postoperative pain, minimizing adverse reactions, and improving patient satisfaction in HCC patients undergoing HAIC. This approach provides valuable clinical strategies for optimizing pain management in this patient population."

Clinical • Journal • Hepatocellular Cancer • Hepatology • Oncology • Pain • Solid Tumor

Effect of mini-open rotator cuff repair combined with intraoperative cocktail therapy in the treatment of rotator cuff injury: a prospective comparative study between the cocktail therapy and the control group. (PubMed, Arch Orthop Trauma Surg) - "The mini-open rotator cuff repair has satisfactory curative effect in the treatment of rotator cuff injury, and intraoperative cocktail therapy can alleviate postoperative pain and speed up postoperative functional rehabilitation and improvement of joint range of motion."

Clinical • Journal • Infectious Disease • Pain

The impact of external oblique intercostal block on early postoperative pain and recovery in patients undergoing J-shaped incisions for upper abdominal surgery: a single-center prospective randomized controlled study. (PubMed, BMC Anesthesiol) - P=N/A | "EOIB significantly enhances postoperative analgesia in patients undergoing upper abdominal J-shaped incision surgery, reducing opioid consumption and analgesic requirements, and improving the quality of recovery. It may be considered as part of a multimodal analgesic regimen following upper abdominal surgery."

Clinical • Journal • Anesthesia • Pain

A Comparative Study on the Effects of Repeated Subacromial Injections of Parecoxib and Triamcinolone in a Rat Model of Normal Rotator Cuff. (PubMed, Clin Orthop Surg) - "The PEG2 level in the subacromial bursa was significantly different among the 3 groups at the third, fifth, and sixth injections (p = 0.019, p = 0.004, and p = 0.004, respectively). In the rat model of normal rotator cuff, repeated local injections of the cyclooxygenase-2 inhibitor showed fewer negative effects on the biomechanical and histological properties of the normal tendon than triamcinolone."

Clinical • Journal • Preclinical

PASC: Analgesic Effect of Parecoxib Versus Morphine in SCD Patients Presenting to the Emergency Department (clinicaltrials.gov) - P3 | N=226 | Not yet recruiting | Sponsor: Oman Medical Speciality Board | Trial completion date: Jul 2026 ➔ Jul 2028 | Trial primary completion date: May 2026 ➔ May 2028

Trial completion date • Trial primary completion date • Genetic Disorders • Hematological Disorders • Pain • Sickle Cell Disease

Non-Opioid Analgesics for Postoperative Pain Management Following Total Joint Arthroplasty: A Systematic Review and Meta-Analysis. (PubMed, J Arthroplasty) - "This review found that postoperative administration of non-opioid co-analgesia may alleviate the need for opioids and have modest protective effects on postoperative pain. The effects of these analgesics, however, may be clinically non-meaningful for reducing pain. These results may further implicate a need to implement non-opioid co-analgesia in postoperative patient care. Future research may include an updated investigation of this research question as more medication-granular research becomes available."

Journal • Retrospective data • Orthopedics • Pain

Nonsteroidal anti-inflammatory drugs (NSAIDs) for acute renal colic. (PubMed, Cochrane Database Syst Rev) - "NSAIDs may reduce pain in adult patients with renal colic compared to placebo. Comparing one NSAID against another, IV ketorolac may be less effective than IV ibuprofen, and pirprofen may result in less need for rescue medication than indomethacin. The intravenous route of administration is probably similar to the intramuscular route but may be better than the rectal route. The evidence is uncertain regarding the potential harms of NSAIDs. We were not able to perform subgroup analysis based on our predefined criteria because there were no eligible studies."

Clinical • Journal • Review • Inflammation • Pain • Renal Calculi • Urolithiasis

Synergistic therapeutic effect of parecoxib and ilomastat combination in osteoarthritis via inhibition of IL-17/PI3K/AKT/NF-κB activity. (PubMed, Mol Immunol) - "The combined administration of parecoxib and ilomastat to inhibit IL-17/PI3K/AKT/NF-κB transduction is beneficial to reduce the infiltration of inflammatory factors and matrix metalloproteinases in osteoarthritis."

Journal • Immunology • Osteoarthritis • Pain • Rheumatology • IL17A • IL1B

Effect of parecoxib on postoperative delirium in patients with hyperlipidemia: a randomized, double-blind, single-center, superiority trial. (PubMed, Int J Surg) - "Parecoxib may help in reducing the hyperlipidemia-related postoperative delirium incidence. The effective anti-inflammatory activity of prostaglandin endoperoxide synthase-2 inhibition by parecoxib and postoperative pain control may be important mechanisms for preventing postoperative delirium."

Clinical • Head-to-Head • Journal • Anesthesia • CNS Disorders • Dyslipidemia • Pain • PTGS2

Effect of parecoxib on postoperative cognitive function (delirium) in patients with hyperlipidemia: a single-center, randomized, double-blind controlled trial (ChiCTR) - P4 | N=442 | Completed | Sponsor: Affiliated Hospital of Southwest Medical University; Affiliated Hospital of Southwest Medical University | Not yet recruiting ➔ Completed

Trial completion • CNS Disorders • Dyslipidemia • PACERR • PTGS2 • TNFA

Effect of esketamine combined with parecoxib sodium on postoperative analgesia and inflammatory response in patients with thoracoscopic pulmonary resection (ChiCTR) - P=N/A | N=80 | Sponsor: Yongchuan Hospital affiliated to Chongqing Medical University; Yongchuan Hospital affiliated to Chongqing Medical University

New trial • Inflammation • Lung Cancer • Oncology • Solid Tumor • IL6

Bioengineered NanoAid synergistically targets inflammatory pro-tumor processes to advance glioblastoma chemotherapy. (PubMed, Nanoscale) - "NanoAid employs macrophage-membrane-liposome hybrids to optimize the delivery of COX-2 inhibitor parecoxib and paclitaxel. This results in substantial tumor growth inhibition and extends the median survival of tumor-bearing mice. Thus, our study bridges clinical insights with fundamental research, potentially revolutionizing tumor therapy paradigms."

Journal • Brain Cancer • CNS Tumor • Glioblastoma • Oncology • Solid Tumor

Identification of novel fructose 1,6-bisphosphate aldolase inhibitors against tuberculosis: QSAR, molecular docking, and molecular dynamics simulation-based analysis of DrugBank compounds. (PubMed, J Biomol Struct Dyn) - "REPTree, chosen for further screening, led to the identification of four promising preclinical anti-TB drug candidates from DrugBank-Serdemetan, Parecoxib, N, N-Diethyl-2-[(2-Thienylcarbonyl) amino], and Visnadine.All screened ligands show stable binding behaviour during a 200-ns molecular dynamics simulation. Density functional theory (DFT) analysis was also employed for the analysis HOMO (highest occupied molecular orbital)/LUMO (lowest unoccupied molecular orbital) gap, and both screened hits showed efficient results. This study presents a potential avenue for effective TB therapeutics development from compounds with proven druggability in other contexts."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis