cyclopentolate hydrochloride / Generic mfg. - LARVOL DELTA

Efficacy and Safety of Cyclopentolate Microdrops for Cycloplegic Refraction in Children (clinicaltrials.gov) - P4 | N=63 | Completed | Sponsor: Aristotle University Of Thessaloniki | Recruiting ➔ Completed

Head-to-Head • Trial completion

Spectroscopic quantification of cyclopentolate using an erythrosine-based resonance rayleigh scattering strategy: application to ophthalmic formulations. (PubMed, Sci Rep) - "Successful application to the assay of cyclopentolate in commercial eye drop formulations confirmed the method's accuracy and precision. This RRS-based methodology utilizing erythrosine presents a straightforward, rapid, cost-effective, and environmentally favorable option for routine quality control and monitoring of CYP in pharmaceutical preparations."

Journal • Ophthalmology

Comparison of Cycloplegic and Non-Cycloplegic Refraction in School-Aged Children: A Cross-Sectional, Observational Study. (PubMed, Cureus) - "The participants were cyclopleged using eye drop cyclopentolate 1%, one drop every 15 minutes in both eyes, for over one hour...Myopia was overestimated, and hypermetropia was underestimated with non-cycloplegic refraction compared to cycloplegic refraction. Hence, cycloplegic refraction is recommended for the precise measurement of refractive error in children."

Journal • Observational data • Ophthalmology

Myopia Prediction Using Machine Learning: An External Validation Study. (PubMed, Vision (Basel)) - "Chinese students (N = 614) aged 8-13 years underwent autorefraction before and after cycloplegia with 0.5% tropicamide (n = 505) or 1% cyclopentolate (n = 109). In this independent cohort of students, XGBoost and random forest performed very well for predicting cycloplegic SER and myopia status using non-cycloplegic data. This external validation study demonstrated that ML may provide a useful tool for estimating cycloplegic SER and myopia prevalence with heterogeneous clinical parameters, and study in additional populations is warranted."

Journal • Ophthalmology

Role of ocular accommodation in emmetropisation among highly farsighted infants. (PubMed, Br J Ophthalmol) - P=N/A | "Contrary to defocus-based models of emmetropisation, greater accommodative response and not hyperopic defocus had the stronger influence on the rate of emmetropisation in hyperopic infants."

Journal • Ophthalmology • Pediatrics

Prevalence and risk factors of premyopia in preschoolers: a kindergarten-based cluster sampling study. (PubMed, Clin Exp Optom) - "Cycloplegic refraction was assessed using 1% cyclopentolate...Significant risk factors for premyopia included male gender (adjusted OR, 1.62; 95% CI, 1.32-2.00), paternal low/moderate myopia (adjusted OR, 1.50; 95% CI, 1.18-1.92), paternal high myopia (adjusted OR, 1.99; 95% CI, 1.41-2.81), and maternal high myopia (adjusted OR, 1.89; 95% CI, 1.35-2.64). Prevention and control of premyopia in preschool children should be emphasised, particularly for boys and children with myopic parents, due to their higher risk of developing premyopia."

Journal • Ophthalmology

Atropine or Cyclopentolate to Diagnose Premyopia in Preschool Children. (PubMed, JAMA Ophthalmol) - "The difference in the percentages of refractive states between the atropine and cycloplegic groups was as follows: moderate to high hyperopia (7.2% vs 2.7% = 4.5%; 95% CI, 2.9%-6.0%; P < .001), low hyperopia (82.8% vs 74.0% = 8.8%; 95% CI, 6.0%-11.8%; P < .001), premyopia (8.7% vs 21.6% = -12.9%; 95% CI, -15.4% to -10.4%; P < .001), and myopia (1.3% vs 1.8% = -0.5%; 95% CI, -1.3% to 0.4%; P = .30). This study found that use of atropine for cycloplegia in preschool children was associated with less myopic refraction compared with cyclopentolate and may potentially avoid overestimation of premyopia prevalence; however, this investigation did not evaluate each cycloplegic agent in the same children."

Journal • Ophthalmology

Atropine vs Cyclopentolate for Cycloplegic Refraction in Children. (PubMed, JAMA Ophthalmol) - No abstract available

Journal

Green RP-UPLC Method for Simultaneous Determination of Cyclopentolate and Organic Impurities Using DoE and Sustainability Metrics. (PubMed, Int J Anal Chem) - "ICH guidelines have been followed to validate the suggested strategy. This approach offers a reliable, fast, and eco-friendly solution for routine pharmaceutical quality control of anticholinergic agents."

Journal • Ophthalmology

Persistent Pupillary Dilation and Irreversible Mydriasis in HLA-B27-Associated Uveitis. (PubMed, Cureus) - "During the acute attack of anterior uveitis, the patient received topical cyclopentolate 1% drops as part of her management. Later, she presented with worsening photophobia and high ocular pressure, in addition to widely dilated and fixed pupils (atonic pupils) in both eyes. Upon assessment during follow-up visits, the pupils were found to be persistently dilated even after the discontinuation of the mydriatic drops and stabilization of both ocular pressure and inflammation."

Journal • Cardiovascular • Inflammation • Ocular Inflammation • Ophthalmology • Uveitis

Accuracy and repeatability of autorefraction in young adults: a comparison of cycloplegic and non-cycloplegic methods. (PubMed, Clin Exp Optom) - "This study evaluated differences between non-cycloplegic and cycloplegic spherical equivalent refraction following cyclopentolate hydrochloride (cycloplegic agent) administration in young adults...Cycloplegic measurements showed better repeatability, supporting their use for accurate refraction. Further research is needed on potential enhancing effects of proxymetacaine hydrochloride, particularly in diverse populations."

Journal • Ophthalmology

Comparative analysis of cycloplegic and non-cycloplegic refraction techniques for assessing refractive error in adults: a population-based study. (PubMed, Clin Exp Optom) - "Measurements of uncorrected distance visual acuity, followed by autorefraction, retinoscopy, subjective refraction, and cycloplegic refraction (using cyclopentolate 1%) were performed for all participants...Cycloplegic refraction is essential for assessing refractive errors, especially in individuals younger than 50 years. Furthermore, subjective refraction in older adults is influenced by numerous confounding variables and should be approached with caution."

Journal • Ophthalmology

Prevalence of visual impairment and refractive error-related risk factors in preschool children in beijing, China. (PubMed, BMC Public Health) - "This extensive study provides contemporary insights into the prevalence and causes of VI in preschool children in Beijing, China. The findings reveal a higher prevalence of VI compared to previous reports from Western countries, highlighting the critical need for ocular screening in preschool children and support from local governments to promote early prevention strategies against refractive errors."

Journal • Astigmatism • CNS Disorders • Ophthalmology • Pediatrics • Strabismus

Anticholinergic syndrome due to mydriatic drops intoxication in a child: A case report. (PubMed, Toxicol Rep) - "It has been described that anticholinergic syndrome can be related to a number of mydriatic drops (such as cyclopentolate) as well as other medications, in adults, children and neonates. It is a clinical diagnosis and requires no etiological testing. Depending on the severity at presentation, it may be required to administer the antidote physostigmine."

Journal • Ophthalmology

Establishment of Myopia Occurrence Prediction Model in Non-myopic Children Using Cycloplegic Refraction and Prior Axial Length Change. (PubMed, Ophthalmology) - P=N/A | "This prospective study combined cycloplegic refraction with prior axial length change to develop and validate a myopia prediction model, establishing potential SER thresholds for pre-myopia definition. Larger-scale studies across diverse populations are warranted to validate these findings."

Journal • Diabetic Retinopathy • Ophthalmology • Pediatrics • Retinal Disorders

Acute Angle-Closure Glaucoma in a 4-Year-Old: A Rare Presentation of Idiopathic Uveitis with Severe Structural Complications (SOE 2025) - "Postoperative treatment included oral acetazolamide, timolol, latanoprost, and topical dexamethasone with cyclopentolate, normalizing IOP and reducing inflammation. Systemic corticosteroids and weekly methotrexate were initiated, with fortnightly 20 mg adalimumab added due to severity, in collaboration with pediatric rheumatology.Two months post-presentation, visual acuity improved to 0.5 (Snellen scale) in the right eye, with a quiet eye, clear cornea, minimal cells and flare, patent iridectomy, iris atrophy, and an IOP of 12 mmHg. This case highlights idiopathic uveitis as a significant pediatric condition that can acutely cause severe complications. Early multidisciplinary management is critical for preserving vision and preventing long-term damage."

Glaucoma • Ocular Inflammation • Ophthalmology • Uveitis

Adjusted Study Protocol: Within-Subject Paired-Eye Design Comparing Pilocarpine 0.1%, Phentolamine 0.75%, and Combination Therapy for Cyclopentolate Reversal in Children (clinicaltrials.gov) - P=N/A | N=60 | Not yet recruiting | Sponsor: Mansoura University

New trial • Conjunctivitis

Interpretable machine learning models for predicting childhood myopia from school-based screening data. (PubMed, Sci Rep) - "Cycloplegia was induced using 1% cyclopentolate eye drops, followed by cycloplegic refraction testing...The AL/CCR demonstrated superior performance in predicting childhood myopia. The ML-based multi-indicator joint diagnostic predictive model enhances the accuracy of childhood myopia diagnosis, screening, and intervention."

Journal • Ophthalmology

Corneal Complications: Drug-Induced Deposits and Food and Drug Administration Adverse Event Reporting System Data Insights-A Retrospective Study. (PubMed, J Ocul Pharmacol Ther) - "Cyclopentolate and chloramphenicol demonstrated robust statistical relevance in association with corneal deposits. Positive signals for drug-induced corneal deposits included both well-known medications such as amiodarone and lesser-studied medications such as prednisolone and timolol. Clinician awareness of these findings alongside further investigation is needed."

Adverse events • Journal • Retrospective data

A Case of Pediatric Myasthenia Revealed by Marked Eyelid Ptosis After Using Cyclopentolate Eye Drops. (PubMed, Cureus) - "Early detection is paramount to prevent complications such as amblyopia and to initiate timely interventions, as demonstrated by the subsequent implementation of an eye patch to preserve visual function in the affected eye of the patient. This report contributes to the growing literature on the variable presentations of PMG and underlines the necessity for vigilance and a comprehensive approach in pediatric ophthalmologic evaluations to ensure that significant underlying conditions are not overlooked."

Journal • CNS Disorders • Immunology • Myasthenia Gravis • Ophthalmology • Pediatrics

Myopia prevalence among Norwegian schoolchildren between 2015 and 2024 was persistently low (ARVO 2025) - "Cycloplegic (n=643: 1–2 drops Cyclopentolate 1%) and non-cycloplegic autorefraction (n=1945) (Huvitz HRK-8000A Auto-REF Keratometer) and ocular biometry (Zeiss IOLMaster 700) were obtained...Forecasts have predicted a global increase in myopia prevalence by 2050. This appear not to be the case in Norway where the prevalence of myopia among schoolchildren remains low despite Norway being a highly developed country with a highly developed education systems, and the school-children having the highest screen time in Europe with reported increased screen time during and after COVID-19."

Ophthalmology

The effects of cyclopentolate 1.0% versus tropicamide 0.5% on autorefraction and ocular biometry in young adults (ARVO 2025) - "Layman Abstract (optional): Provide a 50-200 word description of your work that non-scientists can understand. Describe the big picture and the implications of your findings, not the study itself and the associated details."

Clinical • Ocular Inflammation • Ophthalmology

Exploring the relationship Between BMI and visual function in schoolchildren in Ireland: a cross-sectional study (ARVO 2025) - "The examination included logMAR VA (presenting and pinhole), stereoacuity (TNO stereo-test), cyclopleged autorefraction (1% cyclopentolate), height (cm) and weight (kg)...The study highlights the importance of maintaining a healthy weight for not only general health but also for good vision. Further research is needed to understand how weight loss might improve vision and whether these findings hold true over time."

Observational data • Astigmatism • Ophthalmology

Development and validation of predictive models for myopia onset: A 3-year school-based prospective study (ARVO 2025) - "Cycloplegia was induced using 3 drops of 1% cyclopentolate with an interval of 5 min...Our findings emphasize the importance of regular eye exams to detect early signs of myopia and guide better decision-making in healthcare. This could lead to more personalized care for children and ultimately reduce the long-term impact of myopia, helping kids maintain healthy vision as they grow."

Clinical • Predictive model • Ophthalmology

Quantifying pupillary dilation-induced alterations in intraocular pressure, angle, and anterior segment parameters in pseudoexfoliation syndrome using Scheimpflug imaging. (PubMed, Oman J Ophthalmol) - "All three dilating drops are effective in dilating PEX patients. Phenylephrine is the most effective and ideal for both clinics and surgeries. Cyclopentolate is the least effective dilator in PEX patients compared to healthy controls. Tropicamide 1% provides a good balance between pupil dilation and minimal IOP elevation, making it safer for PEX patients."

Journal • Ophthalmology