Asclera (polidocanol) / Merz Pharma - LARVOL DELTA

EUS-Guided Cyanoacrylate Injection With Balloon-Compression Sclerotherapy Versus Band Ligation for Gastroesophageal Varices: A Randomized Trial. (PubMed, J Gastroenterol Hepatol) - P=N/A | "EUS-CYA combined with bc-EIS significantly improves esophageal variceal eradication and reduces treatment sessions compared with EUS-CYA + EVL, with comparable safety."

Journal • Cardiovascular • Gastroenterology • Gastrointestinal Disorder • Hypertension • Liver Cirrhosis • Portal Hypertension

Polidocanol Sclerotherapy for the Treatment of Symptomatic Hydroceles: Establishment of a Minimally Invasive Treatment Concept at a German Center (PubMed, Aktuelle Urol) - "The success rate was 71.9% after a single treatment and 87.5% after a maximum of 2 treatments. Surgery remains the gold standard, while sclerotherapy represents an effective minimally invasive alternative."

Journal • Anesthesia • Pain

Aspiration-Assisted Catheter-Directed Foam Sclerotherapy Using the Sclerosafe Device for Anterior Saphenous Vein Insufficiency: A Retrospective Study. (PubMed, Healthcare (Basel)) - "All procedures were performed in an outpatient setting under local anaesthesia (2 mL of 1% lignocaine at the puncture site) without tumescent infiltration...Polidocanol 2% foam (5 mL per session, Tessari technique) was administered and a standardised compression regimen was applied...In the absence of a control group and clinical outcome measures, the technique cannot be presented as an established alternative to thermal or non-thermal ablation, but it may be a technically attractive option in patients with clinical CEAP class C2-C4 disease. Prospective comparative studies are warranted to confirm these findings."

Journal • Retrospective data • Anesthesia • Cardiovascular • Hematological Disorders • Pain • Pulmonary Embolism • Respiratory Diseases • Varicose Veins

Letter to the Editor: Methodological Clarification on Polidocanol Dosing and Preparation for Axillary Osmidrosis Sclerotherapy. (PubMed, Dermatol Surg) - No abstract available

Journal

Airway glandular myoepithelial cells mediate airway regeneration and exhibit distinct CFTR functional profiles in a ferret model of cystic fibrosis (NACFC 2026) - "Tamoxifen was administered during postnatal gland development, during CF disease progression, or prior to polidocanol-induced airway epithelial injury in adult ferrets. Together, these findings demonstrate that ferret GMECs are multipotent progenitors involved in SMG development, airway repair, and pathological gland remodeling. They also establish GMECs as a clinically relevant cell population and potential therapeutic target in CF and other obstructive airway diseases that involve glandular remodeling. Importantly, these findings suggest that remodeling processes can directly influence airway CFTR function by mobilizing stem cell compartments with intrinsic biases toward specific cellular specification programs, thereby reshaping the CFTR-dependent functional properties of the regenerated airway epithelium."

Preclinical • Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Pulmonary Disease • Respiratory Diseases • ACTA2 • CFTR • MUC5B

KRT7-lineage airway glandular ductal stem cells drive regeneration and CFTR function (NACFC 2026) - "A KRT7-CreERT2::ROSA26mTmG transgenic ferret model was generated to enable in vivo lineage tracing of KRT7-positive cells following tamoxifen induction. Airway epithelial injury was induced by intratracheal polidocanol administration to assess regenerative potential... This study identifies a subpopulation of ductal epithelial cells in adult ferret SMGs that highly express KRT7 and likely represent GDSCs actively involved in airway epithelial regeneration. These cells can generate CFTR-functional epithelium, highlighting their potential as a cellular source and therapeutic target for regenerative and gene-based strategies aimed at restoring epithelial function in cystic fibrosis and other mucus-obstructive airway diseases."

Chronic Obstructive Pulmonary Disease • Cystic Fibrosis • Genetic Disorders • Immunology • Respiratory Diseases • KRT19 • KRT7

CXCR1 surface expression promotes human airway epithelial cell engraftment (NACFC 2026) - "Engraftment assays were performed on well-differentiated HBEC ALI cultures transiently injured with 0.125% polidocanol (PDOC)... Although CXCR1 WT and CXCR1 DEL proteins were comparably expressed, only the WT receptor underwent full maturation to reach the cell surface. Enhanced engraftment by CXCR1 WT-expressing HBECs may be driven by inflammatory cues, such as IL8, released upon epithelial injury. These results support the feasibility of using engineered "smart cells " to enhance epithelial engraftment for CFTR variant-agnostic cell therapy in CF."

Cystic Fibrosis • Genetic Disorders • Immunology • Respiratory Diseases • CXCL8 • CXCR1

In vivo autologous basal cell transplantation reconstitutes airway epithelium in a ferret model (NACFC 2026) - "GFP+ FBECs were reintroduced into donor ferrets via bronchoscopic instillation 5 hours after airway injury with 2% polidocanol... We established proof-of-concept for successful conduct of autologous in vivo FBEC transplantation in a ferret model, achieving durable engraftment, multilineage epithelial differentiation, and sustained CFTR mediated ion transport and mucociliary function in engrafted areas. These findings support the feasibility of basal cell–based regenerative therapies for CF and provide a foundation for future studies using genetically corrected CF ferret airway cells."

Preclinical • Cystic Fibrosis • Genetic Disorders • Immunology • Respiratory Diseases • Transplantation • KRT5 • MUC5AC

Comparative Study between Isolated Iliac Vein Stenting vs. Concomitant Iliac Vein Stenting with Pelvic Vein Embolization in Patients with Pelvic Venous Insufficiency Secondary to Nonthrombotic Iliac Vein Lesions. (PubMed, Ann Vasc Surg) - "In women with PVI due to nonthrombotic iliac lesions, adding PVE to iliac stenting improved short-term symptom and hemodynamic outcomes, at the cost of longer procedure time."

Journal • Cardiovascular

Laser Cryosclerotherapy versus Conventional Sclerotherapy for Reticular Veins and Telangiectasias: A Randomized Controlled Trial. (PubMed, J Vasc Surg Venous Lymphat Disord) - "Laser Cryosclerotherapy protocol was superior to CS in all GAIS outcomes, with moderate-to-large effect sizes and consistent inter-rater agreement. Aesthetic response is progressive, consolidating between Day 30 and Day 90, with the largest effect size in the late period. Augmented reality amplified the magnitude of detected effects and improved inter-rater agreement, reinforcing its role as a standardizing tool in aesthetic phlebology RCTs. These statistical findings should be weighed against the greater cost and complexity of LCS relative to conventional sclerotherapy in a purely cosmetic CEAP C1 population (see Discussion)."

Clinical • Journal • Varicose Veins

Effect of Mesh on Foam Stability in Foam Preparation for Sclerotherapy. (PubMed, Dermatol Surg) - "Integrating a mesh into the double syringe system enhances foam stability. Smaller pore sizes produce finer, more stable foam, suggesting 40 to 160 mesh as the optimal clinical range."

Journal

Comparative efficacy and safety of sclerosing agents in oral and maxillofacial venous malformations: a systematic review and meta-analysis. (PubMed, Oral Surg Oral Med Oral Pathol Oral Radiol) - "Current comparative evidence is limited and heterogeneous, precluding recommendation of any single sclerosant as superior. Treatment should be individualized, and well-designed randomized controlled trials are needed to establish comparative efficacy and safety."

Journal • Retrospective data • Review

Combined treatment with Nd:YAG laser and polidocanol foam sclerotherapy in venous malformation of the hand: case report. (PubMed, J Vasc Bras) - "The combination of photocoagulation and sclerotherapy proved safe and effective in a superficial and localized lesion. This case underscores the relevance of combined therapy as a minimally invasive alternative for venous malformations of the hand, highlighting the importance of individualized treatment according to lesion location, depth, and extent."

Journal • Rare Diseases

Efficacy and safety of bronchoscopic submucosal polidocanol injection for bronchopleural fistula (PubMed, Zhonghua Jie He He Hu Xi Za Zhi) - "Post-procedural complications included fever in 3 patients (10.3%), mild hemoptysis in 4 (13.8%), and worsening pneumothorax in 1 (3.4%); no procedure-related infections or deaths occurred. These findings suggest that bronchoscopic submucosal polidocanol injection is an effective and safe treatment for postoperative bronchopleural fistulas ≤5 mm in diameter."

Journal • Retrospective data • Infectious Disease • Pulmonary Disease • Respiratory Diseases

Clinical study on the relief of localized pruritus with 3% polidocanol emulsion (ChiCTR) - P=N/A | N=120 | Completed | Sponsor: Peking Union Medical College Hospital; Peking Union Medical College Hospital

New trial • Dermatology • Pruritus

Polidocanol Sclerotherapy Plus Adjuvant Autogenous Bone Marrow Injection for Management of Aneurysmal Bone Cyst: A Prospective Study. (PubMed, Indian J Orthop) - "Reported complications included recurrence (5.0%), ecchymosis (10.0%), and nausea and vomiting (5.0%). Use of polidocanol sclerotherapy followed by adjuvant autogenous bone marrow injection for management of ABCs is highly effective with adequate safety profile."

Journal • Cardiovascular • Orthopedics • Pain

Intralesional therapy for digital myxoid cysts: an updated scoping review. (PubMed, Ital J Dermatol Venerol) - "Intralesional sclerosing therapies exhibit high efficacy and durability, with comparable safety profiles compared to surgery and cure rates approaching those of surgical management. Standardized protocols, longer follow-up, and comparative studies are needed to refine patient selection and optimize outcomes. These results support the incorporation of sclerosant therapies into shared decision-making algorithms for DMC management. Significant heterogeneity in study methods and outcome definitions, as well as short and variable follow-up periods, limit definitive conclusions."

Journal • Infectious Disease • Inflammation • Pain

Watchful waiting versus methylprednisolone or polidocanol injections as treatment of simple bone cysts. (PubMed, Bone Jt Open) - "For treatment of SBCs, watchful waiting showed high chances of necessitating subsequent treatment, leading to lower CI-Healing and prolonged exposure to risk of failure. If treatment is required, polidocanol is a superior injectable compared with methylprednisolone, in terms of both healing and failure prevention."

Journal • Musculoskeletal Diseases • Oncology • Pediatrics

Predictive value of ultrasonographic parameters in the treatment of oral vascular anomalies. (PubMed, Oral Surg Oral Med Oral Pathol Oral Radiol) - "Individuals were submitted to sclerotherapy with 3% polidocanol under ultrasound guidance...Sclerotherapy guided by ultrasound is a safe and effective treatment for oral vascular anomalies. Ultrasonographic parameters, particularly baseline vascular flow, offer prognostic value for treatment response, whereas echogenicity is less informative."

Journal

Comment on "Modified ultrasound-guided polidocanol sclerotherapy is an effective treatment for thyroid cystic-solid nodules: A single-center retrospective study". (PubMed, Am J Otolaryngol) - No abstract available

Journal • Retrospective data

Fatal fulminant septic shock with disseminated intravascular coagulation following percutaneous aspiration and sclerotherapy of a hepatic cyst: a case report. (PubMed, Front Med (Lausanne)) - "This report describes a rare case of a 69-year-old female patient who underwent percutaneous aspiration and polidocanol sclerotherapy for multiple liver cysts...Escherichia coli was detected in both blood and cyst fluid cultures, suggesting a combined pathogenic mechanism involving both percutaneous puncture-related dissemination and biliary-intestinal bacterial translocation. This case demonstrates that percutaneous interventional treatment of liver cysts may lead to complications of fulminant infection, underscoring the critical importance of early recognition and timely intervention."

Journal • Hematological Disorders • Infectious Disease • Septic Shock

Multidisciplinary management of Grade III circumferential mixed hemorrhoids in a patient with Marfan syndrome receiving long-term anticoagulation: a case report. (PubMed, Front Surg) - "After cardiology consultation, and based on the patient's high thromboembolic risk, preoperative warfarin interruption was shortened to 3 days with enoxaparin bridging, and the INR decreased to 1.01 on the day before surgery...The patient therefore underwent external dissection and internal ligation combined with liquid polidocanol injection sclerotherapy, with minimal intraoperative blood loss...This case suggests that surgical intervention for advanced hemorrhoids in anticoagulated MFS patients may be feasible when embedded within a structured, individualized multidisciplinary pathway. The anticoagulation, nutritional, and inpatient-monitoring strategies described here should be interpreted as patient-specific measures requiring further validation."

Journal • Anesthesia • Cardiovascular • Gastroenterology • Gastrointestinal Disorder • Genetic Disorders • Hematological Disorders • Musculoskeletal Diseases • Thrombosis

Ultrasonography-guided sclerotherapy for a benign vascular malformation of the attached gingiva. (PubMed, J Indian Soc Periodontol) - "No recurrence or complications were observed during follow-up. This case highlights the precision, safety, and efficacy of USG-guided polidocanol sclerotherapy as a conservative, tissue-preserving alternative to surgical excision for the management of gingival VMs."

Journal • Mood Disorders • Oncology

Management of Recanalization After Cyanoacrylate Closure: A Single-Center Experience. (PubMed, J Vasc Surg Venous Lymphat Disord) - "Recanalization after CAC demonstrates heterogeneous and often discontinuous patterns. UGFS achieved successful occlusion at 80% success rate. UGFS may be an effective first line treatment in many cases. EVLA and RFA were technically feasible in selected cases, without observed complications. Laser ablation may have unique interactions with polymerized CA, as suggested by preliminary experimental observations. However, these observations are exploratory and require further clinical validation. Careful consideration is warranted when selecting secondary treatment modalities for CAC recanalization."

Journal • Varicose Veins

Predictors of short-term pain relief after polidocanol foam sclerotherapy for painful venous malformations. (PubMed, Eur Radiol) - "Question Identifying specific lesion- and technique-related predictors of short-term pain relief after polidocanol foam sclerotherapy for painful VMs remains an important unmet clinical need. Findings Multivariable analysis identified good sclerosant stasis as the sole independent predictor of a favorable clinical response, overriding baseline characteristics. Clinical relevance Polidocanol foam sclerotherapy safely relieves pain in VMs. To maximize efficacy, clinicians should support a stasis-first treatment strategy, prioritizing optimal intralesional stasis and management of outflow patterns."

Journal • Pain