SR-8993 / University of Miami - LARVOL DELTA

Roles of the nociceptin/orphanin FQ receptor in reward-related behaviors in mice (Neuroscience 2023) - "To address this, we employed a battery of behavior tests combined with systemic administration of a non-peptide, brain-penetrant NOR agonist, SR-8993...In sum, these findings suggest that the NOR system is involved in consummatory and seeking behaviors, yet it appears to contribute to these behaviors in a dose-dependent, relatively selective manner, which depends upon the structure of tasks. Our results provide evidence that the NOR system may present promising targets for the development of novel pharmacotherapies for the treatment of alcohol use and eating disorders."

Preclinical • Addiction (Opioid and Alcohol) • CNS Disorders