carbimazole / Generic mfg. - LARVOL DELTA

Severe agranulocytosis in patient with Graves' disease on second exposure to carbimazole. (PubMed, Endocrinol Diabetes Metab Case Rep) - "Educating the patients regarding the symptoms of agranulocytosis is vital for saving their life. ATD-induced agranulocytosis can happen long time after exposure or even after second exposure to these drugs."

Journal • Agranulocytosis • Dermatology • Endocrine Disorders • Granulocytopenia • Grave’s Disease • Immunology • Infectious Disease • Musculoskeletal Pain • Otorhinolaryngology • Pain • Septic Shock • Urticaria • Vasculitis

Diagnostic and Therapeutic Challenges in Seronegative Autoimmune Hepatitis With Concurrent Graves Disease and Immune Thrombocytopenia. (PubMed, ACG Case Rep J) - "AIH and immune thrombocytopenia were treated with intravenous glucocorticoids, and hyperthyroidism was managed with graded escalation of carbimazole. This case highlights practical strategies for the diagnosis and management of concurrent autoimmune conditions with competing risks."

Journal • Autoimmune Hepatitis • Endocrine Disorders • Grave’s Disease • Hematological Disorders • Immune Thrombocytopenic Purpura • Immunology • Inflammation • Thrombocytopenia • Thrombocytopenic Purpura

Propylthiouracil Induced Neutropenia in Thyroid Storm: A Case Requiring Urgent Total Thyroidectomy. (PubMed, Int Med Case Rep J) - "Bridging therapy with hydrocortisone, cholestyramine, Lugol's solution, was implemented once available, and low-dose carbimazole was cautiously reintroduced under close monitoring without recurrence of neutropenia. Once a euthyroid state was achieved, definitive management with a total thyroidectomy was performed without complications. This case highlights three key learning points: (1) agranulocytosis can occur very early during high-dose PTU therapy; (2) careful bridging strategies are essential to prevent rebound thyroid storm after antithyroid drug withdrawal; and (3) timely transition to definitive surgical management can be lifesaving when antithyroid drug intolerance occurs."

Journal • Agranulocytosis • Endocrine Disorders • Granulocytopenia • Grave’s Disease • Hematological Disorders • Neutropenia

Thyroid Storm With Multiorgan Dysfunction Mimicking Sepsis: Thionamide-Sparing Bridge to Delayed Carbimazole. (PubMed, Cureus) - "Given the hepatic dysfunction, initial management deferred thionamide therapy; treatment comprised propranolol, corticosteroids, cholestyramine, and lithium, along with supportive intensive care and empirical antibiotics. This case illustrates that thyroid storm can closely mimic sepsis with markedly elevated inflammatory biomarkers and may be complicated by severe hepatocellular injury. A thionamide-sparing approach, when thionamides are contraindicated (e.g., agranulocytosis, hypersensitivity reactions, or severe hepatic dysfunction), utilizing lithium and cholestyramine can effectively serve as a bridging strategy, facilitating postponement of thionamide therapy when immediate antithyroid treatment is contraindicated."

Journal • Agranulocytosis • Atrial Fibrillation • Cardiovascular • Critical care • Endocrine Disorders • Gastrointestinal Disorder • Granulocytopenia • Grave’s Disease • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Liver Failure • Psychiatry • Septic Shock

Autoimmune hyperthyroidism following haematopoietic stem cell transplant for multiple sclerosis in an adult female: a case report and literature review. (PubMed, Endocrinol Diabetes Metab Case Rep) - "She was diagnosed with Graves' disease and treated with carbimazole and propranolol acutely; she is currently under regular endocrine follow-up. Thyroid function test should be monitored regularly post-HSCT for MS as both autoimmune hyperthyroidism (Graves' disease) and hypothyroidism can develop. We aim to highlight to clinicians about this rare occurrence of Graves' disease post-HSCT."

Journal • Bone Marrow Transplantation • CNS Disorders • Endocrine Disorders • Fatigue • Grave’s Disease • Immunology • Movement Disorders • Multiple Sclerosis • Pediatrics • Transplantation

Beneath the Cure Lies the Risk: Carbimazole-Induced Angioedema in Graves' Disease. (PubMed, Cureus) - "Prompt drug discontinuation and appropriate management can prevent progression to life-threatening airway involvement. Increased awareness of this uncommon adverse effect may improve patient safety and clinical outcomes during antithyroid therapy."

Journal • Allergy • Cardiovascular • Dermatology • Endocrine Disorders • Grave’s Disease • Immunology • Urticaria

Hyperthyroidism and birth defects: The roles of maternal thyroid function and thyroid autoantibody positivity. (PubMed, J Clin Endocrinol Metab) - "In a large Danish pregnancy cohort, no evidence was found that maternal thyroid function in early pregnancy associated with a risk of birth defects. A possible link with maternal thyroid stimulating antibodies warrants further investigation."

Journal • Endocrine Disorders

Psychosis as the Initial and Main Presentation of Graves' Disease: A Case Report from Saudi Arabia. (PubMed, Cureus) - "She was treated with carbimazole and atenolol, alongside low-dose olanzapine (5 mg daily). Endocrine screening should be routinely performed in new-onset psychosis to identify reversible causes such as thyrotoxicosis. Early recognition and treatment of underlying hyperthyroidism ensures rapid psychiatric recovery and prevents unnecessary prolonged antipsychotic use."

Journal • CNS Disorders • Endocrine Disorders • Grave’s Disease • Ophthalmology • Psychiatry

Coexistence of Adult-Onset Still's Disease and Graves' Disease: Coincidence or Continuum? (PubMed, Cureus) - "The disease course was characterized by recurrent inflammatory flares of both conditions and the development of carbimazole-induced hepatocellular injury, necessitating discontinuation of the drug and subsequent radioiodine ablation...This molecular overlap may account for their coexistence in some patients, regardless of sex. Systematic screening for thyroid dysfunction is advisable in patients with AOSD, irrespective of gender, in order to better identify this underrecognized association."

Journal • Endocrine Disorders • Grave’s Disease • Immunology • Musculoskeletal Pain • Oncology • HLA-DRB1 • IFNG • IL18 • TNFA

Grave's disease as a manifestation of immune reconstitution inflammatory syndrome in an HIV-infected child on highly active antiretroviral therapy: A case report. (PubMed, IDCases) - "He was treated with carbimazole and propranolol with close endocrine and infectious-disease follow-up. This case illustrates that Graves' hyperthyroidism may present as a late IRIS manifestation in children with profound immune recovery after ART. Early recognition, standard antithyroid therapy and continuation of ART can achieve good outcomes."

Journal • Cardiovascular • Endocrine Disorders • Grave’s Disease • Human Immunodeficiency Virus • Immunology • Infectious Disease • Pediatrics • CD4

Thyrotoxicosis-Associated Hypercoagulability Leading to Concurrent Ischemic Stroke and Pulmonary Embolism in Graves' Disease. (PubMed, Cureus) - "Therapeutic anticoagulation with enoxaparin 1 mg/kg twice daily was initiated and transitioned to apixaban 5 mg twice daily, along with carbimazole 20 mg/day and propranolol 40 mg three times daily. This case underscores that uncontrolled Graves' disease can precipitate simultaneous arterial and venous thrombosis and highlights the importance of early recognition of thyrotoxicosis-associated hypercoagulability, prompt anticoagulation, and initiation of antithyroid therapy. Reassessment of thrombophilia after achieving euthyroidism is advised to guide anticoagulation duration."

Journal • Cardiovascular • Endocrine Disorders • Grave’s Disease • Hematological Disorders • Immunology • Ischemic stroke • Pulmonary Embolism • Respiratory Diseases • Thrombosis • PROS1

Thyrotoxic Encephalopathy With Seronegative Thyroiditis: An Unusual Occurrence. (PubMed, Cureus) - "Over the subsequent few weeks, carbimazole was withdrawn, and she was started on levothyroxine. It is important to consider thyrotoxicosis as a cause for unexplained encephalopathy and to remember that it can be seen with seronegative thyroiditis. It is a diagnosis of exclusion with treatment involving antithyroid drugs."

Journal • CNS Disorders • Endocrine Disorders • Grave’s Disease • Immunology • Infectious Disease

DRESS syndrome in a patient with rheumatoid arthritis: Navigating the intersection of drug-induced hypersensitivity and immune-mediated inflammation. (PubMed, BMJ Case Rep) - "We present the case of a woman in her late 30s with recently diagnosed rheumatoid arthritis and hyperthyroidism who developed high-grade fever, diffuse rash and facial oedema following treatment with allopurinol, leflunomide and carbimazole. Discontinuation of the suspected offending drugs and initiation of anti-inflammatory therapy led to complete clinical resolution. This case highlights the complexity of diagnosing DRESS syndrome in patients with autoimmune conditions, the need to differentiate drug hypersensitivity from autoimmune disease flares and the importance of prompt intervention for optimal outcomes."

Journal • Endocrine Disorders • Eosinophilia • Immunology • Inflammation • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology

Subglottic Stenosis After Radioactive Iodine Treatment for Graves' Disease: A Case Report. (PubMed, Head Neck) - "This case report highlights a temporal association between RAI therapy and the subsequent development of SGS, supported by histopathological findings suggestive of radiation-induced tissue injury. In the absence of other established risk factors, RAI treatment may represent a rare but clinically relevant cause of acquired SGS, a complication not previously reported in the literature."

Journal • Chronic Cough • Cough • Dysphonia • Endocrine Disorders • Fibrosis • Grave’s Disease • Hematological Disorders • Immunology • Inflammation • Pulmonary Disease • Respiratory Diseases • Rheumatology

Graves' disease in India: epidemiological, clinical, and genetic differences from Caucasians. (PubMed, Postgrad Med J) - "The phenotype of Indian GD is different than in Caucasians and is characterized by lower age at onset, lower female to male ratio, delayed diagnosis, more signs and symptoms, lower body mass index (BMI) and weight, lower prevalence of Graves' orbitopathy (GO), more inactive GO, lower doses of carbimazole being more effective, different markers of remission, and other things. Mechanistic studies are urgently needed to characterize the pathophysiology of Indian GD. Prevention, early diagnosis, and adequate treatment of GD should become urgently a public health priority in India."

Journal • Endocrine Disorders • Grave’s Disease • Thyroid Eye Disease

A Rare Side Effect of Vaccine-Induced Thyrotoxicosis: A Case Report. (PubMed, Cureus) - "This case highlights a potential link between the ChAdOx1 nCoV-19 (AstraZeneca) vaccine and new-onset Graves' disease. A 49-year-old man presented with a two-week history of palpitations, weight loss, diarrhea, and dyspnea...The patient was treated with carbimazole, propranolol, and corticosteroids, with gradual clinical and biochemical improvement...Early recognition, confirmation through TRAb testing, and appropriate management are critical. Long-term follow-up is essential to monitor for relapse or remission in post-vaccination Graves' disease."

Adverse events • Journal • Cardiovascular • Crohn's disease • Endocrine Disorders • Gastroenterology • Grave’s Disease • Immunology • Infectious Disease • Inflammatory Bowel Disease • Novel Coronavirus Disease • Pulmonary Disease • Respiratory Diseases

Propylthiouracil-Induced Vasculitis in Relapsed Graves' Disease With Recent Iodine Exposure: A Therapeutic Dilemma. (PubMed, Cureus) - "We present a challenging case of Graves' disease complicated by propylthiouracil (PTU)-induced antineutrophil cytoplasmic antibody (ANCA)-positive vasculitis and recent iodine contrast exposure, creating a therapeutic dilemma where standard treatment options were severely limited. A 60-year-old man was diagnosed with Graves' disease in late 2020 and treated with carbimazole for one year. PTU was discontinued, and corticosteroids were initiated, leading to clinical improvement. Given florid hyperthyroidism and recent iodine exposure, his case was reviewed at the Endocrine multidisciplinary meeting. Carbimazole was restarted as a bridging therapy; despite its vasculitis risk, it remained the best option until RAI, which was ineffective due to iodine saturation, could be given. Surgical thyroidectomy was unsafe due to severe thyrotoxicosis. These limitations created a narrow therapeutic window requiring careful multidisciplinary..."

Journal • ANCA Vasculitis • Cardiovascular • Endocrine Disorders • Grave’s Disease • Immunology • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain • Vasculitis

Spontaneous regression of a growth hormone-secreting pituitary adenoma following thyroidectomy for toxic multinodular goiter with superior vena cava obstruction: Report of a rare case. (PubMed, Med Int (Lond)) - "The patient was treated with a somatostatin analog and metformin for glycemic control, followed by carbimazole in preparation for thyroidectomy...Possible mechanisms for regression include perioperative pituitary apoplexy, spontaneous ischemia, or altered vascular dynamics following thyroidectomy. The present case report highlights the importance of reassessing pituitary adenomas following the treatment of coexisting endocrine or compressive disorders and suggests a potential role of vascular factors in pituitary tumor regression."

Journal • Acromegaly • Cardiovascular • Endocrine Disorders • Oncology • Pituitary Gland Carcinoma • Pulmonary Disease • Thyroid Gland Carcinoma • IGF1

When Postoperative Inflammation Isn't Benign: Thyroid Eye Disease Following Cataract Surgery. (PubMed, Cureus) - "He received intravenous methylprednisolone, mycophenolate mofetil, and carbimazole, followed by urgent medial wall decompression due to worsening optic neuropathy, with subsequent visual improvement. TED following cataract surgery is rare but underscores the importance of considering atypical postoperative courses. Early recognition and adherence to guideline-based management are crucial to preserve vision."

Journal • Cataract • Endocrine Disorders • Grave’s Disease • Immunology • Inflammation • Ocular Inflammation • Ophthalmology • Optic Neuritis • Pain • Thyroid Eye Disease

Use of Carbimazole, Methimazole and Propylthiouracil in Women of Childbearing Age and Exposed Pregnancies in Germany: A Population-Based Study. (PubMed, Drugs Real World Outcomes) - "The prescription prevalence of ATD overall and specifically of CMZ/MMI in girls and women of childbearing age decreased between 2005 and 2020 in Germany. The decrease in exposure to CMZ/MMI at pregnancy onset indicates that physicians became increasingly aware of the potential risks of CMZ/MMI to the unborn child."

Journal • Endocrine Disorders • Obstetrics

Iodine Deficiency-Induced Thyrotoxicosis Mimicking Graves' Disease: A Case of Triiodothyronine (T3)-Predominant Hyperthyroidism Without Goiter. (PubMed, Cureus) - "He was treated with carbimazole (20 mg/day, tapered to 5 mg) and propranolol (40 mg/day, later withdrawn) and was advised to switch to iodized salt at an intake of approximately 5 g/day. Although thyrotropin receptor antibody-negative Graves' disease was initially suspected, the combination of sustained remission after therapy cessation, negative antibodies, and exclusive rock salt use supported a diagnosis of iodine deficiency-induced thyrotoxicosis. This case highlights the importance of dietary history and structured follow-up in evaluating atypical thyrotoxicosis and illustrates how iodine deficiency can mimic autoimmune hyperthyroidism in clinical practice."

Journal • Cardiovascular • Endocrine Disorders • Grave’s Disease • Immunology • Movement Disorders

Challenges in the Diagnosis and Management of Graves' Disease in an Elderly Female With Antithyroid Drug Intolerance. (PubMed, Cureus) - "Initial management with carbimazole achieved some biochemical control but led to hepatotoxicity...Thyroid function gradually stabilised on a combination of Lugol's iodine, propranolol, steroid and low-dose propylthiouracil. This case was challenging due to anti-thyroid drug intolerance in conjunction with limited definitive management options, with our endocrinology team resorting to non-standard therapies to stabilise the patient. This case ultimately demonstrates the diagnostic and therapeutic challenges of managing Graves' hyperthyroidism in the elderly. ."

Journal • Atrial Fibrillation • Cardiovascular • Endocrine Disorders • Grave’s Disease • Hypotension

Graves' Disease in the Elderly: A Case of Fluctuating Hyperthyroidism and Hypothyroidism Resulting in Challenging Management. (PubMed, Cureus) - "Carbimazole was discontinued, and levothyroxine was initiated. Over the following four months, she was admitted three more times with alternating hypothyroidism and hyperthyroidism, accompanied by worsening cardiac complications. This case highlights the challenges of recognizing and managing GD and its complications in the elderly."

Journal • Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Dermatology • Endocrine Disorders • Grave’s Disease • Heart Failure • Ophthalmology

A case of severe neonatal hypercalcaemia secondary to neonatal thyrotoxicosis. (PubMed, Endocrinol Diabetes Metab Case Rep) - "Hypercalcaemia was managed with hyperhydration along with a low-calcium infant formula, and thyrotoxicosis responded to treatment with carbimazole...While asymptomatic neonatal hypercalcaemia may be transient and self-limiting, symptomatic patients require treatment with hyperhydration. Serum calcium levels in combination with parathyroid hormone, vitamin D, and urine calcium-creatinine ratios can help narrow the differential diagnoses, but it is important that the underlying cause is carefully investigated."

Journal • Cardiovascular • Endocrine Disorders • Pediatrics

A RARE CASE OF MOYAMOYA SYNDROME ASSOCIATED WITH GRAVES' DISEASE (WSC 2025) - "She was treated with clopidogrel monotherapy, atorvastatin and her Carbimazole was restarted with reinforcement of medication compliance. Moyamoya syndrome can occur as a rare complication of Graves' disease, emphasizing the importance of recognizing its vascular and systemic implications. Early diagnosis and multidisciplinary management, including strict thyrotoxicosis control and preventative therapy, are crucial to prevent further cerebrovascular events."

Clinical • Astrocytoma • Brain Cancer • CNS Disorders • Endocrine Disorders • Grave’s Disease • Movement Disorders • Solid Tumor • Vascular Neurology • Vasculitis