Hepaton (thiazolidine) / SEDICO - LARVOL DELTA

Alizarin Mitigates Paracetamol-Induced Hepatorenal Injury in Mice via Modulation of the Nrf2/HO-1/NFκB/Apoptosis Pathway. (PubMed, J Biochem Mol Toxicol) - "Overall, ALZ demonstrated a protective effect against Para-related hepatonephrotoxicity by attenuating oxidative stress, inflammatory responses, and apoptotic activity through Upregulation of the Nrf2/HO-1 signaling cascade. These results indicate that ALZ has potential therapeutic effects against liver and kidney damage."

IO biomarker • Journal • Preclinical • Inflammation • Pain • Renal Disease • BAX • BCL2 • TNFA

Critical flicker frequency improves after alcohol detoxification and is associated with liver stiffness. (PubMed, World J Gastroenterol) - "CFF is influenced by HE severity and acute alcohol exposure, showing improvement after detoxification. Its weak correlation with fibrosis stage suggests that CFF serves as a sensitive neurocognitive marker in ALD."

Journal • CNS Disorders • Fibrosis • Gastroenterology • Hepatic Encephalopathy • Hepatology • Immunology • Liver Cirrhosis

IL-4-mediated Pro-Regenerative Cellular Reprogramming in 3D Liver Culture. (PubMed, Cell Mol Gastroenterol Hepatol) - "Our study highlights the potential of IL-4-driven modulation of the liver microenvironment, paving the way for cytokine-based therapeutic strategies to enhance immune-mediated hepatic regeneration."

Journal • Hepatology • Immunology • Liver Failure • IL4

Taurine Mitigates Metaflumizone-Induced Hepatonephrotoxicity in Rats by Inhibiting Oxidative Stress, Inflammation, and Apoptosis. (PubMed, J Biochem Mol Toxicol) - "In conclusion, taurine significantly reduced MTF-induced hepatonephrotoxicity by suppressing oxidative stress, inflammatory responses, and programmed cell death. These findings indicate that taurine has the potential to be a treatment option in the case of the prevention of liver and kidney damage caused by SBI."

IO biomarker • Journal • Preclinical • Inflammation • BAX • BCL2 • TNFA

Obtusifolin improves cisplatin-induced hepatonephrotoxicity via the Nrf2/HO-1 signaling pathway. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "In conclusion, OBS significantly improved CIS-induced hepatonephrotoxicity by reducing oxidative stress, inflammation, and apoptosis via modulation of the Nrf2/HO-1 pathway. These findings suggest that OBS could be a potential therapeutic agent for mitigating the side effects of chemotherapeutics."

IO biomarker • Journal • Inflammation • BCL2 • CASP3 • TNFA

Syringaldehyde Mitigates Cyclophosphamide-Induced Liver and Kidney Toxicity in Mice by Inhibiting Oxidative Stress, Inflammation, and Apoptosis Through Modulation of the Nrf2/HO-1/NFκB Pathway. (PubMed, J Biochem Mol Toxicol) - "In conclusion, SYA significantly reduced CYC-induced hepatonephrotoxicity by inhibiting inflammation, oxidative stress, and apoptosis by employing the Nrf2/NFκB/HO-1 pathway. These findings indicate that SYA has the possibility as a treatment option agent in the case of prevention of liver and kidney damage."

IO biomarker • Journal • Preclinical • Inflammation • Oncology • BAX • BCL2 • TNFA

Point-of-Care Ultrasonography in Nephrology: Where Are We and Where Are We Heading? (KIDNEY WEEK 2024) - "Learning Pathway(s). AKI and Critical Care ."

Cardiovascular • Nephrology

Homozygous variants in WDR83OS lead to a neurodevelopmental disorder with hypercholanemia. (PubMed, Am J Hum Genet) - "A zebrafish model lacking Wdr83os function further supports its role in the nervous system, craniofacial development, and lipid absorption. Taken together, our data support a disease-gene association between biallelic loss-of-function of WDR83OS and a neurological disease trait with hypercholanemia."

Journal • CNS Disorders • Dermatology • Developmental Disorders • Hepatology • Liver Failure • Mental Retardation • Pruritus • Psychiatry • MCM7

CCDC47 gene and trichohepatoneurodevelopmental syndrome: Report of the fifth and sixth cases from Saudi Arabia. (PubMed, Am J Med Genet A) - "Furthermore, we evaluated the gene-disease association as per ClinGen guidelines and reached a strong level of association after inclusion of the new patients/variants. The findings from these cases will help to delineate the clinical phenotype and the mutational spectrum of this complex disorder."

Journal • Developmental Disorders • Hepatology • Liver Failure • CD47 • MCM7

EXHALED BREATH ANALYSIS OF VOLATILE ORGANIC COMPOUNDS IS ASSOCIATED WITH LUMINAL DISEASE ACTIVITY IN PATIENTS WITH ULCERATIVE COLITIS (DDW 2024) - "Conclusion VOC exhaled breath analysis shows a robust ability to discriminate patients with severe endoscopic disease from patients with minimal to no endoscopic inflammation. The differences in reported VOC point toward metabolic differences in bacterial fermentation, lipid and carbohydrate metabolism, and an increase in reactive oxygen species in patients with active disease."

Clinical • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammatory Bowel Disease • Oncology • Ulcerative Colitis

Clinical and genetic analysis of trichohepatoneurodevelopmental syndrome caused by a CCDC47 variant. (PubMed, Heliyon) - "The present report is the first of a Chinese infant with homozygous variant in the CCDC47 gene. We expanded the genetic and phenotypic spectrum associated with trichohepatoneurodevelopmental syndrome."

Journal • Dermatology • Developmental Disorders • Gastrointestinal Disorder • Hepatology • Liver Failure • Mental Retardation • Pruritus • CD47 • MCM7

Arsenic exposure to mouse visceral leishmaniasis model through their drinking water linked to the disease exacerbation via modulation in host protective immunity: a preclinical study. (PubMed, Sci Rep) - "We also established that arsenic exposure modulated the host ERK-1/2 and p38 MAPK signaling cascade, limited T lymphocyte proliferation, and a lower IgG2a/IgG1 ratio to favor the Leishmania parasite survival inside the host. This study suggests that the contorted Th1-subtype and exacerbated Th2-subtype immune responses are involved in the increased susceptibility and pathogenesis of Leishmania parasite among subjects/individuals regularly exposed to arsenic."

Journal • Preclinical • Infectious Disease • IFNG • IL10 • IL12A • IL4 • TGFB1 • TNFA

Fungi, including Pithomyces chartarum cause facial eczema and inflammation in grazing sheep in Western China. (PubMed, Microb Pathog) - "These results revealed that Pithomyces chartarum maybe caused facial eczema and inflammation in sheep. The facial eczema was allergic eczema caused by hepatic dysfunction and hepatonecrosis."

Journal • Atopic Dermatitis • Dermatology • Fibrosis • Hepatology • Immunology • Inflammation • Liver Failure • Oncology • IL12A • IL6 • TNFA

Quality of life and depression in Wilson's disease: a large prospective cross-sectional study. (PubMed, Orphanet J Rare Dis) - "Neurological patients should be closely monitored to prevent and treat symptoms of depression that impact their quality of life."

HEOR • Journal • Observational data • CNS Disorders • Depression • Genetic Disorders • Hepatology • Metabolic Disorders • Mood Disorders • Movement Disorders • Psychiatry • ATP7B

Preventive Effects of Mandarin Fruit Peel Hydroethanolic Extract, Hesperidin, and Quercetin on Acetaminophen-Induced Hepatonephrotoxicity in Wistar Rats. (PubMed, Oxid Med Cell Longev) - "The MPHE, hesperidin, and quercetin treatments resulted in marked decrease in liver and kidney histopathological scores including inflammation, necrosis, apoptosis, and congestion. In conclusion, the MPHE, quercetin, and hesperidin may induce hepatonephropreventive impacts in NAPAP-supplemented rats via enhancing the antioxidant defense system, anti-inflammatory activity, and antiapoptotic action."

Journal • Preclinical • Immunology • Inflammation • Oncology • Pain • CASP3 • IL4 • TNFA

The perspective of clinical pharmacologist: what is the safety of complex polypharmacy in hospitalized COVID-19 patients? (ERS 2022) - "Nevertheless, from the point of view of clinical pharmacology, the combination of the above-mentioned drugs groups may increase the risk of side effects. Therefore, even standard treatment requires monitoring of the patient's clinical condition and laboratory parameters to increase the medication safety of personalized complex polypharmacy."

Clinical • Infectious Disease • Novel Coronavirus Disease

Lung- and liver-dominant phenotypes of Korean eight constitution medicine have different profiles of genotype associated with each organ function. (PubMed, Physiol Rep) - "Although genome-wide significant SNPs were not found, the phylogenetic tree showed a clear difference between the two constitutions. This is the first observation suggesting genetic involvement in the ECM and can be extended to all ECM constitutions."

Journal

Changes in Mitochondria-Related Gene Expression upon Acupuncture at LR3 in the D-Galactosamine-Induced Liver Damage Rat Model. (PubMed, Evid Based Complement Alternat Med) - "Furthermore, MA reversed D-GalN-induced inflammatory cell infiltration, destruction of hepatic cell plates, and increase in the levels of the proinflammatory cytokine TNF-α. MA at LR3 can reduce the risk of D-GalN-induced ALF by inducing the expression of metabolic and inflammation-related genes and regulating proinflammatory factor production in hepatic mitochondria."

Journal • Preclinical • Fibrosis • Hepatology • Immunology • Inflammation • Liver Failure • Metabolic Disorders • TNFA

Antioxidant Mechanism of Renal and Hepatic Failure Prevention Related to Paracetamol Overdose by the Aqueous Extract of Amblygonocarpus andongensis Stem Bark. (PubMed, Biomed Res Int) - "The hepatonephroprotective effect of AEAASB might result from its ability to improve the antioxidant status through the stimulation of antioxidant factors and the scavenging of free radicals. This property could be ascribed to the presence of some classes of bioactive compounds such as phenolic compounds in great amounts."

Journal • Hematological Disorders • Hepatology • Liver Failure • Pain • CAT

Moderate exercise relieves fluoride-induced liver and kidney inflammatory responses through the IKKβ/NFκB pathway. (PubMed, Environ Sci Pollut Res Int) - "In addition, the expression levels of IKKβ and NFκB were increased, and the expression of IκBα was decreased after fluoride exposure, indicating that fluoride activated the IKKβ/NFκB pathway. In summary, long-term moderate treadmill exercise relieved fluoride-induced liver and kidney inflammatory responses through the IKKβ/NFκB pathway, and exercise can be used to prevent fluoride-induced liver and kidney damage."

Journal • Immunology • Inflammation • Nephrology • Renal Disease • IFNG • IL10 • IL12A • IL13 • IL1B • IL2 • IL21 • IL4 • IL6 • NFKBIA • TGFB1 • TNFA

The new in the enteral dysbiosis correction intensified by heavy metals and mycotoxins. (PubMed, FASEB J) - "The protocol of 1st group cows (n=10) was included the sorbents' complex as a supplementation to the ration (4 % per the daily rate during 14th days) and the hepatoprotective agent "Hepaton-vet" (the compound: lac Carduus, ursodeoxycholic acid) at a dose of 100 ml per cow during 21 days. The atmospheric methane emissions in the 2d group were decreased by 8 % (84±3.5 mg/m3). So, we can assume that using the complex of sorbents with hepatoprotective agent "Hepaton-vet" has a positive influence on the liver's metabolic process that has evidenced results of morpho-biochemical analysis and clinical diagnostic of animals."

Journal • Gastrointestinal Disorder

The gut-liver axis in the liver's disease: the pathophysiological basic of dysbiosis and hepatopathy's pharmacorrection. (PubMed, FASEB J) - "The protocol of 1st group cows (n=10) was included the complex with herbal and sorbents (reptile thymum, chamaemelon, inula summus, absinthium, juniperi oleum, origanum, perlite, vermiculite, polyphepan) as a supplementation to the ration (4 % per the daily rate during 14th days) and the hepatoprotective agent "Hepaton-vet" (the compound: lac Carduus, ursodeoxycholic acid) at a dose of 100 ml per cow during 21 days. The milk protein content in the cows of the 1st group was up by 2.57±0.3 % compared with the value of the 2d group. So, we can assume that combining the hepatoprotective agent with proven efficiency and the complex with herbal and sorbents is the perspective treatment approach of the liver's disease and the modulation of the gut-liver axis."

Journal • Hepatology

The role of CGPR - receptor antagonist in the plastic process on the hepatopathies with toxical genesis. (PubMed, FASEB J) - "So, we can assume that the CGPR - receptor antagonist drugs have a great variety in their administration, including the potentiation of other drugs used in the pharmacorrection of different pathologies. The balanced influence on the CGPR - receptors significantly influence the homeostasis maintenance and the nociception of the hepatobiliary system."

Journal • Hepatology

Arsenic Induces Continuous Inflammation and Regulates Th1/Th2/Th17/Treg Balance in Liver and Kidney In Vivo. (PubMed, Mediators Inflamm) - "Moreover, arsenic enhanced the expression of MAPK/Nrf2/NF-κB signaling molecules. In conclusion, the results of the study suggested that arsenic induces continuous immune-inflammatory responses in the liver and kidney."

Journal • Preclinical • Immunology • Inflammation • Oncology • IL12A • IL1B • MPO • TNFA

Design and biological evaluation of novel long-acting adalimumab Fab conjugated with the albumin binding domain. (PubMed, Eur J Pharmacol) - "Most notably, the pharmacokinetics of Fab-ABDCon in mice was significantly improved with a 22-fold longer plasma half-life (28.2 h) compared with that of Fab control (1.31 h), which have contributed to its satisfactory therapeutic efficacy in murine TNFα-induced hepatonecrosis model. Thus, Fab-ABDCon could be a promising long-acting candidate suitable for drug development targeting TNFα-mediated inflammatory disease."

Journal • Inflammation • TNFA