Asclera (polidocanol) / Merz Pharma - LARVOL DELTA

Cerebral air embolism induced by polidocanol foam sclerotherapy in chronic venous disease: A case report. (PubMed, Therapie) - No abstract available

Journal • Cardiovascular • Ischemic stroke

POLI-LASER: Polidocanol Foam With or Without Transdermal Laser for Varicose Veins: Randomized Clinical Trial (clinicaltrials.gov) - P=N/A | N=102 | Not yet recruiting | Sponsor: Hospital Universitario Pedro Ernesto

New trial • Varicose Veins

Mouse Vocal Fold Permeability In Vivo: Effects of Novel Low-Tech Injury and Instillation Methods. (PubMed, Laryngoscope) - "High-dose NAPH consistently injures mouse VFs. OA reliably instills mouse VFs. Uninjured murine VF epithelium is highly permeable to low molecular weight dye in vivo. Inherent permeability of mouse VFs may facilitate targeted genetic engineering approaches and studies of environmental hazards and drug treatments."

Journal • Preclinical • Anesthesia • TJP1 • TP63

Endoscopic Hemostasis via Submucosal Polidocanol Injection: A New Paradigm for Hemorrhagic Radiation Proctopathy Management. (PubMed, Gastrointest Endosc) - No abstract available

Journal • Hematological Disorders

Vision-threatening complications of injection sclerotherapy: case report, literature review, and FAERS database analysis. (PubMed, BMC Ophthalmol) - "This case underscores the potential for catastrophic ocular complications after polidocanol sclerotherapy. Given the limited therapeutic efficacy once iatrogenic OAO occurs, we emphasize caution when performing sclerosant injections particularly in the risky regions."

Journal • Cardiovascular • Ophthalmology • Pediatrics • Retinal Vein Occlusion

The effect of endoscopic polidocanol carbon dioxide foam for internal hemorrhoids: a retrospective study. (PubMed, PeerJ) - "The clinical effectiveness of endoscopic polidocanol carbon dioxide foam is on par with that of polidocanol air foam. In sclerotherapy for internal hemorrhoids, the use of endoscopic polidocanol carbon dioxide foam can significantly decrease complications such as anal swelling and pain."

Clinical • Journal • Retrospective data • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Pain

Efficacy of Skin Cooling in Reducing Pain Associated With Non-invasive Treatments of Neurofibromatosis Type 1 Cutaneous Neurofibromas (clinicaltrials.gov) - P1 | N=13 | Completed | Sponsor: Massachusetts General Hospital | Recruiting ➔ Completed | N=30 ➔ 13 | Trial completion date: Oct 2024 ➔ Jul 2025 | Trial primary completion date: Oct 2024 ➔ Jul 2025

Enrollment change • Trial completion • Trial completion date • Trial primary completion date • Genetic Disorders • Neurofibromatosis • Pain • Solid Tumor

Flexible endoscopic treatment of internal hemorrhoids with versus without intravenous anesthesia: a retrospective study of 559 cases. (PubMed, Surg Endosc) - "Flexible endoscopic treatment for internal hemorrhoids is safe and effective regardless of anesthesia use. Intravenous anesthesia improves procedural efficiency and reduces retreatment rates without compromising symptom relief or satisfaction. These findings support individualized anesthesia strategies tailored to patient preferences and institutional resources."

Journal • Retrospective data • Anesthesia • Gastroenterology • Gastrointestinal Disorder

Polidocanol Sclerotherapy in Hereditary Hemorrhagic Telangiectasia Patients Does Not Seem to Decrease Epistaxis-Related Outpatient and Emergency Visits-A Retrospective View. (PubMed, Clin Otolaryngol) - No abstract available

Journal • Retrospective data • Hematological Disorders

Sclerotherapy with Polidocanol for Head and Neck Vascular Anomalies: A Single-Center Experience. (PubMed, Ann Vasc Surg) - "Polidocanol sclerotherapy is a safe and effective treatment option for low-flow vascular malformations of the head and neck, with substantial lesion volume reduction and minimal complications. Its efficacy in haemangiomas highlights a promising therapeutic avenue where limited prior evidence exists. Given its favorable safety profile compared to ethanol and other sclerosants, polidocanol should be considered particularly suitable for cosmetically and functionally sensitive head and neck lesions."

Journal • Pain

Double balloon enteroscopy in pediatrics: Evaluation of midgut pathologies at a national medical center. (PubMed, Rev Gastroenterol Mex (Engl Ed)) - "We consider double balloon enteroscopy in pediatric patients a feasible procedure, offering good results with minor complications and directly contributing to medical and/or endoscopic decision-making."

Journal • Gastroenterology • Pediatrics

Lauromacrogol sclerotherapy in large endometriomas: Report of two cases (ESGE 2025) - "To enhance the sclerosing effect of ethanol, combined protocols using lauromacrogol (polidocanol) and ethanol have been previously used...Transvajinal sclerotherapy can be incorporated into infertility treatment algorithms as a non-surgical option. However, prospective cohort studies with Lauromacrogol is required to determine long-term fertility outcomes and recurrence rates"

Clinical • Anesthesia • Cardiovascular • Endometriosis • Gynecology • Infertility • Musculoskeletal Pain • Sexual Disorders • Thrombosis

Restoration of in vivo CFTR function by tracheal basal cell engraftment (NACFC 2025) - " Primary mouse basal cells were isolated and expanded from fresh tracheas and subsequently transplanted into CFTR−/− mice (B6.129P2-KOCftrtm1Unc) or littermate controls (n = 18 each) via aspiration of 1) polidocanol for preconditioning then 2) fluorescently labeled basal cells... Cell replacement can restore normal CFTR expression and function in the trachea of CFTR−/− mice and holds significant potential for a future variant-agnostic therapy for all individuals with CF."

Preclinical • Cystic Fibrosis • Genetic Disorders • Immunology • Respiratory Diseases • CFTR

Targeted pre-conditioning and cell transplantation in the murine lower respiratory tract (NACFC 2025) - "Our group has successfully transplanted mouse primary or pluripotent stem cell (PSC)-derived basal cells into the tracheas of syngeneic recipient mice post-polidocanol (PDOC) injury... We find evidence of engraftment of primary tracheal BCs throughout the intrapulmonary airways but also within the alveolar space. This finding highlights the need for robust translational, pre-clinical models for cellular therapeutics within the lung to pair pre-conditioning and donor cell type for engraftment into the intended niche while minimizing off target injury or engraftment."

Preclinical • Anesthesia • Cystic Fibrosis • Genetic Disorders • Immunology • Otorhinolaryngology • Pulmonary Disease • Respiratory Diseases • Transplantation • KRT5 • SOX2

Efficacy, Safety and Predictive Factors for Outcomes and Adverse Events in Sclerotherapy for Venous Malformations in Children. (PubMed, J Pediatr Surg) - "Polidocanol-based sclerotherapy is an effective and safe treatment option for pediatric VMs. Complications are more common in VMs of the extremities due to higher mobility and hypostatic pressure. Notably, despite therapeutic size reduction is often limited, clinical improvement, such as pain relief, can often be achieved, which needs to be considered for treatment planning."

Adverse events • Biomarker • Journal • Pain • Pediatrics

Case Report: A case of giant emphysematous bullae successfully treated with percutaneous aspiration and sclerotherapy for staged reduction of pulmonary bullae. (PubMed, Front Med (Lausanne)) - "This report describes a 70-year-old man with COPD GOLD 3 and bilateral GEB (dominant bulla 8.5 cm× 6.2 cm) who underwent a novel percutaneous serial sclerotherapy protocol: Under CT guidance, a puncture needle was inserted into the bulla cavity on 3 consecutive days, with daily instillation of polidocanol (total 30 mL) and attempted air aspiration (successfully retrieving 1,000 mL of gas on day 3)...A follow-up CT scan at 3 months demonstrated>70% bullae volume reduction with lung re-expansion, correlating with significant clinical improvement. This first-reported percutaneous aspiration and sclerotherapy for staged reduction of pulmonary bullae (PASS) approach offers a safe, effective, minimally invasive option for GEB management in surgically high-risk COPD patients, warranting further validation of the protocol."

Journal • Chronic Obstructive Pulmonary Disease • Immunology • Pulmonary Disease • Respiratory Diseases

THE DOUBLE-EDGED NEEDLE: GASTRIC ISCHEMIA FOLLOWING POLIDOCANOL INJECTION IN A REFRACTORY BLEEDING ULCER (UEGW 2025) - "Subsequent therapy with epinephrine and two through-the-scope (TTS) clips achieved initial hemostasis. Literature describes similar risks with adrenaline and sclerosant agents. In this case, we suggest that direct arterial injury by the needle, followed by immediate luminal obliteration, led to ischemic damage."

Cardiovascular • CNS Disorders • Gastrointestinal Neuroendocrine Carcinoma • Peptic Ulcer

The Use of Fluoroscopy-guided Sclerotherapy with Foam Polidocanol for Retromolar Trigon Venous Malformation: A Case Report and Review of the Literature. (PubMed, J Stomatol Oral Maxillofac Surg) - "This case highlights the efficacy and safety of polidocanol foam sclerotherapy as a minimally invasive treatment option for pediatric maxillofacial VMs. Further studies are warranted to evaluate the long-term outcomes and broader applicability of this technique."

Journal • Pediatrics

Polidocanol foam injection sclerotherapy in patients with mixed hemorrhoids with severe anemia: a case report. (PubMed, J Surg Case Rep) - "Sclerotherapy for anemia-related hemorrhoids is considered relatively safe and effective. Here, we report a case of sclerotherapy for severe anemia-related hemorrhoids, aiming to provide a reference for the diagnosis and treatment of comparable patients."

Journal • Anemia • Anesthesia • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Infectious Disease

Evaluation of the tolerance and efficacy of a shampoo and a spray containing polidocanol in patients with anti-cancer treatment and suffering of trichodynia and scalp discomfort sensations (EADV 2025) - "Our study's results show that the shampoo and spray containing polidocanol has beneficial effects for relieving the unpleasant scalp sensations and trichodynia in patients with cancer treatment. We conclude that the accompaniment with dermo-cosmetic hair care in cancer treatment has its importance during the establishment of the treatment strategies."

Clinical • Dermatology • Oncology • Pruritus

Grover's disease successfully treated with dupilumab (EADV 2025) - "We initially treated the patient systemically with isotretinoin and topically with calcineurin inhibitors and polidocanol for five months without any improvement. Several months of treatment with pregabalin were also unsuccessful... The successful treatment of Grover's disease with the IL-4/IL-13 antagonist dupilumab suggests that type 2 inflammation plays a role in the pathogenesis of Grover's disease. Dupilumab could therefore represent a very safe treatment alternative with little side effects for therapy-refractory Grover's disease. Further studies are needed to substantiate this hypothesis."

Dermatology • Hematological Malignancies • Infectious Disease • Pruritus • Renal Disease • IL13 • IL4

Sclerotherapy: A novel approach for recurrent pyogenic granuloma in a 5-year-old child (EADV 2025) - "After obtaining consent from the patient's legal guardian, a topical anesthetic cream using Lidocaine 2.5%/Prilocaine2.5% was applied one-hour prior sclerotherapy to reduce the anticipated local injection site pain. As only few published studies on the use of sclerotherapy for the treatment of pyogenic granuloma in children, there is a need to explore this treatment modality. In this case report, sclerotherapy with polidocanol is found to be safe, feasible and cost-effective. Long-term follow-up however is recommended to monitor for delayed side effects and to identify potential recurrences or complications."

Clinical • Anesthesia • Cardiovascular • Fibrosis • Hematological Disorders • Infectious Disease • Pediatrics • Skin Cancer • Thrombosis • Varicose Veins

Investigation of the sclerosing effect of increasing doses of polidocanol on pulmonary vessels: Experimental study (ERS 2025) - "In our study,a single injection of 0.5ml2% polidocanol via the femoral vein.Animal lungs,congestion in pulmonary vessels,emphysematous changes and intra-alveolar hemorrhage were found.As a result,our study demonstrated pulmonary vascular damage with increasing doses of polidocanol.So the dose of polidocanol should be used in a limited manner."

Cardiovascular • Hematological Disorders • Pulmonary Embolism • Respiratory Diseases

Tibial Vein Thrombosis After Foam Sclerotherapy: A Single Institution Case Series. (PubMed, J Vasc Surg Venous Lymphat Disord) - "In our series, tibial DVTs following foam sclerotherapy demonstrate a benign clinical course regardless of management strategy. Routine anticoagulation or antiplatelet therapy may not be necessary in asymptomatic patients with isolated distal thrombus. Prospective studies are required to confirm these findings and guide evidence-based recommendations."

Journal • Cardiovascular • Hematological Disorders • Pulmonary Embolism • Respiratory Diseases • Thrombosis

Comments on: "Factors that Enhance the Stability of Polidocanol and Monoethanolamine Oleic Acid Foams, and Identification of the Optimal Foam-Creating Device, by Higashino et al. (2025). (PubMed, Cardiovasc Intervent Radiol) - No abstract available

Journal