carbimazole / Generic mfg. - LARVOL DELTA

Spontaneous regression of a growth hormone-secreting pituitary adenoma following thyroidectomy for toxic multinodular goiter with superior vena cava obstruction: Report of a rare case. (PubMed, Med Int (Lond)) - "The patient was treated with a somatostatin analog and metformin for glycemic control, followed by carbimazole in preparation for thyroidectomy...Possible mechanisms for regression include perioperative pituitary apoplexy, spontaneous ischemia, or altered vascular dynamics following thyroidectomy. The present case report highlights the importance of reassessing pituitary adenomas following the treatment of coexisting endocrine or compressive disorders and suggests a potential role of vascular factors in pituitary tumor regression."

Journal • Acromegaly • Cardiovascular • Endocrine Disorders • Oncology • Pituitary Gland Carcinoma • Pulmonary Disease • Thyroid Gland Carcinoma • IGF1

When Postoperative Inflammation Isn't Benign: Thyroid Eye Disease Following Cataract Surgery. (PubMed, Cureus) - "He received intravenous methylprednisolone, mycophenolate mofetil, and carbimazole, followed by urgent medial wall decompression due to worsening optic neuropathy, with subsequent visual improvement. TED following cataract surgery is rare but underscores the importance of considering atypical postoperative courses. Early recognition and adherence to guideline-based management are crucial to preserve vision."

Journal • Cataract • Endocrine Disorders • Grave’s Disease • Immunology • Inflammation • Ocular Inflammation • Ophthalmology • Optic Neuritis • Pain • Thyroid Eye Disease

Use of Carbimazole, Methimazole and Propylthiouracil in Women of Childbearing Age and Exposed Pregnancies in Germany: A Population-Based Study. (PubMed, Drugs Real World Outcomes) - "The prescription prevalence of ATD overall and specifically of CMZ/MMI in girls and women of childbearing age decreased between 2005 and 2020 in Germany. The decrease in exposure to CMZ/MMI at pregnancy onset indicates that physicians became increasingly aware of the potential risks of CMZ/MMI to the unborn child."

Journal • Endocrine Disorders • Obstetrics

Iodine Deficiency-Induced Thyrotoxicosis Mimicking Graves' Disease: A Case of Triiodothyronine (T3)-Predominant Hyperthyroidism Without Goiter. (PubMed, Cureus) - "He was treated with carbimazole (20 mg/day, tapered to 5 mg) and propranolol (40 mg/day, later withdrawn) and was advised to switch to iodized salt at an intake of approximately 5 g/day. Although thyrotropin receptor antibody-negative Graves' disease was initially suspected, the combination of sustained remission after therapy cessation, negative antibodies, and exclusive rock salt use supported a diagnosis of iodine deficiency-induced thyrotoxicosis. This case highlights the importance of dietary history and structured follow-up in evaluating atypical thyrotoxicosis and illustrates how iodine deficiency can mimic autoimmune hyperthyroidism in clinical practice."

Journal • Cardiovascular • Endocrine Disorders • Grave’s Disease • Immunology • Movement Disorders

Challenges in the Diagnosis and Management of Graves' Disease in an Elderly Female With Antithyroid Drug Intolerance. (PubMed, Cureus) - "Initial management with carbimazole achieved some biochemical control but led to hepatotoxicity...Thyroid function gradually stabilised on a combination of Lugol's iodine, propranolol, steroid and low-dose propylthiouracil. This case was challenging due to anti-thyroid drug intolerance in conjunction with limited definitive management options, with our endocrinology team resorting to non-standard therapies to stabilise the patient. This case ultimately demonstrates the diagnostic and therapeutic challenges of managing Graves' hyperthyroidism in the elderly. ."

Journal • Atrial Fibrillation • Cardiovascular • Endocrine Disorders • Grave’s Disease • Hypotension

Graves' Disease in the Elderly: A Case of Fluctuating Hyperthyroidism and Hypothyroidism Resulting in Challenging Management. (PubMed, Cureus) - "Carbimazole was discontinued, and levothyroxine was initiated. Over the following four months, she was admitted three more times with alternating hypothyroidism and hyperthyroidism, accompanied by worsening cardiac complications. This case highlights the challenges of recognizing and managing GD and its complications in the elderly."

Journal • Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Dermatology • Endocrine Disorders • Grave’s Disease • Heart Failure • Ophthalmology

A case of severe neonatal hypercalcaemia secondary to neonatal thyrotoxicosis. (PubMed, Endocrinol Diabetes Metab Case Rep) - "Hypercalcaemia was managed with hyperhydration along with a low-calcium infant formula, and thyrotoxicosis responded to treatment with carbimazole...While asymptomatic neonatal hypercalcaemia may be transient and self-limiting, symptomatic patients require treatment with hyperhydration. Serum calcium levels in combination with parathyroid hormone, vitamin D, and urine calcium-creatinine ratios can help narrow the differential diagnoses, but it is important that the underlying cause is carefully investigated."

Journal • Cardiovascular • Endocrine Disorders • Pediatrics

A RARE CASE OF MOYAMOYA SYNDROME ASSOCIATED WITH GRAVES' DISEASE (WSC 2025) - "She was treated with clopidogrel monotherapy, atorvastatin and her Carbimazole was restarted with reinforcement of medication compliance. Moyamoya syndrome can occur as a rare complication of Graves' disease, emphasizing the importance of recognizing its vascular and systemic implications. Early diagnosis and multidisciplinary management, including strict thyrotoxicosis control and preventative therapy, are crucial to prevent further cerebrovascular events."

Clinical • Astrocytoma • Brain Cancer • CNS Disorders • Endocrine Disorders • Grave’s Disease • Movement Disorders • Solid Tumor • Vascular Neurology • Vasculitis

A RARE CASE OF TYPE 3 AUTOIMMUNE POLYGLANDULAR SYNDROME WITH DISSEMINATED TUBERCULOSIS (CHEST 2025) - "The patient was started on empiric anti-tuberculous oral drugs, carbimazole and propranolol, and high dose corticosteroids for the autoimmune state. This is the first reported case of APS type 3 with disseminated TB in literature. It signifies the need for high clinical suspicion and a thorough workup for accurate diagnosis and management."

Clinical • Alopecia • Anemia • Candidiasis • Cardiovascular • Celiac Disease • CNS Disorders • Cough • Dermatology • Diabetes • Endocrine Disorders • Heart Failure • Hematological Disorders • Hypoparathyroidism • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus • Metabolic Disorders • Myasthenia Gravis • Pulmonary Disease • Rare Diseases • Respiratory Diseases • Sjogren's Syndrome • Systemic Lupus Erythematosus • Tuberculosis • Type 1 Diabetes Mellitus • Vitiligo

PULMONARY RENAL SYNDROME WITH DIFFUSE ALVEOLAR HEMORRHAGE IN A YOUNG FEMALE WITH SUSPECTED AUTOIMMUNE DISEASE: A RARE CASE REPORT (CHEST 2025) - "CASE PRESENTATION: A 16-year-old girl with hyperthyroidism (on Carbimazole) and recurrent anemia requiring transfusions presented with palpitations, epigastric pain, vomiting, periorbital puffiness, and foamy urine...A CT chest showed bilateral ground-glass opacities, consistent with diffuse alveolar hemorrhage (DAH), leading to ICU admission and mechanical ventilation.ICU Management:Methylprednisolone, plasmapheresis (three cycles)Hemodialysis (three sessions)Antibiotics (Meropenem), blood transfusions, vasopressorsDespite intensive treatment, she developed refractory hypotension, multi-organ failure, and succumbed to cardiac arrest... This case highlights the challenges of diagnosing and managing PRS in young patients with negative autoimmune markers. Rapid progression to multi-organ failure stresses the need for better diagnostics and targeted therapies. Early recognition and a multidisciplinary approach are key, while further research is needed to improve diagnostics..."

Case report • Clinical • Acute Kidney Injury • Anemia • Cardiovascular • Endocrine Disorders • Glomerulonephritis • Hematological Disorders • Hypotension • Immunology • Lupus Nephritis • Nephrology • Pediatrics • Pulmonary Disease • Renal Disease • Thrombocytopenia

Association of Serum IL-35 and TGF-β Levels with the Incidence, Severity, and Treatment Response in Iraqi Patients with Graves' Disease. (PubMed, Iran J Pathol) - "TGF-β levels were inversely correlated with FT3, FT4, and TRAb (P < .05) and were higher in carbimazole nonresponders and in patients with severe exophthalmos (P < .05). IL-35 may serve as a promising biomarker for monitoring disease activity, prognosis, and therapeutic response in patients with GD."

Journal • Endocrine Disorders • Grave’s Disease • Immunology • Ophthalmology • IL12A • TGFB1

Neonatal hyperthyroidism in an extremely low birth weight infant born to a mother with Graves' disease. (PubMed, Clin Pediatr Endocrinol) - "Carbimazole was administered. After 1 wk of treatment, levothyroxine was added due to a rapid decline in thyroid function...NH should be considered in ELBW infants with a maternal history of Graves' disease who present with persistent tachycardia. Monitoring thyroid function may be required more closely in ELBW infants when NH management is administered."

Journal • Cardiovascular • Endocrine Disorders • Grave’s Disease

Delayed Presentation With Atypical Extrathyroidal Manifestations of Sporadic Non-autoimmune Congenital Hyperthyroidism: A Case Report and Literature Review. (PubMed, Cureus) - "Despite initial biochemical control with carbimazole, the patient experienced disease progression requiring two radioiodine ablations...The delayed clinical onset in this case, compared to the typically early presentation in SNAH, underscores the importance of considering this diagnosis even beyond infancy in cases of persistent thyrotoxicosis. Early recognition of atypical phenotypes and consideration of SNAH in differential diagnosis can prompt timely intervention, improving developmental and metabolic outcomes."

Journal • Cardiovascular • Endocrine Disorders • Immunology • Pediatrics • SNAI1 • TSHR

A rare case of McCune-Albright syndrome in a young male with hyperthyroidism and hypertrophic scars. (PubMed, Oxf Med Case Reports) - "His condition was initially misdiagnosed as osteogenesis imperfecta but the finding of hyperthyroidism reaffirms the diagnosis of MAS. He was treated with pamidronate, carbimazole and surgical operations to correct bony deformities."

Journal • Endocrine Disorders • Genetic Disorders • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain • GNAS

An update on the safety of antithyroid drugs in pregnancy: the power of real-world data. (PubMed, Expert Opin Drug Saf) - "The level of evidence has evolved within the last century and current state of the art points toward a teratogenic role of Methimazole and Carbimazole...Future research should focus on the combined use of different sources of RWD in large cohorts and across populations. Detailed assessment of exposure and outcome and considerations on other thyroidal and non-thyroidal related factors in the associations observed are important to inform and support the clinical guidance."

Journal • Real-world evidence • Review • Endocrine Disorders • Grave’s Disease

Suspected liraglutide (glucagon-like peptide-1 receptor agonist)-induced hyperthyroidism: A case report. (PubMed, Malays Fam Physician) - "Liraglutide was discontinued, and the patient was treated with carbimazole and propranolol, resulting in symptom resolution and normalisation of thyroid function within weeks. Monitoring of thyroid function should be considered in symptomatic patients. Further research is warranted to better understand the underlying mechanisms and prevalence of GLP-1 RA-induced thyroid abnormalities."

Journal • Cardiovascular • CNS Disorders • Endocrine Disorders • Grave’s Disease • Inflammation • Insomnia • Movement Disorders • Sleep Disorder

McCune-Albright syndrome with multiple hyperfunctional endocrinopathies: diagnosis, treatment, and long-term follow-up: a case report. (PubMed, Front Endocrinol (Lausanne)) - "The patient was appropriately managed with a combination of carbimazole (an imidazole), letrozole (an aromatase inhibitor), lanreotide (a somatostatin analogue), and zoledronic acid (a bisphosphonate). We describe an effective approach to treatment, emphasizing how each condition was managed while considering the interactions among the various manifestations. Given the rarity of long-term follow-up reports, this case provides valuable insights into the management of MAS in pediatric patients with complex, multisystem presentations."

Journal • Endocrine Disorders • Genetic Disorders • Pediatrics • GNAS

Hyperthyroidism in Disguise: A Case of New-Onset Atrial Fibrillation and Acute Reversible Paralysis. (PubMed, JCEM Case Rep) - "He was subsequently started on carbimazole for long-term thyroid hormone suppression. The occurrence of atrial fibrillation in TPP is an uncommon yet significant complication. Additionally, elevated lactate is an extremely rare finding."

Journal • Atrial Fibrillation • Cardiovascular • Endocrine Disorders • Grave’s Disease • Renal Disease

High grade sinonasal adenosquamous carcinoma with focal ciliated and apocrine features (ECP 2025) - "Patient had history of Asthma and Graves disease on Carbimazole... High Grade Sinonasal carcinoma with glandular and squamous differentiation are rare. Unusual features such as presence of Ciliated tumour cells as well as apocrine differentiation were seen. The differential considered included apocrine adenocarcinoma of minor salivary gland origin however GATA3 was negative."

Asthma • Endocrine Disorders • Grave’s Disease • Immunology • Oncology • Respiratory Diseases • Salivary Gland Cancer • Squamous Cell Carcinoma • AR • GATA3 • SMARCA4

Hyperthyroidism Presenting as Jaundice in a Child. (PubMed, Oman Med J) - "There is scarce data on its clinical and histological features and management. We report the case of a five-year-old girl with thyrotoxicosis associated with hepatitis, which was managed solely and successfully with carbimazole and propranolol."

Journal • Autoimmune Hepatitis • Endocrine Disorders • Hepatology • Immunology • Inflammation • Pediatrics

Unveiling the Anti-aging Activities and Mechanism of Melibiose: Insights from Metabolomics and RT-qPCR Analyses. (PubMed, Free Radic Res) - "Activation of transcription factors DAF-16, SKN-1, and HSF-1 was observed, moreover, delaying the aging process by promoting autophagy (upregulation of lgg-1 and bec-1) and mitochondrial function (upregulation of hsp-6, hsp-60, and mev-1) to resist oxidative damage. And its anti-aging signature metabolites may be Carbimazole, 4-Hydroxy-2-oxoglutaric acid, and 1,4-Dithiothreitol."

Journal • MAPK8 • SOD3

Potential Mechanisms Underlying Carbimazole-Induced Cardiotoxicity and Hepatotoxicity in Zebrafish. (PubMed, J Appl Toxicol) - "These findings demonstrate that carbimazole induces early embryonic developmental abnormalities, cardiotoxicity, and hepatotoxicity in zebrafish. This research provides new insights into carbimazole toxicity and valuable perspectives for optimizing its clinical dosing regimen."

Journal • Cardiovascular • Endocrine Disorders

Transplanted mesenchymal stem cells isolated from the bone marrow ameliorate the histological alterations in the parotid glands of hypothyroid male rats. (PubMed, Arch Oral Biol) - "Transplanted BM-MSCs resumed the normal parotid gland acinar, intercalated, striated and excretory duct structure in the hypothyroid male rats, suggesting restored tissue function."

Journal • Preclinical • Endocrine Disorders • Transplantation • ENG • PTPRC • THY1

Concurrent Ludwig's Angina and Agranulocytosis: A Two-Case Series Highlighting Diagnostic and Therapeutic Challenges. (PubMed, Cureus) - "Both patients responded well to the timely initiation of granulocyte colony-stimulating factor (G-CSF) and antimicrobial therapy, with complete resolution and neutrophil recovery by day 5-6. These cases reinforce the importance of routine hematologic monitoring in patients prescribed antithyroid drugs such as carbimazole and underscore the need for early clinical vigilance for deep neck infections in immunocompromised individuals."

Journal • Agranulocytosis • Cardiovascular • Granulocytopenia • Hematological Disorders • Infectious Disease

Hesperidin alleviates hypothyroidism-related cardiac dysfunction by targeting cardiac miRNAs, Nrf2/NF-κB signaling, oxidative stress and inflammation. (PubMed, Front Pharmacol) - "This study aimed to investigate the cardioprotective efficacy of HSD on carbimazole (CMZ)-induced hypothyroidism in rats in comparison to the traditional thyroid hormone replacement therapy; levothyroxine (LT4). Despite HSD and LT4 effectively alleviating the THs profile, only HSD offered substantial protection from hypothyroidism-associated cardiac inflammation and injury through its potent impact on the transcriptional miRNAs level and Nrf2/NF-κB protein expression (key regulators of the redox biomarkers and the inflammatory mediators). HSD provides dual thyroprotective and cardioprotective effects that enhance THs bioavailability and functionality in the cardiovascular system."

Journal • Cardiovascular • Dyslipidemia • Endocrine Disorders • Inflammation • Metabolic Disorders • MIR21 • NFKB1