cyclopentolate hydrochloride / Generic mfg. - LARVOL DELTA

Pseudomyopia and cycloplegic changes in young cynomolgus macaques. (PubMed, Mol Vis) - "The use of 1% cyclopentolate yielded discernible alterations in refractive and biometric parameters in 3- to 6-year-old cynomolgus macaques. Notably, compared with non-myopia and true myopia, pseudomyopia exhibited associations and discrepancies in accommodative status. These findings underscore the importance of investigating the role of the lens in animal models employed in myopia research."

Journal • Ophthalmology

Comparative Analysis of the Efficacy of 1% Tropicamide and 1% Cyclopentolate Eye Drops for Cycloplegic Refraction in Indonesian Paediatric Population. (PubMed, Br Ir Orthopt J) - "This randomised, double-blind, controlled non-inferiority trial compared the residual accommodation amplitude (AA) following two drops of 1% Tropicamide (TRP1%) or 1% Cyclopentolate (CYC1%), administered 5 min apart. Given its comparable efficacy and lower incidence of side effects, Tropicamide 1% may serve as a safer alternative for paediatric cycloplegic refraction. Further studies with larger samples are warranted to refine dosing strategies and enhance clinical outcomes."

Journal • Ophthalmology • Pediatrics

At-Home Pupil Dilation During the COVID-19 Pandemic in the Pediatric Population. (PubMed, J Pediatr Ophthalmol Strabismus) - "Cyclopentolate 1% eye drops were prescribed...AHPD can be a useful and cost-effective tool, can offer convenience, and may reduce anxiety in the office. The decision to use this approach should be individualized, considering the child's specific needs, parental comfort and ability, and the nature of the assessed ophthalmologic condition."

Journal • Infectious Disease • Mood Disorders • Novel Coronavirus Disease • Ophthalmology • Pediatrics • Psychiatry • Respiratory Diseases

Pharmacological and light-driven pupillary accommodation in guinea pigs: comparative effects of muscarinic modulators and illumination across developmental stages. (PubMed, Int J Ophthalmol) - "This study investigates pupillary responses in developing guinea pigs, revealing a direct pupillary light reflex (PLR) with light intensity-dependent responses, while indirect PLR was undetectable. The differential effects of muscarinic modulators on pupillary responses underscore the critical role of cholinergic signaling in ocular accommodation, with age-related variations in sensitivity. Additionally, a novel non-contact measurement methodology achieved a precision of 0.01 mm for pupillary quantification, enhancing accuracy in ocular studies."

Journal

Efficacy of Topical Nepafenac Versus Nepafenac With Perioperative Cyclopentolate for Pain Management After Photorefractive Keratectomy: A Comparative Clinical Evaluation. (PubMed, J Refract Surg) - "Contrary to theoretical expectations, adding cyclopentolate to nepafenac therapy worsened postoperative pain outcomes after PRK. For optimal pain management, a regimen of nepafenac alone appears superior to the combination therapy approach."

Clinical • Journal • Retrospective data • CNS Disorders • Pain • Sleep Disorder

Prevalence and Risk Factors for Myopia in Primary School Children in Madrid: A School-Based Cycloplegic Refraction Study. (PubMed, Int J Environ Res Public Health) - "This large school-based study using cycloplegic refraction provides more accurate prevalence data for Spanish schoolchildren. It confirms family history as a major risk factor and highlights the association of outdoor activities with lower prevalence of myopia. These results underline the need for preventive measures and suggest areas for future interventional research."

Journal • Ophthalmology

Efficacy and Safety of Cyclopentolate Microdrops for Cycloplegic Refraction in Children (clinicaltrials.gov) - P4 | N=63 | Completed | Sponsor: Aristotle University Of Thessaloniki | Recruiting ➔ Completed

Head-to-Head • Trial completion

Spectroscopic quantification of cyclopentolate using an erythrosine-based resonance rayleigh scattering strategy: application to ophthalmic formulations. (PubMed, Sci Rep) - "Successful application to the assay of cyclopentolate in commercial eye drop formulations confirmed the method's accuracy and precision. This RRS-based methodology utilizing erythrosine presents a straightforward, rapid, cost-effective, and environmentally favorable option for routine quality control and monitoring of CYP in pharmaceutical preparations."

Journal • Ophthalmology

Comparison of Cycloplegic and Non-Cycloplegic Refraction in School-Aged Children: A Cross-Sectional, Observational Study. (PubMed, Cureus) - "The participants were cyclopleged using eye drop cyclopentolate 1%, one drop every 15 minutes in both eyes, for over one hour...Myopia was overestimated, and hypermetropia was underestimated with non-cycloplegic refraction compared to cycloplegic refraction. Hence, cycloplegic refraction is recommended for the precise measurement of refractive error in children."

Journal • Observational data • Ophthalmology

Myopia Prediction Using Machine Learning: An External Validation Study. (PubMed, Vision (Basel)) - "Chinese students (N = 614) aged 8-13 years underwent autorefraction before and after cycloplegia with 0.5% tropicamide (n = 505) or 1% cyclopentolate (n = 109). In this independent cohort of students, XGBoost and random forest performed very well for predicting cycloplegic SER and myopia status using non-cycloplegic data. This external validation study demonstrated that ML may provide a useful tool for estimating cycloplegic SER and myopia prevalence with heterogeneous clinical parameters, and study in additional populations is warranted."

Journal • Ophthalmology

Role of ocular accommodation in emmetropisation among highly farsighted infants. (PubMed, Br J Ophthalmol) - P=N/A | "Contrary to defocus-based models of emmetropisation, greater accommodative response and not hyperopic defocus had the stronger influence on the rate of emmetropisation in hyperopic infants."

Journal • Ophthalmology • Pediatrics

Prevalence and risk factors of premyopia in preschoolers: a kindergarten-based cluster sampling study. (PubMed, Clin Exp Optom) - "Cycloplegic refraction was assessed using 1% cyclopentolate...Significant risk factors for premyopia included male gender (adjusted OR, 1.62; 95% CI, 1.32-2.00), paternal low/moderate myopia (adjusted OR, 1.50; 95% CI, 1.18-1.92), paternal high myopia (adjusted OR, 1.99; 95% CI, 1.41-2.81), and maternal high myopia (adjusted OR, 1.89; 95% CI, 1.35-2.64). Prevention and control of premyopia in preschool children should be emphasised, particularly for boys and children with myopic parents, due to their higher risk of developing premyopia."

Journal • Ophthalmology

Atropine or Cyclopentolate to Diagnose Premyopia in Preschool Children. (PubMed, JAMA Ophthalmol) - "The difference in the percentages of refractive states between the atropine and cycloplegic groups was as follows: moderate to high hyperopia (7.2% vs 2.7% = 4.5%; 95% CI, 2.9%-6.0%; P < .001), low hyperopia (82.8% vs 74.0% = 8.8%; 95% CI, 6.0%-11.8%; P < .001), premyopia (8.7% vs 21.6% = -12.9%; 95% CI, -15.4% to -10.4%; P < .001), and myopia (1.3% vs 1.8% = -0.5%; 95% CI, -1.3% to 0.4%; P = .30). This study found that use of atropine for cycloplegia in preschool children was associated with less myopic refraction compared with cyclopentolate and may potentially avoid overestimation of premyopia prevalence; however, this investigation did not evaluate each cycloplegic agent in the same children."

Journal • Ophthalmology

Atropine vs Cyclopentolate for Cycloplegic Refraction in Children. (PubMed, JAMA Ophthalmol) - No abstract available

Journal

Green RP-UPLC Method for Simultaneous Determination of Cyclopentolate and Organic Impurities Using DoE and Sustainability Metrics. (PubMed, Int J Anal Chem) - "ICH guidelines have been followed to validate the suggested strategy. This approach offers a reliable, fast, and eco-friendly solution for routine pharmaceutical quality control of anticholinergic agents."

Journal • Ophthalmology

Persistent Pupillary Dilation and Irreversible Mydriasis in HLA-B27-Associated Uveitis. (PubMed, Cureus) - "During the acute attack of anterior uveitis, the patient received topical cyclopentolate 1% drops as part of her management. Later, she presented with worsening photophobia and high ocular pressure, in addition to widely dilated and fixed pupils (atonic pupils) in both eyes. Upon assessment during follow-up visits, the pupils were found to be persistently dilated even after the discontinuation of the mydriatic drops and stabilization of both ocular pressure and inflammation."

Journal • Cardiovascular • Inflammation • Ocular Inflammation • Ophthalmology • Uveitis

Accuracy and repeatability of autorefraction in young adults: a comparison of cycloplegic and non-cycloplegic methods. (PubMed, Clin Exp Optom) - "This study evaluated differences between non-cycloplegic and cycloplegic spherical equivalent refraction following cyclopentolate hydrochloride (cycloplegic agent) administration in young adults...Cycloplegic measurements showed better repeatability, supporting their use for accurate refraction. Further research is needed on potential enhancing effects of proxymetacaine hydrochloride, particularly in diverse populations."

Journal • Ophthalmology

Comparative analysis of cycloplegic and non-cycloplegic refraction techniques for assessing refractive error in adults: a population-based study. (PubMed, Clin Exp Optom) - "Measurements of uncorrected distance visual acuity, followed by autorefraction, retinoscopy, subjective refraction, and cycloplegic refraction (using cyclopentolate 1%) were performed for all participants...Cycloplegic refraction is essential for assessing refractive errors, especially in individuals younger than 50 years. Furthermore, subjective refraction in older adults is influenced by numerous confounding variables and should be approached with caution."

Journal • Ophthalmology

Prevalence of visual impairment and refractive error-related risk factors in preschool children in beijing, China. (PubMed, BMC Public Health) - "This extensive study provides contemporary insights into the prevalence and causes of VI in preschool children in Beijing, China. The findings reveal a higher prevalence of VI compared to previous reports from Western countries, highlighting the critical need for ocular screening in preschool children and support from local governments to promote early prevention strategies against refractive errors."

Journal • Astigmatism • CNS Disorders • Ophthalmology • Pediatrics • Strabismus

Anticholinergic syndrome due to mydriatic drops intoxication in a child: A case report. (PubMed, Toxicol Rep) - "It has been described that anticholinergic syndrome can be related to a number of mydriatic drops (such as cyclopentolate) as well as other medications, in adults, children and neonates. It is a clinical diagnosis and requires no etiological testing. Depending on the severity at presentation, it may be required to administer the antidote physostigmine."

Journal • Ophthalmology

Establishment of Myopia Occurrence Prediction Model in Non-myopic Children Using Cycloplegic Refraction and Prior Axial Length Change. (PubMed, Ophthalmology) - P=N/A | "This prospective study combined cycloplegic refraction with prior axial length change to develop and validate a myopia prediction model, establishing potential SER thresholds for pre-myopia definition. Larger-scale studies across diverse populations are warranted to validate these findings."

Journal • Diabetic Retinopathy • Ophthalmology • Pediatrics • Retinal Disorders

Acute Angle-Closure Glaucoma in a 4-Year-Old: A Rare Presentation of Idiopathic Uveitis with Severe Structural Complications (SOE 2025) - "Postoperative treatment included oral acetazolamide, timolol, latanoprost, and topical dexamethasone with cyclopentolate, normalizing IOP and reducing inflammation. Systemic corticosteroids and weekly methotrexate were initiated, with fortnightly 20 mg adalimumab added due to severity, in collaboration with pediatric rheumatology.Two months post-presentation, visual acuity improved to 0.5 (Snellen scale) in the right eye, with a quiet eye, clear cornea, minimal cells and flare, patent iridectomy, iris atrophy, and an IOP of 12 mmHg. This case highlights idiopathic uveitis as a significant pediatric condition that can acutely cause severe complications. Early multidisciplinary management is critical for preserving vision and preventing long-term damage."

Glaucoma • Ocular Inflammation • Ophthalmology • Uveitis

Adjusted Study Protocol: Within-Subject Paired-Eye Design Comparing Pilocarpine 0.1%, Phentolamine 0.75%, and Combination Therapy for Cyclopentolate Reversal in Children (clinicaltrials.gov) - P=N/A | N=60 | Not yet recruiting | Sponsor: Mansoura University

New trial • Conjunctivitis

Interpretable machine learning models for predicting childhood myopia from school-based screening data. (PubMed, Sci Rep) - "Cycloplegia was induced using 1% cyclopentolate eye drops, followed by cycloplegic refraction testing...The AL/CCR demonstrated superior performance in predicting childhood myopia. The ML-based multi-indicator joint diagnostic predictive model enhances the accuracy of childhood myopia diagnosis, screening, and intervention."

Journal • Ophthalmology

Corneal Complications: Drug-Induced Deposits and Food and Drug Administration Adverse Event Reporting System Data Insights-A Retrospective Study. (PubMed, J Ocul Pharmacol Ther) - "Cyclopentolate and chloramphenicol demonstrated robust statistical relevance in association with corneal deposits. Positive signals for drug-induced corneal deposits included both well-known medications such as amiodarone and lesser-studied medications such as prednisolone and timolol. Clinician awareness of these findings alongside further investigation is needed."

Adverse events • Journal • Retrospective data