cloxacillin / Generic mfg. - LARVOL DELTA

Nanocurcumin: An Innovative Strategy to Combat Virulence and Methicillin Resistance in Staphylococcus aureus Isolated from Burn Wounds. (PubMed, Iran J Med Sci) - "The 50 selected isolates were resistant to cefoxitin, amoxicillin, benzylpenicillin, ampicillin/sulbactam, piperacillin/tazobactam, cloxacillin, oxacillin, and azithromycin. No significant changes were seen in fnbA and ftsZ. Nanocurcumin inhibits S. aureus virulence and resistance genes, reducing biofilm formation and toxin production, but lacks effect on fnbA and ftsZ, requiring further research."

Journal • Infectious Disease

In vitro exebacase (CF-301) activity against methicillin-susceptible or methicillin-resistant Staphylococcus aureus and coagulase-negative staphylococci strains isolated from patients with infective endocarditis. (PubMed, J Antimicrob Chemother) - "Exebacase activity was independent of methicillin resistance and consistently higher against S. aureus than S. epidermidis. Further research is warranted to explore lysins in combination against staphylococcal infections."

Journal • Preclinical • Cardiovascular • Infectious Disease

Campylobacter jejuni versus Campylobacter coli: Occurrence and antimicrobial resistance in red meat sold in markets in Wasit, Iraq. (PubMed, J Adv Vet Anim Res) - "One hundred percent of bacterial isolates exhibited resistance to oxacillin, erythromycin, nalidixic acid, and cloxacillin. According to the current study, cattle and sheep meat pose a potential threat to public health. Therefore, minimizing Campylobacter infection and ensuring the safe use of antibiotics requires strict monitoring, regulatory measures, and suitable treatments."

Journal • Gastroenterology • Gastrointestinal Disorder • Infectious Disease

Binding mode of Isoxazolyl Penicillins to a Class-A β-lactamase at ambient conditions. (PubMed, Commun Chem) - "We demonstrate the acyl-enzyme intermediates of the catalytically impaired CTX-M-14 mutant E166A in complex with three Isoxazolyl-Penicillins: Oxacillin, Cloxacillin and Dicloxacillin. Structural comparisons of CTX-M-Penicillin complexes show that, while conserved active-site interactions are maintained, each Isoxazolyl-Penicillin adopts a distinct conformation. While the three derivatives differ only by one and two chlorine atoms, respectively, their conformational heterogeneity appears to be increased by chlorination of the phenyl ring."

Journal • Infectious Disease • Pneumonia

CLOCEBA: Non-inferiority Trial Comparing Cloxacillin vs Cefazolin in Methicillin-susceptible Staphylococcus Aureus Bacteremia (clinicaltrials.gov) - P=N/A | N=315 | Completed | Sponsor: Assistance Publique - Hôpitaux de Paris | Active, not recruiting ➔ Completed | Trial completion date: Dec 2024 ➔ Mar 2025

Head-to-Head • Trial completion • Trial completion date

Aetiology, factors associated with injury severity, and bacterial susceptibility patterns among burn patients in six selected hospitals in Uganda. (PubMed, Int J Burns Trauma) - "Implementation of burn infection control policies is needed. There is a need to include sites mandating admission in the parameters of the ABSI score. Based on microorganisms isolated, empirical treatment with ciprofloxacin or cloxacillin should be considered."

Journal • Infectious Disease • Thermal Injury

Activity of cloxacillin against Cutibacterium acnes: MIC evaluation and utility of gradient test. (PubMed, Infect Dis (Lond)) - "We aimed to compare MIC distributions of C.acnes to benzylpenicillin and cloxacillin. Gradient test results for cloxacillin showed high agreement with agar dilution (essential agreement 0.87), supporting its use as a practical alternative to agar dilution cloxacillin MIC determination if susceptibility testing is necessary. Our findings indicate that intravenous cloxacillin is an effective treatment of C. acnes infections, and that cloxacillin gradient testing is a convenient and reliable alternative for MIC determination for clinical laboratories."

Journal • Infectious Disease • Orthopedics

In Vitro Activity of Manuka Honey, Either Alone or in Combination With Topical Antibiotics, Against Bacteria Commonly Found in Equine Ulcerative Keratitis. (PubMed, Vet Ophthalmol) - "Manuka honey has in vitro inhibitory and bactericidal activity against equine corneal surface pathogens including multi-resistant isolates. Further studies are required to assess potential synergistic and antagonistic effects of manuka honey in combination with antibiotics."

Journal • Preclinical • Keratitis • Ocular Inflammation • Ophthalmology

Sublethal concentrations of antibiotics enhance transmission of antibiotic resistance genes in environmental Escherichia coli. (PubMed, Front Microbiol) - "For this study, 39 E. coli were isolated from a single dairy farm over 4 months, using cefotaxime-supplemented selective media...In total, 35 of the 39 ESBL-Ec strains were multidrug resistant, displaying bla CTX-M type cephalosporin resistance and resistance to fluoroquinolones and tetracyclines...We found that sub-lethal levels of ampicillin, cloxacillin, and ceftazidime could enhance the transfer of ISEcp1 bla CTX-M-15 from the chromosome of these dairy farm strains into endogenous self-transmissible plasmids, which can themselves then transfer into and confer phenotypic antibiotic resistance in a recipient E. coli K-12 strain. In conclusion, we observed not only clonal dissemination of these environmentally occurring ESBL-producing strains within the farm environment but also showed experimentally that these strains had the ability to mobilise their ESBL producing genes, and that these and other resistance genes can be acquired or lost on transfer. This shows the..."

Journal

Cloxacillin versus cefazolin for meticillin-susceptible Staphylococcus aureus bacteraemia (CloCeBa): a prospective, open-label, multicentre, non-inferiority, randomised clinical trial. (PubMed, Lancet) - P=N/A | "Cefazolin constitutes an alternative to cloxacillin for the treatment of MSSA bacteraemia, offering non-inferior clinical efficacy and potentially enhanced tolerability."

Head-to-Head • Journal • Acute Kidney Injury • Cardiovascular • Infectious Disease • Nephrology • Renal Disease

The Rapid CarbaLux Combination Test to Uncover Bacterial Resistance and Heteroresistance Prior to Antibiotic Treatment. (PubMed, Diagnostics (Basel)) - "It was expected that a specific inhibitor that protects imipenem or meropenem from enzymatic deactivation during antibacterial therapy would perform the same in vitro with fluorescent carbapenem and preserve its fluorescence. The new additional CarbaLux combination test is used if the classic test is positive for carbapenemases: a classic test tube pre-dosed with fluorescent carbapenem is spiked with cloxacillin; with recently launched carbapenemase inhibitors, e.g., avibactam, relebactam, zidebactam, nacubactam, or vaborbactam; or with picolinic acid...They are simpler, broader in scope, and more cost-effective; they can also detect antimicrobial heteroresistance or AmpC beta-lactamase hyperproduction, which is normally undetected when performing automated antibiotic susceptibility testing. The new tests are suitable for clinical diagnosis, public health purposes, and infection control."

Journal • Infectious Disease

Prevention of infection in peripheral arterial reconstruction of the lower limb. (PubMed, Cochrane Database Syst Rev) - "Prophylactic antibiotics may reduce SSIs in peripheral arterial reconstruction of the lower limb with low-certainty evidence. We found no superiority among specific antibiotics or differences in extended use (over 24 hours) compared with shorter use (up to 24 hours), with low-certainty evidence. Closed incision negative pressure therapy may lower the SSI risk, but this is based on very low-certainty evidence. For other interventions, very low- to moderate-certainty evidence showed little or no significant differences across various outcomes. We advise caution when interpreting these conclusions due to the limited number of events in all groups and comparisons."

Clinical • Journal • Review • Cardiovascular • Infectious Disease • Pain • Peripheral Arterial Disease

Antibiotic use according to the World Health Organization AWaRe classification and antimicrobial resistance pattern among hospitalized under-five children with suspected pneumococcal disease in Bangladesh (ASTMH 2025) - "Of those receiving antibiotics, the top three prescribed antibiotics were ceftriaxone (Watch, 77%), cloxacillin (Access, 14%), and vancomycin (Access, 11%). Isolates showed high levels of resistance to erythromycin (Watch, 100%), tetracycline (Access, 83%), and trimethoprim/sulfamethoxazole (Access, 70%), and lower levels of resistance to benzylpenicillin (Access, 45%) and clindamycin (Access, 40%). Frequent usage of "Watch" antibiotics and the high prevalence of MDR S. pneumoniae colonization underscores the necessity to implement antibiotic stewardship programs."

Clinical • CNS Disorders • Infectious Disease • Pneumococcal Infections • Pneumonia • Respiratory Diseases • Septic Shock

Enterobacterial Profiling and Molecular Studies of Resistant Isolates Among Food Handlers in Selected Restaurants in Nnewi Metropolis (ASTMH 2025) - "The results showed that food handlers represent a frequent source of bacterial strains exhibiting high resistance to several antibiotics, including cefotaxime, ampicillin + cloxacillin, and amoxicillin + clavulanic acid. Genetic sequencing identified the isolates with their accession number, and a phylogenetic tree was used to visualize their genetic relatedness. This study has revealed a high prevalence of ESBL-producing Enterobacteriaceae in food handlers, highlighting a potential route for the transmission of antibiotic-resistant pathogens through the food chain, which has important implications for public health, emphasizing the need for continuous surveillance and targeted interventions to mitigate the spread of antibiotic resistance."

Oral ivermectin is safe in children weighing 5 to less than 15 kg - a multicenter trial (ASTMH 2025) - "One participant had a severe adverse event with transient liver enzyme increase, possibly related to study treatment, and was also co-administered cloxacillin for a septic abscess on their right foot. As expected, both ivermectin and permethrin treatments were efficacious in this weight class. The Ivermectin Safety in Small Children trial provides further evidence that ivermectin in children weighing less than 15 kg is as safe and efficacious as in persons weighing more than 15 kg."

Clinical • Hematological Disorders • Hepatology • Infectious Disease

Development and application of a wipe sampling method for detection of antibiotic surface contamination in hospital wards. (PubMed, Ann Work Expo Health) - "A widespread environmental contamination of antibiotics was observed in hospital wards that potentially can contribute to the development of antibiotic-resistant bacteria as well as health impacts of exposed personnel. Probable sources include compounding, handling and administration of drug tablets, antibiotic contaminated waste as well as other sources such as excretions from patients and contaminated drug vials. Current surface cleaning routines do not sufficiently reduce spills and leakage regardless of source."

Journal • Immunology • Infectious Disease

Graft Polymers Derived from Pharmaceutically Active Choline-Based Ionic Liquid Monomers: Dual Incorporation of Ampicillin and Cloxacillin. (PubMed, Int J Mol Sci) - "In an aqueous solution, the polymer self-assemblies appeared to be nanosized particles (90-360 nm). The results demonstrate that the synthesized TMAMA-based graft copolymers act as effective ionic conjugates and dual drug systems, offering a promising platform for controlled and multi-drug delivery applications."

Journal

Correlation between Biofilm Development and Antibiotic Resistance in Staphylococcus haemolyticus. (PubMed, Med Glas (Zenica)) - "The study highlights the alarming antibiotic resistance, strong biofilm-forming ability, and high prevalence of virulence and resistance genes in S. haemolyticus, reinforcing concerns over the global spread of multidrug-resistant organisms."

Journal • Infectious Disease • Nephrology

Staphylococcus aureus can cause rapid progress in submandibular, masticatory and submental space abscess in young non-co-morbid female patient. (EUSEM 2025) - "The patient received cloxacillin antibiotic by intravenous then orally...CT scan has more sensitive to determine the abscess size , extension and surgical needed in the deep space abscess. We reported rapid progress in submandibular, masticatory and submental space abscess caused by Staphylococcus aureus in young female patients who denied any co-morbidity."

Clinical • Otorhinolaryngology

Pemphigus Vegetans: A Clinical Rarity Detected from the Emergency Department (EADV 2025) - "The lesions initially appeared during a trip to Germany, where the patient was diagnosed with bullous impetigo and treated with oral cloxacillin...Treatment was initiated with prednisone and clindamycin to address bacterial superinfection... Multidisciplinary management and good coordination between services are essential when treating severe dermatological conditions that, as in this case, may require urgent medical attention."

Clinical • Dermatology • Immunology • Pemphigus Vulgaris

Prevalence and Antimicrobial Resistance Patterns of Escherichia coli Isolated From Broiler Chickens in Sylhet District of Bangladesh. (PubMed, Vet Med Sci) - "Antibiotic susceptibility testing revealed complete (100%) resistance to tetracycline (TE), cloxacillin (CLOX) and co-trimoxazole (COT), with 91.8% resistance to erythromycin (E). Gentamicin (GEN) exhibited intermediate resistance (69.4%), whereas azithromycin (AZM) was the most sensitive, with 58.8% of the isolates demonstrating susceptibility...The correlation and coexistence network analysis identified frequent resistance linkages among specific antibiotics, suggesting shared pathways that could drive co-selection in resistant E. coli populations. The study emphasizes the pressing need for stricter antibiotic regulations, enhanced AMR surveillance and improved biosecurity measures to mitigate the spread of multidrug-resistant E. coli, with implications for both human and animal health."

Journal

IDIOPATHIC BRONCHIECTASIS: GENUINE ENTITY OR ARTIFACT OF LIMITED DIAGNOSTICS (MTS 2025) - "He completed 14 days of IV cloxacillin and cefazolin post-culture clearance. J Bras Pneumol, 2023. 49(5): p. e20230249."

Alpha-1 Antitrypsin Deficiency • Asthma • Bronchiectasis • Chronic Obstructive Pulmonary Disease • Cough • Cystic Fibrosis • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Genetic Disorders • Hepatology • Immunology • Infectious Disease • Inflammation • Inflammatory Arthritis • Inflammatory Bowel Disease • Metabolic Disorders • Otorhinolaryngology • Pneumonia • Pulmonary Disease • Respiratory Diseases • Rheumatoid Arthritis • Rheumatology • Septic Shock • CFTR

Characterization of antimicrobial use and detection of antimicrobial residues in bulk tank milk from specialized dairy herds in Antioquia, Colombia. (PubMed, J Food Prot) - "One BTM sample per herd (n=150) was evaluated with the Brilliant Black Reduction Test (BRT), Milksafe™ 2BC, and Milksafe™ 3BTS, for the selective detection of beta-lactams, sulfonamides, and tetracyclines residues...Cloxacillin-ampicillin was the most used for dry cow therapy, while benzylpenicillin was preferred for mastitis...According to survey data, bovine mastitis is the primary disease in herds for which antibiotics are used and antimicrobial residues in raw milk are present imposing a significant risk for consumers in the region. Therefore, it is a priority to reduce bovine mastitis incidence as well as the application of a program for on-farm antimicrobial administration, oriented to the reduction of the economic impact of inadequate treatments that lead to therapeutic failure and penalties in the price of milk."

Journal

Prevalence, safety evidence, and determinants of medicine use during breastfeeding among women in Kampala, Uganda. (PubMed, BMC Womens Health) - "The overall prevalence of medicine use among breastfeeding women was high, with frequent self-medication using over-the-counter drugs. There is urgent need for strengthened regulatory frameworks, enhanced healthcare provider training, with community based education to promote rational medicine use and improve public health literacy. Further pharmacokinetic research is critical to generate safety data on commonly used medications, hence informing clinical guidelines and supporting evidence-based decision-making among breastfeeding women."

Journal

Adjunctive Fosfomycin for the Treatment of Staphylococcus aureus Bacteremia: A Pooled Post-hoc Analysis of Individual Participant Data from Two Randomized Trials. (PubMed, Clin Infect Dis) - P | "Adjunctive fosfomycin may improve early bacterial clearance and treatment success in SAB but at the cost of increased toxicity."

Journal • Retrospective data • Infectious Disease