carbimazole / Generic mfg. - LARVOL DELTA

Carbimazole-Induced Severe Acquired Aplastic Anemia in a Patient with Graves' Disease: A Case Report. (PubMed, Reports (MDPI)) - "Immediate discontinuation of carbimazole was done, and supportive care, including blood transfusions, broad-spectrum antibiotics, G-CSF, and eltrombopag, was started. She was stabilized and discharged, with a referral to a tertiary medical center for starting antithymocyte globulin (ATG) immunosuppressive therapy, which she subsequently completed; two months after discharge she was transfusion independent with near-normalization of her blood counts. This case serves as a stark reminder of how lethal thionamide-induced bone marrow failure can be, highlighting the vital need for immediate drug cessation, swift intensive care, and thorough patient education on early warning signs."

Journal • Anemia • Aplastic Anemia • Critical care • Endocrine Disorders • Grave’s Disease • Gynecology • Hematological Disorders • Infectious Disease • Respiratory Diseases • Septic Shock

Exploring Thyrotoxic Hypercalcaemia Through Two Cases: A Myriad of Uncertainties. (PubMed, Case Rep Endocrinol) - "Both patients improved clinically and biochemically with adequate intravenous hydration, frusemide, carbimazole, propranolol, and bisphosphonates. Prompt recognition and management is essential to prevent bone loss, correct metabolic abnormalities, and avoid complications. Clinicians should also consider the possibility of hypercalcaemia associated with thyroid dysfunction in patients presenting with nonspecific symptoms such as fatigue, constipation, proximal weakness, polyuria, or mood changes."

Journal • Constipation • Endocrine Disorders • Fatigue • Gastroenterology • Gastrointestinal Disorder • Mood Disorders • Ophthalmology • Osteoporosis • Pain • Psychiatry • Pulmonary Disease • Renal Disease • Rheumatology

Refractory Amiodarone-Induced Thyrotoxicosis Requiring the Consideration of Thyroidectomy: A Case Report and Review of Management Challenges. (PubMed, Cureus) - "Carbimazole therapy was initiated, but persistent thyrotoxicosis necessitated dose escalation, discontinuation of amiodarone, and commencement of prednisolone for suspected AIT. Although thyroid function tests initially improved with combined medical therapy, biochemical response later plateaued with a fT4 level of 52 pmol/L at the end of month 8, prompting referral for thyroidectomy. This case describes a challenging presentation of AIT with an incomplete response to conventional medical management and progression to consideration of definitive surgical treatment."

Journal • Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Coronary Artery Disease • Diabetes • Genetic Disorders • Heart Failure • Metabolic Disorders • Obesity

Thyroid Storm at Onset: An Uncommon Presentation of Graves' Disease. (PubMed, Cureus) - "Treatment with carbimazole, hydrocortisone, and beta-blockade led to rapid biochemical and clinical improvement, with restoration of sinus rhythm and return towards cognitive baseline. This case, therefore, presents thyroid storm as the first presentation of Graves' disease, masquerading as acute decompensated heart failure and delirium. It emphasises the importance of considering endocrine causes in unexplained multisystem deterioration, as early recognition and prompt treatment are essential to reduce significant morbidity and mortality."

Journal • Atrial Fibrillation • Cardiovascular • Chronic Obstructive Pulmonary Disease • CNS Disorders • Congestive Heart Failure • Diabetes • Endocrine Cancer • Endocrine Disorders • Grave’s Disease • Heart Failure • Hypertension • Immunology • Metabolic Disorders • Pain • Pulmonary Disease • Respiratory Diseases • Type 2 Diabetes Mellitus

Patient with Resistance to Thyroid Hormone Syndrome treated initially with Anti-thyroid medication (ETA 2026) - "He was started on carbimazole, with progressive dose escalation as fT4 failed to normalise... Dynamic testing of the hypothalamic-pituitary-thyroid axis has high specificity in differentiating TSHoma from RTH, while genetic sequencing confirms RTH. However, mutations are undetectable in approximately 15% of patients, and up to one-quarter may have incidental pituitary lesions, potentially confounding diagnosis. Management of RTH is symptom-directed."

Clinical • Dyslipidemia • Endocrine Disorders • Pituitary Gland Carcinoma

Carbimazole resistant Graves' disease: A case report. (ETA 2026) - "Adjunctive therapy including beta-blockers, dexamethasone, and cholestyramine provided minimal biochemical improvement...The patient was subsequently switched to propylthiouracil (200 mg twice daily), with only partial biochemical response. Given persistent thyrotoxicosis and the risk of long-term drug toxicity, definitive surgical management with total thyroidectomy was undertaken, following which the patient achieved biochemical remission and was maintained on levothyroxine replacement... This case highlights the importance of recognizing true ATD resistance after excluding non-adherence and malabsorption. Early consideration of definitive therapy, particularly thyroidectomy, can provide rapid and effective control of hyperthyroidism when medical therapy fails."

Case report • Clinical • Cardiovascular • Celiac Disease • Endocrine Disorders • Grave’s Disease • Immunology • Movement Disorders • Ophthalmology

Case series of amiodarone-induced thyrotoxicosis following semaglutide-induced weight loss (ETA 2026) - "before AIT 1.5 months before AIT, 0.5 mg/week 14.7% carbimazole 2 (♂, 41) 5 y. before AIT, ongoing 4 months before AIT, 2.4 mg/week 5.6% prednisone 3 (♀, 57) From 6 mo. In conjunction with previous reports of AIT following bariatric surgery and a recent report following tirzepatide treatment, the case series presented here suggests a possible association between significant weight loss and the development of AIT. The hypothesis is the release of stored amiodarone from adipose tissue during rapid weight reduction. This hypothesis is supported by the pharmacokinetic properties of amiodarone and evidence of lipophilic toxin release during weight loss."

Clinical • Cardiovascular • Endocrine Disorders

Thermal Ablation for Treatment of Amiodarone-Induced Thyrotoxicosis: a report of two cases (ETA 2026) - P=N/A | "One is a 38-year-old male with atypical atrial flutter who developed AIT several months after stopping amiodarone and remained markedly symptomatic despite prednisone and carbimazole treatment. Thermal ablation of almost the entire thyroid gland represents an alternative treatment option for AIT in patients with compromised cardiac function in whom conventional treatment is contraindicated or not tolerated."

Clinical • Cardiovascular • Congestive Heart Failure • Heart Failure

Comparative Mathematical Modeling of FT4 Dynamics across Three Pediatric Thyroid Diseases Using Retrospective Data from an International Multicenter Study (ETA 2026) - "All models incorporate weight progression and rely exclusively on clinically relevant and routinely available information (age, gestational age, and disease severity at diagnosis, measured FT4 under treatment, and administered dose of levothyroxine or carbimazole/methimazole). Developed mathematical models for pediatric CH, HT, and GD accurately predict individual disease dynamics. In combination with dose optimization algorithms, these models are expected to facilitate personalized pharmacotherapy and have the potential to mitigate the risk for under- or overdosing in children with thyroid diseases, thereby avoiding drug-related side effects and improving quality of life. A randomized controlled trial has been initiated to further assess predictive performance in clinical practice."

Retrospective data • Endocrine Disorders • Grave’s Disease • Pediatrics

Thyrotoxic Periodic Paralysis Following a 75-g Oral Glucose Load Revealing Previously Undiagnosed Graves' Disease: A Case Report. (PubMed, Clin Med Insights Case Rep) - "Limited potassium replacement, magnesium supplementation, and propranolol produced complete neurological recovery without rebound hyperkalemia. Carbimazole therapy achieved progressive biochemical control, with no recurrent paralysis during 24 weeks of follow-up...The episode supports an interaction between endogenous insulin stimulation and thyrotoxic skeletal-muscle susceptibility rather than hyperinsulinemia as an isolated cause. Unrecognized thyrotoxicosis should be considered before carbohydrate provocation testing in patients with unexplained hyperadrenergic symptoms."

Journal • Endocrine Disorders • Grave’s Disease • Renal Disease

Unveiling the Healing Power of Artemisia campestris: A Breakthrough in Hypothyroidism Treatment Through In Vitro, In Vivo, and In Silico Insights. (PubMed, Curr Med Chem) - "A. campestris leaf extract offers significant therapeutic potential as an alternative or adjunct therapy for hypothyroidism, fully reversing CMZ-induced effects in rats, comparable to standard LT4 treatment, highlighting its promise for further exploration in endocrine disorder management."

Journal • Preclinical • Endocrine Disorders

The Hidden Crisis: A Rare Case of Thyrotoxicosis in a Young Female, Mimicking Neuromuscular Disease. (PubMed, J Community Hosp Intern Med Perspect) - "Prompt potassium replacement and initiation of antithyroid therapy led to complete clinical recovery. This case highlights the importance of considering both endocrine disorders and electrolyte disturbances, such as hypokalemia, in the differential diagnosis of acute paralysis."

Journal • CNS Disorders • Endocrine Disorders

Thyrotoxicosis presenting with periodic paralysis in a young male: a case report. (PubMed, Ann Med Surg (Lond)) - "The patient was managed with cautious potassium supplementation, propranolol, and carbimazole, followed by definitive therapy with radioactive iodine ablation. Thyrotoxicosis should be suspected in patients presenting with hypokalemic periodic paralysis, especially in men of Asian descent. Definitive treatment of the underlying thyroid disorder is essential for the prevention of recurrence."

Journal • Cardiovascular • Endocrine Disorders • Grave’s Disease

Risk of Significant Liver Enzyme Elevation After Switching Antithyroid Drugs. (PubMed, Eur J Endocrinol) - "Using TriNetX, we conducted a retrospective cohort study of patients with hyperthyroidism who initiated methimazole/carbimazole (MMI) or propylthiouracil (PTU), developed significant liver enzyme elevation within 4 months, and switched to the alternate ATD within 12 months. Hepatocellular-pattern elevation occurred in 48/276 (17%) and 13/82 (16%), while cholestatic-pattern elevation occurred in 91/276 (33%) and 15/82 (18%). These findings demonstrate that significant liver injury after ATD switching is frequent but not inevitable and occurs at comparable rates across switch groups, underscoring the need for close biochemical monitoring and individualized treatment decisions."

Journal • Endocrine Disorders • Hepatology • Liver Failure

Atypical Management of Type 2 Amiodarone-Induced Thyrotoxicosis Without Corticosteroids: A Case Report and Review of Therapeutic Challenges. (PubMed, Cureus) - "Amiodarone-induced thyrotoxicosis (AIT) is a complex endocrine disorder associated with significant morbidity, particularly in patients with underlying cardiac disease. The patient was managed with low-dose carbimazole, resulting in gradual normalization of thyroid function. This case highlights the complexity of diagnosing and managing AIT and demonstrates that thionamides may be a viable alternative in selected patients in whom corticosteroids are contraindicated, particularly in cases with overlapping features of type 1 and type 2 AIT."

Journal • Atrial Fibrillation • Cardiomyopathy • Cardiovascular • Endocrine Disorders • Genetic Disorders • Heart Failure • Hepatology • Oncology

Racing Heart Under Stormy Skies: A Journey From Agranulocytosis to Thyroid Storm. (PubMed, Cureus) - "We present a 31-year-old female with newly diagnosed Graves' disease complicated by carbimazole-induced agranulocytosis. The delay in initiating adjunctive therapy to control the thyrotoxicosis due to suspected sepsis was followed by rapid development of thyroid storm requiring therapeutic plasma exchange (TPE) and urgent thyroidectomy. This case highlights the importance of prompt recognition and of distinguishing thyroid storm from sepsis in the setting of anti-thyroid drug-induced agranulocytosis and underscores TPE as an effective, well-tolerated bridging therapy for thyroid storm before definitive treatment."

Journal • Agranulocytosis • Cardiovascular • Cognitive Disorders • Endocrine Disorders • Granulocytopenia • Grave’s Disease • Infectious Disease • Septic Shock

A Diagnostic Tightrope: Carbimazole-Induced Microscopic Polyangiitis With Co-Existent Antiphospholipid Syndrome and Diffuse Alveolar Hemorrhage. (PubMed, Cureus) - "This case highlights the "triple-hit" of drug-induced vasculitis, thrombosis, and immune-complex deposition. The patient's rapid clinical stabilization following the initiation of plasmapheresis emphasizes the role of this intervention as a life-saving therapeutic bridge in complex vasculitis presentations."

Journal • ANCA Vasculitis • Cardiovascular • Genetic Disorders • Hematological Disorders • Respiratory Diseases • Thrombosis • Vasculitis • MPO

Drug cross-reactivity between methimazole and propylthiouracil causing recurrent pancreatitis in thyroid storm. (PubMed, Endocrinol Diabetes Metab Case Rep) - "To date, eight cases of antithyroid drug (ATD)-induced pancreatitis have been reported, including seven associated with methimazole (MMI) and one with carbimazole; however, no cases related to propylthiouracil (PTU) have been reported in the literature. In the event that MMI or PTU results in adverse effects, alternative therapeutic modalities should be considered, including radioactive iodine (131I) therapy or surgical interventions. These considerations should be informed by the concomitant increase in IgG4 concentration."

Journal • Endocrine Disorders • Grave’s Disease • Immunology • Pain • Pancreatitis

A Case of Myopathic Dysphagia Secondary to Thyrotoxicosis. (PubMed, AACE Endocrinol Diabetes) - "Evaluation was done to exclude other causes including mechanical compression, neuromuscular causes, and malignancy.The patient's dysphagia improved with carbimazole doses of up to 30 mg twice daily, and propranolol doses of up to 20 mg 3 times daily, titrated as thyrotoxicosis improved. Our patient's dysphagia resolved rapidly with normalization of free thyroxine and free triiodothyronine. It is important to render the patient euthyroid as soon as possible to minimize risks of aspiration, pneumonia, and other complications."

Journal • Endocrine Disorders • Gastrointestinal Disorder • Grave’s Disease • Infectious Disease • Myositis • Oncology • Pneumonia • Respiratory Diseases

Pulmonary Arterial Hypertension in Graves' Disease: Role of Thyroid Autoimmunity and NEDD9. (PubMed, Indian J Endocrinol Metab) - "Delta change in TRAb levels was the only significant factor for predicting a ≥10 mmHg reduction in mPAP post-carbimazole therapy. Thyroid autoimmunity significantly contributes to PAH in GD, while NEDD9 showed no association."

Journal • Cardiovascular • Endocrine Disorders • Grave’s Disease • Hypertension • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • KEAP1 • NEDD9

Severe agranulocytosis in patient with Graves' disease on second exposure to carbimazole. (PubMed, Endocrinol Diabetes Metab Case Rep) - "Educating the patients regarding the symptoms of agranulocytosis is vital for saving their life. ATD-induced agranulocytosis can happen long time after exposure or even after second exposure to these drugs."

Journal • Agranulocytosis • Dermatology • Endocrine Disorders • Granulocytopenia • Grave’s Disease • Immunology • Infectious Disease • Musculoskeletal Pain • Otorhinolaryngology • Pain • Septic Shock • Urticaria • Vasculitis

Diagnostic and Therapeutic Challenges in Seronegative Autoimmune Hepatitis With Concurrent Graves Disease and Immune Thrombocytopenia. (PubMed, ACG Case Rep J) - "AIH and immune thrombocytopenia were treated with intravenous glucocorticoids, and hyperthyroidism was managed with graded escalation of carbimazole. This case highlights practical strategies for the diagnosis and management of concurrent autoimmune conditions with competing risks."

Journal • Autoimmune Hepatitis • Endocrine Disorders • Grave’s Disease • Hematological Disorders • Immune Thrombocytopenic Purpura • Immunology • Inflammation • Thrombocytopenia • Thrombocytopenic Purpura

Propylthiouracil Induced Neutropenia in Thyroid Storm: A Case Requiring Urgent Total Thyroidectomy. (PubMed, Int Med Case Rep J) - "Bridging therapy with hydrocortisone, cholestyramine, Lugol's solution, was implemented once available, and low-dose carbimazole was cautiously reintroduced under close monitoring without recurrence of neutropenia. Once a euthyroid state was achieved, definitive management with a total thyroidectomy was performed without complications. This case highlights three key learning points: (1) agranulocytosis can occur very early during high-dose PTU therapy; (2) careful bridging strategies are essential to prevent rebound thyroid storm after antithyroid drug withdrawal; and (3) timely transition to definitive surgical management can be lifesaving when antithyroid drug intolerance occurs."

Journal • Agranulocytosis • Endocrine Disorders • Granulocytopenia • Grave’s Disease • Hematological Disorders • Neutropenia

Thyroid Storm With Multiorgan Dysfunction Mimicking Sepsis: Thionamide-Sparing Bridge to Delayed Carbimazole. (PubMed, Cureus) - "Given the hepatic dysfunction, initial management deferred thionamide therapy; treatment comprised propranolol, corticosteroids, cholestyramine, and lithium, along with supportive intensive care and empirical antibiotics. This case illustrates that thyroid storm can closely mimic sepsis with markedly elevated inflammatory biomarkers and may be complicated by severe hepatocellular injury. A thionamide-sparing approach, when thionamides are contraindicated (e.g., agranulocytosis, hypersensitivity reactions, or severe hepatic dysfunction), utilizing lithium and cholestyramine can effectively serve as a bridging strategy, facilitating postponement of thionamide therapy when immediate antithyroid treatment is contraindicated."

Journal • Agranulocytosis • Atrial Fibrillation • Cardiovascular • Critical care • Endocrine Disorders • Gastrointestinal Disorder • Granulocytopenia • Grave’s Disease • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Liver Failure • Psychiatry • Septic Shock

Autoimmune hyperthyroidism following haematopoietic stem cell transplant for multiple sclerosis in an adult female: a case report and literature review. (PubMed, Endocrinol Diabetes Metab Case Rep) - "She was diagnosed with Graves' disease and treated with carbimazole and propranolol acutely; she is currently under regular endocrine follow-up. Thyroid function test should be monitored regularly post-HSCT for MS as both autoimmune hyperthyroidism (Graves' disease) and hypothyroidism can develop. We aim to highlight to clinicians about this rare occurrence of Graves' disease post-HSCT."

Journal • Bone Marrow Transplantation • CNS Disorders • Endocrine Disorders • Fatigue • Grave’s Disease • Immunology • Movement Disorders • Multiple Sclerosis • Pediatrics • Transplantation