cyclopentolate hydrochloride / Generic mfg. - LARVOL DELTA

Tolerability of administration of cyclopentolate 1% eye drops in healthy adults: Study 1  (ANZCTR) - P2 | N=15 | Not yet recruiting | Sponsor: Queensland University of Technology

New P2 trial

Vision-Threatening Peripheral Ulcerative Keratitis as an Extraintestinal Manifestation of Crohnâs Disease in a Monocular Patient (ACG 2026) - "She was treated with intravenous methylprednisolone followed by oral prednisone 60 mg daily, doxycycline, topical prednisolone, cyclopentolate, artificial tears, and vitamin C. Gastroenterology was consulted, and she received an inpatient infliximab infusion with plans for continued biologic therapy. Early recognition and aggressive treatment were essential in preserving vision. Figure: Image showing Peripheral Ulcerative Keratitis of the right eye"

Clinical • Crohn's disease • Gastroenterology • Hematological Disorders • Immunology • Inflammation • Inflammatory Bowel Disease • Keratitis • Mood Disorders • Ocular Inflammation • Ophthalmology • Scleritis • Uveitis

Use of visual acuity to screen for significant refractive errors in preschool children. (PubMed, Strabismus) - "Children aged 3-6 years had a comprehensive eye examination including VA (monocularly tested using the Electronic Visual Acuity HOTV test) and cycloplegic (cyclopentolate 1%) refraction using the table-mounted autorefractor (RK-F1 Auto Ref-Keratometer; Canon, Tokyo, Japan)...Astigmatism and hyperopia, even at high levels, did not consistently impact VA. This remains a challenge for detecting significant refractive errors when screening in preschool children."

Journal • Astigmatism • Ophthalmology • Pediatrics

Choroidal Detachment in a Patient on a CPAP Therapy. (PubMed, Case Rep Ophthalmol Med) - "The patient was diagnosed with choroidal detachment and was treated with topical dexamethasone 0.1% and cyclopentolate...The patient received a combination of dorzolamide and timolol in addition to the aforementioned treatment...The CPAP treatment is a possible, though unproven, contributor to the choroidal detachment. The patient improved during corticosteroid, cycloplegic, and IOP-lowering treatment."

Journal • Eye Cancer • Obstructive Sleep Apnea • Ocular Melanoma • Oncology • Respiratory Diseases • Sleep Disorder

The Effect of Pupil Dilation on Preoperative Optical Biometry Results for Phacoemulsification: A Meta-analysis. (PubMed, J Refract Surg) - "When compared to using tropicamide, cyclopentolate resulted in a greater increase in ACD (0.03 mm, P = .03) and greater reduction in LT (0.04 mm, P = .001), whereas phenylephrine resulted in less increase in ACD by 0.06 mm (P = .001). Pupil dilation significantly increases ACD and reduces LT, which in turn significantly increases IOL power recommendations by later generation IOL calculation formulas. It would be prudent to consider performing biometry without dilation to avoid its impact on IOL calculation and subsequently final refractive outcome."

Clinical • Journal • Retrospective data • Review

Ocular Effects of Topical 1% Cyclopentolate in New Zealand White Rabbits: A Controlled Evaluation of Intraocular Pressure, Pupil Size, and Tear Production. (PubMed, Vet Ophthalmol) - "Topical 1% cyclopentolate causes transient alterations in IOP and HPD without affecting tear production in healthy rabbits, supporting its safety and diagnostic utility in veterinary ophthalmology."

Journal • Preclinical • Ophthalmology

Accommodative Spasm Presenting as Pseudomyopia in a 47-Year-Old Male With Headache as the Primary Complaint: A Case Report. (PubMed, Cureus) - "Cycloplegic refraction remains central to the diagnosis of accommodative spasm and pseudomyopia, and a marked shift toward reduced myopia or hypermetropia after cycloplegia supports the diagnosis. In this patient, optical management with near-addition correction was preferred over pharmacologic cycloplegia because of occupational and driving requirements."

Journal • Ophthalmology • Pain

ON-pathway deficits and ON/OFF retinal imbalance is observed during experimentally induced myopic eye growth (ARVO 2026) - "Light-adapted full-field flash ERGs were recorded monthly under anesthesia with dilated pupils (1% cyclopentolate) within one week of optometric measurements...Conclusions Marmosets exhibit ON-pathway deficits and ON/OFF pathway imbalances similar to human myopia. The associations with axial length, contrast, and age highlight pathway-specific ON-system vulnerability during eye growth."

Ophthalmology

Wavelength-Specific Visual Acuity Under Infrared Two-Photon Stimulation (ARVO 2026) - "Accommodation was paralyzed with cyclopentolate, and a tunable optoelectronic lens optimized focus for each condition...This wavelength-specific enhancement may reflect differences in cone contributions under 2P excitation or other wavelength-dependent factors in visual processing. These results highlight the importance of understanding chromatic factors in 2P vision and may guide wavelength selection and color strategies for emerging 2P-based displays."

Ophthalmology

Distribution and Patterns of Refractive Errors in a Pediatric Amblyopic Cohort Aged 3-5 Years: A Descriptive Study in a Pakistani Tertiary Eye Care Center. (PubMed, Clin Optom (Auckl)) - "All participants underwent a comprehensive ophthalmic examination, including cycloplegic refraction (using 1% cyclopentolate) and dilated fundus evaluation...By establishing these amblyogenic patterns, our study provides the surveillance data essential for early intervention. These findings advocate for preschool screening to prevent irreversible vision loss, directly advancing the WHO SPECS 2030 goal of people-centered eye care."

Journal • Astigmatism • CNS Disorders • Ophthalmology • Pediatrics

Pseudomyopia and cycloplegic changes in young cynomolgus macaques. (PubMed, Mol Vis) - "The use of 1% cyclopentolate yielded discernible alterations in refractive and biometric parameters in 3- to 6-year-old cynomolgus macaques. Notably, compared with non-myopia and true myopia, pseudomyopia exhibited associations and discrepancies in accommodative status. These findings underscore the importance of investigating the role of the lens in animal models employed in myopia research."

Journal • Ophthalmology

Comparative Analysis of the Efficacy of 1% Tropicamide and 1% Cyclopentolate Eye Drops for Cycloplegic Refraction in Indonesian Paediatric Population. (PubMed, Br Ir Orthopt J) - "This randomised, double-blind, controlled non-inferiority trial compared the residual accommodation amplitude (AA) following two drops of 1% Tropicamide (TRP1%) or 1% Cyclopentolate (CYC1%), administered 5 min apart. Given its comparable efficacy and lower incidence of side effects, Tropicamide 1% may serve as a safer alternative for paediatric cycloplegic refraction. Further studies with larger samples are warranted to refine dosing strategies and enhance clinical outcomes."

Journal • Ophthalmology • Pediatrics

At-Home Pupil Dilation During the COVID-19 Pandemic in the Pediatric Population. (PubMed, J Pediatr Ophthalmol Strabismus) - "Cyclopentolate 1% eye drops were prescribed...AHPD can be a useful and cost-effective tool, can offer convenience, and may reduce anxiety in the office. The decision to use this approach should be individualized, considering the child's specific needs, parental comfort and ability, and the nature of the assessed ophthalmologic condition."

Journal • Infectious Disease • Mood Disorders • Novel Coronavirus Disease • Ophthalmology • Pediatrics • Psychiatry • Respiratory Diseases

Pharmacological and light-driven pupillary accommodation in guinea pigs: comparative effects of muscarinic modulators and illumination across developmental stages. (PubMed, Int J Ophthalmol) - "This study investigates pupillary responses in developing guinea pigs, revealing a direct pupillary light reflex (PLR) with light intensity-dependent responses, while indirect PLR was undetectable. The differential effects of muscarinic modulators on pupillary responses underscore the critical role of cholinergic signaling in ocular accommodation, with age-related variations in sensitivity. Additionally, a novel non-contact measurement methodology achieved a precision of 0.01 mm for pupillary quantification, enhancing accuracy in ocular studies."

Journal

Efficacy of Topical Nepafenac Versus Nepafenac With Perioperative Cyclopentolate for Pain Management After Photorefractive Keratectomy: A Comparative Clinical Evaluation. (PubMed, J Refract Surg) - "Contrary to theoretical expectations, adding cyclopentolate to nepafenac therapy worsened postoperative pain outcomes after PRK. For optimal pain management, a regimen of nepafenac alone appears superior to the combination therapy approach."

Clinical • Journal • Retrospective data • CNS Disorders • Pain • Sleep Disorder

Prevalence and Risk Factors for Myopia in Primary School Children in Madrid: A School-Based Cycloplegic Refraction Study. (PubMed, Int J Environ Res Public Health) - "This large school-based study using cycloplegic refraction provides more accurate prevalence data for Spanish schoolchildren. It confirms family history as a major risk factor and highlights the association of outdoor activities with lower prevalence of myopia. These results underline the need for preventive measures and suggest areas for future interventional research."

Journal • Ophthalmology

Efficacy and Safety of Cyclopentolate Microdrops for Cycloplegic Refraction in Children (clinicaltrials.gov) - P4 | N=63 | Completed | Sponsor: Aristotle University Of Thessaloniki | Recruiting ➔ Completed

Head-to-Head • Trial completion

Spectroscopic quantification of cyclopentolate using an erythrosine-based resonance rayleigh scattering strategy: application to ophthalmic formulations. (PubMed, Sci Rep) - "Successful application to the assay of cyclopentolate in commercial eye drop formulations confirmed the method's accuracy and precision. This RRS-based methodology utilizing erythrosine presents a straightforward, rapid, cost-effective, and environmentally favorable option for routine quality control and monitoring of CYP in pharmaceutical preparations."

Journal • Ophthalmology

Comparison of Cycloplegic and Non-Cycloplegic Refraction in School-Aged Children: A Cross-Sectional, Observational Study. (PubMed, Cureus) - "The participants were cyclopleged using eye drop cyclopentolate 1%, one drop every 15 minutes in both eyes, for over one hour...Myopia was overestimated, and hypermetropia was underestimated with non-cycloplegic refraction compared to cycloplegic refraction. Hence, cycloplegic refraction is recommended for the precise measurement of refractive error in children."

Journal • Observational data • Ophthalmology

Myopia Prediction Using Machine Learning: An External Validation Study. (PubMed, Vision (Basel)) - "Chinese students (N = 614) aged 8-13 years underwent autorefraction before and after cycloplegia with 0.5% tropicamide (n = 505) or 1% cyclopentolate (n = 109). In this independent cohort of students, XGBoost and random forest performed very well for predicting cycloplegic SER and myopia status using non-cycloplegic data. This external validation study demonstrated that ML may provide a useful tool for estimating cycloplegic SER and myopia prevalence with heterogeneous clinical parameters, and study in additional populations is warranted."

Journal • Ophthalmology

Role of ocular accommodation in emmetropisation among highly farsighted infants. (PubMed, Br J Ophthalmol) - P=N/A | "Contrary to defocus-based models of emmetropisation, greater accommodative response and not hyperopic defocus had the stronger influence on the rate of emmetropisation in hyperopic infants."

Journal • Ophthalmology • Pediatrics

Prevalence and risk factors of premyopia in preschoolers: a kindergarten-based cluster sampling study. (PubMed, Clin Exp Optom) - "Cycloplegic refraction was assessed using 1% cyclopentolate...Significant risk factors for premyopia included male gender (adjusted OR, 1.62; 95% CI, 1.32-2.00), paternal low/moderate myopia (adjusted OR, 1.50; 95% CI, 1.18-1.92), paternal high myopia (adjusted OR, 1.99; 95% CI, 1.41-2.81), and maternal high myopia (adjusted OR, 1.89; 95% CI, 1.35-2.64). Prevention and control of premyopia in preschool children should be emphasised, particularly for boys and children with myopic parents, due to their higher risk of developing premyopia."

Journal • Ophthalmology

Atropine or Cyclopentolate to Diagnose Premyopia in Preschool Children. (PubMed, JAMA Ophthalmol) - "The difference in the percentages of refractive states between the atropine and cycloplegic groups was as follows: moderate to high hyperopia (7.2% vs 2.7% = 4.5%; 95% CI, 2.9%-6.0%; P < .001), low hyperopia (82.8% vs 74.0% = 8.8%; 95% CI, 6.0%-11.8%; P < .001), premyopia (8.7% vs 21.6% = -12.9%; 95% CI, -15.4% to -10.4%; P < .001), and myopia (1.3% vs 1.8% = -0.5%; 95% CI, -1.3% to 0.4%; P = .30). This study found that use of atropine for cycloplegia in preschool children was associated with less myopic refraction compared with cyclopentolate and may potentially avoid overestimation of premyopia prevalence; however, this investigation did not evaluate each cycloplegic agent in the same children."

Journal • Ophthalmology

Atropine vs Cyclopentolate for Cycloplegic Refraction in Children. (PubMed, JAMA Ophthalmol) - No abstract available

Journal

Green RP-UPLC Method for Simultaneous Determination of Cyclopentolate and Organic Impurities Using DoE and Sustainability Metrics. (PubMed, Int J Anal Chem) - "ICH guidelines have been followed to validate the suggested strategy. This approach offers a reliable, fast, and eco-friendly solution for routine pharmaceutical quality control of anticholinergic agents."

Journal • Ophthalmology