HB-101 / Hookipa Pharma - LARVOL DELTA

A Study of CMV Vaccine (HB-101) in Kidney Transplant Patients (clinicaltrials.gov) - P2 | N=83 | Completed | Sponsor: Hookipa Biotech GmbH | Active, not recruiting ➔ Completed

Trial completion • Cytomegalovirus Infection • Infectious Disease • Transplantation

A Study of CMV Vaccine (HB-101) in Kidney Transplant Patients (clinicaltrials.gov) - P2; N=83; Active, not recruiting; Sponsor: Hookipa Biotech GmbH; Trial completion date: Oct 2022 ➔ Jun 2022; Trial primary completion date: Oct 2022 ➔ Jun 2022

Clinical • Trial completion date • Trial primary completion date • Cytomegalovirus Infection • Infectious Disease • Transplantation • IFNG

HOOKIPA Pharma Reports Second Quarter 2021 Financial Results and Recent Highlights (GlobeNewswire) - "HB-101...final top-line data readout in the first half of 2023. The protocol requires a 12-month follow up after transplantation, which is typically two to three months after enrollment."

P2 data • Cytomegalovirus Infection • Infectious Disease

A Study of CMV Vaccine (HB-101) in Kidney Transplant Patients (clinicaltrials.gov) - P2; N=83; Active, not recruiting; Sponsor: Hookipa Biotech GmbH; Recruiting ➔ Active, not recruiting

Enrollment closed • Cytomegalovirus Infection • Infectious Disease • Transplantation • IFNG

HOOKIPA Reports Fourth Quarter and Full Year 2020 Financial Results and Provides 2021 Outlook (BioSpace) - P2, N=150; NCT03629080; Sponsor: Hookipa Biotech GmbH; "In November, interim Phase 2 data were released for patients who received a three-dose CMV vaccination with HB-101 prior to a kidney organ transplantation....Expects to conclude enrollment of the ongoing Phase 2 trial in mid-2021 and to report additional data in the second half of 2021....Phase 1 safety and immunogenicity data on HB-101 were published in The Journal of Infectious Diseases....A successful follow-on offering to close the year with a cash balance of $143.2 million. Funding will support advancement of the HPV16+ and CMV programs."

Enrollment closed • Financing • P1 data • P2 data • Cytomegalovirus Infection • Infectious Disease

Microbial biosensor for Salmonella using anti-bacterial antibodies isolated from human serum. (PubMed, Enzyme Microb Technol) - "From the FACS analysis, the isolated anti-Salmonella antibodies were estimated to have more than 6-fold higher binding affinity for S. enteritidis compared to antibodies against other kinds of Gram-negative bacterial strains, including HB101, ClearColi, JM110, DH5α, and BL21(DE3). Finally, the anti-Salmonella antibodies isolated herein were used for bacterial detection using electrochemical biosensors based on impedance spectrometry and the R value of the antibodies was estimated for S. enteritidis from the Nyquist plot. The limit of detection of the isolated anti-Salmonella antibodies was estimated to be 1.0 × 10 cells/mL for S. enteritidis and 1.0 × 10 cells/mL for BL21(DE3), respectively."

Journal

A Study of CMV Vaccine (HB-101) in Kidney Transplant Patients (clinicaltrials.gov) - P2; N=150; Recruiting; Sponsor: Hookipa Biotech; Trial completion date: Oct 2021 ➔ Oct 2022; Trial primary completion date: Oct 2021 ➔ Oct 2022

Clinical • Trial completion date • Trial primary completion date • Cytomegalovirus Infection • Infectious Disease • Renal Disease • Transplantation

Characterization of a LuxR repressor for 3,17β-HSD in Comamonas testosteroni ATCC11996. (PubMed, Chem Biol Interact) - "Further, luxr point mutant plasmids were prepared by PCR and co-transformed with pUC3.2-4 into E. coli HB101...Molecular interaction experiments showed that LuxR protein binds to a nucleotides fragment which locates 87 bp upstream of the βhsd promoter. Our results revealed that steroid induction of 3,17β-HSD in C. testosteroni in fact appears to be a de-repression, where testosterone prevents the LuxR regulator protein binding to the 3,17β-HSD promoter domain."

Journal

Effect of Pyrolytic Temperature and Time on Characteristics of Typha angustifolia Derived Biochar and Preliminary Assessment of the Ecological Risk (PubMed, Huan Jing Ke Xue) - "All the TBCs had no significant effect on the growth of E. coli HB101 and the seed germination of Helianthus annuus, indicating the little ecological risk of TBCs under the experimental conditions. These findings provide an alternative way for resource utilization of waste wetland biomass and provide important theoretical data for screening biochar in soil reclamation."

Journal

Differentiation of meat-related microorganisms using paper-based surface-enhanced Raman spectroscopy combined with multivariate statistical analysis. (PubMed, Talanta) - "Enteritidis DSM 14221, Listeria monocytogenes DSM 19094, Micrococcus luteus DSM 20030, Escherichia coli HB101 and Bacillus thuringiensis sv...Because of the spike correction rather than exclusion, and therefore the use of a balanced data set, the multivariate analysis of the data is significantly resilient and meaningful. The analysis showed that the differentiation of meat-associated microorganisms and thereby the detection of important meat-related pathogenic bacteria was successful on genera level and a cross-validation as well as a classification of ungrouped data showed promising results, with 99.5% and 97.5%, respectively."

Journal

Heterologous expression of the Salmonella enterica serovar Paratyphi A stk fimbrial operon suggests a potential for repeat sequence-mediated low-frequency phase variation. (PubMed, Infect Genet Evol) - "The observed intragenic, 26 bp tandem repeat triplication event in stkF would suggest that slipped-strand mispairing and/or recombination within a signature stkF-borne tandem repeat motif as a likely mechanism for a form of low-frequency phase switching at the translational level leading to allelic OFF forms, hence the inability of production and/or absence of fimbriae by EM-examination on E. coli HB101/pUCstk-stkF. The in vitro profile of marked anti-StkF-mediated opsonophagocytosis and complement-mediated killing activity observed coupled with the mice immunogenicity profile strongly supports further investigation of StkF as a potential Salmonella vaccine candidate."

Journal • Infectious Disease

Biochemical and molecular characterization of an acido-thermostable endo-chitinase from Bacillus altitudinis KA15 for industrial degradation of chitinous waste. (PubMed, Carbohydr Res) - "The chiA-Ba43 gene (1332 bp) encoding ChiA-Ba43 (409 aa) was cloned, sequenced, and expressed in Escherichia coli strain HB101. The biochemical properties of the recombinant chitinase (rChiA-Ba43) were equivalent to those of the natively expressed enzyme. These properties make ChiA-Ba43 an ideal candidate for industrial bioconversion of chitinous waste."

Journal

Occurrence of the genes encoding carbapenemases, ESBLs and class 1 integron-integrase among fermenting and non-fermenting bacteria from retail goat meat. (PubMed, Lett Appl Microbiol) - "Conjugation assay was performed using bla -positive isolates as the donor, and Escherichia coli HB101 as the recipient. Isolates showed the high rates of resistance to ceftazidime (77.2%), cefotaxime (70.2%), meropenem (22.8%) and imipenem (17.5%)...The conjugative movement of bla gene could not be proved after three repetitive mating experiments. The presence of genes encoding carbapenemases and ESBLs in bacteria from goat meat poses public health risks."

Journal • Complement-mediated Rare Disorders

Microwave Irradiation Synthesis and Characterization of Reduced-(Graphene Oxide-(Polystyrene-Polymethyl Methacrylate))/Silver Nanoparticle Nanocomposites and their Anti-Microbial Activity. (PubMed, Polymers (Basel)) - "In addition, the antibacterial activity of the prepared nanocomposites against the E. coli HB 101 K-12 was investigated, whereby an inhibition zone of 3 mm (RGO/AgNPs-(PS-PMMA) and 27 mm (R-(GO-(PS-PMMA))/AgNPs) was achieved. This indicates that the MWI-prepared nanocomposite has stronger antibacterial activity than the in situ-prepared nanocomposite."

Journal

A Randomized Dose-Escalating Phase I Trial of a Replication-Deficient Lymphocytic Choriomeningitis Virus Vector-Based Vaccine Against Human Cytomegalovirus. (PubMed, J Infect Dis) - "HB-101 was well tolerated and induced cytomegalovirus-specific polyfunctional CD8 T-cell and neutralizing Ab responses in the majority of subjects. Lack of vector-neutralizing Ab responses should facilitate booster vaccinations. These results justify further clinical evaluation of this vaccine candidate."

Clinical • Journal • P1 data • Cytomegalovirus Infection • Immunology • Infectious Disease • CD8