osemozotan (MKC-242) / Tanabe Pharma - LARVOL DELTA

AI-based assessment of brain volume decrease after treatment with stereotactic radiosurgery versus whole brain radiotherapy. (PubMed, Radiother Oncol) - "Radiotherapy is associated with a decrease in brain volume, which seems be less pronounced in patients treated with SRS as compared to WBRT. The clinical implication of this finding, e.g., the impact of brain volume decrease on overall-survival and neuro-cognitive function, is yet to be determined."

Journal • CNS Disorders • Oncology • Solid Tumor • Ventriculomegaly

Primary tumor type influences anatomical destination in large metastases to the brain and shows a preference for the posterior fossa (SNO 2025) - "Lesion centroids were calculated from T1 weighted post-contrast imaging and their precise locations on a template brain obtained and displayed (Montreal Neurological Institute Atlas (MNI305))...Metastatic melanoma appeared less likely to be in the posterior fossa. Metastatic renal lesions showed a preference for the temporal lobe."

Breast Cancer • Kidney Cancer • Lung Cancer • Melanoma • Non Small Cell Lung Cancer • Oncology • Renal Cell Carcinoma • Solid Tumor

Primary tumor type influences anatomical destination in large metastases to the brain and shows a preference for the posterior fossa (SNO 2025) - "Lesion centroids were calculated from T1 weighted post-contrast imaging and their precise locations on a template brain obtained and displayed (Montreal Neurological Institute Atlas (MNI305))...Metastatic melanoma appeared less likely to be in the posterior fossa. Metastatic renal lesions showed a preference for the temporal lobe."

Breast Cancer • Kidney Cancer • Lung Cancer • Melanoma • Non Small Cell Lung Cancer • Oncology • Renal Cell Carcinoma • Solid Tumor

Primary tumor type influences anatomical destination in large metastases to the brain and shows a preference for the posterior fossa (WFNOS 2025) - "Lesion centroids were calculated from T1 weighted post-contrast imaging and their precise locations on a template brain obtained and displayed (Montreal Neurological Institute Atlas (MNI305))...Metastatic melanoma appeared less likely to be in the posterior fossa. Metastatic renal lesions showed a preference for the temporal lobe."

Breast Cancer • Kidney Cancer • Lung Cancer • Melanoma • Non Small Cell Lung Cancer • Renal Cell Carcinoma • Solid Tumor

Primary tumor type influences anatomical destination in large metastases to the brain and shows a preference for the posterior fossa (WFNOS 2025) - "Lesion centroids were calculated from T1 weighted post-contrast imaging and their precise locations on a template brain obtained and displayed (Montreal Neurological Institute Atlas (MNI305))...Metastatic melanoma appeared less likely to be in the posterior fossa. Metastatic renal lesions showed a preference for the temporal lobe."

Breast Cancer • Kidney Cancer • Lung Cancer • Melanoma • Non Small Cell Lung Cancer • Renal Cell Carcinoma • Solid Tumor

AI-based assessment of brain volume decrease after SRS and WBRT (SNO 2023) - "Images were registered to the MNI305 space utilizing the Advanced Normalization Tools (ANTs) Toolkit... Brain volume decrease is less extensive in patients treated with SRS than WBRT. The clinical implication of this finding, e.g., prolonged survival and better clinical status, is yet to be determined and quantified."

Oncology • Solid Tumor

A PET Molecular Imaging Brain Atlas of Cyclooxygenase-1 (OHBM 2023) - "The results are provided as ROI tables and as voxel-wise maps on the MNI152 and the FreeSurfer fsaverage (MNI305) brain; for fsaverage, the VT was mapped to both the volume and the surface... We have created a prototype Molecular Imaging Brain Atlas (MIBA) using MRI and [11C]PS13/COX-1 PET scans publicly available on OpenNeuro. Non-PET experts who are familiar with MRI-based neuroimaging analysis tools (eg, SPM, FSL, AFNI, and FreeSurfer) can immediately download these results and view the PET-derived measures in combination with their MRI results. Our plan is to add many more molecular targets as they become available as well as to add more analysis options such as partial volume correction."

CNS Disorders

A PET Molecular Imaging Brain Atlas of Cyclooxygenase-1 (OHBM 2023) - "The results are provided as ROI tables and as voxel-wise maps on the MNI152 and the FreeSurfer fsaverage (MNI305) brain; for fsaverage, the VT was mapped to both the volume and the surface... We have created a prototype Molecular Imaging Brain Atlas (MIBA) using MRI and [11C]PS13/COX-1 PET scans publicly available on OpenNeuro. Non-PET experts who are familiar with MRI-based neuroimaging analysis tools (eg, SPM, FSL, AFNI, and FreeSurfer) can immediately download these results and view the PET-derived measures in combination with their MRI results. Our plan is to add many more molecular targets as they become available as well as to add more analysis options such as partial volume correction."

CNS Disorders

A Fast and Memory-Efficient Brain MRI Segmentation Framework for Clinical Applications. (PubMed, Annu Int Conf IEEE Eng Med Biol Soc) - "In the first step, single label patches are extracted from the T1w and segmentation maps by locating the approximate area of each structure on the MNI305 template, including the safety margin...We plan to release the framework as a part of a free clinical brain imaging analysis tool. The code for this framework is publicly available."

Journal • CNS Disorders

A detailed comparison of the cytoarchitectonic and myeloarchitectonic maps of the human neocortex produced by the Vogt-Vogt school. (PubMed, Brain Struct Funct) - "As such the MNI305 template was selected...Finally, the standardized combined BR-NI and SA-NI maps were united into a single combined BR-SA-NI map (Fig. 13). This map renders it possible to make direct comparisons between the results of the architectonic studies of the V-V school and current parcellations of the human neocortex."

Journal