rHIgM22 / Acorda, Mayo Clinic - LARVOL DELTA

Plasma metabolites, metabolic risk score and the risk of depression and anxiety disorders: A prospective cohort study. (PubMed, J Affect Disord) - "Plasma metabolites and MRS were significantly associated with depression and anxiety risk. Maintaining normal metabolite levels is crucial for depression and anxiety prevention, even among individuals with healthy lifestyles."

Journal • CNS Disorders • Depression • Mood Disorders • Psychiatry

Metabolic labeling kinetics of brain-derived 24S-hydroxycholesterol in blood in multiple sclerosis: Effects of treatment with the remyelinating antibody rHIgM22. (PubMed, Mult Scler J Exp Transl Clin) - "The latter showed significantly higher turnover rates in MS compared to non-MS subjects, which was significantly reduced in patients with MS treated with rHIgM22. Plasma 24-OHC kinetics provide a minimally invasive biomarker of brain cholesterol metabolism and revealed differences between healthy and clinically stable MS subjects, with increased turnover of the metabolically active 24-OHC pool that normalized in response to rHIgM22 therapy."

Journal • CNS Disorders • Multiple Sclerosis • Solid Tumor

Cold hearts and dark minds: a systematic review and meta-analysis of empathy across dark triad personalities. (PubMed, Front Psychiatry) - "Moderate-to-high heterogeneity was found across all analyses (I2 range: 40.56% - 94.03%)...Further research should examine situational and subtype -specific factors influencing empathy in Dark Triad traits to enhance theoretical understanding and inform interventions. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024559533, identifier CRD42024559533."

Journal • Retrospective data • Review

Comparison of Hemopoietic Biochemical Parameters in the First, Second, and Third Trimester of Pregnant Females Attending a Tertiary Care Hospital of Western Rajasthan. (PubMed, Cureus) - " The findings emphasize the dynamic nature of hematological and biochemical changes during pregnancy. The observed trends have profound implications for maternal healthcare practices, urging targeted interventions, early monitoring, and supportive supplementation. Recognizing these variations contributes to the optimization of health outcomes for both mother and child."

Journal • Hematological Disorders

ASPTF: A computational tool to predict abiotic stress-responsive transcription factors in plants by employing machine learning algorithms. (PubMed, Biochim Biophys Acta Gen Subj) - "To facilitate the adoption of the proposed strategy by users, the technique was implemented and made available as a prediction server called ASPTF, accessible at https://iasri-sg.icar.gov.in/asptf/. The developed approach and the corresponding web application are anticipated to complement experimental methods in the identification of transcription factors (TFs) responsive to abiotic stress in plants."

Journal • Machine learning

Dose to the Bladder Trigone and Acute Urinary Toxicity after Prostate SBRT in a Randomized Phase 3 Trial (ASTRO 2022) - P=N/A | "Materials/ We included patients treated with prostate SBRT in an ongoing international, prospective randomized phase 3 trial (NCT01794403) between April 2013 and January 2022... In an ongoing phase 3 clinical trial assessing prostate SBRT, we confirm previously reported relationships of urethral dose and GU toxicity. There is also a trend in the association of maximal dose to the bladder trigone with patient-reported outcomes, suggesting that attention should be paid to this subvolume. Further investigation in larger studies on the dosimetric impact to urinary tract subvolumes in prostate SBRT is warranted."

Clinical • P3 data • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor

Identification of the Lipid Antigens Recognized by rHIgM22, a Remyelination-Promoting Antibody. (PubMed, Neurochem Res) - "Remarkably, binding of rHIgM22 to sulfatide in lipid monolayers can be positively or negatively regulated by the presence of other lipids. Moreover, rHIgM22 also binds to phosphatidylinositol, phosphatidylserine and phosphatidic acid, suggesting that not only sulfatide, but also other membrane lipids might play a role in the binding of rHIgM22 to oligodendrocytes and to other cell types not expressing sulfatide."

Journal • CNS Disorders • Multiple Sclerosis • Solid Tumor

A double-blind, placebo-controlled, single-ascending-dose intravenous infusion study of rHIgM22 in subjects with multiple sclerosis immediately following a relapse. (PubMed, Mult Scler J Exp Transl Clin) - P1 | "This study demonstrated safety of an antibody directed to myelin and oligodendrocytes in the course of active demyelinating disease. Further research into rHIgM22 is warranted.ClinicalTrials.gov: NCT02398461 https://clinicaltrials.gov/ct2/show/study/NCT02398461?term=M22&draw=2&rank=8."

Journal • CNS Disorders • Multiple Sclerosis • Solid Tumor

The Effect of Protein Quality and Time-factor by Consumption of a Pre-meal on Postprandial Lipemia in Subjects With the Metabolic Syndrome. (clinicaltrials.gov) - P=N/A; N=20; Recruiting; Sponsor: Aarhus University Hospital

New trial • Biosimilar • Diabetes • Dyslipidemia

Animal naming test is simple and reliable for diagnosis of minimal hepatic encephalopathy and prediction of development of overt hepatic encephalopathy in patients with cirrhosis (EASL-ILC 2019) - "...ANT ( < 14) was present in 36 (34.95%) patients with MHE with sensitivity of 89.19% and specificity of 95.7%, PPV of 91.67%, NPV of 94.03% and diagnostic accuracy of 93.20%... ANT is a simple and reliable test for the diagnosis of MHE and prediction of overt episodes of HE in patients of cirrhosis as compared to PHES and correlates well with the Child-Pugh and MELD scores."