Asclera (polidocanol) / Merz Pharma - LARVOL DELTA

Evaluation of Injectable Deoxycholic Acid and Polidocanol as an Alternative Non-Surgical Method of Cutaneous Neurofibroma Removal (AAD 2026) - "Intratumor injection of deoxycholate or polidocanol produces significant, dose-dependent tumor cell necrosis and are promising alternative methods of tumor management. These minimally invasive local injections could be administered early in tumor development before patients sustain the burden of disfigurement, pain, or pruritus, and therefore provide a potential replacement of the current approach of surgical excision when cNF become problematic."

Genetic Disorders • Neurofibromatosis • Pruritus • Solid Tumor • NF1

Local therapeutic strategies for neurocutaneous dysesthesia: from capsaicin to cannabinoids. (PubMed, J Dermatolog Treat) - "The following local treatment options are described: capsaicin, calcineurin inhibitors, menthol, pramoxine/lidocaine/prilocaine, ambroxol, phenytoin, strontium, amitriptyline, doxepin, duloxetine, baclofen, gabapentin, cannabinoids, loperamide, naltrexone, clonidine, prazosin, acetylsalicylic acid, diclofenac, aprepitant, ketamine, calamine, polidocanol, and botulinum toxin type A. Local therapy offers a valuable and often well-tolerated first step in managing ND...Clinicians are advised to start with low concentrations, discuss off-label use, and monitor for side effects. Until robust guidelines are available, a cautious trial-and-error approach remains the cornerstone of management."

Journal • Review • Dermatology • Neuralgia • Pain • Pruritus

Long-term follow-up of sclerotherapy of telangiectasias and reticular veins in lower limbs: Glucose versus polidocanol diluted in glucose. (PubMed, Vasc Med) - "Telangiectasia recurrence was common after 3 years, regardless of treatment. In contrast, reticular veins showed minimal recurrence, particularly with PDHG. Pigmentation generally resolved spontaneously. Matting was more persistent in telangiectasias than in reticular veins. These findings support the long-term viability of both approaches in clinical practice."

Journal

Polidocanol in Sclerotherapy for Lymphovenous Disorders: Mechanisms, Clinical Uses, and Future Prospects. (PubMed, Drugs) - "Polidocanol use is associated with a very low incidence of complications, and the development of foam formulations has further enhanced its efficacy by improving retrograde flow dynamics. During sclerotherapy, forceful injection of polidocanol can cause intervention with plasma proteins, increasing its foam stability and therapeutic effectiveness."

Journal • Review • Cardiovascular • Gastroenterology • Hypertension

Comparative efficacy of urea, bleomycin, and polidocanol for infantile hemangioma: a retrospective cohort study with ultrasound correlation ultrasound characteristics of infantile hemangioma. (PubMed, Front Med (Lausanne)) - "The conclusions drawn from this study should be interpreted with caution due to these limitations. Future research should include prospective, randomized controlled trials to validate the findings and minimize biases."

Journal • Retrospective data

Treatment of Polidocanol Sclerotherapy in Persistent Lymphatic Drainage After Radical Surgery for Endometrial cancer: A Case Report and Literature Review. (PubMed, Cancer Manag Res) - "Fortunately, the cyst exhibited significant reduction in size and did not recur subsequently. Our findings suggest a novel therapeutic strategy for the management of symptomatic lymphocysts, and it appears to be a safe and effective approach."

Journal • Endometrial Cancer • Gynecologic Cancers • Oncology • Solid Tumor

A LIVING NETWORK META-ANALYSIS FRAMEWORK FOR COMPARATIVE EFFECTIVENESS RESEARCH IN CHRONIC VENOUS INSUFFICIENCY TREATMENT (ISPOR 2026) - "The LNMA compares FDA-approved commercially manufactured polidocanol 1% endovenous microfoam (PEM) ablation versus endovenous thermal ablation (ETA) with radiofrequency or laser energy... This LNMA represents a novel application of living evidence synthesis methodology in the venous disease space. The approach balances scientific rigor with practical implementation through industry partnership, offering a model for maintaining current comparative effectiveness evidence in evolving treatment landscapes. This framework could be a template for conditions requiring ongoing evidence monitoring."

HEOR • Retrospective data • Cardiovascular

Effectiveness and safety of 3% polidocanol foam sclerotherapy in hemorrhoidal disease: a multicenter, prospective study. (PubMed, Int J Colorectal Dis) - P4 | "Patients treated with PFS showed similar effectiveness and safety as those treated with RBL under anoscopy, and a quick improvement trend in hemorrhage score post-treatment was observed in patients treated with PFS, but it needs further verification."

Journal • Gastroenterology • Hematological Disorders

Modified ultrasound-guided polidocanol sclerotherapy is an effective treatment for thyroid cystic-solid nodules: A single-center retrospective study. (PubMed, Am J Otolaryngol) - "Modified ultrasound-guided polidocanol sclerotherapy for benign cystic-solid thyroid nodules is safe and effective, and the treatment efficacy is positively associated with the proportion of cystic components. This technique may represent a promising alternative to ethanol injection for the management of cystic-solid thyroid nodules."

Journal • Retrospective data • Hematological Disorders • Infectious Disease • Pain

Percutaneous Sclerotherapy of Postoperative Lymphoceles: A Systematic Review and Meta-analysis of Different Sclerosant Agents. (PubMed, Cardiovasc Intervent Radiol) - "Percutaneous sclerotherapy yielded favorable results with all agents; however, ethanol is the best-characterized agent, with consistent outcomes and moderate certainty of evidence. High-quality, prospective research is needed in order to choose the best sclerosant agent and standardize the procedure."

Journal • Retrospective data

Predicting treatment outcome in sclerotherapy of reticular veins and telangiectasia using machine learning: A comprehensive analysis and performance evaluation. (PubMed, Vascular) - "(p < .001) The group receiving a 2% polidocanol dosage showed a higher rate of "Good" responses than the group receiving a 1% polidocanol dosage. (p = .008) XGBoost outperformed other ML algorithms, particularly excelling in predicting "Poor" responses.DiscussionML-based predictive models for assessing sclerotherapy outcomes in varicose veins, uncovering significant efficacy determinants such as dosage and prior treatment history. While pioneering ML in sclerotherapy prediction, our study acknowledges limitations and proposes future research directions, including additional variable incorporation and real-time predictive tool development."

Journal • Varicose Veins

Endoscopic rubber band ligation, injection sclerotherapy, and sclerobanding for the treatment of internal hemorrhoids. (PubMed, World J Gastroenterol) - "The three treatments evaluated (ERBL, IS, and ESB) provide durable clinical outcomes for grade I hemorrhoids, with no significant differences in postoperative adverse events. For grade II-III hemorrhoids, ESB possesses the dual advantages of lower recurrence rates and reduced postoperative pain compared with IS and ERBL."

Clinical • Journal • Retrospective data • Gastroenterology • Gastrointestinal Disorder • Pain

Long-Term Outcomes of Combined Cystic Duct Embolization and Chemical Gallbladder Ablation in High-Risk Acute Cholecystitis Patients. (PubMed, J Vasc Interv Radiol) - "CDE combined with CGA appears to be a viable and effective minimally invasive option for AC in non-surgical patients, yielding high long-term success. However, late recurrence is possible, necessitating careful patient selection and long-term surveillance."

Journal • Gastroenterology • Hepatology

Evaluation of the feasibility, safety, and preliminary effectiveness of coil and foam embolization in patients with venous-origin chronic pelvic pain. (PubMed, Front Med (Lausanne)) - "Ovarian vein embolization combined with polidocanol sclerotherapy is a feasible and safe endovascular procedure for the treatment of VO-CPP. Multiparous and comorbidities were the independent risk factor associated with poor prognosis."

Journal • Cardiovascular • Gynecology • Hematological Disorders • Musculoskeletal Pain • Pain • Thrombosis

Surgical management of juvenile and aneurysmal bone cysts in children and adolescents : Curettage, ceramic bone graft substitution and adjuvants (PubMed, Oper Orthop Traumatol) - "The defect is filled with ceramic bone substitute and/or allogeneic cancellous bone soaked in methylprednisolone (UBC) or polidocanol (ABC)...Recurrence with refracture occurred in 4 patients after ESIN removal. The overall complication rate was low."

Journal • Cardiovascular • Endocrine Disorders • Musculoskeletal Diseases • Oncology • Orthopedics • Pain

Clinical Application Analysis of Polidocanol Combined with Electrocoagulation in the Treatment of Epistaxis Caused by Hereditary Telangiectasia (ChiCTR) - P=N/A | N=100 | Recruiting | Sponsor: Rugao People's Hospital; Rugao People's Hospital

New trial • Hematological Disorders

Efficacy and Safety of Different Polidocanol Injection Methods for Pediatric Pyogenic Granuloma: A Prospective Randomized Controlled Trial (ChiCTR) - P=N/A | N=64 | Not yet recruiting | Sponsor: Jinan Children's Hospital; Jinan Children's Hospital

New trial • Pediatrics

Transperineal approach technique for the treatment of slow-flow perirectal vascular malformations. (PubMed, J Endovasc Ther) - "The transperineal approach provides a safe and effective alternative for treating perirectal vascular malformations, offering excellent anatomic control and reduced morbidity. Combined polidocanol-bleomycin sclerotherapy appears to be a feasible and well-tolerated therapeutic option; however, larger studies are needed to confirm its efficacy and long-term outcomes.Clinical ImpactThe transperineal approach for the management of slow-flow vascular malformations represents a practical, safe, and reproducible therapeutic option that provides minimally invasive access to complex perirectal lesions. By eliminating the need for endoscopic instruments or major surgical procedures, it reduces both procedural risks and associated costs. Its technical simplicity and minimal equipment requirements facilitate its implementation in most vascular centers, broadening access to specialized care across various clinical settings."

Journal • Cardiovascular • Colorectal Cancer • Hematological Disorders • Mood Disorders • Pain • Thrombosis

A Rare Presentation of Concurrent Typical, Atypical and Aggressive Thoracic Vertebral Haemangiomas: Insights into Histological Variability and Multidisciplinary Management. (PubMed, J Neurol Surg A Cent Eur Neurosurg) - "Aggressive vertebral haemangiomas, though rare, should be considered in patients with progressive neurological symptoms. Early diagnosis, embolization, surgical decompression and stabilization can yield excellent outcomes."

Journal • Back Pain • CNS Disorders • Musculoskeletal Pain • Oncology • Pain

Aneurysmal Bone Cyst of Talus: Case Report of a Rare Presentation. (PubMed, J Orthop Case Rep) - "The patient was managed conservatively using percutaneous polidocanol injection and was relieved of her symptoms soon after. Although ABC is most commonly found in long bones, it can be considered a differential in other bones as well. Sclerotherapy may be considered over curettage as a treatment modality due to its numerous advantages."

Journal • Cardiovascular • Pain

Polidocanol augments high-intensity focused ultrasound efficacy for hyperintense fibroids on T2WI: a retrospective cohort study. (PubMed, Int J Hyperthermia) - "Pretreatment with ultrasound-guided intratumoral polidocanol injection may improve the immediate ablation efficacy of HIFU in T2-hyperintense uterine fibroids, reducing energy requirements and mitigating procedure-related sacrococcygeal pain. These findings highlight the potential of this combined therapy and underscore the need for prospective studies to confirm its long-term clinical benefits."

Journal • Retrospective data • Review • Gynecology • Oncology • Pain • Solid Tumor • Uterine Leiomyoma • Women's Health

Furosemide-Digoxin vs. Polidocanol for Cutaneous Warts (clinicaltrials.gov) - P2 | N=64 | Completed | Sponsor: Benha University

Head-to-Head • New P2 trial • Dermatology • Oncology

Cerebral air embolism induced by polidocanol foam sclerotherapy in chronic venous disease: A case report. (PubMed, Therapie) - No abstract available

Journal • Cardiovascular • Ischemic stroke

POLI-LASER: Polidocanol Foam With or Without Transdermal Laser for Varicose Veins: Randomized Clinical Trial (clinicaltrials.gov) - P=N/A | N=102 | Not yet recruiting | Sponsor: Hospital Universitario Pedro Ernesto

New trial • Varicose Veins

Mouse Vocal Fold Permeability In Vivo: Effects of Novel Low-Tech Injury and Instillation Methods. (PubMed, Laryngoscope) - "High-dose NAPH consistently injures mouse VFs. OA reliably instills mouse VFs. Uninjured murine VF epithelium is highly permeable to low molecular weight dye in vivo. Inherent permeability of mouse VFs may facilitate targeted genetic engineering approaches and studies of environmental hazards and drug treatments."

Journal • Preclinical • Anesthesia • TJP1 • TP63