Renogen (epoetin alfa biosimilar) / Unilab - LARVOL DELTA

Clinical Comparison of Renogen, a Biosimilar Epoetin-a, with the Originator, Eprex, in Chronic Kidney Disease Anemia in Indonesia: A Preliminary Study. (PubMed, Acta Med Indones) - "Hb level at >10 g/dL could be maintained for 8 weeks of treatment with both originator and biosimilar EPO (more consistent with originator EPO and more fluctuations with biosimilar EPO), with similar epoetin dose and no drug-related adverse event."

Clinical • Journal

Vaccine-Induced Protection Against Furunculosis Involves Pre-emptive Priming of Humoral Immunity in Arctic Charr. (PubMed, Front Immunol) - "Furthermore, where pathways of actin assembly and FcγR-mediated phagocytosis were significantly differentially regulated in unvaccinated fish, vaccinated fish showed either the opposite regulation (ForteMicro®), or no impact at all (ForteMicro®Renogen®). The present data indicates that vaccine-induced protection against Asal relies on the pre-activation and immediate control of humoral immune parameters that is coincident with reduced activation of apoptotic (e.g., NF-κB) and actin-associated pathways."

Journal

Avoiding over and undertreatment by optimizing of the timing of glucocorticoïd treatment in children with cnogenital adrenal hyperplasia Vermijden van over en onderbehandeling door optimalisatie van de timing van glucorticoid behandeling bij kinderen met het adrenogenitala syndroom (clinicaltrialsregister.eu) - P2; N=50; Ongoing; Sponsor: Radboud University Nijmegen Medical Centre

Clinical • New P2 trial

Renogenic characterization and in vitro differentiation of rat amniotic fluid stem cells into renal proximal tubular- and juxtaglomerular-like cells. (PubMed, In Vitro Cell Dev Biol Anim) - "The AFSCs also expressed pluripotency markers OCT4, NANOG, and SOX2 and could be induced into embryoid bodies with differentiation into all the three germ layers, highlighting the pluripotent nature of these cells. Our results show that amniotic fluid contains a population of primitive stem cells that express renal-progenitor markers and also possess the propensity to differentiate into two renal lineage cell types and, thus, may have a therapeutic potential in renal regenerative medicine."

Journal • Preclinical