Carafate (sucralfate) / AbbVie - LARVOL DELTA

ESUS-ESD: Esomeprazole Plus Sucralfate for Post-ESD Ulcer Healing (clinicaltrials.gov) - P4 | N=120 | Not yet recruiting | Sponsor: LanZhou University | Initiation date: Jan 2026 ➔ Apr 2026

Trial initiation date • Gastric Cancer • Gastroenterology • Oncology • Peptic Ulcer • Solid Tumor

Sucralfate plus Pantoprazole versus Pantoprazole alone for healing of post–endoscopic variceal ligation ulcers: an open label randomized controlled trial (EASL 2026) - No abstract available

Clinical • Cardiovascular • Fibrosis • Hepatology • Hypertension • Immunology • Portal Hypertension

Acute Esophageal Necrosis: A Rare Complication of Diabetic Ketoacidosis: A Case Report (SCCM 2026) - "Patient treated with IV pantoprazole, sucralfate, lidocaine swish/swallow, metoclopramide and after 24 hours NPO, a clear liquid diet was started, leading to significant improvement in symptoms. Acute esophageal necrosis (AEN) associated with diabetic ketoacidosis (DKA) remains an exceedingly rare clinical entity. It is critical to recognize AEN as it is associated with a mortality of 32%. Because AEN shares many symptoms with DKA, maintaining a high clinical suspicion and carefully evaluating patients in the appropriate context can help prevent serious complications and reduce mortality."

Case report • Clinical • Benign Prostatic Hyperplasia • Cardiovascular • Diabetes • Dyslipidemia • Gastrointestinal Disorder • Hypertension • Hypotension • Metabolic Disorders

Efficacy of Acid-Suppressive Therapy for CIGB Prevention in ICU Patients: An Umbrella Review (SCCM 2026) - "(2018), which included PPIs, H2RAs, sucralfate, and antacids compared to placebo or no prophylaxis, showed a significant reduction in CIGB (RR 0.47; 95% CI, 0.39–0.57)... Both PPIs and H2RAs are effective in reducing the risk of CIGB in critically ill patients, with PPIs demonstrating greater relative efficacy. These findings support the continued use of pharmacologic prophylaxis for gastrointestinal bleeding prevention in ICU settings."

Clinical • Review • Gastroenterology • Stress Ulcer

Effect of sucralfate suspension gel on gastroscopic pathology and inflammatory cytokines in patients with Helicobacter pylori-positive chronic non-atrophic gastritis. (PubMed, Pak J Med Sci) - "The addition of sucralfate suspension gel to standard therapy in the treatment of Hp-positive chronic non-atrophic gastritis yields favorable clinical outcomes. It can significantly improve gastroscopic pathology, reduce inflammatory cytokine levels and enhance gastrointestinal hormone secretion without compromising treatment safety."

Journal • Gastrointestinal Disorder • Infectious Disease • Oncology • IL2 • MMP9 • TNFA

GLP-1 receptor agonists associated with improved response to immune checkpoint inhibitors in solid tumors: a multi-institutional retrospective cohort study (AACR-IO 2026) - "Surveillance bias was evaluated using Ondansetron and Sucralfate as negative controls. Concurrent GLP-1 receptor agonist use is associated with improved survival in ICI-treated patients. Elevated HbA1c across cohorts and higher MACE specifically in Lung/Breast cohorts suggest higher baseline metabolic/cardiovascular risk ("sick user bias") persisting despite matching. This indicates survival benefits are not attributable to improved cardiovascular outcomes or glycemic control."

Checkpoint inhibition • Retrospective data • Breast Cancer • Diabetes • Endocrine Disorders • Gastroenterology • Gastrointestinal Disorder • Genetic Disorders • Genito-urinary Cancer • Hepatology • Immunology • Lung Cancer • Melanoma • Metabolic Disorders • Metabolic Dysfunction-Associated Steatohepatitis • Obesity • Oncology • Renal Cell Carcinoma • Solid Tumor • Type 2 Diabetes Mellitus

When Sevelamer Crystals Masquerade as a Rectal Mass: A Case of Unexpected Histologic Findings (NKF-SCM 2026) - "METHODS/CASE SUMMARY A 71-year-old woman with ESKD on hemodialysis, atrial fibrillation and recent cerebrovascular accident presented with bright red blood per rectum in the setting of recent apixaban and clopidogrel initiation...Sevelamer was discontinued, and supportive therapy with proton pump inhibitor and sucralfate was initiated...Management primarily involves discontinuing sevelamer and supportive care; symptoms typically resolve promptly. Clinicians should consider medication-related crystal deposition in ESKD patients with unexplained colitis or gastrointestinal bleeding."

Clinical • Atrial Fibrillation • Cardiovascular • Endocrine Disorders • Gastroenterology • Gastrointestinal Disorder • Immunology • Metabolic Disorders • Nephrology • Renal Disease • Secondary Hyperparathyroidism

Aluminum-Containing Medication Exposure and Toxicity-Related Diagnoses in End-Stage Kidney Disease Patients on Hemodialysis (NKF-SCM 2026) - "Patients with peptic ulcer or liver disease were overrepresented among exposed patients, likely reflecting sucralfate use. Because aluminum accumulates in renal failure, clinicians should exercise caution when prescribing sucralfate in ESKD and consider non-aluminum alternatives."

Clinical • Alzheimer's Disease • Chronic Kidney Disease • CNS Disorders • Cognitive Disorders • Dementia • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hepatology • Nephrology • Orthopedics • Peptic Ulcer • Renal Disease

The two-hit hypothesis in acute esophageal necrosis: black esophagus in severe atherosclerosis and untreated gastroesophageal reflux disease: a case report. (PubMed, J Med Case Rep) - "This case highlights an atypical, nonbleeding presentation of acute esophageal necrosis and reinforces the importance of maintaining clinical suspicion even in the absence of classic symptoms. It underscores the relevance of the "two-hit" hypothesis, where ischemic insult and impaired mucosal defense act synergistically to cause esophageal necrosis. Timely endoscopic evaluation and early initiation of appropriate therapy led to favorable outcomes in this high-risk patient. Increased awareness of such presentations can aid in earlier diagnosis and reduce the high morbidity and mortality associated with acute esophageal necrosis."

Journal • Atherosclerosis • Candidiasis • Cardiovascular • Coronary Artery Disease • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Infectious Disease • Pain • Peptic Ulcer

ENDOSCOPIC APPLICATION OF TRANEXAMIC ACID AND SUCRALFATE IN UPPER GASTROINTESTINAL BLEEDING: A RANDOMIZED CONTROLLED TRIAL (DDW 2026) - No abstract available

Clinical • Gastroenterology

Recommendations for Stress Ulcer Prophylaxis in Critically Ill Adults: A Contextualized Clinical Practice Guideline From the Saudi Critical Care Society and the Scandinavian Society of Anaesthesiology and Intensive Care Medicine, Endorsed by the Kuwait Anesthesia and Critical Care Society. (PubMed, Acta Anaesthesiol Scand) - "This guideline offers five context-specific, evidence-informed recommendations for SUP in critically ill adults in Saudi Arabia, Kuwait, and the Nordic countries. While grounded in the health system realities of these regions, the recommendations may inform practice in other settings with similar ICU structures and resource contexts. The panel also identified key research priorities to address remaining evidence gaps and support future updates."

Clinical guideline • Journal • Anesthesia • Critical care • Gastroenterology • Hematological Disorders • Hepatology • Infectious Disease • Stress Ulcer

Management of postoperative pain associated with sleep disordered breathing surgery: A systematic review. (PubMed, J Craniomaxillofac Surg) - "Across the available evidence, multiple pharmacological approaches-including local anesthetics, non-steroidal anti-inflammatory drugs, corticosteroids, sucralfate, and vitamin C demonstrated varying degrees of analgesic benefit...These findings underscore the need to integrate postoperative pain considerations into preoperative evaluation and surgical planning for patients with SDB. Collectively, the current evidence supports the use of multimodal analgesia that combines pharmacological and non-pharmacological measures; however, further high-quality trials are warranted to refine postoperative analgesic strategies and to strengthen the evidence base for this patient population."

Journal • Review • Anesthesia • CNS Disorders • Pain • Sleep Disorder

A Ruptured Pseudoaneurysm of Pancreaticoduodenal Artery: A Case Report. (PubMed, Case Rep Surg) - "He had a medical background characterized by a history of gastritis and peptic ulcer disease (PUD) with ongoing use of pantoprazole and sucralfate. This case highlights the importance of considering a ruptured PDA pseudoaneurysm, which should be evaluated in the differential diagnosis of abdominal discomfort and related symptoms, especially in patients with duodenal ulcers. The successful management of the condition is accomplished through suture ligation, and the diagnosis is effectively made through CT angiography."

Journal • Cardiovascular • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Pain • Peptic Ulcer

Orally Administered Nanoparticle Coacervate for Therapeutic Coating of Full Gastrointestinal Tract. (PubMed, Adv Mater) - "Here, a Sucralfate-based oral formulation is developed that incorporates therapeutic nanoparticles and transforms into a paste-like coacervate upon contact with intestinal fluid, uniformly coating the entire gastrointestinal tract within 6 h, and clearing through fecal transit by 12 h. Systematic investigation shows that nanoparticle hydrophobicity is essential for stable incorporation into Sucralfate-based formulation, supporting compatibility with a wide range of nanoparticle types...In radiation-induced enteropathy, our system attenuated weight loss from 25.5% to 11.4%, doubled villus length, and markedly enhanced epithelial regeneration. The formulation also accommodates nanoparticles with imaging capability, demonstrating versatility for both therapeutic and diagnostic applications in gastrointestinal diseases."

Journal • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease

ESUS-ESD: Esomeprazole Plus Sucralfate for Post-ESD Ulcer Healing: A Randomized Controlled Trial (clinicaltrials.gov) - P4 | N=120 | Not yet recruiting | Sponsor: LanZhou University

New P4 trial • Gastric Cancer • Gastroenterology • Oncology • Peptic Ulcer • Solid Tumor

Alginate vs Sucralfate for GERD Symptomatic Relief (clinicaltrials.gov) - P2/3 | N=140 | Recruiting | Sponsor: CMH Lahore Medical College and Institute of Dentistry

New P2/3 trial • Gastroesophageal Reflux Disease

A systematic review of therapeutic options for lymphocytic esophagitis. (PubMed, Dis Esophagus) - "For patients with LyE, topical steroids seem to provide greater symptomatic and histologic benefit compared to PPIs, although recurrence is more common. For patients not already on acid suppression therapy, PPIs may still be a reasonable first-line option, especially when prioritizing safety. Further prospective studies are needed to formally assess the comparative safety and efficacy of the various treatment modalities, including novel immunosuppressive therapies."

Journal • Review • Gastrointestinal Disorder

High-Throughput Screening Using the Self-Controlled Tree-Based Scan Statistic to Identify Medications Associated With Hospitalization for Severe Acute Liver Injury. (PubMed, Pharmacoepidemiol Drug Saf) - "High-throughput screening using tree-based scan statistics detected potentially hepatotoxic drugs for investigation in future pharmacoepidemiology studies."

Journal • CNS Disorders • Gastroenterology • Hepatology • Liver Failure • Pain

Prevention of Delayed Post-polypectomy Bleeding by Endoscopic Sucralfate Spray in High-risk Patients: A Randomized Controlled Trial (clinicaltrials.gov) - P4 | N=160 | Not yet recruiting | Sponsor: National Cheng-Kung University Hospital

New P4 trial

Severe Corrosive Gastritis Caused by Accidental Ingestion of Mildly Alkaline Calcium Chloride Desiccant: A Case Report. (PubMed, DEN Open) - "The patient was diagnosed with severe corrosive gastritis and was treated with omeprazole, sucralfate, and antibiotics (SBT/ABPC). However, as in this case, even mildly alkaline agents can cause severe injuries depending on the amount ingested, presence of solid components, and time elapsed after ingestion. Therefore, it is crucial to consider this possibility in clinical practice."

Journal • Alzheimer's Disease • CNS Disorders • Dementia • Gastrointestinal Disorder

Unmasking Hidden Threat of GI Tract: Duodenal Carcinoma (ACG 2025) - "He was started on Protonix and Carafate...Patient started on systemic therapy with modified FOLFIRINOX regimen (5-FU, irinotecan, oxaliplatin, leucovorin calcium)...Chemotherapy regimens include 5-fluorouracil, capecitabine, oxaliplatin or gemcitabine with radiation therapy less commonly used. Targeted immunotherapy is still investigational, and the prognosis depends on the spread of the disease. Those without lymph node involvement have a 65% 5-year survival rate and those with lymph node involvement have a 21% 5-year survival rate."

Addiction (Opioid and Alcohol) • Anemia • Celiac Disease • Colorectal Cancer • Crohn's disease • Fatigue • Gastric Cancer • Gastroenterology • Gastrointestinal Cancer • Gastrointestinal Disorder • Genetic Disorders • Hepatology • Hypertension • Immunology • Inflammatory Bowel Disease • Oncology • Pancreatic Cancer • Pulmonary Disease • Small Intestinal Carcinoma • Solid Tumor

Petersen's Hernia in the Setting of Gastrointestinal Bleeding: A Diagnostic Challenge After Roux-en-Y Gastric Bypass (ACG 2025) - "Three weeks prior, she had an upper endoscopy (EGD) performed which showed LA grade D esophagitis and a 4 cm gastrojejunostomy (GJ) large clean based ulcer which was treated with oral proton pump inhibitor (PPI) and sucralfate...Endoscopic evaluation. Upper endoscopy revealed clean based ulceration on the jejunal limb and inflamed, friable jejunal mucosa with subepithelial hemorrhage."

Bariatric surgery • Colon Cancer • Colorectal Cancer • Dermatology • Fatigue • Gastric Cancer • Gastroenterology • Gastrointestinal Disorder • Solid Tumor

Endoscopic Vacuum Therapy for Boerhaave Syndrome and Recurrent Esophageal Perforation: A Minimally Invasive Approach (ACG 2025) - "Repeat EGD revealed LA Grade D esophagitis and a cratered esophageal ulcer with active bleeding, which was managed with epinephrine injection, bipolar cautery, and Purastat...Follow-up endoscopy showed severe diffuse esophagitis with contact oozing, and sucralfate was added to promote mucosal healing...C) Upper GI Series with Small Bowel Follow Through demonstrating gastrografin contrast accumulation in right lung base consistent with recurrent EP. D) Benign-appearing, intrinsic severe stenosis approximately 25cm from the incisors."

Addiction (Opioid and Alcohol) • Anemia • CNS Disorders • Gastrointestinal Disorder • Hematological Disorders • Respiratory Diseases

When Crohn's Climbs Higher: Esophageal Crohn's Disease (ACG 2025) - "After the biopsy result, prednisolone and sucralfate were added, and the patient responded very well to corticosteroid therapy...Corticosteroids help manage acute inflammation; anti-tumor necrosis factor (anti-TNF) and immunomodulators remain the mainstay of therapy for esophageal Crohn's. In conclusion, clinicians should consider CD in atypical presentations of esophageal disease.Figure: Esophageal ulcersFigure: "Bamboo-joint-like junctions' at the esophagus."

Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Hepatitis B • Hepatitis C • Hepatology • Human Immunodeficiency Virus • Immunology • Infectious Disease • Inflammatory Bowel Disease • CRP

A Case Report of Idiopathic Esophageal Ulcer in a Renal Transplant Patient Responsive to Steroid Therapy (ACG 2025) - "We describe a case of idiopathic esophageal ulceration ultimately responsive to steroid therapy in an immunosuppressed, HIV-negative renal transplant patient.Case Description/ A 59-year-old female with renal transplant in 2023 for ADPKD presented with odynophagia after a week-long course of doxycycline for outpatient pneumonia treatment...She was initially treated with daily pantoprazole, famotidine, sucralfate and an NG tube was placed for nutrition. Her odynophagia continued and a month later repeat EGD showed persistence of the ulcer for which Vonoprazan was started...Acyclovir was initiated and NG tube was transitioned to a PEG tube to facilitate healing...Due to suspicion for idiopathic giant esophageal ulcer, she was trialed on a prednisone taper of 40 mg, decreasing by 10 mg each week...Staining for CMV, HSV, VZV, EBV negative. No fungal organisms visualized."

Case report • Clinical • Autosomal Dominant Polycystic Kidney Disease • Fibrosis • Gastrointestinal Disorder • Human Immunodeficiency Virus • Immunology • Infectious Disease • Pneumonia • Polycystic Kidney Disease • Respiratory Diseases • Solid Organ Transplantation • Transplantation