cyclopentolate hydrochloride / Generic mfg. - LARVOL DELTA

A Case of Pediatric Myasthenia Revealed by Marked Eyelid Ptosis After Using Cyclopentolate Eye Drops. (PubMed, Cureus) - "Early detection is paramount to prevent complications such as amblyopia and to initiate timely interventions, as demonstrated by the subsequent implementation of an eye patch to preserve visual function in the affected eye of the patient. This report contributes to the growing literature on the variable presentations of PMG and underlines the necessity for vigilance and a comprehensive approach in pediatric ophthalmologic evaluations to ensure that significant underlying conditions are not overlooked."

Journal • CNS Disorders • Immunology • Myasthenia Gravis • Ophthalmology • Pediatrics

Myopia prevalence among Norwegian schoolchildren between 2015 and 2024 was persistently low (ARVO 2025) - "Cycloplegic (n=643: 1–2 drops Cyclopentolate 1%) and non-cycloplegic autorefraction (n=1945) (Huvitz HRK-8000A Auto-REF Keratometer) and ocular biometry (Zeiss IOLMaster 700) were obtained...Forecasts have predicted a global increase in myopia prevalence by 2050. This appear not to be the case in Norway where the prevalence of myopia among schoolchildren remains low despite Norway being a highly developed country with a highly developed education systems, and the school-children having the highest screen time in Europe with reported increased screen time during and after COVID-19."

Ophthalmology

The effects of cyclopentolate 1.0% versus tropicamide 0.5% on autorefraction and ocular biometry in young adults (ARVO 2025) - "Layman Abstract (optional): Provide a 50-200 word description of your work that non-scientists can understand. Describe the big picture and the implications of your findings, not the study itself and the associated details."

Clinical • Ocular Inflammation • Ophthalmology

Exploring the relationship Between BMI and visual function in schoolchildren in Ireland: a cross-sectional study (ARVO 2025) - "The examination included logMAR VA (presenting and pinhole), stereoacuity (TNO stereo-test), cyclopleged autorefraction (1% cyclopentolate), height (cm) and weight (kg)...The study highlights the importance of maintaining a healthy weight for not only general health but also for good vision. Further research is needed to understand how weight loss might improve vision and whether these findings hold true over time."

Observational data • Astigmatism • Ophthalmology

Development and validation of predictive models for myopia onset: A 3-year school-based prospective study (ARVO 2025) - "Cycloplegia was induced using 3 drops of 1% cyclopentolate with an interval of 5 min...Our findings emphasize the importance of regular eye exams to detect early signs of myopia and guide better decision-making in healthcare. This could lead to more personalized care for children and ultimately reduce the long-term impact of myopia, helping kids maintain healthy vision as they grow."

Clinical • Predictive model • Ophthalmology

Quantifying pupillary dilation-induced alterations in intraocular pressure, angle, and anterior segment parameters in pseudoexfoliation syndrome using Scheimpflug imaging. (PubMed, Oman J Ophthalmol) - "All three dilating drops are effective in dilating PEX patients. Phenylephrine is the most effective and ideal for both clinics and surgeries. Cyclopentolate is the least effective dilator in PEX patients compared to healthy controls. Tropicamide 1% provides a good balance between pupil dilation and minimal IOP elevation, making it safer for PEX patients."

Journal • Ophthalmology

Efficacy and Safety of Cyclopentolate Microdrops for Cycloplegic Refraction in Children (clinicaltrials.gov) - P4 | N=62 | Recruiting | Sponsor: Aristotle University Of Thessaloniki

Head-to-Head • New P4 trial

Prevalence of Accommodative Insufficiency in Children With Normal Accommodative-Convergence/Accommodation Ratio and Its Association With Refractive Error: A Cross-Sectional Study. (PubMed, Cureus) - "In this study, with an overall AI prevalence of 32.4%, the ability to maintain comfortable, clear, and effective vision is notably affected by accommodative dysfunction alone, even when AI and convergence insufficiency (CI) coexist. Our investigation found no correlation between refractive error and the AA."

Journal • Observational data • Ophthalmology • Pediatrics • Retinal Disorders • Strabismus

Comparative efficacy of tropicamide 1% and cyclopentolate 1% for cycloplegic refraction: A systematic review and meta-analysis of randomized controlled trials. (PubMed, Optom Vis Sci) - "Tropicamide 1% and cyclopentolate 1% showed similar efficacies for cycloplegic refraction in nonstrabismic children and adults. Considering patient tolerability and drug safety, it may be practical to use tropicamide 1% in routine cycloplegic refractions."

Journal • Retrospective data

Retinitis linked to human herpesvirus type 6: a case study in a splenectomised patient. (PubMed, J Ophthalmic Inflamm Infect) - "He was treated with topical corticosteroid eyedrops, cyclopentolate, and prednisolone acetate ointment and systemically with intravenous ganciclovir 5 mg/kg bid for 14 days and then oral valganciclovir 900 mg bid for 4 weeks. The diagnosis was promptly presumed, enabling the early initiation of appropriate treatment and contributing to the preservation of the good visual acuity initially observed."

Journal • Epstein-Barr Virus Infections • Genetic Disorders • Infectious Disease • Ocular Infections • Ocular Inflammation • Ophthalmology • Pneumococcal Infections • Retinal Disorders • Uveitis

Bilateral Acute Myopia: Do Not Overlook Bilateral Uveal Effusion. (PubMed, Ocul Immunol Inflamm) - "The patient was treated with topical dexamethasone, cyclopentolate, and oral azithromycin. Healthcare professionals should consider uveal effusion in the differential diagnosis of patients presenting with bilateral acute myopia, particularly when associated with recent medication use. Further research is needed to explore the potential role of amoxicillin in inducing uveal effusion."

Journal • Infectious Disease • Ophthalmology • Pain • Pneumonia • Respiratory Diseases

Choroidal thickness under pilocarpine versus cyclopentolate. (PubMed, Sci Rep) - "In the left eyes, SFCT changed by 5.8 ± 22.2 μm (examiner 1), 5.5 ± 36.5 μm (examiner 2), and 3.9 ± 29.5 μm (examiner 3), respectively, and the midperipheral choroidal thickness changed by -6.9 ± 47.9 μm (examiner 1), -3.5 ± 28.7 μm (examiner 2), and 16.0 ± 28.2 μm (examiner3), respectively, without significant differences between baseline and study end (all P > 0.05). Application of cyclopentolate 1% and of pilocarpine 1% did not result in a statistically significant change in choroidal thickness in young healthy adults."

Journal • Ophthalmology

Influence of lens thickness on the accommodative range in healthy eyes. (PubMed, J Optom) - "The crystalline lens shape does not affect the accommodative range of the eye. This may be due to the smaller deformation required to bring a thicker lens to the same level of accommodation as a thinner lens. The amount of force on the zonular fibres may therefore be similar, in all lenses, regardless of the lens shape."

Journal

In-Office Suprachoroidal Viscopexy for Acute Rhegmatogenous Retinal Detachment. (PubMed, JAMA Ophthalmol) - "One patient developed a localized choroidal effusion unrelated to the SCVEXY site following laser retinopexy that resolved in 1 week associated with topical prednisolone, 1%, 4 times daily and cyclopentolate, 1%, twice daily. In this case series, the outcomes of these 6 cases suggest that SCVEXY may offer durable retinal reattachment in RRD. However, randomized clinical trial data, larger sample sizes, and longer-term follow-up are necessary to assess the risk-benefit profile of SCVEXY compared with the standard of care."

Clinical • Journal • Ophthalmology • Retinal Disorders

A comparison of cycloplegic effect of cyclopentolate 0.5% versus 1.0% eye drops with five different refraction measurement modalities in young adults. (PubMed, Graefes Arch Clin Exp Ophthalmol) - "What is known Cycloplegic refraction is a key test in the evaluation of any patient with active accommodation. The most frequently used clinical tests to determine the exact refraction are retinoscopy, subjective refraction, and objective refraction using autorefractometry. What is new No significant differences in the refraction between cycloplegia using 0.5% and 1.0% cyclopentolate eye drops were found. In noncycloplegia, hand-held autorefractometers tend to measure higher myopia. The evaluation of cycloplegic refraction showed good comparability between retinoscopy and subjective refraction as well as three different autorefractometers."

Journal • Ophthalmology

Comp arison of c yclop legic refraction in ch i ldren w i th different iris c olou r cat eg ories: A cross- sec tio na l survey. (PubMed, J Pak Med Assoc) - "Children with light iris colour accommodated more and needed a low concentration of cyclopentolate compared to those with m edi u m and dark ir is col ours. More accomm odation was noted among child ren ag ed 9-12 years."

Journal • Ophthalmology

A Case Report of Cyclopentolate-induced Brief Psychotic Disorder in a Child with Mild Intellectual Disability. (PubMed, Indian J Psychol Med) - No abstract available

Journal • CNS Disorders • Developmental Disorders • Mental Retardation • Psychiatry

Impact of proxymetacaine on the dynamics of cyclopentolate in White 6- to 7-year-olds. (PubMed, Ophthalmic Physiol Opt) - "Accurate autorefraction values can be obtained 20-min post-instillation of 1.0% cyclopentolate in white children aged 6-7 years, potentially reducing clinical testing times. Proxymetacaine pre-instillation allows for reliable measurements as early as 10-min post-instillation of cyclopentolate. Further research is needed to validate these findings in non-White populations and to determine the safe discharge time post-proxymetacaine instillation."

Journal

Uveitis in Nephrology: A Presentation of a Case of Tubulointerstitial Nephritis with Uveitis (TINU) (KIDNEY WEEK 2024) - "Here we presented a case of TINU initially presented with uveitis.Case Description: A 24-year-old female patient with a red eye, pain, and blurry vision was diagnosed with uveitis/episcleritis a few months ago and was treated with prednisone and cyclopentolate eye drops with mild improvement in her symptoms. Pulse steroid (methyl-prednisone, 250 mg IV) was initiated, followed by a steroid tapering regimen (1 mg/kg PO). The patient was followed up in our outpatient clinic with normal kidney function. TINU should be considered in the differential diagnosis with other oculorenal diseases including Sjogren's syndrome, sarcoidosis, tuberculosis, and Behcet's disease."

Clinical • Anemia • Eosinophilia • Hematological Disorders • Immunology • Infectious Disease • Nephrology • Ocular Inflammation • Ophthalmology • Pain • Rare Diseases • Respiratory Diseases • Sarcoidosis • Scleritis • Sjogren's Syndrome • Tuberculosis • Uveitis

Adverse reactions of cycloplegic and mydriatic eye drops in routine ophthalmologic examination of pediatric patients in Saudi Arabia: A retrospective study and survey of pediatric ophthalmologists. (PubMed, Saudi J Ophthalmol) - "Side effects caused by cycloplegic agents are usually mild and rarely severe. There are some systemic side effects such as hallucinations, psychosis, or seizures. Proper parental counseling before administering cycloplegic agents and proper clinical management in case of severe side effects is crucial. Prophylactic measures to reduce the incidence of these side effects are advisable."

Journal • Retrospective data • CNS Disorders • Epilepsy • Ophthalmology • Pediatrics • Psychiatry

Invasive Aspergillosis After Orthotopic Heart Transplant: Left Ventricular Aspergilloma Masquerading As A Left Ventricular Thrombus (HFSA 2024) - "She was treated with ophthalmic cyclopentolate, and systemic anti-fungal therapy was initiated with voriconazole. We describe the first case, to our knowledge, of disseminated invasive aspergillosis following OHT presenting as purulent pericarditis with intra-cardiac and ocular involvement. Furthermore, LV aspergilloma following OHT is a novel finding, and we demonstrate that percutaneous extraction with AngioVac may be feasible in select patients who are deemed high surgical risk."

Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Infectious Disease • Inflammation • Ophthalmology • Respiratory Diseases • Thrombosis • Transplantation

Objective Refraction Status before and after Cycloplegia: From Childhood to Young Adulthood. (PubMed, Vision (Basel)) - "Cycloplegia was induced with one drop of cyclopentolate 1% in each eye, and eye refraction was measured 30 ± 5 min later using an objective autorefractometer...The average spherical equivalent difference (mean ± SD) induced by cycloplegia was 0.72 ± 0.73 D, with the highest difference observed in the 3-5 years age group (1.18 ± 0.85 D). The differences in astigmatism power (p = 0.84) and astigmatism axis (p = 0.97) between non-cycloplegic and cycloplegic conditions were not statistically significant."

Journal • Astigmatism • Ophthalmology

Ocular Surface Reconstruction With Amniotic Membrane Transplantation For Lyme Keratitis Associated Symblepharon (ESCRS 2024) - "Five days earlier, he was seen at another ophthalmology clinic, where he was commenced on moxifloxacin eye drops, nepafenac eye drops, and oxytetracycline pomade therapy...He was started on topical administration of cefazolin and amikacin empirically and cyclopentolate eye drops, alongside oral tetracycline...In Lyme Disease, symblepharon can occur secondary to conjunctivitis, scleritis, episcleritis, or keratitis. Combining symblepharon removal and AM transplantation is an effective treatment modality for symblepharon linked with infection related inflammatory etiologies."

Conjunctivitis • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology • Scleritis

Streptococcus Mitis Keratitis: A Case Report (ESCRS 2024) - " Topical vancomycin, amikacin, fluconazole and cyclopentolate were started empirically... : Although Streptoccus mitis species rarely cause ocular infection, oral hygiene and cardiological examination of the patient should also be kept in mind because of viridians group bacteria. Diagnosis is made by corneal scraping and culture. Vancomycin is a good option treatment for Streptococcus mitis."

Case report • Clinical • Achromatopsia • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

Intracameral anaesthetic mydriatic versus topical mydriasis in Pediatric Cataract Surgery: a randomised control study. (PubMed, Am J Ophthalmol) - "Topical drugs achieved larger maximum pupil size as compared to ICAM. However, Intracameral mydriatic anaesthetic combination provided adequate and stable mydriasis without need for augmentation as compared to topical drops in children undergoing cataract surgery."

Journal • Surgery • Anesthesia • Cataract • Ophthalmology • Pediatrics